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Items: 1 to 50 of 236

1.

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.

Suvakov S, Cubro H, White WM, Butler Tobah YS, Weissgerber TL, Jordan KL, Zhu XY, Woollard JR, Chebib FT, Milic NM, Grande JP, Xu M, Tchkonia T, Kirkland JL, Lerman LO, Garovic VD.

Biol Sex Differ. 2019 Sep 14;10(1):49. doi: 10.1186/s13293-019-0263-5.

2.

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity.

Colon G, Saccon T, Schneider A, Cavalcante MB, Huffman DM, Berryman D, List E, Ikeno Y, Musi N, Bartke A, Kopchick J, Kirkland JL, Tchkonia T, Masternak MM.

Geroscience. 2019 Sep 4. doi: 10.1007/s11357-019-00096-w. [Epub ahead of print] Review.

PMID:
31485887
3.

Cellular senescence: at the nexus between ageing and diabetes.

Palmer AK, Gustafson B, Kirkland JL, Smith U.

Diabetologia. 2019 Oct;62(10):1835-1841. doi: 10.1007/s00125-019-4934-x. Epub 2019 Aug 27. Review.

4.

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin.

Kim SR, Jiang K, Ogrodnik M, Chen X, Zhu XY, Lohmeier H, Ahmed L, Tang H, Tchkonia T, Hickson LJ, Kirkland JL, Lerman LO.

Transl Res. 2019 Jul 15. pii: S1931-5244(19)30138-0. doi: 10.1016/j.trsl.2019.07.005. [Epub ahead of print]

PMID:
31356770
5.

Creating the Next Generation of Translational Geroscientists.

Newman JC, Sokoloski JL, Robbins PD, Niedernhofer LJ, Reed MJ, Wei J, Austad SN, Barzilai N, Cohen HJ, Kuchel GA, Kirkland JL, Pignolo RJ.

J Am Geriatr Soc. 2019 Sep;67(9):1934-1939. doi: 10.1111/jgs.16055. Epub 2019 Jul 9.

PMID:
31287934
6.

Proceedings of the Canadian Frailty Network Workshop: Identifying Biomarkers of Frailty to Support Frailty Risk Assessment, Diagnosis and Prognosis. Toronto, January 15, 2018.

Muscedere J, Kim PM, Afilalo J, Balion C, Baracos VE, Bowdish D, Cesari M, Erusalimsky JD, Fülöp T, Heckman G, Howlett SE, Khadaroo RG, Kirkland JL, Rodriguez Mañas L, Marzetti E, Paré G, Raina P, Rockwood K, Sinclair A, Skappak C, Verschoor C, Walter S.

J Frailty Aging. 2019;8(3):106-116. doi: 10.14283/jfa.2019.12.

PMID:
31237310
7.

Senescent cell clearance by the immune system: Emerging therapeutic opportunities.

Prata LGPL, Ovsyannikova IG, Tchkonia T, Kirkland JL.

Semin Immunol. 2019 May 11:101275. doi: 10.1016/j.smim.2019.04.003. [Epub ahead of print] Review.

PMID:
31088710
8.

Short-term calorie restriction and 17α-estradiol administration elicit divergent effects on proteostatic processes and protein content in metabolically active tissues.

Miller BF, Pharaoh GA, Hamilton KL, Peelor FF, Kirkland JL, Freeman WM, Mann SN, Kinter M, Price JC, Stout MB.

J Gerontol A Biol Sci Med Sci. 2019 May 10. pii: glz113. doi: 10.1093/gerona/glz113. [Epub ahead of print]

PMID:
31074767
9.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 May 7;29(5):1233. doi: 10.1016/j.cmet.2019.01.013. No abstract available.

10.

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline.

Chini C, Hogan KA, Warner GM, Tarragó MG, Peclat TR, Tchkonia T, Kirkland JL, Chini E.

Biochem Biophys Res Commun. 2019 May 28;513(2):486-493. doi: 10.1016/j.bbrc.2019.03.199. Epub 2019 Apr 8.

11.

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans.

Farr JN, Rowsey JL, Eckhardt BA, Thicke BS, Fraser DG, Tchkonia T, Kirkland JL, Monroe DG, Khosla S.

J Bone Miner Res. 2019 Aug;34(8):1407-1418. doi: 10.1002/jbmr.3729. Epub 2019 Jun 21.

PMID:
30913313
12.

