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RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours.

Longerich T, Endris V, Neumann O, Rempel E, Kirchner M, Abadi Z, Uhrig S, Kriegsmann M, Weiss KH, Breuhahn K, Mehrabi A, Weber TF, Wilkens L, Straub BK, Rosenwald A, Schulze F, Brors B, Froehling S, Pellegrino R, Budczies J, Schirmacher P, Stenzinger A.

Gut. 2019 Feb 2. pii: gutjnl-2018-317632. doi: 10.1136/gutjnl-2018-317632. [Epub ahead of print]


PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPb.

Dittmar G, Hernandez DP, Kowenz-Leutz E, Kirchner M, Kahlert G, Wesolowski R, Baum K, Knoblich M, Hofstätter M, Muller A, Wolf J, Reimer U, Leutz A.

iScience. 2019 Mar 1;13:351-370. doi: 10.1016/j.isci.2019.02.026. [Epub ahead of print]


Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.

Jochner MCE, An J, Lättig-Tünnemann G, Kirchner M, Dagane A, Dittmar G, Dirnagl U, Eickholt BJ, Harms C.

Sci Rep. 2019 Feb 28;9(1):3183. doi: 10.1038/s41598-019-39438-1.


Detection of TP53 Mutations in Tissue or Liquid Rebiopsies at Progression Identifies ALK+ Lung Cancer Patients with Poor Survival.

Christopoulos P, Dietz S, Kirchner M, Volckmar AL, Endris V, Neumann O, Ogrodnik S, Heussel CP, Herth FJ, Eichhorn M, Meister M, Budczies J, Allgäuer M, Leichsenring J, Zemojtel T, Bischoff H, Schirmacher P, Thomas M, Sültmann H, Stenzinger A.

Cancers (Basel). 2019 Jan 21;11(1). pii: E124. doi: 10.3390/cancers11010124.


Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases.

Volckmar AL, Leichsenring J, Kirchner M, Christopoulos P, Neumann O, Budczies J, Morais de Oliveira CM, Rempel E, Buchhalter I, Brandt R, Allgäuer M, Talla SB, von Winterfeld M, Herpel E, Goeppert B, Lier A, Winter H, Brummer T, Fröhling S, Faehling M, Fischer JR, Heußel CP, Herth F, Lasitschka F, Schirmacher P, Thomas M, Endris V, Penzel R, Stenzinger A.

Int J Cancer. 2019 Jan 17. doi: 10.1002/ijc.32133. [Epub ahead of print]


Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application.

Lang A, Kirchner M, Stefanowski J, Durst M, Weber MC, Pfeiffenberger M, Damerau A, Hauser AE, Hoff P, Duda GN, Buttgereit F, Schmidt-Bleek K, Gaber T.

Acta Biomater. 2019 Mar 1;86:171-184. doi: 10.1016/j.actbio.2018.12.043. Epub 2019 Jan 5.


Electrophysiological properties of identified oxytocin and vasopressin neurones.

Armstrong WE, Foehring RC, Kirchner MK, Sladek CD.

J Neuroendocrinol. 2019 Mar;31(3):e12666. doi: 10.1111/jne.12666. Epub 2019 Feb 14. Review.


Implementing tumor mutational burden (TMB) analysis in routine diagnostics-a primer for molecular pathologists and clinicians.

Allgäuer M, Budczies J, Christopoulos P, Endris V, Lier A, Rempel E, Volckmar AL, Kirchner M, von Winterfeld M, Leichsenring J, Neumann O, Fröhling S, Penzel R, Thomas M, Schirmacher P, Stenzinger A.

Transl Lung Cancer Res. 2018 Dec;7(6):703-715. doi: 10.21037/tlcr.2018.08.14. Review.


Measurement of tumor mutational burden (TMB) in routine molecular diagnostics: in silico and real-life analysis of three larger gene panels.

Endris V, Buchhalter I, Allgäuer M, Rempel E, Lier A, Volckmar AL, Kirchner M, von Winterfeld M, Leichsenring J, Neumann O, Penzel R, Weichert W, Glimm H, Fröhling S, Winter H, Herth F, Thomas M, Schirmacher P, Budczies J, Stenzinger A.

Int J Cancer. 2019 May 1;144(9):2303-2312. doi: 10.1002/ijc.32002. Epub 2019 Feb 4.


Genetic profiling of melanoma in routine diagnostics: assay performance and molecular characteristics in a consecutive series of 274 cases.

