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Items: 1 to 50 of 224

1.

Aged-senescent cells contribute to impaired heart regeneration.

Lewis-McDougall FC, Ruchaya PJ, Domenjo-Vila E, Shin Teoh T, Prata L, Cottle BJ, Clark JE, Punjabi PP, Awad W, Torella D, Tchkonia T, Kirkland JL, Ellison-Hughes GM.

Aging Cell. 2019 Mar 10:e12931. doi: 10.1111/acel.12931. [Epub ahead of print]

2.

Therapeutic Approaches to Aging-Reply.

Tchkonia T, Kirkland JL.

JAMA. 2019 Mar 5;321(9):901-902. doi: 10.1001/jama.2018.20554. No abstract available.

PMID:
30835305
3.

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Mar 1;38(5). pii: e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8.

4.

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.

Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R.

J Am Geriatr Soc. 2019 Mar;67(3):428-433. doi: 10.1111/jgs.15788. Epub 2019 Jan 29.

PMID:
30693953
5.

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, Prata L, Masternak MM, Kritchevsky SB, Musi N, Kirkland JL.

EBioMedicine. 2019 Feb;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 5.

6.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 Jan 3. pii: S1550-4131(18)30745-9. doi: 10.1016/j.cmet.2018.12.008. [Epub ahead of print]

7.

Mixing old and young: enhancing rejuvenation and accelerating aging.

Lau A, Kennedy BK, Kirkland JL, Tullius SG.

J Clin Invest. 2019 Jan 2;129(1):4-11. doi: 10.1172/JCI123946. Epub 2019 Jan 2. Review.

8.

Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS.

Am J Respir Cell Mol Biol. 2018 Dec 3. doi: 10.1165/rcmb.2018-0176OC. [Epub ahead of print]

PMID:
30508396
9.

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.

Larsson L, Degens H, Li M, Salviati L, Lee YI, Thompson W, Kirkland JL, Sandri M.

Physiol Rev. 2019 Jan 1;99(1):427-511. doi: 10.1152/physrev.00061.2017. Review.

PMID:
30427277
10.

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging.

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, LeBrasseur NK, Schafer MJ, Mielke MM, Kantarci K, Stewart EA, Miller VM.

Physiology (Bethesda). 2018 Nov 1;33(6):374-383. doi: 10.1152/physiol.00024.2018. Review.

PMID:
30303778
11.

Fisetin is a senotherapeutic that extends health and lifespan.

Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ.

EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.

12.

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies.

Tchkonia T, Kirkland JL.

JAMA. 2018 Oct 2;320(13):1319-1320. doi: 10.1001/jama.2018.12440. No abstract available.

PMID:
30242336
13.

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model.

Akkad H, Cacciani N, Llano-Diez M, Corpeno Kalamgi R, Tchkonia T, Kirkland JL, Larsson L.

Acta Physiol (Oxf). 2019 Feb;225(2):e13172. doi: 10.1111/apha.13172. Epub 2018 Sep 6.

PMID:
30120816
14.

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential.

Nath KA, O'Brien DR, Croatt AJ, Grande JP, Ackerman AW, Nath MC, Yamada S, Terzic A, Tchkonia T, Kirkland JL, Katusic ZS.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1493-F1499. doi: 10.1152/ajprenal.00308.2018. Epub 2018 Jul 18.

PMID:
30019935
15.

Senolytics improve physical function and increase lifespan in old age.

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL.

Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9.

16.

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer.

Ness KK, Kirkland JL, Gramatges MM, Wang Z, Kundu M, McCastlain K, Li-Harms X, Zhang J, Tchkonia T, Pluijm SMF, Armstrong GT.

J Clin Oncol. 2018 Jul 20;36(21):2206-2215. doi: 10.1200/JCO.2017.76.7467. Epub 2018 Jun 6.

PMID:
29874132
17.

Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.

Hadley EC, Kuchel GA, Newman AB, Allore HG, Bartley JM, Bergeman CS, Blinov ML, Colon-Emeric CS, Dabhar FS, Dugan LL, Dutta C, Eldadah BA, Ferrucci L, Kirkland JL, Kritchevsky SB, Lipsitz LA, Nadkarni NK, Reed MJ, Schmader KE, Sierra F, Studenski SA, Varadhan R, Walston JD, Whitson HE, Yung R.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):995. doi: 10.1093/gerona/glx172. No abstract available.

18.

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis.

Khosla S, Farr JN, Kirkland JL.

J Clin Endocrinol Metab. 2018 Apr 1;103(4):1282-1290. doi: 10.1210/jc.2017-02694. Review.

PMID:
29425296
19.

Biology of premature ageing in survivors of cancer.

Cupit-Link MC, Kirkland JL, Ness KK, Armstrong GT, Tchkonia T, LeBrasseur NK, Armenian SH, Ruddy KJ, Hashmi SK.

ESMO Open. 2017 Dec 18;2(5):e000250. doi: 10.1136/esmoopen-2017-000250. eCollection 2017. Review.

20.

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion.

Kandhaya-Pillai R, Miro-Mur F, Alijotas-Reig J, Tchkonia T, Kirkland JL, Schwartz S.

Aging (Albany NY). 2017 Nov 22;9(11):2411-2435. doi: 10.18632/aging.101328.

21.

Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384c.

PMID:
29117174
22.

Muscle-specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long-term mechanical ventilation and immobilization in rats.

