Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 201


Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.

Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E.

Science. 2019 Jan 18;363(6424). pii: eaau8302. doi: 10.1126/science.aau8302.


Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis.

Böcking T, Upadhyayula S, Rapoport I, Capraro BR, Kirchhausen T.

Methods Mol Biol. 2018;1847:121-146. doi: 10.1007/978-1-4939-8719-1_10. Erratum in: Methods Mol Biol. 2018;1847:E1.


The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.

Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA.

Cell Rep. 2018 Jul 24;24(4):973-986.e8. doi: 10.1016/j.celrep.2018.06.100.


Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.

Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu TL, Hildebrand DGC, Tsai TY, Chen A, Al-Obeidi E, Fass AK, Malhotra S, Engert F, Lichtman JW, Kirchhausen T, Betzig E, Megason SG.

Elife. 2018 Jun 19;7. pii: e37131. doi: 10.7554/eLife.37131.


Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.

Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E.

Science. 2018 Apr 20;360(6386). pii: eaaq1392. doi: 10.1126/science.aaq1392.


Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic.

He K, Marsland R III, Upadhyayula S, Song E, Dang S, Capraro BR, Wang W, Skillern W, Gaudin R, Ma M, Kirchhausen T.

Nature. 2017 Dec 21;552(7685):410-414. doi: 10.1038/nature25146. Epub 2017 Dec 13.


NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP.

Cell Host Microbe. 2017 Nov 8;22(5):688-696.e5. doi: 10.1016/j.chom.2017.10.002.


Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding.

Adell MAY, Migliano SM, Upadhyayula S, Bykov YS, Sprenger S, Pakdel M, Vogel GF, Jih G, Skillern W, Behrouzi R, Babst M, Schmidt O, Hess MW, Briggs JA, Kirchhausen T, Teis D.

Elife. 2017 Oct 11;6. pii: e31652. doi: 10.7554/eLife.31652.


Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration.

Schuler MH, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, Shaw JM, Cunniff B.

Mol Biol Cell. 2017 Aug 1;28(16):2159-2169. doi: 10.1091/mbc.E16-10-0741. Epub 2017 Jun 14.


Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9.

Chou YY, Krupp A, Kaynor C, Gaudin R, Ma M, Cahir-McFarland E, Kirchhausen T.

Sci Rep. 2016 Nov 14;6:36921. doi: 10.1038/srep36921.


Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.

Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F.

J Exp Med. 2016 Nov 14;213(12):2759-2772. Epub 2016 Oct 24.


Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy.

Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T.

Mol Biol Cell. 2016 Nov 7;27(22):3418-3435. Epub 2016 Aug 17.


Membrane fission by dynamin: what we know and what we need to know.

Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S.

EMBO J. 2016 Nov 2;35(21):2270-2284. Epub 2016 Sep 26. Review.


Seipin is required for converting nascent to mature lipid droplets.

Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV.

Elife. 2016 Aug 26;5. pii: e16582. doi: 10.7554/eLife.16582.


Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.


Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor.

Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R.

J Virol. 2016 Apr 14;90(9):4494-4510. doi: 10.1128/JVI.00103-16. Print 2016 May.


Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells.

Gaudin R, Kirchhausen T.

Sci Rep. 2015 Nov 9;5:15990. doi: 10.1038/srep15990.


Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway.

Reeves PM, Kang YL, Kirchhausen T.

Traffic. 2016 Jan;17(1):40-52. doi: 10.1111/tra.12343. Epub 2015 Dec 9.


ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics.

Li D, Shao L, Chen BC, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA 3rd, Pasham M, Kirchhausen T, Baird MA, Davidson MW, Xu P, Betzig E.

Science. 2015 Aug 28;349(6251):aab3500. doi: 10.1126/science.aab3500.


Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.

Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J.

Nat Biotechnol. 2015 Aug;33(8):870-6. doi: 10.1038/nbt.3298. Epub 2015 Jul 20.


Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes.

Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J.

Cell. 2015 May 21;161(5):1229. doi: 10.1016/j.cell.2015.05.021. Epub 2015 May 21. No abstract available.


Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells.

Kural C, Akatay AA, Gaudin R, Chen BC, Legant WR, Betzig E, Kirchhausen T.

Mol Biol Cell. 2015 Jun 1;26(11):2044-53. doi: 10.1091/mbc.E15-01-0055. Epub 2015 Apr 7.


Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.

Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T.

Haematologica. 2015 Apr;100(4):439-51. doi: 10.3324/haematol.2014.119537. Epub 2014 Dec 31.


Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit.

Cocucci E, Gaudin R, Kirchhausen T.

Mol Biol Cell. 2014 Nov 5;25(22):3595-609. doi: 10.1091/mbc.E14-07-1240. Epub 2014 Sep 17.


Structural correlates of rotavirus cell entry.

Abdelhakim AH, Salgado EN, Fu X, Pasham M, Nicastro D, Kirchhausen T, Harrison SC.

PLoS Pathog. 2014 Sep 11;10(9):e1004355. doi: 10.1371/journal.ppat.1004355. eCollection 2014 Sep.


In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos.

Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S.

J Cell Sci. 2014 Sep 15;127(Pt 18):3970-82. doi: 10.1242/jcs.148767. Epub 2014 Jul 29. Erratum in: J Cell Sci. 2014 Dec 15;127(24):5331.


Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J.

Cell. 2014 Jun 5;157(6):1309-23. doi: 10.1016/j.cell.2014.03.062. Erratum in: Cell. 2015 May 21;161(5):1229.


Key interactions for clathrin coat stability.

Böcking T, Aguet F, Rapoport I, Banzhaf M, Yu A, Zeeh JC, Kirchhausen T.

Structure. 2014 Jun 10;22(6):819-29. doi: 10.1016/j.str.2014.04.002. Epub 2014 May 8.


Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.

Kirchhausen T, Owen D, Harrison SC.

Cold Spring Harb Perspect Biol. 2014 May 1;6(5):a016725. doi: 10.1101/cshperspect.a016725. Review.


The timing of pre-mRNA splicing visualized in real-time.

Carmo-Fonseca M, Kirchhausen T.

Nucleus. 2014 Jan-Feb;5(1):11-4. doi: 10.4161/nucl.28056. Epub 2014 Jan 30.


Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity.

Martin RM, Rino J, Carvalho C, Kirchhausen T, Carmo-Fonseca M.

Cell Rep. 2013 Sep 26;4(6):1144-55. doi: 10.1016/j.celrep.2013.08.013. Epub 2013 Sep 12.


Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.

Piccinotti S, Kirchhausen T, Whelan SP.

J Virol. 2013 Nov;87(21):11637-47. doi: 10.1128/JVI.01648-13. Epub 2013 Aug 21.


Clathrin-mediated endocytosis persists during unperturbed mitosis.

Tacheva-Grigorova SK, Santos AJ, Boucrot E, Kirchhausen T.

Cell Rep. 2013 Aug 29;4(4):659-68. doi: 10.1016/j.celrep.2013.07.017. Epub 2013 Aug 15.


Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation.

Heesters BA, Chatterjee P, Kim YA, Gonzalez SF, Kuligowski MP, Kirchhausen T, Carroll MC.

Immunity. 2013 Jun 27;38(6):1164-75. doi: 10.1016/j.immuni.2013.02.023. Epub 2013 Jun 13.


Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.

Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV.

J Cell Biol. 2013 Apr 29;201(3):449-65. doi: 10.1083/jcb.201209077.


Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells.

Boulant S, Stanifer M, Kural C, Cureton DK, Massol R, Nibert ML, Kirchhausen T.

Mol Biol Cell. 2013 Apr;24(8):1196-207. doi: 10.1091/mbc.E12-12-0852. Epub 2013 Feb 20.


The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export.

Lu L, Hannoush RN, Goess BC, Varadarajan S, Shair MD, Kirchhausen T.

Mol Biol Cell. 2013 Apr;24(7):1020-9. doi: 10.1091/mbc.E12-08-0575. Epub 2013 Feb 6.


Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers.

Kural C, Tacheva-Grigorova SK, Boulant S, Cocucci E, Baust T, Duarte D, Kirchhausen T.

Cell Rep. 2012 Nov 29;2(5):1111-9. doi: 10.1016/j.celrep.2012.09.025. Epub 2012 Oct 25.


Regulation of ligand-independent Notch signal through intracellular trafficking.

Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S.

Commun Integr Biol. 2012 Jul 1;5(4):374-6. doi: 10.4161/cib.19995.


Bending membranes.

Kirchhausen T.

Nat Cell Biol. 2012 Sep;14(9):906-8. doi: 10.1038/ncb2570.


The first five seconds in the life of a clathrin-coated pit.

Cocucci E, Aguet F, Boulant S, Kirchhausen T.

Cell. 2012 Aug 3;150(3):495-507. doi: 10.1016/j.cell.2012.05.047.


Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M.

Cell Stem Cell. 2012 Aug 3;11(2):242-52. doi: 10.1016/j.stem.2012.04.025.


Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures.

Cureton DK, Harbison CE, Cocucci E, Parrish CR, Kirchhausen T.

J Virol. 2012 May;86(9):5330-40. doi: 10.1128/JVI.07194-11. Epub 2012 Feb 22.


Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments.

Strang BL, Boulant S, Kirchhausen T, Coen DM.

MBio. 2012 Feb 7;3(1). pii: e00301-11. doi: 10.1128/mBio.00301-11. Print 2012.


Live-cell imaging of clathrin coats.

Kural C, Kirchhausen T.

Methods Enzymol. 2012;505:59-80. doi: 10.1016/B978-0-12-388448-0.00012-7.


Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal.

Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S.

J Cell Biol. 2011 Dec 12;195(6):1005-15. doi: 10.1083/jcb.201104146.


Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis.

Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM.

J Virol. 2012 Feb;86(4):2089-95. doi: 10.1128/JVI.06720-11. Epub 2011 Dec 7.


Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.

Boulant S, Kural C, Zeeh JC, Ubelmann F, Kirchhausen T.

Nat Cell Biol. 2011 Aug 14;13(9):1124-31. doi: 10.1038/ncb2307.


Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly.

Lu L, Ladinsky MS, Kirchhausen T.

J Cell Biol. 2011 Aug 8;194(3):425-40. doi: 10.1083/jcb.201012063.

Supplemental Content

Loading ...
Support Center