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Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.

Musa J, Cidre-Aranaz F, Aynaud MM, Orth MF, Knott MML, Mirabeau O, Mazor G, Varon M, Hölting TLB, Grossetête S, Gartlgruber M, Surdez D, Gerke JS, Ohmura S, Marchetto A, Dallmayer M, Baldauf MC, Stein S, Sannino G, Li J, Romero-Pérez L, Westermann F, Hartmann W, Dirksen U, Gymrek M, Anderson ND, Shlien A, Rotblat B, Kirchner T, Delattre O, Grünewald TGP.

Nat Commun. 2019 Sep 11;10(1):4128. doi: 10.1038/s41467-019-12071-2.


In situ metabolomics of aldosterone-producing adenomas.

Murakami M, Rhayem Y, Kunzke T, Sun N, Feuchtinger A, Ludwig P, Strom TM, Gomez-Sanchez C, Knösel T, Kirchner T, Williams TA, Reincke M, Walch AK, Beuschlein F.

JCI Insight. 2019 Sep 5;4(17). pii: 130356. doi: 10.1172/jci.insight.130356.


Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients.

Sannino G, Marchetto A, Ranft A, Jabar S, Zacherl C, Alba-Rubio R, Stein S, Wehweck FS, Kiran MM, Hölting TLB, Musa J, Romero-Pérez L, Cidre-Aranaz F, Knott MML, Li J, Jürgens H, Sastre A, Alonso J, Da Silveira W, Hardiman G, Gerke JS, Orth MF, Hartmann W, Kirchner T, Ohmura S, Dirksen U, Grünewald TGP.

EBioMedicine. 2019 Aug 16. pii: S2352-3964(19)30518-3. doi: 10.1016/j.ebiom.2019.08.002. [Epub ahead of print]


TNFAIP3 is a key player in childhood asthma development and environment-mediated protection.

Krusche J, Twardziok M, Rehbach K, Böck A, Tsang MS, Schröder PC, Kumbrink J, Kirchner T, Xing Y, Riedler J, Dalphin JC, Pekkanen J, Lauener R, Roponen M, Li J, Wong CK, Wong GWK, Schaub B; PASTURE study group, Ege M, Depner M, Illi S, Loss GJ, Renz H, Pfefferle PI, Kabesch M, Genuneit J, Karvonen AM, Hyvärinen A, Kirjavainen PV, Remes S, Braun-Fahrländer C, Roduit C, Frei R, Kaulek V, Dalphin ML, Divaret-Chauveau A, Doekes G.

J Allergy Clin Immunol. 2019 Aug 2. pii: S0091-6749(19)30978-9. doi: 10.1016/j.jaci.2019.07.029. [Epub ahead of print]


Photoacoustics can image spreading depolarization deep in gyrencephalic brain.

Kirchner T, Gröhl J, Herrera MA, Adler T, Hernández-Aguilera A, Santos E, Maier-Hein L.

Sci Rep. 2019 Jun 17;9(1):8661. doi: 10.1038/s41598-019-44935-4.


Prognostic value and association with epithelial-mesenchymal transition and molecular subtypes of the proteoglycan biglycan in advanced bladder cancer.

Schulz GB, Grimm T, Sers C, Riemer P, Elmasry M, Kirchner T, Stief CG, Karl A, Horst D.

Urol Oncol. 2019 Aug;37(8):530.e9-530.e18. doi: 10.1016/j.urolonc.2019.05.011. Epub 2019 Jun 5.


In vivo effects of chemotherapy on oncogenic pathways in colorectal cancer.

Spartalis C, Schmidt EM, Elmasry M, Schulz GB, Kirchner T, Horst D.

Cancer Sci. 2019 Aug;110(8):2529-2539. doi: 10.1111/cas.14077. Epub 2019 Jun 17.


Crowdsourcing for Food Purchase Receipt Annotation via Amazon Mechanical Turk: A Feasibility Study.

Lu W, Guttentag A, Elbel B, Kiszko K, Abrams C, Kirchner TR.

J Med Internet Res. 2019 Apr 5;21(4):e12047. doi: 10.2196/12047.


GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults.

Quevenco FC, Schreiner SJ, Preti MG, van Bergen JMG, Kirchner T, Wyss M, Steininger SC, Gietl A, Leh SE, Buck A, Pruessmann KP, Hock C, Nitsch RM, Henning A, Van De Ville D, Unschuld PG.