Salah H, Fury W, Gromada J, Bai Y, Tchkonia T, Kirkland JL, Larsson L.

Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12980. Epub 2017 Oct 30.

PMID:
29032602
23.

Identification of HSP90 inhibitors as a novel class of senolytics.

Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, Corbo L, Tang P, Bukata C, Ring N, Giacca M, Li X, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD.

Nat Commun. 2017 Sep 4;8(1):422. doi: 10.1038/s41467-017-00314-z.

24.

The Clinical Potential of Senolytic Drugs.

Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD.

J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4.

25.

Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

26.

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.

Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC.

Hepatology. 2018 Jan;67(1):247-259. doi: 10.1002/hep.29464. Epub 2017 Nov 29.

27.

Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women.

Justice JN, Gregory H, Tchkonia T, LeBrasseur NK, Kirkland JL, Kritchevsky SB, Nicklas BJ.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):939-945. doi: 10.1093/gerona/glx134.

PMID:
28658942
28.

Cellular senescence drives age-dependent hepatic steatosis.

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D.

Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.

29.

Cellular Senescence: A Translational Perspective.

Kirkland JL, Tchkonia T.

EBioMedicine. 2017 Jul;21:21-28. doi: 10.1016/j.ebiom.2017.04.013. Epub 2017 Apr 12. Review.

30.

Bilateral Oophorectomy and Accelerated Aging: Cause or Effect?

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, Stewart EA, Miller VM.

J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1213-1217. doi: 10.1093/gerona/glx026.

31.

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463.

Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL.

Aging (Albany NY). 2017 Mar 8;9(3):955-963. doi: 10.18632/aging.101202.

32.

Cellular senescence mediates fibrotic pulmonary disease.

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK.

Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532.

33.

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty.

Stout MB, Justice JN, Nicklas BJ, Kirkland JL.

Physiology (Bethesda). 2017 Jan;32(1):9-19. Review.

34.

Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.

Singh M, Jensen MD, Lerman A, Kushwaha S, Rihal CS, Gersh BJ, Behfar A, Tchkonia T, Thomas RJ, Lennon RJ, Keenan LR, Moore AG, Kirkland JL.

J Frailty Aging. 2016;5(4):204-207.

PMID:
27883166
35.

Identification of Senescent Cells in the Bone Microenvironment.

Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Nov;31(11):1920-1929. doi: 10.1002/jbmr.2892. Epub 2016 Oct 24.

36.

Molecular pathology endpoints useful for aging studies.

Niedernhofer LJ, Kirkland JL, Ladiges W.

Ageing Res Rev. 2017 May;35:241-249. doi: 10.1016/j.arr.2016.09.012. Epub 2016 Oct 6. Review.

37.

Accelerated Accumulation of Multimorbidity After Bilateral Oophorectomy: A Population-Based Cohort Study.

Rocca WA, Gazzuola-Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, Stewart EA, Miller VM.

Mayo Clin Proc. 2016 Nov;91(11):1577-1589. doi: 10.1016/j.mayocp.2016.08.002. Epub 2016 Sep 29.

38.

Strategies and Challenges in Clinical Trials Targeting Human Aging.

Newman JC, Milman S, Hashmi SK, Austad SN, Kirkland JL, Halter JB, Barzilai N.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1424-1434. Epub 2016 Aug 16.

39.

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience.

Huffman DM, Justice JN, Stout MB, Kirkland JL, Barzilai N, Austad SN.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1395-1406. Epub 2016 Aug 16.

40.

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes.

Justice J, Miller JD, Newman JC, Hashmi SK, Halter J, Austad SN, Barzilai N, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1415-1423. Epub 2016 Aug 16.

41.

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.

Burd CE, Gill MS, Niedernhofer LJ, Robbins PD, Austad SN, Barzilai N, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1388-1394. Epub 2016 Aug 16.

42.

Resilience in Aging Mice.

Kirkland JL, Stout MB, Sierra F.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1407-1414. Epub 2016 Aug 16.

43.

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.

Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO, Lowe V, Tchkonia T, Westendorf JJ, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):780-785. doi: 10.1093/gerona/glw154.

44.

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.

Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ.

Sci Signal. 2016 Aug 9;9(440):ra79. doi: 10.1126/scisignal.aaf3273.

45.

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction.

Xu M, Tchkonia T, Kirkland JL.

Pharmacol Res. 2016 Sep;111:152-154. doi: 10.1016/j.phrs.2016.05.015. Epub 2016 May 27. Review.

46.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

47.

Translating the Science of Aging into Therapeutic Interventions.

Kirkland JL.

Cold Spring Harb Perspect Med. 2016 Mar 1;6(3):a025908. doi: 10.1101/cshperspect.a025908. Review.

48.

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine.

Palmer AK, Kirkland JL.

Exp Gerontol. 2016 Dec 15;86:97-105. doi: 10.1016/j.exger.2016.02.013. Epub 2016 Feb 26. Review.

49.

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.

Roos CM, Zhang B, Palmer AK, Ogrodnik MB, Pirtskhalava T, Thalji NM, Hagler M, Jurk D, Smith LA, Casaclang-Verzosa G, Zhu Y, Schafer MJ, Tchkonia T, Kirkland JL, Miller JD.

Aging Cell. 2016 Oct;15(5):973-7. doi: 10.1111/acel.12458. Epub 2016 Aug 5.

50.

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization.

Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):3-15. Epub 2016 Jan 24.

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