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Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model.

Natoni A, Farrell ML, Harris S, Falank C, Kirkham-McCarthy L, Macauley MS, Reagan MR, O'Dwyer M.

Haematologica. 2020 Jan 31;105(2):457-467. doi: 10.3324/haematol.2018.212266. Print 2020.


A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice.

Suelves N, Kirkham-McCarthy L, Lahue RS, Ginés S.

Sci Rep. 2017 Jul 20;7(1):6082. doi: 10.1038/s41598-017-05125-2.


E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271.

Natoni A, Smith TAG, Keane N, McEllistrim C, Connolly C, Jha A, Andrulis M, Ellert E, Raab MS, Glavey SV, Kirkham-McCarthy L, Kumar SK, Locatelli-Hoops SC, Oliva I, Fogler WE, Magnani JL, O'Dwyer ME.

Leukemia. 2017 Dec;31(12):2642-2651. doi: 10.1038/leu.2017.123. Epub 2017 Apr 25.


The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.

Ye Y, Kirkham-McCarthy L, Lahue RS.

DNA Repair (Amst). 2016 Jul;43:1-8. doi: 10.1016/j.dnarep.2016.04.012. Epub 2016 May 2.


Histone deacetylase complexes promote trinucleotide repeat expansions.

Debacker K, Frizzell A, Gleeson O, Kirkham-McCarthy L, Mertz T, Lahue RS.

PLoS Biol. 2012 Feb;10(2):e1001257. doi: 10.1371/journal.pbio.1001257. Epub 2012 Feb 21.

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