Neuroimage Clin. 2019;22:101776. doi: 10.1016/j.nicl.2019.101776. Epub 2019 Mar 12.


Uncertainty-aware performance assessment of optical imaging modalities with invertible neural networks.

Adler TJ, Ardizzone L, Vemuri A, Ayala L, Gröhl J, Kirchner T, Wirkert S, Kruse J, Rother C, Köthe U, Maier-Hein L.

Int J Comput Assist Radiol Surg. 2019 Jun;14(6):997-1007. doi: 10.1007/s11548-019-01939-9. Epub 2019 Mar 22.


DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.

Koelsche C, Kriegsmann M, Kommoss FKF, Stichel D, Kriegsmann K, Vokuhl C, Grünewald TGP, Romero-Pérez L, Kirchner T, de Alava E, Diaz-Martin J, Hartmann W, Baumhoer D, Antonescu CR, Szuhai K, Flucke U, Dirksen U, Pfister SM, Jones DTW, Mechtersheimer G, von Deimling A.

J Cancer Res Clin Oncol. 2019 May;145(5):1273-1281. doi: 10.1007/s00432-019-02895-2. Epub 2019 Mar 20.


Mitochondrial Dynamics in Tachycardiomyopathy.

Heinzmann D, Klingel K, Müller K, Kumbrink J, Kirchner T, Schreieck J, Gawaz M, Seizer P.

Cell Physiol Biochem. 2019;52(3):435-438. doi: 10.33594/000000031. Epub 2019 Mar 15.


Biosynthesis of Stereoisomers of Dill Ether and Wine Lactone by Pleurotus sapidus.

Trapp T, Kirchner T, Birk F, Fraatz MA, Zorn H.

J Agric Food Chem. 2019 Mar 14. doi: 10.1021/acs.jafc.8b07263. [Epub ahead of print]


An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking.

Kozlitina J, Risso D, Lansu K, Olsen RHJ, Sainz E, Luiselli D, Barik A, Frigerio-Domingues C, Pagani L, Wooding S, Kirchner T, Niaura R, Roth B, Drayna D.

PLoS Genet. 2019 Feb 15;15(2):e1007916. doi: 10.1371/journal.pgen.1007916. eCollection 2019 Feb.


Flavored cigar smoking among African American young adult dual users: An ecological momentary assessment.

Chen-Sankey JC, Choi K, Kirchner TR, Feldman RH, Butler J 3rd, Mead EL.

Drug Alcohol Depend. 2019 Mar 1;196:79-85. doi: 10.1016/j.drugalcdep.2018.12.020. Epub 2019 Jan 31.


Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma.

Dallmayer M, Li J, Ohmura S, Alba Rubio R, Baldauf MC, Hölting TLB, Musa J, Knott MML, Stein S, Cidre-Aranaz F, Wehweck FS, Romero-Pérez L, Gerke JS, Orth MF, Marchetto A, Kirchner T, Bach H, Sannino G, Grünewald TGP.

Cell Death Dis. 2019 Feb 11;10(2):116. doi: 10.1038/s41419-019-1372-0.


Comprehensive analysis of PD-L1 expression, HER2 amplification, ALK/EML4 fusion, and mismatch repair deficiency as putative predictive and prognostic factors in ovarian carcinoma.

Schmoeckel E, Hofmann S, Fromberger D, Rottmann M, Luthardt B, Burges A, Jeschke U, Kirchner T, Lax SF, Mayr D.

Virchows Arch. 2019 May;474(5):599-608. doi: 10.1007/s00428-019-02528-6. Epub 2019 Feb 7.


Immune checkpoint markers in gastroenteropancreatic neuroendocrine neoplasia.

Bösch F, Brüwer K, Altendorf-Hofmann A, Auernhammer CJ, Spitzweg C, Westphalen CB, Boeck S, Schubert-Fritschle G, Werner J, Heinemann V, Kirchner T, Angele M, Knösel T.

Endocr Relat Cancer. 2019 Mar 1;26(3):293-301. doi: 10.1530/ERC-18-0494.


Neurotrophic tropomyosin receptor kinase (NTRK) and nerve growth factor (NGF) are not expressed in Caucasian patients with biliary tract cancers: pooled data from three independent cohorts.

Westphalen CB, Preinfalk A, Kruger S, Haas M, Renz BW, Riener MO, Weber A, Kirchner T, Werner J, Heinemann V, von Bergwelt-Baildon M, Baba HA, Siveke JT, Ormanns S, Boeck S.