Leichsenring J, Stögbauer F, Volckmar AL, Buchhalter I, Oliveira C, Kirchner M, Fröhling S, Hassel J, Enk A, Schirmacher P, Endris V, Penzel R, Stenzinger A.

Pathology. 2018 Dec;50(7):703-710. doi: 10.1016/j.pathol.2018.08.004. Epub 2018 Oct 20.


Identification of a highly lethal V3+ TP53+ subset in ALK+ lung adenocarcinoma.

Christopoulos P, Kirchner M, Bozorgmehr F, Endris V, Elsayed M, Budczies J, Ristau J, Penzel R, Herth FJ, Heussel CP, Eichhorn M, Muley T, Meister M, Fischer JR, Rieken S, Lasitschka F, Bischoff H, Sotillo R, Schirmacher P, Thomas M, Stenzinger A.

Int J Cancer. 2019 Jan 1;144(1):190-199. doi: 10.1002/ijc.31893. Epub 2018 Oct 30.


Size matters: Dissecting key parameters for panel-based tumor mutational burden analysis.

Buchhalter I, Rempel E, Endris V, Allgäuer M, Neumann O, Volckmar AL, Kirchner M, Leichsenring J, Lier A, von Winterfeld M, Penzel R, Christopoulos P, Thomas M, Fröhling S, Schirmacher P, Budczies J, Stenzinger A.

Int J Cancer. 2019 Feb 15;144(4):848-858. doi: 10.1002/ijc.31878. Epub 2018 Dec 4.


Next generation sequencing of the cellular and liquid fraction of pancreatic cyst fluid supports discrimination of IPMN from pseudocysts and reveals cases with multiple mutated driver clones: First findings from the prospective ZYSTEUS biomarker study.

Volckmar AL, Endris V, Gaida MM, Leichsenring J, Stögbauer F, Allgäuer M, von Winterfeld M, Penzel R, Kirchner M, Brandt R, Neumann O, Sültmann H, Schirmacher P, Rudi J, Schmitz D, Stenzinger A.

Genes Chromosomes Cancer. 2019 Jan;58(1):3-11. doi: 10.1002/gcc.22682. Epub 2018 Oct 17.


Risk factors associated with beef cattle losses on intensive fattening farms in Austria, Germany and Italy.

Brščić M, Kirchner MK, Knierim U, Contiero B, Gottardo F, Winckler C, Cozzi G.

Vet J. 2018 Sep;239:48-53. doi: 10.1016/j.tvjl.2018.08.002. Epub 2018 Aug 13.


Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs.

Meyer K, Kirchner M, Uyar B, Cheng JY, Russo G, Hernandez-Miranda LR, Szymborska A, Zauber H, Rudolph IM, Willnow TE, Akalin A, Haucke V, Gerhardt H, Birchmeier C, Kühn R, Krauss M, Diecke S, Pascual JM, Selbach M.

Cell. 2018 Sep 20;175(1):239-253.e17. doi: 10.1016/j.cell.2018.08.019. Epub 2018 Sep 6.


Optimal sample size allocation and go/no-go decision rules for phase II/III programs where several phase III trials are performed.

Preussler S, Kieser M, Kirchner M.

Biom J. 2019 Mar;61(2):357-378. doi: 10.1002/bimj.201700241. Epub 2018 Sep 5.


On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility.

Dolati S, Kage F, Mueller J, Müsken M, Kirchner M, Dittmar G, Sixt M, Rottner K, Falcke M.

Mol Biol Cell. 2018 Nov 1;29(22):2674-2686. doi: 10.1091/mbc.E18-02-0082. Epub 2018 Aug 29.


Molecular epidemiology of isolates with multiple mcr plasmids from a pig farm in Great Britain: the effects of colistin withdrawal in the short and long term.

Duggett NA, Randall LP, Horton RA, Lemma F, Kirchner M, Nunez-Garcia J, Brena C, Williamson SM, Teale C, Anjum MF.

J Antimicrob Chemother. 2018 Nov 1;73(11):3025-3033. doi: 10.1093/jac/dky292.


mcr-1 and mcr-2 (mcr-6.1) variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015.

AbuOun M, Stubberfield EJ, Duggett NA, Kirchner M, Dormer L, Nunez-Garcia J, Randall LP, Lemma F, Crook DW, Teale C, Smith RP, Anjum MF.

