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Items: 1 to 50 of 269

1.

EML4-ALK V3, treatment resistance, and survival: refining the diagnosis of ALK+ NSCLC.

Christopoulos P, Kirchner M, Endris V, Stenzinger A, Thomas M.

J Thorac Dis. 2018 Jun;10(Suppl 17):S1989-S1991. doi: 10.21037/jtd.2018.05.61. No abstract available.

2.

Specificity in the Interaction of High-Voltage-Activated Ca2+ Channel Types with Ca2+-dependent Afterhyperpolarizations in Magnocellular Supraoptic Neurons.

Kirchner MK, Foehring RC, Callaway JC, Armstrong WE Ph.D.

J Neurophysiol. 2018 Jul 18. doi: 10.1152/jn.00285.2018. [Epub ahead of print]

PMID:
30020842
3.

Mortality, diarrhea and respiratory disease in Danish dairy heifer calves: Effect of production system and season.

Reiten M, Rousing T, Thomsen PT, Otten ND, Forkman B, Houe H, Sørensen JT, Kirchner MK.

Prev Vet Med. 2018 Jul 1;155:21-26. doi: 10.1016/j.prevetmed.2018.04.007. Epub 2018 Apr 12.

PMID:
29786521
4.

Longitudinal study on the occurrence in pigs of colistin-resistant Escherichia coli carrying mcr-1 following the cessation of use of colistin.

Randall LP, Horton RA, Lemma F, Martelli F, Duggett NAD, Smith RP, Kirchner MJ, Ellis RJ, Rogers JP, Williamson SM, Simons RRL, Brena CM, Evans SJ, Anjum MF, Teale CJ.

J Appl Microbiol. 2018 Aug;125(2):596-608. doi: 10.1111/jam.13907. Epub 2018 May 23.

PMID:
29741287
5.

Optimal planning of phase II/III programs for clinical trials with multiple endpoints.

Kieser M, Kirchner M, Dölger E, Götte H.

Pharm Stat. 2018 Apr 26. doi: 10.1002/pst.1861. [Epub ahead of print]

PMID:
29700949
6.

Prevalence of Hypertension in Children with Early-Stage ADPKD.

Massella L, Mekahli D, Paripović D, Prikhodina L, Godefroid N, Niemirska A, Ağbaş A, Kalicka K, Jankauskiene A, Mizerska-Wasiak M, Afonso AC, Salomon R, Deschênes G, Ariceta G, Özçakar ZB, Teixeira A, Duzova A, Harambat J, Seeman T, Hrčková G, Lungu AC, Papizh S, Peco-Antic A, De Rechter S, Giordano U, Kirchner M, Lutz T, Schaefer F, Devuyst O, Wühl E, Emma F.

Clin J Am Soc Nephrol. 2018 Jun 7;13(6):874-883. doi: 10.2215/CJN.11401017. Epub 2018 Apr 19.

PMID:
29674338
7.

Picky: a simple online PRM and SRM method designer for targeted proteomics.

Zauber H, Kirchner M, Selbach M.

Nat Methods. 2018 Feb 28;15(3):156-157. doi: 10.1038/nmeth.4607. No abstract available.

PMID:
29489744
8.

Three molecular pathways model colorectal carcinogenesis in Lynch syndrome.

Ahadova A, Gallon R, Gebert J, Ballhausen A, Endris V, Kirchner M, Stenzinger A, Burn J, von Knebel Doeberitz M, Bläker H, Kloor M.

Int J Cancer. 2018 Jul 1;143(1):139-150. doi: 10.1002/ijc.31300. Epub 2018 Feb 23.

PMID:
29424427
9.

CLCN2 chloride channel mutations in familial hyperaldosteronism type II.

Scholl UI, Stölting G, Schewe J, Thiel A, Tan H, Nelson-Williams C, Vichot AA, Jin SC, Loring E, Untiet V, Yoo T, Choi J, Xu S, Wu A, Kirchner M, Mertins P, Rump LC, Onder AM, Gamble C, McKenney D, Lash RW, Jones DP, Chune G, Gagliardi P, Choi M, Gordon R, Stowasser M, Fahlke C, Lifton RP.

Nat Genet. 2018 Mar;50(3):349-354. doi: 10.1038/s41588-018-0048-5. Epub 2018 Feb 5.

PMID:
29403011
10.