Clin Transl Oncol. 2019 Aug;21(8):1108-1111. doi: 10.1007/s12094-018-02030-6. Epub 2019 Jan 3.


Ecological momentary assessment of various tobacco product use among young adults.

Berg CJ, Haardörfer R, Payne JB, Getachew B, Vu M, Guttentag A, Kirchner TR.

Addict Behav. 2019 May;92:38-46. doi: 10.1016/j.addbeh.2018.12.014. Epub 2018 Dec 11.


How do adolescents with Adjustment Disorder cope with stressful situations? Relationship with suicidal risk.

Ferrer L, Kirchner T.

Rev Psiquiatr Salud Ment. 2018 Dec 14. pii: S1888-9891(18)30101-0. doi: 10.1016/j.rpsm.2018.11.002. [Epub ahead of print] English, Spanish.


Amphiregulin (AREG) and Epiregulin (EREG) Gene Expression as Predictor for Overall Survival (OS) in Oxaliplatin/Fluoropyrimidine Plus Bevacizumab Treated mCRC Patients-Analysis of the Phase III AIO KRK-0207 Trial.

Stintzing S, Ivanova B, Ricard I, Jung A, Kirchner T, Tannapfel A, Juette H, Hegewisch-Becker S, Arnold D, Reinacher-Schick A.

Front Oncol. 2018 Nov 8;8:474. doi: 10.3389/fonc.2018.00474. eCollection 2018.


The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.

Brandl L, Kirstein N, Neumann J, Sendelhofert A, Vieth M, Kirchner T, Menssen A.

Med Oncol. 2018 Nov 20;36(1):5. doi: 10.1007/s12032-018-1225-1.


Youth Access to Tobacco Products in the United States: Findings from Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) Study.

Tanski S, Emond J, Stanton C, Kirchner T, Choi K, Yang L, Ryant C, Robinson J, Hyland A, Emond J, Stanton C, Kirchner T, Choi K, Yang L, Ryant C, Robinson J, Hyland A.

Nicotine Tob Res. 2018 Nov 8. doi: 10.1093/ntr/nty238. [Epub ahead of print]


Sequential Versus Combination Therapy of Metastatic Colorectal Cancer Using Fluoropyrimidines, Irinotecan, and Bevacizumab: A Randomized, Controlled Study-XELAVIRI (AIO KRK0110).

Modest DP, Fischer von Weikersthal L, Decker T, Vehling-Kaiser U, Uhlig J, Schenk M, Freiberg-Richter J, Peuser B, Denzlinger C, Peveling Genannt Reddemann C, Graeven U, Schuch G, Schwaner I, Stahler A, Jung A, Kirchner T, Held S, Stintzing S, Giessen-Jung C, Heinemann V; XELAVIRI/AIO KRK0110 Investigators.

J Clin Oncol. 2019 Jan 1;37(1):22-32. doi: 10.1200/JCO.18.00052. Epub 2018 Nov 2.


Repeated mutKRAS ctDNA measurements represent a novel and promising tool for early response prediction and therapy monitoring in advanced pancreatic cancer.

Kruger S, Heinemann V, Ross C, Diehl F, Nagel D, Ormanns S, Liebmann S, Prinz-Bravin I, Westphalen CB, Haas M, Jung A, Kirchner T, von Bergwelt-Baildon M, Boeck S, Holdenrieder S.

Ann Oncol. 2018 Dec 1;29(12):2348-2355. doi: 10.1093/annonc/mdy417.


Beyond blunts: Reasons for cigarette and cigar use among African American young adult dual users.

Mead EL, Johnson SL, Siddiqui J, Butler J 3rd, Kirchner T, Feldman RH.

Addict Res Theory. 2018;26(5):349-360. doi: 10.1080/16066359.2017.1366456. Epub 2017 Sep 1.


[Centralized molecular tumor diagnostics by commercial providers : Consequences for patients, patient care, and research].

Schirmacher P, Stenzinger A, Kirchner T.

Pathologe. 2018 Nov;39(6):583-586. doi: 10.1007/s00292-018-0523-x. German. No abstract available.


Over-discretized SENSE reconstruction and B0 correction for accelerated non-lipid-suppressed 1 H FID MRSI of the human brain at 9.4 T.

Nassirpour S, Chang P, Kirchner T, Henning A.