J Antimicrob Chemother. 2018 Oct 1;73(10):2904. doi: 10.1093/jac/dky272. No abstract available.


EML4-ALK V3, treatment resistance, and survival: refining the diagnosis of ALK+ NSCLC.

Christopoulos P, Kirchner M, Endris V, Stenzinger A, Thomas M.

J Thorac Dis. 2018 Jun;10(Suppl 17):S1989-S1991. doi: 10.21037/jtd.2018.05.61. No abstract available.


Specificity in the interaction of high-voltage-activated Ca2+ channel types with Ca2+-dependent afterhyperpolarizations in magnocellular supraoptic neurons.

Kirchner MK, Foehring RC, Callaway J, Armstrong WE.

J Neurophysiol. 2018 Oct 1;120(4):1728-1739. doi: 10.1152/jn.00285.2018. Epub 2018 Jul 18.


Mortality, diarrhea and respiratory disease in Danish dairy heifer calves: Effect of production system and season.

Reiten M, Rousing T, Thomsen PT, Otten ND, Forkman B, Houe H, Sørensen JT, Kirchner MK.

Prev Vet Med. 2018 Jul 1;155:21-26. doi: 10.1016/j.prevetmed.2018.04.007. Epub 2018 Apr 12.


Longitudinal study on the occurrence in pigs of colistin-resistant Escherichia coli carrying mcr-1 following the cessation of use of colistin.

Randall LP, Horton RA, Lemma F, Martelli F, Duggett NAD, Smith RP, Kirchner MJ, Ellis RJ, Rogers JP, Williamson SM, Simons RRL, Brena CM, Evans SJ, Anjum MF, Teale CJ.

J Appl Microbiol. 2018 Aug;125(2):596-608. doi: 10.1111/jam.13907. Epub 2018 May 23.


Optimal planning of phase II/III programs for clinical trials with multiple endpoints.

Kieser M, Kirchner M, Dölger E, Götte H.

Pharm Stat. 2018 Sep;17(5):437-457. doi: 10.1002/pst.1861. Epub 2018 Apr 26.


Prevalence of Hypertension in Children with Early-Stage ADPKD.

Massella L, Mekahli D, Paripović D, Prikhodina L, Godefroid N, Niemirska A, Ağbaş A, Kalicka K, Jankauskiene A, Mizerska-Wasiak M, Afonso AC, Salomon R, Deschênes G, Ariceta G, Özçakar ZB, Teixeira A, Duzova A, Harambat J, Seeman T, Hrčková G, Lungu AC, Papizh S, Peco-Antic A, De Rechter S, Giordano U, Kirchner M, Lutz T, Schaefer F, Devuyst O, Wühl E, Emma F.

Clin J Am Soc Nephrol. 2018 Jun 7;13(6):874-883. doi: 10.2215/CJN.11401017. Epub 2018 Apr 19.


Picky: a simple online PRM and SRM method designer for targeted proteomics.

Zauber H, Kirchner M, Selbach M.

Nat Methods. 2018 Feb 28;15(3):156-157. doi: 10.1038/nmeth.4607. No abstract available.


Three molecular pathways model colorectal carcinogenesis in Lynch syndrome.

Ahadova A, Gallon R, Gebert J, Ballhausen A, Endris V, Kirchner M, Stenzinger A, Burn J, von Knebel Doeberitz M, Bläker H, Kloor M.

Int J Cancer. 2018 Jul 1;143(1):139-150. doi: 10.1002/ijc.31300. Epub 2018 Feb 23.


CLCN2 chloride channel mutations in familial hyperaldosteronism type II.

Scholl UI, Stölting G, Schewe J, Thiel A, Tan H, Nelson-Williams C, Vichot AA, Jin SC, Loring E, Untiet V, Yoo T, Choi J, Xu S, Wu A, Kirchner M, Mertins P, Rump LC, Onder AM, Gamble C, McKenney D, Lash RW, Jones DP, Chune G, Gagliardi P, Choi M, Gordon R, Stowasser M, Fahlke C, Lifton RP.

Nat Genet. 2018 Mar;50(3):349-354. doi: 10.1038/s41588-018-0048-5. Epub 2018 Feb 5.


EML4-ALK fusion variant V3 is a high-risk feature conferring accelerated metastatic spread, early treatment failure and worse overall survival in ALK+ non-small cell lung cancer.