EML4-ALK fusion variant V3 is a high-risk feature conferring accelerated metastatic spread, early treatment failure and worse overall survival in ALK+ non-small cell lung cancer.

Christopoulos P, Endris V, Bozorgmehr F, Elsayed M, Kirchner M, Ristau J, Buchhalter I, Penzel R, Herth FJ, Heussel CP, Eichhorn M, Muley T, Meister M, Fischer JR, Rieken S, Warth A, Bischoff H, Schirmacher P, Stenzinger A, Thomas M.

Int J Cancer. 2018 Jun 15;142(12):2589-2598. doi: 10.1002/ijc.31275. Epub 2018 Jan 24.

PMID:
29363116
11.

Is There a Role for Functional MRI for the Assessment of Extracapsular Extension in Prostate Cancer?

Sertdemir M, Weidner AM, Schoenberg SO, Morelli JN, Haecker A, Kirchner M, Weiss C, Hausmann D, Dinter DJ, Attenberger UI.

Anticancer Res. 2018 Jan;38(1):427-432.

PMID:
29277805
12.

Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas.

Bosic M, Kirchner M, Brasanac D, Leichsenring J, Lier A, Volckmar AL, Oliveira C, Buchhalter I, Stögbauer F, Zivkovic-Perisic S, Goeppert B, Schirmacher P, Penzel R, Endris V, Stenzinger A.

Pathology. 2018 Apr;50(3):327-332. doi: 10.1016/j.pathol.2017.10.011. Epub 2017 Dec 18.

PMID:
29269125
13.

mcr-1 and mcr-2 variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015.

AbuOun M, Stubberfield EJ, Duggett NA, Kirchner M, Dormer L, Nunez-Garcia J, Randall LP, Lemma F, Crook DW, Teale C, Smith RP, Anjum MF.

J Antimicrob Chemother. 2017 Oct 1;72(10):2745-2749. doi: 10.1093/jac/dkx286.

PMID:
29091227
14.

Targeted deep sequencing of effusion cytology samples is feasible, informs spatiotemporal tumor evolution, and has clinical and diagnostic utility.

Leichsenring J, Volckmar AL, Kirchner M, Kazdal D, Kriegsmann M, Stögbauer F, Bockmayr T, Klauschen F, Herth FJF, Penzel R, Warth A, Schirmacher P, Endris V, Stenzinger A.

Genes Chromosomes Cancer. 2018 Feb;57(2):70-79. doi: 10.1002/gcc.22509. Epub 2017 Nov 16.

PMID:
29044880
15.

Cognitive Change in Rehabilitation Patients with Dementia: Prevalence and Association with Rehabilitation Success.

Dutzi I, Schwenk M, Kirchner M, Bauer JM, Hauer K.

J Alzheimers Dis. 2017;60(3):1171-1182. doi: 10.3233/JAD-170401.

PMID:
28984597
16.

Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children.

Schaefer F, Trachtman H, Wühl E, Kirchner M, Hayek SS, Anarat A, Duzova A, Mir S, Paripovic D, Yilmaz A, Lugani F, Arbeiter K, Litwin M, Oh J, Matteucci MC, Gellermann J, Wygoda S, Jankauskiene A, Klaus G, Dusek J, Testa S, Zurowska A, Caldas Afonso A, Tracy M, Wei C, Sever S, Smoyer W, Reiser J; ESCAPE Trial Consortium and the 4C Study Group.

JAMA Pediatr. 2017 Nov 6;171(11):e172914. doi: 10.1001/jamapediatrics.2017.2914. Epub 2017 Nov 6.

PMID:
28873129
17.

Implementation of a novel efficacy score to compare sealing and cutting devices in a porcine model.

Brecht L, Wallwiener M, Schott S, Domschke C, Dinkic C, Golatta M, Schuetz F, Fluhr H, Stenzinger A, Kirchner M, Sohn C, Rom J.

Surg Endosc. 2018 Feb;32(2):1002-1011. doi: 10.1007/s00464-017-5778-4. Epub 2017 Aug 24.

PMID:
28840380
18.

An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system.

Kirchner M, Schorpp K, Hadian K, Schneider S.

Sci Rep. 2017 Aug 10;7(1):7732. doi: 10.1038/s41598-017-07870-w.

19.

Direct diode-pumped Kerr Lens 13 fs Ti:sapphire ultrafast oscillator using a single blue laser diode.

