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Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.

Kirkby NS, Raouf J, Ahmetaj-Shala B, Liu B, Mazi SI, Edin ML, Chambers MG, Korotkova M, Wang X, Wahli W, Zeldin DC, Nüsing R, Zhou Y, Jakobsson PJ, Mitchell JA.

Cardiovasc Res. 2019 Nov 5. pii: cvz290. doi: 10.1093/cvr/cvz290. [Epub ahead of print]


Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox.

Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR, Kirkby NS.

Circ Res. 2019 Oct 11;125(9):847-854. doi: 10.1161/CIRCRESAHA.119.314927. Epub 2019 Sep 12.


Mechanistic modelling supports entwined rather than exclusively competitive DNA double-strand break repair pathway.

Ingram SP, Warmenhoven JW, Henthorn NT, Smith EAK, Chadwick AL, Burnet NG, Mackay RI, Kirkby NF, Kirkby KJ, Merchant MJ.

Sci Rep. 2019 Apr 23;9(1):6359. doi: 10.1038/s41598-019-42901-8.


Imaging of Tissue-Specific and Temporal Activation of GPCR Signaling Using DREADD Knock-In Mice.

Akhmedov D, Kirkby NS, Mitchell JA, Berdeaux R.

Methods Mol Biol. 2019;1947:361-376. doi: 10.1007/978-1-4939-9121-1_21.


Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping.

Ahmetaj-Shala B, Olanipekun M, Tesfai A, MacCallum N, Kirkby NS, Quinlan GJ, Shih CC, Kawai R, Mumby S, Paul-Clark M, Want EJ, Mitchell JA.

Sci Rep. 2018 Sep 18;8(1):13987. doi: 10.1038/s41598-018-31055-8.


Impact of CMV PCR Blips in Recipients of Solid Organ and Hematopoietic Stem Cell Transplantation.

Lodding IP, Mocroft A, da Cunha Bang C, Gustafsson F, Iversen M, Kirkby N, Perch M, Rasmussen A, Sengeløv H, Sørensen SS, Lundgren JD.

Transplant Direct. 2018 May 16;4(6):e355. doi: 10.1097/TXD.0000000000000787. eCollection 2018 Jun.


Cytomegalovirus (CMV) Disease Despite Weekly Preemptive CMV Strategy for Recipients of Solid Organ and Hematopoietic Stem Cell Transplantation.

Lodding IP, da Cunha Bang C, Sørensen SS, Gustafsson F, Iversen M, Kirkby N, Perch M, Rasmussen A, Sengeløv H, Mocroft A, Lundgren JD.

Open Forum Infect Dis. 2018 Apr 17;5(5):ofy080. doi: 10.1093/ofid/ofy080. eCollection 2018 May.


The value of EBV DNA in early detection of post-transplant lymphoproliferative disorders among solid organ and hematopoietic stem cell transplant recipients.

Wareham NE, Mocroft A, Sengeløv H, Da Cunha-Bang C, Gustafsson F, Heilmann C, Iversen M, Kirkby NS, Rasmussen A, Sørensen SS, Lundgren JD; MATCH in PERSIMUNE study group.

J Cancer Res Clin Oncol. 2018 Aug;144(8):1569-1580. doi: 10.1007/s00432-018-2674-9. Epub 2018 May 26.


Cytomegalovirus-Specific CD4+ T-cell Responses and CMV-IgG Levels Are Associated With Neurocognitive Impairment in People Living With HIV.

Ballegaard V, Pedersen KK, Pedersen M, Brændstrup P, Kirkby N, Buus AS, Ryder LP, Gerstoft J, Nielsen SD.

J Acquir Immune Defic Syndr. 2018 Sep 1;79(1):117-125. doi: 10.1097/QAI.0000000000001753.


Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment".

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 May 11;122(10):e84-e85. doi: 10.1161/CIRCRESAHA.118.312976. No abstract available.


Impact of Oral Hygiene Discontinuation on Supragingival and Salivary Microbiomes.

Belstrøm D, Sembler-Møller ML, Grande MA, Kirkby N, Cotton SL, Paster BJ, Twetman S, Holmstrup P.

JDR Clin Trans Res. 2018 Jan;3(1):57-64. doi: 10.1177/2380084417723625. Epub 2017 Jul 31.


Influence of periodontal treatment on subgingival and salivary microbiotas.