Christopoulos P, Endris V, Bozorgmehr F, Elsayed M, Kirchner M, Ristau J, Buchhalter I, Penzel R, Herth FJ, Heussel CP, Eichhorn M, Muley T, Meister M, Fischer JR, Rieken S, Warth A, Bischoff H, Schirmacher P, Stenzinger A, Thomas M.

Int J Cancer. 2018 Jun 15;142(12):2589-2598. doi: 10.1002/ijc.31275. Epub 2018 Jan 24.


Is There a Role for Functional MRI for the Assessment of Extracapsular Extension in Prostate Cancer?

Sertdemir M, Weidner AM, Schoenberg SO, Morelli JN, Haecker A, Kirchner M, Weiss C, Hausmann D, Dinter DJ, Attenberger UI.

Anticancer Res. 2018 Jan;38(1):427-432.


Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas.

Bosic M, Kirchner M, Brasanac D, Leichsenring J, Lier A, Volckmar AL, Oliveira C, Buchhalter I, Stögbauer F, Zivkovic-Perisic S, Goeppert B, Schirmacher P, Penzel R, Endris V, Stenzinger A.

Pathology. 2018 Apr;50(3):327-332. doi: 10.1016/j.pathol.2017.10.011. Epub 2017 Dec 18.


mcr-1 and mcr-2 variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015.

AbuOun M, Stubberfield EJ, Duggett NA, Kirchner M, Dormer L, Nunez-Garcia J, Randall LP, Lemma F, Crook DW, Teale C, Smith RP, Anjum MF.

J Antimicrob Chemother. 2017 Oct 1;72(10):2745-2749. doi: 10.1093/jac/dkx286.


Targeted deep sequencing of effusion cytology samples is feasible, informs spatiotemporal tumor evolution, and has clinical and diagnostic utility.

Leichsenring J, Volckmar AL, Kirchner M, Kazdal D, Kriegsmann M, Stögbauer F, Bockmayr T, Klauschen F, Herth FJF, Penzel R, Warth A, Schirmacher P, Endris V, Stenzinger A.

Genes Chromosomes Cancer. 2018 Feb;57(2):70-79. doi: 10.1002/gcc.22509. Epub 2017 Nov 16.


Cognitive Change in Rehabilitation Patients with Dementia: Prevalence and Association with Rehabilitation Success.

Dutzi I, Schwenk M, Kirchner M, Bauer JM, Hauer K.

J Alzheimers Dis. 2017;60(3):1171-1182. doi: 10.3233/JAD-170401.


Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children.

Schaefer F, Trachtman H, Wühl E, Kirchner M, Hayek SS, Anarat A, Duzova A, Mir S, Paripovic D, Yilmaz A, Lugani F, Arbeiter K, Litwin M, Oh J, Matteucci MC, Gellermann J, Wygoda S, Jankauskiene A, Klaus G, Dusek J, Testa S, Zurowska A, Caldas Afonso A, Tracy M, Wei C, Sever S, Smoyer W, Reiser J; ESCAPE Trial Consortium and the 4C Study Group.

JAMA Pediatr. 2017 Nov 6;171(11):e172914. doi: 10.1001/jamapediatrics.2017.2914. Epub 2017 Nov 6. Erratum in: JAMA Pediatr. 2017 Nov 1;171(11):1127.


Implementation of a novel efficacy score to compare sealing and cutting devices in a porcine model.

Brecht L, Wallwiener M, Schott S, Domschke C, Dinkic C, Golatta M, Schuetz F, Fluhr H, Stenzinger A, Kirchner M, Sohn C, Rom J.

Surg Endosc. 2018 Feb;32(2):1002-1011. doi: 10.1007/s00464-017-5778-4. Epub 2017 Aug 24.


An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system.

Kirchner M, Schorpp K, Hadian K, Schneider S.

Sci Rep. 2017 Aug 10;7(1):7732. doi: 10.1038/s41598-017-07870-w.


Direct diode-pumped Kerr Lens 13 fs Ti:sapphire ultrafast oscillator using a single blue laser diode.

Backus S, Kirchner M, Durfee C, Murnane M, Kapteyn H.

Opt Express. 2017 May 29;25(11):12469-12477. doi: 10.1364/OE.25.012469.


Real-time PCR for the detection of Leptospira species in lungworm preparations.

Sharma M, Kirchner M, Fearnley C, Giles M, Smith L, Brown D, Anjum MF.