Backus S, Kirchner M, Durfee C, Murnane M, Kapteyn H.

Opt Express. 2017 May 29;25(11):12469-12477. doi: 10.1364/OE.25.012469.

PMID:
28786603
20.

Real-time PCR for the detection of Leptospira species in lungworm preparations.

Sharma M, Kirchner M, Fearnley C, Giles M, Smith L, Brown D, Anjum MF.

Vet Rec. 2017 Aug 19;181(8):197. doi: 10.1136/vr.104063. Epub 2017 Aug 1. No abstract available.

PMID:
28765499
21.

Precision oncology based on omics data: The NCT Heidelberg experience.

Horak P, Klink B, Heining C, Gröschel S, Hutter B, Fröhlich M, Uhrig S, Hübschmann D, Schlesner M, Eils R, Richter D, Pfütze K, Geörg C, Meißburger B, Wolf S, Schulz A, Penzel R, Herpel E, Kirchner M, Lier A, Endris V, Singer S, Schirmacher P, Weichert W, Stenzinger A, Schlenk RF, Schröck E, Brors B, von Kalle C, Glimm H, Fröhling S.

Int J Cancer. 2017 Sep 1;141(5):877-886. doi: 10.1002/ijc.30828. Epub 2017 Jun 21.

PMID:
28597939
22.

Trained-user opinion about Welfare Quality measures and integrated scoring of dairy cattle welfare.

de Graaf S, Ampe B, Winckler C, Radeski M, Mounier L, Kirchner MK, Haskell MJ, van Eerdenburg FJCM, des Roches AB, Andreasen SN, Bijttebier J, Lauwers L, Verbeke W, Tuyttens FAM.

J Dairy Sci. 2017 Aug;100(8):6376-6388. doi: 10.3168/jds.2016-12255. Epub 2017 May 30.

PMID:
28571983
23.

Loop-mediated isothermal amplification for extended spectrum β-lactamase gene detection in poultry carcase.

Kirchner M, Lemma F, Randall L, Anjum MF.

Vet Rec. 2017 Jul 29;181(5):119. doi: 10.1136/vr.104150. Epub 2017 May 16. No abstract available.

PMID:
28512232
24.

Simulation-based adjustment after exploratory biomarker subgroup selection in phase II.

Götte H, Kirchner M, Sailer MO, Kieser M.

Stat Med. 2017 Jul 10;36(15):2378-2390. doi: 10.1002/sim.7294. Epub 2017 Apr 24.

PMID:
28436046
25.

Phosphatidylinositol 4,5-bisphosphate (PIP2 ) modulates afterhyperpolarizations in oxytocin neurons of the supraoptic nucleus.

Kirchner MK, Foehring RC, Wang L, Chandaka GK, Callaway JC, Armstrong WE.

J Physiol. 2017 Jul 15;595(14):4927-4946. doi: 10.1113/JP274219. Epub 2017 May 15.

26.

The Value of PSA Density in Combination with PI-RADS™ for the Accuracy of Prostate Cancer Prediction.

Distler FA, Radtke JP, Bonekamp D, Kesch C, Schlemmer HP, Wieczorek K, Kirchner M, Pahernik S, Hohenfellner M, Hadaschik BA.

J Urol. 2017 Sep;198(3):575-582. doi: 10.1016/j.juro.2017.03.130. Epub 2017 Mar 31.

PMID:
28373135
27.

CRISPR-Cas9: From a bacterial immune system to genome-edited human cells in clinical trials.

Kick L, Kirchner M, Schneider S.

Bioengineered. 2017 May 4;8(3):280-286. doi: 10.1080/21655979.2017.1299834. Epub 2017 Mar 13. Review.

28.

Direct diode pumped Ti:sapphire ultrafast regenerative amplifier system.

Backus S, Kirchner M, Lemons R, Schmidt D, Durfee C, Murnane M, Kapteyn H.

Opt Express. 2017 Feb 20;25(4):3666-3674. doi: 10.1364/OE.25.003666.

PMID:
28241579
29.

Probability of success for phase III after exploratory biomarker analysis in phase II.

Götte H, Kirchner M, Sailer MO.

Pharm Stat. 2017 May;16(3):178-191. doi: 10.1002/pst.1804. Epub 2017 Feb 23.

PMID:
28230320
30.

Gene expression control by Bacillus anthracis purine riboswitches.