Belstrøm D, Grande MA, Sembler-Møller ML, Kirkby N, Cotton SL, Paster BJ, Holmstrup P.

J Periodontol. 2018 May;89(5):531-539. doi: 10.1002/JPER.17-0377. Epub 2018 Apr 23.


Cytomegalovirus-specific T-cells are associated with immune senescence, but not with systemic inflammation, in people living with HIV.

Ballegaard V, Brændstrup P, Pedersen KK, Kirkby N, Stryhn A, Ryder LP, Gerstoft J, Nielsen SD.

Sci Rep. 2018 Feb 28;8(1):3778. doi: 10.1038/s41598-018-21347-4.


Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system.

Mitchell JA, Kirkby NS.

Br J Pharmacol. 2019 Apr;176(8):1038-1050. doi: 10.1111/bph.14167. Epub 2018 Apr 14. Review.


Mathematical Modelling for Patient Selection in Proton Therapy.

Mee T, Kirkby NF, Kirkby KJ.

Clin Oncol (R Coll Radiol). 2018 May;30(5):299-306. doi: 10.1016/j.clon.2018.01.007. Epub 2018 Feb 14.


Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo.

Lee SY, Chang WL, Li ZX, Kirkby NS, Tsai WC, Huang SF, Ou CH, Chang TC.

Phytomedicine. 2018 Jan 1;38:183-191. doi: 10.1016/j.phymed.2017.12.003. Epub 2017 Dec 6.


In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density.

Henthorn NT, Warmenhoven JW, Sotiropoulos M, Mackay RI, Kirkby NF, Kirkby KJ, Merchant MJ.

Sci Rep. 2018 Feb 8;8(1):2654. doi: 10.1038/s41598-018-21111-8.


Tumour Volume and Dose Influence Outcome after Surgery and High-dose Photon Radiotherapy for Chordoma and Chondrosarcoma of the Skull Base and Spine.

Gatfield ER, Noble DJ, Barnett GC, Early NY, Hoole ACF, Kirkby NF, Jefferies SJ, Burnet NG.

Clin Oncol (R Coll Radiol). 2018 Apr;30(4):243-253. doi: 10.1016/j.clon.2018.01.002.


Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3.


Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway.

Kirkby NS, Sampaio W, Etelvino G, Alves DT, Anders KL, Temponi R, Shala F, Nair AS, Ahmetaj-Shala B, Jiao J, Herschman HR, Wang X, Wahli W, Santos RA, Mitchell JA.

Hypertension. 2018 Feb;71(2):297-305. doi: 10.1161/HYPERTENSIONAHA.117.09906. Epub 2018 Jan 2. Erratum in: Hypertension. 2018 Mar;71(3):e10.


Melaleuca alternifolia Induces Heme Oxygenase-1 Expression in Murine RAW264.7 Cells through Activation of the Nrf2-ARE Pathway.

Lee SY, Chen PY, Lin JC, Kirkby NS, Ou CH, Chang TC.

Am J Chin Med. 2017;45(8):1631-1648. doi: 10.1142/S0192415X17500884. Epub 2017 Nov 9.


Aerobic exercise training lowers platelet reactivity and improves platelet sensitivity to prostacyclin in pre- and postmenopausal women.

Lundberg Slingsby MH, Nyberg M, Egelund J, Mandrup CM, Frikke-Schmidt R, Kirkby NS, Hellsten Y.

J Thromb Haemost. 2017 Dec;15(12):2419-2431. doi: 10.1111/jth.13866. Epub 2017 Oct 27.


Cytomegalovirus Viral Load in Bronchoalveolar Lavage to Diagnose Lung Transplant Associated CMV Pneumonia.

Lodding IP, Schultz HH, Jensen JU, Kirkby N, Perch M, Andersen C, Lundgren JD, Iversen M.

Transplantation. 2018 Feb;102(2):326-332. doi: 10.1097/TP.0000000000001927.


Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways.

Tesfai A, MacCallum N, Kirkby NS, Gashaw H, Gray N, Want E, Quinlan GJ, Mumby S, Leiper JM, Paul-Clark M, Ahmetaj-Shala B, Mitchell JA.

PLoS One. 2017 Aug 15;12(8):e0183025. doi: 10.1371/journal.pone.0183025. eCollection 2017.