NMR Biomed. 2018 Dec;31(12):e4014. doi: 10.1002/nbm.4014. Epub 2018 Oct 18.


Comparison of health-related quality of life after transarterial chemoembolization and transarterial radioembolization in patients with unresectable hepatocellular carcinoma.

Kirchner T, Marquardt S, Werncke T, Kirstein MM, Brunkhorst T, Wacker F, Vogel A, Rodt T.

Abdom Radiol (NY). 2019 Apr;44(4):1554-1561. doi: 10.1007/s00261-018-1802-y.


Molecular Background of Pi Deficiency-Induced Root Hair Growth in Brassica carinata - A Fasciclin-Like Arabinogalactan Protein Is Involved.

Kirchner TW, Niehaus M, Rössig KL, Lauterbach T, Herde M, Küster H, Schenk MK.

Front Plant Sci. 2018 Sep 19;9:1372. doi: 10.3389/fpls.2018.01372. eCollection 2018.


Initiation, continuation of use and cessation of alternative tobacco products among young adults: A qualitative study.

Vu M, Getachew B, Payne JB, Kirchner TR, Berg CJ.

Tob Prev Cessat. 2018 Feb;4. pii: 8. doi: 10.18332/tpc/84869.


Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.

Xu G, Gaul MD, Kuo GH, Du F, Xu JZ, Wallace N, Hinke S, Kirchner T, Silva J, Huebert ND, Lee S, Murray W, Liang Y, Demarest K.

Bioorg Med Chem Lett. 2018 Nov 15;28(21):3446-3453. doi: 10.1016/j.bmcl.2018.09.025. Epub 2018 Sep 19.


Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma.

Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, Stein S, Hölting TLB, Cidre-Aranaz F, Romero-Pérez L, Dallmayer M, Baldauf MC, Marchetto A, Sannino G, Knott MML, Wehweck F, Ohmura S, Li J, Hakozaki M, Kirchner T, Dandekar T, Butt E, Grünewald TGP.

Int J Cancer. 2019 Feb 15;144(4):859-867. doi: 10.1002/ijc.31903. Epub 2018 Dec 4.


A prognostic mRNA expression signature of four 16q24.3 genes in radio(chemo)therapy-treated head and neck squamous cell carcinoma (HNSCC).

Wintergerst L, Selmansberger M, Maihoefer C, Schüttrumpf L, Walch A, Wilke C, Pitea A, Woischke C, Baumeister P, Kirchner T, Belka C, Ganswindt U, Zitzelsberger H, Unger K, Hess J.

Mol Oncol. 2018 Dec;12(12):2085-2101. doi: 10.1002/1878-0261.12388. Epub 2018 Oct 26.


Systematic identification of cancer-specific MHC-binding peptides with RAVEN.

Baldauf MC, Gerke JS, Kirschner A, Blaeschke F, Effenberger M, Schober K, Rubio RA, Kanaseki T, Kiran MM, Dallmayer M, Musa J, Akpolat N, Akatli AN, Rosman FC, Özen Ö, Sugita S, Hasegawa T, Sugimura H, Baumhoer D, Knott MML, Sannino G, Marchetto A, Li J, Busch DH, Feuchtinger T, Ohmura S, Orth MF, Thiel U, Kirchner T, Grünewald TGP.

Oncoimmunology. 2018 Jul 23;7(9):e1481558. doi: 10.1080/2162402X.2018.1481558. eCollection 2018.


POLE gene hotspot mutations in advanced pancreatic cancer.

Guenther M, Veninga V, Kumbrink J, Haas M, Westphalen CB, Kruger S, Heinemann V, Kirchner T, Boeck S, Jung A, Ormanns S.

J Cancer Res Clin Oncol. 2018 Nov;144(11):2161-2166. doi: 10.1007/s00432-018-2746-x. Epub 2018 Sep 7.


Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.

Brandl L, Hartmann D, Kirchner T, Menssen A.

Acta Derm Venereol. 2019 Jan 1;99(1):63-71. doi: 10.2340/00015555-3031.


A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV Infection.

Hess J, Unger K, Maihoefer C, Schüttrumpf L, Wintergerst L, Heider T, Weber P, Marschner S, Braselmann H, Samaga D, Kuger S, Pflugradt U, Baumeister P, Walch A, Woischke C, Kirchner T, Werner M, Werner K, Baumann M, Budach V, Combs SE, Debus J, Grosu AL, Krause M, Linge A, Rödel C, Stuschke M, Zips D, Zitzelsberger H, Ganswindt U, Henke M, Belka C.