Targeting senescent cells alleviates obesity-induced metabolic dysfunction.

Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL.

Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111/acel.12950. Epub 2019 Mar 25.

13.

Aged-senescent cells contribute to impaired heart regeneration.

Lewis-McDougall FC, Ruchaya PJ, Domenjo-Vila E, Shin Teoh T, Prata L, Cottle BJ, Clark JE, Punjabi PP, Awad W, Torella D, Tchkonia T, Kirkland JL, Ellison-Hughes GM.

Aging Cell. 2019 Jun;18(3):e12931. doi: 10.1111/acel.12931. Epub 2019 Mar 10.

14.

Therapeutic Approaches to Aging-Reply.

Tchkonia T, Kirkland JL.

JAMA. 2019 Mar 5;321(9):901-902. doi: 10.1001/jama.2018.20554. No abstract available.

PMID:
30835305
15.

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Mar 1;38(5). pii: e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8.

16.

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.

Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R.

J Am Geriatr Soc. 2019 Mar;67(3):428-433. doi: 10.1111/jgs.15788. Epub 2019 Jan 29.

PMID:
30693953
17.

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, Prata L, Masternak MM, Kritchevsky SB, Musi N, Kirkland JL.

EBioMedicine. 2019 Feb;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 5.

18.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 May 7;29(5):1061-1077.e8. doi: 10.1016/j.cmet.2018.12.008. Epub 2019 Jan 3. Erratum in: Cell Metab. 2019 May 7;29(5):1233.

19.

Mixing old and young: enhancing rejuvenation and accelerating aging.

Lau A, Kennedy BK, Kirkland JL, Tullius SG.

J Clin Invest. 2019 Jan 2;129(1):4-11. doi: 10.1172/JCI123946. Epub 2019 Jan 2. Review.

20.

Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):51-60. doi: 10.1165/rcmb.2018-0176OC.

PMID:
30508396
21.

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.

Larsson L, Degens H, Li M, Salviati L, Lee YI, Thompson W, Kirkland JL, Sandri M.

Physiol Rev. 2019 Jan 1;99(1):427-511. doi: 10.1152/physrev.00061.2017. Review.

PMID:
30427277
22.

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging.

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, LeBrasseur NK, Schafer MJ, Mielke MM, Kantarci K, Stewart EA, Miller VM.

Physiology (Bethesda). 2018 Nov 1;33(6):374-383. doi: 10.1152/physiol.00024.2018. Review.

PMID:
30303778
23.

Fisetin is a senotherapeutic that extends health and lifespan.

Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ.

EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.

24.

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies.

Tchkonia T, Kirkland JL.

JAMA. 2018 Oct 2;320(13):1319-1320. doi: 10.1001/jama.2018.12440. No abstract available.

PMID:
30242336
25.

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model.

Akkad H, Cacciani N, Llano-Diez M, Corpeno Kalamgi R, Tchkonia T, Kirkland JL, Larsson L.

Acta Physiol (Oxf). 2019 Feb;225(2):e13172. doi: 10.1111/apha.13172. Epub 2018 Sep 6.

PMID:
30120816
26.

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential.

Nath KA, O'Brien DR, Croatt AJ, Grande JP, Ackerman AW, Nath MC, Yamada S, Terzic A, Tchkonia T, Kirkland JL, Katusic ZS.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1493-F1499. doi: 10.1152/ajprenal.00308.2018. Epub 2018 Jul 18.

PMID:
30019935
27.

Senolytics improve physical function and increase lifespan in old age.

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL.

Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9.

28.

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer.

Ness KK, Kirkland JL, Gramatges MM, Wang Z, Kundu M, McCastlain K, Li-Harms X, Zhang J, Tchkonia T, Pluijm SMF, Armstrong GT.

J Clin Oncol. 2018 Jul 20;36(21):2206-2215. doi: 10.1200/JCO.2017.76.7467. Epub 2018 Jun 6.

29.

Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.

Hadley EC, Kuchel GA, Newman AB, Allore HG, Bartley JM, Bergeman CS, Blinov ML, Colon-Emeric CS, Dabhar FS, Dugan LL, Dutta C, Eldadah BA, Ferrucci L, Kirkland JL, Kritchevsky SB, Lipsitz LA, Nadkarni NK, Reed MJ, Schmader KE, Sierra F, Studenski SA, Varadhan R, Walston JD, Whitson HE, Yung R.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):995. doi: 10.1093/gerona/glx172. No abstract available.

