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Items: 1 to 50 of 53

1.

Initial characterization of transgenic mice overexpressing human histamine H2 receptors.

Gergs U, Bernhardt G, Buchwalow I, Edler H, Froeba J, Keller M, Kirchhefer U, Koehler F, Misslinger N, Wache H, Neumann J.

J Pharmacol Exp Ther. 2019 Feb 6. pii: jpet.118.255711. doi: 10.1124/jpet.118.255711. [Epub ahead of print]

2.

Chronic β-adrenergic stimulation reverses depressed Ca handling in mice overexpressing inhibitor-2 of protein phosphatase 1.

Kirchhefer U, Hammer E, Heinick A, Herpertz T, Isensee G, Müller FU, Neumann J, Schulte K, Seidl MD, Boknik P, Schulte JS.

J Mol Cell Cardiol. 2018 Dec;125:195-204. doi: 10.1016/j.yjmcc.2018.10.022. Epub 2018 Oct 31.

PMID:
30389400
3.

Role of type 2A phosphatase regulatory subunit B56α in regulating cardiac responses to β-adrenergic stimulation in vivo.

Puhl SL, Weeks KL, Güran A, Ranieri A, Boknik P, Kirchhefer U, Müller FU, Avkiran M.

Cardiovasc Res. 2019 Mar 1;115(3):519-529. doi: 10.1093/cvr/cvy230.

PMID:
30203051
4.

Overexpression of the Na+ /Ca2+ exchanger influences ouabain-mediated spontaneous Ca2+ activity but not positive inotropy.

Bögeholz N, Pauls P, Bauer BK, Schulte JS, Frommeyer G, Dechering DG, Boknik P, Kirchhefer U, Müller FU, Pott C, Eckardt L.

Fundam Clin Pharmacol. 2019 Feb;33(1):43-51. doi: 10.1111/fcp.12404. Epub 2018 Aug 30.

PMID:
30092622
5.

Successful overexpression of wild-type inhibitor-2 of PP1 in cardiovascular cells.

Krause T, Grote-Wessels S, Balzer F, Boknik P, Gergs U, Kirchhefer U, Buchwalow IB, Müller FU, Schmitz W, Neumann J.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug;391(8):859-873. doi: 10.1007/s00210-018-1515-3. Epub 2018 May 24.

PMID:
29797049
6.

Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors.

Boknik P, Drzewiecki K, Eskandar J, Gergs U, Grote-Wessels S, Fabritz L, Kirchhof P, Müller FU, Stümpel F, Schmitz W, Zimmermann N, Kirchhefer U, Neumann J.

Front Pharmacol. 2018 Jan 22;9:13. doi: 10.3389/fphar.2018.00013. eCollection 2018.

7.

The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models.

Bögeholz N, Schulte JS, Kaese S, Bauer BK, Pauls P, Dechering DG, Frommeyer G, Goldhaber JI, Kirchhefer U, Eckardt L, Pott C, Müller FU.

Front Pharmacol. 2017 Sep 21;8:649. doi: 10.3389/fphar.2017.00649. eCollection 2017.

8.

Triggered activity in atrial myocytes is influenced by Na+/Ca2+ exchanger activity in genetically altered mice.

Bögeholz N, Pauls P, Kaese S, Schulte JS, Lemoine MD, Dechering DG, Frommeyer G, Goldhaber JI, Seidl MD, Kirchhefer U, Eckardt L, Müller FU, Pott C.

J Mol Cell Cardiol. 2016 Dec;101:106-115. doi: 10.1016/j.yjmcc.2016.11.004. Epub 2016 Nov 9.

9.

Suppression of Early and Late Afterdepolarizations by Heterozygous Knockout of the Na+/Ca2+ Exchanger in a Murine Model.

Bögeholz N, Pauls P, Bauer BK, Schulte JS, Dechering DG, Frommeyer G, Kirchhefer U, Goldhaber JI, Müller FU, Eckardt L, Pott C.

Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1210-8. doi: 10.1161/CIRCEP.115.002927. Epub 2015 Sep 3.

PMID:
26338832
10.

Unbalanced upregulation of ryanodine receptor 2 plays a particular role in early development of daunorubicin cardiomyopathy.

Kucerova D, Doka G, Kruzliak P, Turcekova K, Kmecova J, Brnoliakova Z, Kyselovic J, Kirchhefer U, Müller FU, Krenek P, Boknik P, Klimas J.

Am J Transl Res. 2015 Jul 15;7(7):1280-94. eCollection 2015.

11.

Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.

Heinick A, Husser X, Himmler K, Kirchhefer U, Nunes F, Schulte JS, Seidl MD, Rolfes C, Dedman JR, Kaetzel MA, Gerke V, Schmitz W, Müller FU.