Clin Cancer Res. 2019 Mar 1;25(5):1505-1516. doi: 10.1158/1078-0432.CCR-18-0776. Epub 2018 Aug 31.


An Ecological Momentary Assessment of Cigarette and Cigar Dual Use Among African American Young Adults.

Mead EL, Chen JC, Kirchner TR, Butler J 3rd, Feldman RH.

Nicotine Tob Res. 2018 Aug 14;20(suppl_1):S12-S21. doi: 10.1093/ntr/nty061.


The DNA-polymorphism rs849142 is associated with skin toxicity induced by targeted anti-EGFR therapy using cetuximab.

Froelich MF, Stintzing S, Kumbrink J, Grünewald TGP, Mansmann U, Heinemann V, Kirchner T, Jung A.

Oncotarget. 2018 Jul 13;9(54):30279-30288. doi: 10.18632/oncotarget.25689. eCollection 2018 Jul 13.


Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.

Öner MG, Rokavec M, Kaller M, Bouznad N, Horst D, Kirchner T, Hermeking H.

Gastroenterology. 2018 Dec;155(6):1868-1882. doi: 10.1053/j.gastro.2018.08.011. Epub 2018 Aug 10.


Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.

Machiela MJ, Grünewald TGP, Surdez D, Reynaud S, Mirabeau O, Karlins E, Rubio RA, Zaidi S, Grossetete-Lalami S, Ballet S, Lapouble E, Laurence V, Michon J, Pierron G, Kovar H, Gaspar N, Kontny U, González-Neira A, Picci P, Alonso J, Patino-Garcia A, Corradini N, Bérard PM, Freedman ND, Rothman N, Dagnall CL, Burdett L, Jones K, Manning M, Wyatt K, Zhou W, Yeager M, Cox DG, Hoover RN, Khan J, Armstrong GT, Leisenring WM, Bhatia S, Robison LL, Kulozik AE, Kriebel J, Meitinger T, Metzler M, Hartmann W, Strauch K, Kirchner T, Dirksen U, Morton LM, Mirabello L, Tucker MA, Tirode F, Chanock SJ, Delattre O.

Nat Commun. 2018 Aug 9;9(1):3184. doi: 10.1038/s41467-018-05537-2.


Subtyping Of Triple Negative Breast Carcinoma On The Basis Of RTK Expression.

Hessel H, Poignée-Heger M, Lohmann S, Hirscher B, Herold A, Assmann G, Budczies J, Sotlar K, Kirchner T.

J Cancer. 2018 Jun 23;9(15):2589-2602. doi: 10.7150/jca.23023. eCollection 2018.


Adolescent Marijuana Use, Marijuana-Related Perceptions, and Use of Other Substances Before and After Initiation of Retail Marijuana Sales in Colorado (2013-2015).

Brooks-Russell A, Ma M, Levinson AH, Kattari L, Kirchner T, Anderson Goodell EM, Johnson RM.

Prev Sci. 2019 Feb;20(2):185-193. doi: 10.1007/s11121-018-0933-2.


Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck - clinical results from the cohort of the clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer".

Maihoefer C, Schüttrumpf L, Macht C, Pflugradt U, Hess J, Schneider L, Woischke C, Walch A, Baumeister P, Kirchner T, Zitzelsberger H, Belka C, Ganswindt U.

Radiat Oncol. 2018 Jul 3;13(1):123. doi: 10.1186/s13014-018-1067-1.


Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR.

Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14.


Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?

Baldauf MC, Gerke JS, Orth MF, Dallmayer M, Baumhoer D, de Alava E, Hartmann W, Kirchner T, Grünewald TGP.

Mod Pathol. 2018 Jun;31(6):997-999. doi: 10.1038/s41379-018-0009-7. Epub 2018 Jun 12. No abstract available.


Context encoding enables machine learning-based quantitative photoacoustics.

Kirchner T, Gröhl J, Maier-Hein L.

J Biomed Opt. 2018 May;23(5):1-9. doi: 10.1117/1.JBO.23.5.056008.


Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer.

Schmidt EM, Lamprecht S, Blaj C, Schaaf C, Krebs S, Blum H, Hermeking H, Jung A, Kirchner T, Horst D.

J Exp Med. 2018 Jun 4;215(6):1693-1708. doi: 10.1084/jem.20171455. Epub 2018 May 16.

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