Kirchner M, Schneider S.

RNA. 2017 May;23(5):762-769. doi: 10.1261/rna.058792.116. Epub 2017 Feb 16.

31.

Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia.

Bochtler T, Granzow M, Stölzel F, Kunz C, Mohr B, Kartal-Kaess M, Hinderhofer K, Heilig CE, Kramer M, Thiede C, Endris V, Kirchner M, Stenzinger A, Benner A, Bornhäuser M, Ehninger G, Ho AD, Jauch A, Krämer A; Study Alliance Leukemia Investigators.

Blood. 2017 Mar 9;129(10):1333-1342. doi: 10.1182/blood-2016-09-738161. Epub 2017 Jan 24.

32.

Carriage of antimicrobial resistant Escherichia coli in dogs: Prevalence, associated risk factors and molecular characteristics.

Wedley AL, Dawson S, Maddox TW, Coyne KP, Pinchbeck GL, Clegg P, Nuttall T, Kirchner M, Williams NJ.

Vet Microbiol. 2017 Feb;199:23-30. doi: 10.1016/j.vetmic.2016.11.017. Epub 2016 Nov 23.

PMID:
28110781
33.

Occurrence and characterization of mcr-1-harbouring Escherichia coli isolated from pigs in Great Britain from 2013 to 2015.

Duggett NA, Sayers E, AbuOun M, Ellis RJ, Nunez-Garcia J, Randall L, Horton R, Rogers J, Martelli F, Smith RP, Brena C, Williamson S, Kirchner M, Davies R, Crook D, Evans S, Teale C, Anjum MF.

J Antimicrob Chemother. 2017 Mar 1;72(3):691-695. doi: 10.1093/jac/dkw477.

34.

A novel integrated modelling framework to assess the impacts of climate and socio-economic drivers on land use and water quality.

Zessner M, Schönhart M, Parajka J, Trautvetter H, Mitter H, Kirchner M, Hepp G, Blaschke AP, Strenn B, Schmid E.

Sci Total Environ. 2017 Feb 1;579:1137-1151. doi: 10.1016/j.scitotenv.2016.11.092. Epub 2016 Nov 29.

35.

Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report.

Volckmar AL, Endris V, Bozorgmehr F, Lier C, Porcel C, Kirchner M, Leichsenring J, Penzel R, Thomas M, Schirmacher P, Warth A, Stenzinger A.

Diagn Pathol. 2016 Nov 18;11(1):133.

36.

Cardiovascular Phenotypes in Children with CKD: The 4C Study.

Schaefer F, Doyon A, Azukaitis K, Bayazit A, Canpolat N, Duzova A, Niemirska A, Sözeri B, Thurn D, Anarat A, Ranchin B, Litwin M, Caliskan S, Candan C, Baskin E, Yilmaz E, Mir S, Kirchner M, Sander A, Haffner D, Melk A, Wühl E, Shroff R, Querfeld U; 4C Study Consortium.

Clin J Am Soc Nephrol. 2017 Jan 6;12(1):19-28. doi: 10.2215/CJN.01090216. Epub 2016 Nov 8.

37.

Targeted next-generation sequencing enables reliable detection of HER2 (ERBB2) status in breast cancer and provides ancillary information of clinical relevance.

Pfarr N, Penzel R, Endris V, Lier C, Flechtenmacher C, Volckmar AL, Kirchner M, Budczies J, Leichsenring J, Herpel E, Noske A, Weichert W, Schneeweiss A, Schirmacher P, Sinn HP, Stenzinger A.

Genes Chromosomes Cancer. 2017 Apr;56(4):255-265. doi: 10.1002/gcc.22431. Epub 2016 Nov 23.

PMID:
27792260
38.

Synonymous EGFR variant p.Q787Q is neither prognostic nor predictive in patients with lung adenocarcinoma.

Leichsenring J, Volckmar AL, Magios N, Morais de Oliveira CM, Penzel R, Brandt R, Kirchner M, Bozorgmehr F, Thomas M, Schirmacher P, Warth A, Endris V, Stenzinger A.

Genes Chromosomes Cancer. 2017 Mar;56(3):214-220. doi: 10.1002/gcc.22427. Epub 2016 Nov 30.

PMID:
27750395
39.

Adaptive emotion regulation mediates the relationship between self-compassion and depression in individuals with unipolar depression.