Microbial profile comparisons of saliva, pooled and site-specific subgingival samples in periodontitis patients.

Belstrøm D, Sembler-Møller ML, Grande MA, Kirkby N, Cotton SL, Paster BJ, Holmstrup P.

PLoS One. 2017 Aug 11;12(8):e0182992. doi: 10.1371/journal.pone.0182992. eCollection 2017.


Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy.

Mohamed NA, Davies RP, Lickiss PD, Ahmetaj-Shala B, Reed DM, Gashaw HH, Saleem H, Freeman GR, George PM, Wort SJ, Morales-Cano D, Barreira B, Tetley TD, Chester AH, Yacoub MH, Kirkby NS, Moreno L, Mitchell JA.

Pulm Circ. 2017 Jul-Sep;7(3):643-653. doi: 10.1177/2045893217710224. Epub 2017 Jun 27.


Salivary microbiota in individuals with different levels of caries experience.

Belstrøm D, Holmstrup P, Fiehn NE, Kirkby N, Kokaras A, Paster BJ, Bardow A.

J Oral Microbiol. 2017 Jan 23;9(1):1270614. doi: 10.1080/20002297.2016.1270614. eCollection 2017.


Soluble CD52 is an indicator of disease activity in chronic lymphocytic leukemia.

Vojdeman FJ, Herman SEM, Kirkby N, Wiestner A, van T' Veer MB, Tjønnfjord GE, Itälä-Remes MA, Kimby E, Farooqui MZ, Polliack A, Wu KL, Doorduijn JK, Alemayehu WG, Wittebol S, Kozak T, Walewski J, Abrahamse-Testroote MCJ, van Oers MHJ, Geisler CH, Niemann CU.

Leuk Lymphoma. 2017 Oct;58(10):2356-2362. doi: 10.1080/10428194.2017.1285027. Epub 2017 Feb 7.


Differential role of pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes.

Parzych K, Zetterqvist AV, Wright WR, Kirkby NS, Mitchell JA, Paul-Clark MJ.

FASEB J. 2017 Jun;31(6):2439-2445. doi: 10.1096/fj.201600256. Epub 2017 Feb 28.


Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing.

Ahmetaj-Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan MV, Gashaw H, Galaris G, Mazi S, Warner TD, Kirkby NS, Mitchell JA.

Biochem Biophys Res Commun. 2017 Mar 18;484(4):762-766. doi: 10.1016/j.bbrc.2017.01.161. Epub 2017 Jan 31.


Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling.

Miller E, Czopek A, Duthie KM, Kirkby NS, van de Putte EE, Christen S, Kimmitt RA, Moorhouse R, Castellan RF, Kotelevtsev YV, Kuc RE, Davenport AP, Dhaun N, Webb DJ, Hadoke PW.

Hypertension. 2017 Feb;69(2):275-285. doi: 10.1161/HYPERTENSIONAHA.115.07031. Epub 2016 Dec 27.


Using the Malthus programme to predict the recruitment of patients to MR-linac research trials in prostate and lung cancer.

Sanderson B, McWilliam A, Faivre-Finn C, Kirkby NF, Jena R, Mee T, Choudhury A.

Radiother Oncol. 2017 Jan;122(1):159-162. doi: 10.1016/j.radonc.2016.11.014. Epub 2016 Dec 7.


Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD.

FASEB J. 2016 Dec;30(12):4256-4266. Epub 2016 Sep 15.


Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis.

Kirkby NS, Tesfai A, Ahmetaj-Shala B, Gashaw HH, Sampaio W, Etelvino G, Leão NM, Santos RA, Mitchell JA.

FASEB J. 2016 Dec;30(12):4172-4179. Epub 2016 Sep 6.


A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension.

Mohamed NA, Ahmetaj-Shala B, Duluc L, Mackenzie LS, Kirkby NS, Reed DM, Lickiss PD, Davies RP, Freeman GR, Wojciak-Stothard B, Chester AH, El-Sherbiny IM, Mitchell JA, Yacoub MH.

J Cardiovasc Transl Res. 2016 Apr;9(2):162-4. doi: 10.1007/s12265-016-9684-2. Epub 2016 Mar 9.


Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis.

Paul-Clark M, Elsheikh W, Kirkby N, Chan M, Devchand P, Agbor TA, Flannigan KL, Cheadle C, Freydin M, Ianaro A, Mitchell JA, Wallace JL.

