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Items: 25


Report of the international conference on manufacturing and testing of pluripotent stem cells.

Abbot S, Agbanyo F, Ahlfors JE, Baghbaderani BA, Bartido S, Bharti K, Burke C, Carlsson B, Cavagnaro J, Creasey A, DiGiusto D, Francissen K, Gaffney A, Goldring C, Gorba T, Griffiths E, Hanatani T, Hayakawa T, Heki T, Hoogendoorn K, Kawamata S, Kimura H, Kirkeby A, Knezevic I, Lebkowski J, Lin S, Lin-Gibson S, Lubiniecki A, O'Shea O, Pera M, Petricciani J, Pigeau G, Ratcliffe A, Sato Y, Schumann GG, Shingleton W, Stacey Chair G, Sullivan S, Svendsen CN, Trouvin JH, Vandeputte J, Yuan BZ, Zoon K.

Biologicals. 2018 Nov;56:67-83. doi: 10.1016/j.biologicals.2018.08.004. Epub 2018 Aug 24.


Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats.

Cardoso T, Adler AF, Mattsson B, Hoban DB, Nolbrant S, Wahlestedt JN, Kirkeby A, Grealish S, Björklund A, Parmar M.

J Comp Neurol. 2018 Sep 1;526(13):2133-2146. doi: 10.1002/cne.24500. Epub 2018 Jul 31.


A symphony of stem cells in Vienna - looking to the future.

Porrello ER, Kirkeby A.

Development. 2018 Jun 8;145(11). pii: dev163501. doi: 10.1242/dev.163501.


Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis.

Mondal T, Juvvuna PK, Kirkeby A, Mitra S, Kosalai ST, Traxler L, Hertwig F, Wernig-Zorc S, Miranda C, Deland L, Volland R, Bartenhagen C, Bartsch D, Bandaru S, Engesser A, Subhash S, Martinsson T, Carén H, Akyürek LM, Kurian L, Kanduri M, Huarte M, Kogner P, Fischer M, Kanduri C.

Cancer Cell. 2018 Mar 12;33(3):417-434.e7. doi: 10.1016/j.ccell.2018.01.020.


IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells.

Lehnen D, Barral S, Cardoso T, Grealish S, Heuer A, Smiyakin A, Kirkeby A, Kollet J, Cremer H, Parmar M, Bosio A, Knöbel S.

Stem Cell Reports. 2017 Oct 10;9(4):1207-1220. doi: 10.1016/j.stemcr.2017.08.016. Epub 2017 Sep 21.


Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation.

Nolbrant S, Heuer A, Parmar M, Kirkeby A.

Nat Protoc. 2017 Sep;12(9):1962-1979. doi: 10.1038/nprot.2017.078. Epub 2017 Aug 31.


Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications.

Moraghebi R, Kirkeby A, Chaves P, Rönn RE, Sitnicka E, Parmar M, Larsson M, Herbst A, Woods NB.

Stem Cell Res Ther. 2017 Aug 25;8(1):190. doi: 10.1186/s13287-017-0582-6.


Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD).

Kirkeby A, Parmar M, Barker RA.

Prog Brain Res. 2017;230:165-190. doi: 10.1016/bs.pbr.2016.11.011. Epub 2017 Feb 7.


Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.

Kee N, Volakakis N, Kirkeby A, Dahl L, Storvall H, Nolbrant S, Lahti L, Björklund ÅK, Gillberg L, Joodmardi E, Sandberg R, Parmar M, Perlmann T.

Cell Stem Cell. 2017 Jan 5;20(1):29-40. doi: 10.1016/j.stem.2016.10.003. Epub 2016 Oct 27.


Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.

Kirkeby A, Nolbrant S, Tiklova K, Heuer A, Kee N, Cardoso T, Ottosson DR, Lelos MJ, Rifes P, Dunnett SB, Grealish S, Perlmann T, Parmar M.

Cell Stem Cell. 2017 Jan 5;20(1):135-148. doi: 10.1016/j.stem.2016.09.004. Epub 2016 Oct 27.


The stem cell niche finds its true north.

Kirkeby A, Perlmann T, Pereira CF.

Development. 2016 Aug 15;143(16):2877-81. doi: 10.1242/dev.140095. Review.


hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation.

Heuer A, Kirkeby A, Pfisterer U, Jönsson ME, Parmar M.

Exp Neurol. 2016 Aug;282:78-85. doi: 10.1016/j.expneurol.2016.05.027. Epub 2016 May 25.


Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

Barker RA, Parmar M, Kirkeby A, Björklund A, Thompson L, Brundin P.

J Parkinsons Dis. 2016;6(1):57-63. doi: 10.3233/JPD-160798.


Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.

Jönsson ME, Nelander Wahlestedt J, Åkerblom M, Kirkeby A, Malmevik J, Brattaas PL, Jakobsson J, Parmar M.

Development. 2015 Sep 15;142(18):3166-77. doi: 10.1242/dev.122747.


Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons.

Grealish S, Heuer A, Cardoso T, Kirkeby A, Jönsson M, Johansson J, Björklund A, Jakobsson J, Parmar M.

Stem Cell Reports. 2015 Jun 9;4(6):975-83. doi: 10.1016/j.stemcr.2015.04.011. Epub 2015 May 21.


Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease.

Grealish S, Diguet E, Kirkeby A, Mattsson B, Heuer A, Bramoulle Y, Van Camp N, Perrier AL, Hantraye P, Björklund A, Parmar M.

Cell Stem Cell. 2014 Nov 6;15(5):653-65. doi: 10.1016/j.stem.2014.09.017. Epub 2014 Nov 6.


Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.

Kirkeby A, Nelander J, Parmar M.

Front Cell Neurosci. 2013 Jan 3;6:64. doi: 10.3389/fncel.2012.00064. eCollection 2012.


Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.

Kirkeby A, Grealish S, Wolf DA, Nelander J, Wood J, Lundblad M, Lindvall O, Parmar M.

Cell Rep. 2012 Jun 28;1(6):703-14. doi: 10.1016/j.celrep.2012.04.009. Epub 2012 May 26.


Direct conversion of human fibroblasts to dopaminergic neurons.

Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10343-8. doi: 10.1073/pnas.1105135108. Epub 2011 Jun 6.


Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.

Sachdeva R, Jönsson ME, Nelander J, Kirkeby A, Guibentif C, Gentner B, Naldini L, Björklund A, Parmar M, Jakobsson J.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11602-7. doi: 10.1073/pnas.1006568107. Epub 2010 Jun 7.


The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy.

Leist M, Bremer S, Brundin P, Hescheler J, Kirkeby A, Krause KH, Poerzgen P, Puceat M, Schmidt M, Schrattenholz A, Zak NB, Hentze H.

ALTEX. 2008;25(3):163-90.


Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits.

Lapchak PA, Kirkeby A, Zivin JA, Sager TN.

Brain Res. 2008 Oct 31;1238:208-14. doi: 10.1016/j.brainres.2008.08.017. Epub 2008 Aug 16.


High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO).

Kirkeby A, Torup L, Bochsen L, Kjalke M, Abel K, Theilgaard-Monch K, Johansson PI, Bjørn SE, Gerwien J, Leist M.

Thromb Haemost. 2008 Apr;99(4):720-8. doi: 10.1160/TH07-03-0208.


Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor.

Kirkeby A, van Beek J, Nielsen J, Leist M, Helboe L.

J Neurosci Methods. 2007 Aug 15;164(1):50-8. Epub 2007 Apr 12.


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