30.

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis.

Khosla S, Farr JN, Kirkland JL.

J Clin Endocrinol Metab. 2018 Apr 1;103(4):1282-1290. doi: 10.1210/jc.2017-02694. Review.

31.

Biology of premature ageing in survivors of cancer.

Cupit-Link MC, Kirkland JL, Ness KK, Armstrong GT, Tchkonia T, LeBrasseur NK, Armenian SH, Ruddy KJ, Hashmi SK.

ESMO Open. 2017 Dec 18;2(5):e000250. doi: 10.1136/esmoopen-2017-000250. eCollection 2017. Review.

32.

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion.

Kandhaya-Pillai R, Miro-Mur F, Alijotas-Reig J, Tchkonia T, Kirkland JL, Schwartz S.

Aging (Albany NY). 2017 Nov 22;9(11):2411-2435. doi: 10.18632/aging.101328.

33.

Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384c.

PMID:
29117174
34.

Muscle-specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long-term mechanical ventilation and immobilization in rats.

Salah H, Fury W, Gromada J, Bai Y, Tchkonia T, Kirkland JL, Larsson L.

Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12980. Epub 2017 Oct 30.

PMID:
29032602
35.

Identification of HSP90 inhibitors as a novel class of senolytics.

Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, Corbo L, Tang P, Bukata C, Ring N, Giacca M, Li X, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD.

Nat Commun. 2017 Sep 4;8(1):422. doi: 10.1038/s41467-017-00314-z.

36.

The Clinical Potential of Senolytic Drugs.

Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD.

J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4.

37.

Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

38.

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.

Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC.

Hepatology. 2018 Jan;67(1):247-259. doi: 10.1002/hep.29464. Epub 2017 Nov 29.

39.

Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women.

Justice JN, Gregory H, Tchkonia T, LeBrasseur NK, Kirkland JL, Kritchevsky SB, Nicklas BJ.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):939-945. doi: 10.1093/gerona/glx134.

40.

Cellular senescence drives age-dependent hepatic steatosis.

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D.

Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.

41.

Cellular Senescence: A Translational Perspective.

Kirkland JL, Tchkonia T.

EBioMedicine. 2017 Jul;21:21-28. doi: 10.1016/j.ebiom.2017.04.013. Epub 2017 Apr 12. Review.

42.

Bilateral Oophorectomy and Accelerated Aging: Cause or Effect?

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, Stewart EA, Miller VM.

J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1213-1217. doi: 10.1093/gerona/glx026.

43.

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463.

Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL.

Aging (Albany NY). 2017 Mar 8;9(3):955-963. doi: 10.18632/aging.101202.

44.

Cellular senescence mediates fibrotic pulmonary disease.

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK.

Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532.

45.

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty.

Stout MB, Justice JN, Nicklas BJ, Kirkland JL.

Physiology (Bethesda). 2017 Jan;32(1):9-19. Review.

46.

Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.

Singh M, Jensen MD, Lerman A, Kushwaha S, Rihal CS, Gersh BJ, Behfar A, Tchkonia T, Thomas RJ, Lennon RJ, Keenan LR, Moore AG, Kirkland JL.

J Frailty Aging. 2016;5(4):204-207.

PMID:
27883166
47.

Identification of Senescent Cells in the Bone Microenvironment.

Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Nov;31(11):1920-1929. doi: 10.1002/jbmr.2892. Epub 2016 Oct 24.

48.

Molecular pathology endpoints useful for aging studies.

Niedernhofer LJ, Kirkland JL, Ladiges W.

Ageing Res Rev. 2017 May;35:241-249. doi: 10.1016/j.arr.2016.09.012. Epub 2016 Oct 6. Review.

49.

Accelerated Accumulation of Multimorbidity After Bilateral Oophorectomy: A Population-Based Cohort Study.

Rocca WA, Gazzuola-Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, Stewart EA, Miller VM.

Mayo Clin Proc. 2016 Nov;91(11):1577-1589. doi: 10.1016/j.mayocp.2016.08.002. Epub 2016 Sep 29.

50.

Strategies and Challenges in Clinical Trials Targeting Human Aging.

Newman JC, Milman S, Hashmi SK, Austad SN, Kirkland JL, Halter JB, Barzilai N.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1424-1434. Epub 2016 Aug 16.

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