PLoS One. 2016 Feb 24;11(2):e0147289. doi: 10.1371/journal.pone.0147289. eCollection 2016.


Modelling and Bayesian adaptive prediction of individual patients' tumour volume change during radiotherapy.

Tariq I, Chen T, Kirkby NF, Jena R.

Phys Med Biol. 2016 Mar 7;61(5):2145-61.


Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways.

Kirkby NS, Chan MV, Zaiss AK, Garcia-Vaz E, Jiao J, Berglund LM, Verdu EF, Ahmetaj-Shala B, Wallace JL, Herschman HR, Gomez MF, Mitchell JA.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):434-9. doi: 10.1073/pnas.1517642113. Epub 2015 Dec 28.


Hyaluronic Acid Assays: Turbidimetric or Enzyme-Based Immune Assay? A Method Comparison Study.

Itenov TS, Kirkby NS, Bestle MH, Nilsson AC, Erlandsen EJ, Peters L, Jensen JU.

J Clin Lab Anal. 2016 Sep;30(5):524-8. doi: 10.1002/jcla.21897. Epub 2015 Dec 14.


P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation.

Chan MV, Knowles RB, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PC, Mitchell JA, Warner TD.

Br J Clin Pharmacol. 2016 Apr;81(4):621-33. doi: 10.1111/bcp.12826. Epub 2016 Feb 10.


Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs".

Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie LS, Armstrong PC, Nüsing RM, Tomlinson JA, Warner TD, Leiper J, Mitchell JA.

Circulation. 2015 Oct 27;132(17):e213-4. doi: 10.1161/CIRCULATIONAHA.115.017260. No abstract available.


Clinical Application of Variation in Replication Kinetics During Episodes of Post-transplant Cytomegalovirus Infections.

Lodding IP, Sengeløv H, da Cunha-Bang C, Iversen M, Rasmussen A, Gustafsson F, Downing JG, Grarup J, Kirkby N, Frederiksen CM, Mocroft A, Sørensen SS, Lundgren JD; MATCH Programme Study Group.

EBioMedicine. 2015 May 8;2(7):699-705. doi: 10.1016/j.ebiom.2015.05.003. eCollection 2015 Jul.


Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy.

Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD.

Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2122-33. doi: 10.1161/ATVBAHA.115.306219. Epub 2015 Aug 13.


Automatic cell detection in bright-field microscopy for microbeam irradiation studies.

Georgantzoglou A, Merchant MJ, Jeynes JC, Wéra AC, Kirkby KJ, Kirkby NF, Jena R.

Phys Med Biol. 2015 Aug 21;60(16):6289-303. doi: 10.1088/0031-9155/60/16/6289. Epub 2015 Aug 3.


Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction.

Armstrong PC, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD.

Blood. 2015 Sep 3;126(10):e11-8. doi: 10.1182/blood-2015-01-621656. Epub 2015 Jul 27.


Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD.

FASEB J. 2015 Nov;29(11):4568-78. doi: 10.1096/fj.15-275065. Epub 2015 Jul 16.


Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography.

Kirkby NS, Low L, Wu J, Miller E, Seckl JR, Walker BR, Webb DJ, Hadoke PW.

J Vis Exp. 2015 May 26;(99):e50627. doi: 10.3791/50627.


Mathematical modelling of tumour volume dynamics in response to stereotactic ablative radiotherapy for non-small cell lung cancer.

Tariq I, Humbert-Vidan L, Chen T, South CP, Ezhil V, Kirkby NF, Jena R, Nisbet A.

Phys Med Biol. 2015 May 7;60(9):3695-713. doi: 10.1088/0031-9155/60/9/3695. Epub 2015 Apr 17.


Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injury.

Duthie KM, Hadoke PW, Kirkby NS, Miller E, Ivy JR, McShane JF, Lim WG, Webb DJ.

Br J Pharmacol. 2015 Jun;172(11):2827-37. doi: 10.1111/bph.13086. Epub 2015 Apr 23.


Quantifying uncertainty in radiotherapy demand at the local and national level using the Malthus model.

Jena R, Mee T, Kirkby NF, Williams MV.

Clin Oncol (R Coll Radiol). 2015 Feb;27(2):92-8. doi: 10.1016/j.clon.2014.11.003. Epub 2014 Dec 8.


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