Diedrich A, Burger J, Kirchner M, Berking M.

Psychol Psychother. 2017 Sep;90(3):247-263. doi: 10.1111/papt.12107. Epub 2016 Oct 15.

PMID:
27743450
40.

Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.

Mauri M, Kirchner M, Aharoni R, Ciolli Mattioli C, van den Bruck D, Gutkovitch N, Modepalli V, Selbach M, Moran Y, Chekulaeva M.

Nucleic Acids Res. 2017 Jan 25;45(2):938-950. doi: 10.1093/nar/gkw792. Epub 2016 Sep 6.

41.

Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway.

Volckmar AL, Leichsenring J, Flechtenmacher C, Pfarr N, Siebolts U, Kirchner M, Budczies J, Bockmayr M, Ridinger K, Lorenz K, Herpel E, Noske A, Weichert W, Klauschen F, Schirmacher P, Penzel R, Endris V, Stenzinger A.

Genes Chromosomes Cancer. 2017 Jan;56(1):11-17. doi: 10.1002/gcc.22396. Epub 2016 Aug 9.

PMID:
27438523
42.

Near and intermediate visual and reading performance of patients with a multifocal apodized diffractive intraocular lens using an electronic reading desk.

Attia MS, Khoramnia R, Auffarth GU, Kirchner M, Holzer MP.

J Cataract Refract Surg. 2016 Apr;42(4):582-90. doi: 10.1016/j.jcrs.2015.11.047.

PMID:
27113882
43.

Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients.

Schlick B, Massoner P, Lueking A, Charoentong P, Blattner M, Schaefer G, Marquart K, Theek C, Amersdorfer P, Zielinski D, Kirchner M, Trajanoski Z, Rubin MA, Müllner S, Schulz-Knappe P, Klocker H.

PLoS One. 2016 Feb 10;11(2):e0147739. doi: 10.1371/journal.pone.0147739. eCollection 2016.

44.

Anatomy of the bacitracin resistance network in Bacillus subtilis.

Radeck J, Gebhard S, Orchard PS, Kirchner M, Bauer S, Mascher T, Fritz G.

Mol Microbiol. 2016 May;100(4):607-20. doi: 10.1111/mmi.13336. Epub 2016 Mar 10.

45.

Differences in Gait Performance, Quadriceps Strength, and Physical Activity Between Fallers and Nonfallers in Women with Osteoporosis.

Stief F, Schäfer A, Vogt L, Kirchner M, Hübscher M, Thiel C, Banzer W, Meurer A.

J Aging Phys Act. 2016 Jul;24(3):430-4. doi: 10.1123/japa.2015-0170. Epub 2015 Dec 22.

PMID:
26696127
46.

Sample size planning for phase II trials based on success probabilities for phase III.

Götte H, Schüler A, Kirchner M, Kieser M.

Pharm Stat. 2015 Nov-Dec;14(6):515-24. doi: 10.1002/pst.1717. Epub 2015 Sep 28.

PMID:
26412484
47.

CRISPR-Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome Engineering.

Kirchner M, Schneider S.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13508-14. doi: 10.1002/anie.201504741. Epub 2015 Sep 18. Review.

PMID:
26382836
48.

Prevalence and Spatial Distribution of Salmonella Infections in the Pennsylvania Raccoon (Procyon lotor).

Very KJ, Kirchner MK, Shariat N, Cottrell W, Sandt CH, Dudley EG, Kariyawasam S, Jayarao BM.

Zoonoses Public Health. 2016 May;63(3):223-33. doi: 10.1111/zph.12222. Epub 2015 Aug 14.

PMID:
26272724
49.

Utility-based optimization of phase II/III programs.

Kirchner M, Kieser M, Götte H, Schüler A.

Stat Med. 2016 Jan 30;35(2):305-16. doi: 10.1002/sim.6624. Epub 2015 Aug 9.

PMID:
26256550
50.

Impact of Ciprofloxacin and Clindamycin Administration on Gram-Negative Bacteria Isolated from Healthy Volunteers and Characterization of the Resistance Genes They Harbor.

Card RM, Mafura M, Hunt T, Kirchner M, Weile J, Rashid MU, Weintraub A, Nord CE, Anjum MF.

Antimicrob Agents Chemother. 2015 Aug;59(8):4410-6. doi: 10.1128/AAC.00068-15. Epub 2015 May 18.

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