FASEB J. 2015 Sep;29(9):3773-87. doi: 10.1096/fj.14-269837. Epub 2015 May 28.

PMID:
26023182
12.

Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat.

Matus M, Kucerova D, Kruzliak P, Adameova A, Doka G, Turcekova K, Kmecova J, Kyselovic J, Krenek P, Kirchhefer U, Mueller FU, Boknik P, Klimas J.

Mol Cell Biochem. 2015 May;403(1-2):199-208. doi: 10.1007/s11010-015-2350-1. Epub 2015 Feb 8.

PMID:
25663023
13.

First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart.

Kirchhof P, Tal T, Fabritz L, Klimas J, Nesher N, Schulte JS, Ehling P, Kanyshkova T, Budde T, Nikol S, Fortmueller L, Stallmeyer B, Müller FU, Schulze-Bahr E, Schmitz W, Zlotkin E, Kirchhefer U.

Circ Heart Fail. 2015 Jan;8(1):79-88. doi: 10.1161/CIRCHEARTFAILURE.113.001066. Epub 2014 Nov 25.

PMID:
25424392
14.

Cardiac function is regulated by B56α-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates.

Kirchhefer U, Brekle C, Eskandar J, Isensee G, Kučerová D, Müller FU, Pinet F, Schulte JS, Seidl MD, Boknik P.

J Biol Chem. 2014 Dec 5;289(49):33862-73. doi: 10.1074/jbc.M114.598938. Epub 2014 Oct 15.

15.

Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41.

Kirchhefer U, Heinick A, König S, Kristensen T, Müller FU, Seidl MD, Boknik P.

J Biol Chem. 2014 Jan 3;289(1):163-76. doi: 10.1074/jbc.M113.507996. Epub 2013 Nov 13.

16.

Gene construction, expression and functional testing of an inotropic peptide from the venom of the black scorpion Hottentotta judaicus.

Tekook MA, Fabritz L, Kirchhof P, König S, Müller FU, Schmitz W, Tal T, Zlotkin E, Kirchhefer U.

Toxicon. 2012 Dec 15;60(8):1415-27. doi: 10.1016/j.toxicon.2012.10.008. Epub 2012 Oct 22.

PMID:
23085191
17.

Arrhythmia-associated cardiac Ca²(+) cycling proteins and gene mutations.

Kochhäuser S, Schulze-Bahr E, Kirchhefer U.

Wien Med Wochenschr. 2012 Jul;162(13-14):292-6. Epub 2012 Jun 25. Review. Erratum in: Wien Med Wochenschr. 2012 Dec;162(23-24):544.

PMID:
22733365
18.

Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.

Kučerová D, Baba HA, Bokník P, Fabritz L, Heinick A, Mát'uš M, Müller FU, Neumann J, Schmitz W, Kirchhefer U.

Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2008-17. doi: 10.1152/ajpheart.00457.2011. Epub 2012 Mar 16.

19.

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium.

Wijnker PJ, Boknik P, Gergs U, Müller FU, Neumann J, dos Remedios C, Schmitz W, Sindermann JR, Stienen GJ, van der Velden J, Kirchhefer U.

J Muscle Res Cell Motil. 2011 Nov;32(3):221-33. doi: 10.1007/s10974-011-9261-x. Epub 2011 Sep 30.

20.

Mutational spectrum in the Ca(2+)--activated cation channel gene TRPM4 in patients with cardiac conductance disturbances.

Stallmeyer B, Zumhagen S, Denjoy I, Duthoit G, Hébert JL, Ferrer X, Maugenre S, Schmitz W, Kirchhefer U, Schulze-Bahr E, Guicheney P, Schulze-Bahr E.

Hum Mutat. 2012 Jan;33(1):109-17. doi: 10.1002/humu.21599. Epub 2011 Oct 20.

PMID:
21887725
21.

Sarcoplasmic reticulum Ca2+ release in neonatal rat cardiac myocytes.

Gergs U, Kirchhefer U, Buskase J, Kiele-Dunsche K, Buchwalow IB, Jones LR, Schmitz W, Traub O, Neumann J.

J Mol Cell Cardiol. 2011 Nov;51(5):682-8. doi: 10.1016/j.yjmcc.2011.08.007. Epub 2011 Aug 17.

PMID:
21871897
22.

[Limited toxicity of the pediculicides pyrethrin, pyrethroids, and permethrin].

Sunderkötter C, Kirchhefer U.

Hautarzt. 2010 Oct;61(10):906-9. doi: 10.1007/s00105-010-2034-4. German. No abstract available.

PMID:
20835808
23.

Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.

Blana A, Kaese S, Fortmüller L, Laakmann S, Damke D, van Bragt K, Eckstein J, Piccini I, Kirchhefer U, Nattel S, Breithardt G, Carmeliet P, Carmeliet E, Schotten U, Verheule S, Kirchhof P, Fabritz L.