Vet Rec. 2017 Aug 19;181(8):197. doi: 10.1136/vr.104063. Epub 2017 Aug 1. No abstract available.


Precision oncology based on omics data: The NCT Heidelberg experience.

Horak P, Klink B, Heining C, Gröschel S, Hutter B, Fröhlich M, Uhrig S, Hübschmann D, Schlesner M, Eils R, Richter D, Pfütze K, Geörg C, Meißburger B, Wolf S, Schulz A, Penzel R, Herpel E, Kirchner M, Lier A, Endris V, Singer S, Schirmacher P, Weichert W, Stenzinger A, Schlenk RF, Schröck E, Brors B, von Kalle C, Glimm H, Fröhling S.

Int J Cancer. 2017 Sep 1;141(5):877-886. doi: 10.1002/ijc.30828. Epub 2017 Jun 21.


Trained-user opinion about Welfare Quality measures and integrated scoring of dairy cattle welfare.

de Graaf S, Ampe B, Winckler C, Radeski M, Mounier L, Kirchner MK, Haskell MJ, van Eerdenburg FJCM, des Roches AB, Andreasen SN, Bijttebier J, Lauwers L, Verbeke W, Tuyttens FAM.

J Dairy Sci. 2017 Aug;100(8):6376-6388. doi: 10.3168/jds.2016-12255. Epub 2017 May 30.


Loop-mediated isothermal amplification for extended spectrum β-lactamase gene detection in poultry carcase.

Kirchner M, Lemma F, Randall L, Anjum MF.

Vet Rec. 2017 Jul 29;181(5):119. doi: 10.1136/vr.104150. Epub 2017 May 16. No abstract available.


Simulation-based adjustment after exploratory biomarker subgroup selection in phase II.

Götte H, Kirchner M, Sailer MO, Kieser M.

Stat Med. 2017 Jul 10;36(15):2378-2390. doi: 10.1002/sim.7294. Epub 2017 Apr 24.


Phosphatidylinositol 4,5-bisphosphate (PIP2 ) modulates afterhyperpolarizations in oxytocin neurons of the supraoptic nucleus.

Kirchner MK, Foehring RC, Wang L, Chandaka GK, Callaway JC, Armstrong WE.

J Physiol. 2017 Jul 15;595(14):4927-4946. doi: 10.1113/JP274219. Epub 2017 May 15.


The Value of PSA Density in Combination with PI-RADS™ for the Accuracy of Prostate Cancer Prediction.

Distler FA, Radtke JP, Bonekamp D, Kesch C, Schlemmer HP, Wieczorek K, Kirchner M, Pahernik S, Hohenfellner M, Hadaschik BA.

J Urol. 2017 Sep;198(3):575-582. doi: 10.1016/j.juro.2017.03.130. Epub 2017 Mar 31.


CRISPR-Cas9: From a bacterial immune system to genome-edited human cells in clinical trials.

Kick L, Kirchner M, Schneider S.

Bioengineered. 2017 May 4;8(3):280-286. doi: 10.1080/21655979.2017.1299834. Epub 2017 Mar 13. Review.


Direct diode pumped Ti:sapphire ultrafast regenerative amplifier system.

Backus S, Kirchner M, Lemons R, Schmidt D, Durfee C, Murnane M, Kapteyn H.

Opt Express. 2017 Feb 20;25(4):3666-3674. doi: 10.1364/OE.25.003666.


Probability of success for phase III after exploratory biomarker analysis in phase II.

Götte H, Kirchner M, Sailer MO.

Pharm Stat. 2017 May;16(3):178-191. doi: 10.1002/pst.1804. Epub 2017 Feb 23.


Gene expression control by Bacillus anthracis purine riboswitches.

Kirchner M, Schneider S.

RNA. 2017 May;23(5):762-769. doi: 10.1261/rna.058792.116. Epub 2017 Feb 16.


Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia.

Bochtler T, Granzow M, Stölzel F, Kunz C, Mohr B, Kartal-Kaess M, Hinderhofer K, Heilig CE, Kramer M, Thiede C, Endris V, Kirchner M, Stenzinger A, Benner A, Bornhäuser M, Ehninger G, Ho AD, Jauch A, Krämer A; Study Alliance Leukemia Investigators.

Blood. 2017 Mar 9;129(10):1333-1342. doi: 10.1182/blood-2016-09-738161. Epub 2017 Jan 24.

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