Heart Rhythm. 2010 Dec;7(12):1862-9. doi: 10.1016/j.hrthm.2010.08.016. Epub 2010 Aug 19.

PMID:
20728579
24.

The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling.

Kirchhefer U, Wehrmeister D, Postma AV, Pohlentz G, Mormann M, Kucerova D, Müller FU, Schmitz W, Schulze-Bahr E, Wilde AA, Neumann J.

J Mol Cell Cardiol. 2010 Jul;49(1):95-105. doi: 10.1016/j.yjmcc.2010.03.006. Epub 2010 Mar 17.

PMID:
20302875
25.

Damage of guinea pig heart and arteries by a trioleate-enriched diet and of cultured cardiomyocytes by oleic acid.

Krieglstein J, Kewitz T, Kirchhefer U, Hofnagel O, Weissen-Plenz G, Reinbold M, Klumpp S.

PLoS One. 2010 Mar 8;5(3):e9561. doi: 10.1371/journal.pone.0009561.

26.

Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.

Fabritz L, Damke D, Emmerich M, Kaufmann SG, Theis K, Blana A, Fortmüller L, Laakmann S, Hermann S, Aleynichenko E, Steinfurt J, Volkery D, Riemann B, Kirchhefer U, Franz MR, Breithardt G, Carmeliet E, Schäfers M, Maier SK, Carmeliet P, Kirchhof P.

Cardiovasc Res. 2010 Jul 1;87(1):60-72. doi: 10.1093/cvr/cvq029. Epub 2010 Jan 28.

27.

Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance.

Schwoerer AP, Neuber C, Schmechel A, Melnychenko I, Mearini G, Boknik P, Kirchhefer U, Schmitz W, Ehmke H, Eschenhagen T, El-Armouche A.

J Mol Cell Cardiol. 2008 Dec;45(6):846-52. doi: 10.1016/j.yjmcc.2008.09.003. Epub 2008 Sep 20.

PMID:
18848565
28.

Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.

Brüchert N, Mavila N, Boknik P, Baba HA, Fabritz L, Gergs U, Kirchhefer U, Kirchhof P, Matus M, Schmitz W, DePaoli-Roach AA, Neumann J.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1539-46. doi: 10.1152/ajpheart.00515.2008. Epub 2008 Aug 8.

29.

Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.

Grote-Wessels S, Baba HA, Boknik P, El-Armouche A, Fabritz L, Gillmann HJ, Kucerova D, Matus M, Müller FU, Neumann J, Schmitz M, Stümpel F, Theilmeier G, Wohlschlaeger J, Schmitz W, Kirchhefer U.

Cardiovasc Res. 2008 Aug 1;79(3):464-71. doi: 10.1093/cvr/cvn113. Epub 2008 May 3.

PMID:
18453636
30.

Triadin is a critical determinant of cellular Ca cycling and contractility in the heart.

Kirchhefer U, Klimas J, Baba HA, Buchwalow IB, Fabritz L, Hüls M, Matus M, Müller FU, Schmitz W, Neumann J.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3165-74. Epub 2007 Sep 21.

31.

Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin.

Kirchhof P, Klimas J, Fabritz L, Zwiener M, Jones LR, Schäfers M, Hermann S, Boknik P, Schmitz W, Breithardt G, Kirchhefer U, Neumann J.

J Mol Cell Cardiol. 2007 May;42(5):962-71. Epub 2007 Mar 7.

PMID:
17408688
32.

On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure.

Gergs U, Berndt T, Buskase J, Jones LR, Kirchhefer U, Müller FU, Schlüter KD, Schmitz W, Neumann J.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H728-34. Epub 2007 Mar 30.

33.

Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling.

Kirchhefer U, Hanske G, Jones LR, Justus I, Kaestner L, Lipp P, Schmitz W, Neumann J.

Cell Calcium. 2006 Feb;39(2):131-42. Epub 2005 Nov 9.

PMID:
16289269
34.

Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2.

Kirchhefer U, Baba HA, Bokník P, Breeden KM, Mavila N, Brüchert N, Justus I, Matus M, Schmitz W, Depaoli-Roach AA, Neumann J.

Cardiovasc Res. 2005 Oct 1;68(1):98-108.

PMID:
15975567
35.

Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice.

Müller FU, Lewin G, Baba HA, Bokník P, Fabritz L, Kirchhefer U, Kirchhof P, Loser K, Matus M, Neumann J, Riemann B, Schmitz W.

J Biol Chem. 2005 Feb 25;280(8):6906-14. Epub 2004 Nov 29.

36.

Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin.

Kirchhefer U, Baba HA, Hanske G, Jones LR, Kirchhof P, Schmitz W, Neumann J.

Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2216-25. Epub 2004 Jun 17.

37.

Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists.

Kirchhefer U, Jones LR, Begrow F, Boknik P, Hein L, Lohse MJ, Riemann B, Schmitz W, Stypmann J, Neumann J.

Cardiovasc Res. 2004 Apr 1;62(1):122-34.

PMID:
15023559
38.

[High non-specific binding of the beta(1) -selective radioligand 2-(125)I-ICI-H].

Riemann B, Law MP, Kopka K, Wagner S, Luthra S, Pike VW, Neumann J, Kirchhefer U, Schmitz W, Schober O, Schäfers M.

Nuklearmedizin. 2003 Aug;42(4):173-80. German.

PMID:
12937696
39.

Impaired relaxation in transgenic mice overexpressing junctin.

Kirchhefer U, Neumann J, Bers DM, Buchwalow IB, Fabritz L, Hanske G, Justus I, Riemann B, Schmitz W, Jones LR.

Cardiovasc Res. 2003 Aug 1;59(2):369-79.

PMID:
12909320
40.

Junctional sarcoplasmic reticulum transmembrane proteins in the heart.

Müller FU, Kirchhefer U, Begrow F, Reinke U, Neumann J, Schmitz W.

Basic Res Cardiol. 2002;97 Suppl 1:I52-5. Review.

PMID:
12479235
41.

Altered function in atrium of transgenic mice overexpressing triadin 1.

Kirchhefer U, Baba HA, Kobayashi YM, Jones LR, Schmitz W, Neumann J.

Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1334-43.

42.

Enhanced protein phosphorylation in hypertensive hypertrophy.

Bokník P, Heinroth-Hoffmann I, Kirchhefer U, Knapp J, Linck B, Lüss H, Müller T, Schmitz W, Brodde O, Neumann J.

Cardiovasc Res. 2001 Sep;51(4):717-28.

PMID:
11530105
43.

Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1.

Kirchhefer U, Neumann J, Baba HA, Begrow F, Kobayashi YM, Reinke U, Schmitz W, Jones LR.

J Biol Chem. 2001 Feb 9;276(6):4142-9. Epub 2000 Nov 7.

44.

Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na(+)-Ca(2+) exchanger.

Linck B, Bokník P, Huke S, Kirchhefer U, Knapp J, Lüss H, Müller FU, Neumann J, Tanriseven Z, Vahlensieck U, Baba HA, Jones LR, Philipson KD, Schmitz W.

J Pharmacol Exp Ther. 2000 Aug;294(2):648-57.

PMID:
10900244
45.

Biochemical mechanism(s) of stunning in conscious dogs.

Lüss H, Meissner A, Rolf N, Van Aken H, Bokník P, Kirchhefer U, Knapp J, Läer S, Linck B, Lüss I, Müller FU, Neumann J, Schmitz W.

Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H176-84.

46.

The early response genes c-jun and HSP-70 are induced in regional cardiac stunning in conscious mammals.

Meissner A, Lüss I, Rolf N, Boknik P, Kirchhefer U, Kehm V, Knapp J, Linck B, Lüss H, Müller FU, Weber T, Schmitz W, Van Aken H, Neumann J.

J Thorac Cardiovasc Surg. 2000 Apr;119(4 Pt 1):820-5.

47.

Regional expression of phospholamban in the human heart.

Bokník P, Unkel C, Kirchhefer U, Kleideiter U, Klein-Wiele O, Knapp J, Linck B, Lüss H, Müller FU, Schmitz W, Vahlensieck U, Zimmermann N, Jones LR, Neumann J.

Cardiovasc Res. 1999 Jul;43(1):67-76.

PMID:
10536691
48.

Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.

Kirchhefer U, Schmitz W, Scholz H, Neumann J.

Cardiovasc Res. 1999 Apr;42(1):254-61.

PMID:
10435018
49.

Expression of cardiac calcium regulatory proteins in atrium v ventricle in different species.

Lüss I, Boknik P, Jones LR, Kirchhefer U, Knapp J, Linck B, Lüss H, Meissner A, Müller FU, Schmitz W, Vahlensieck U, Neumann J.

J Mol Cell Cardiol. 1999 Jun;31(6):1299-314.

PMID:
10371704
50.

Long-term beta adrenoceptor-mediated alteration in contractility and expression of phospholamban and sarcoplasmic reticulum Ca(++)-ATPase in mammalian ventricle.

Linck B, Bokník P, Baba HA, Eschenhagen T, Haverkamp U, Jäckel E, Jones LR, Kirchhefer U, Knapp J, Läer S, Müller FU, Schmitz W, Scholz H, Syska A, Vahlensieck U, Neumann J.

J Pharmacol Exp Ther. 1998 Jul;286(1):531-8.

PMID:
9655899

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