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Items: 31


Imaging Flow Cytometry for Multiparametric Analysis of Molecular Mechanism Involved in the Cytotoxicity of Human CD8+ T-cells.

Wabnitz GH, Kirchgessner H, Samstag Y.

J Cell Biochem. 2017 Sep;118(9):2528-2533. doi: 10.1002/jcb.25963. Epub 2017 Apr 27.


Qualitative and quantitative analysis of PMN/T-cell interactions by InFlow and super-resolution microscopy.

Balta E, Stopp J, Castelletti L, Kirchgessner H, Samstag Y, Wabnitz GH.

Methods. 2017 Jan 1;112:25-38. doi: 10.1016/j.ymeth.2016.09.013. Epub 2016 Sep 28.


The pro-oxidative drug WF-10 inhibits serial killing by primary human cytotoxic T-cells.

Wabnitz GH, Balta E, Schindler S, Kirchgessner H, Jahraus B, Meuer S, Samstag Y.

Cell Death Discov. 2016 Jul 25;2:16057. doi: 10.1038/cddiscovery.2016.57. eCollection 2016.


InFlow microscopy of human leukocytes: A tool for quantitative analysis of actin rearrangements in the immune synapse.

Wabnitz GH, Nessmann A, Kirchgessner H, Samstag Y.

J Immunol Methods. 2015 Aug;423:29-39. doi: 10.1016/j.jim.2015.03.003. Epub 2015 Mar 17.


Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation.

Riplinger SM, Wabnitz GH, Kirchgessner H, Jahraus B, Lasitschka F, Schulte B, van der Pluijm G, van der Horst G, Hämmerling GJ, Nakchbandi I, Samstag Y.

Mol Cancer. 2014 Jan 18;13:10. doi: 10.1186/1476-4598-13-10.


A reducing milieu renders cofilin insensitive to phosphatidylinositol 4,5-bisphosphate (PIP2) inhibition.

Schulte B, John I, Simon B, Brockmann C, Oelmeier SA, Jahraus B, Kirchgessner H, Riplinger S, Carlomagno T, Wabnitz GH, Samstag Y.

J Biol Chem. 2013 Oct 11;288(41):29430-9. doi: 10.1074/jbc.M113.479766. Epub 2013 Sep 3.


L-plastin phosphorylation: a novel target for the immunosuppressive drug dexamethasone in primary human T cells.

Wabnitz GH, Michalke F, Stober C, Kirchgessner H, Jahraus B, van den Boomen DJ, Samstag Y.

Eur J Immunol. 2011 Nov;41(11):3157-69. doi: 10.1002/eji.201041366. Epub 2011 Sep 19.


Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells.

Wabnitz GH, Goursot C, Jahraus B, Kirchgessner H, Hellwig A, Klemke M, Konstandin MH, Samstag Y.

Cell Death Dis. 2010 Jul 22;1:e58. doi: 10.1038/cddis.2010.36.


Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin.

Wabnitz GH, Lohneis P, Kirchgessner H, Jahraus B, Gottwald S, Konstandin M, Klemke M, Samstag Y.

Eur J Immunol. 2010 Sep;40(9):2437-49. doi: 10.1002/eji.201040345.


Beta2-integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectoris.

Konstandin MH, Aksoy H, Wabnitz GH, Volz C, Erbel C, Kirchgessner H, Giannitsis E, Katus HA, Samstag Y, Dengler TJ.

Basic Res Cardiol. 2009 May;104(3):341-51. doi: 10.1007/s00395-008-0770-8. Epub 2009 Jan 12.


Oxidation of cofilin mediates T cell hyporesponsiveness under oxidative stress conditions.

Klemke M, Wabnitz GH, Funke F, Funk B, Kirchgessner H, Samstag Y.

Immunity. 2008 Sep 19;29(3):404-13. doi: 10.1016/j.immuni.2008.06.016. Epub 2008 Sep 4.


Ras/PI3kinase/cofilin-independent activation of human CD45RA+ and CD45RO+ T cells by superagonistic CD28 stimulation.

Sester U, Wabnitz GH, Kirchgessner H, Samstag Y.

Eur J Immunol. 2007 Oct;37(10):2881-91.


A sensitive assay for the quantification of integrin-mediated adhesiveness of human stem cells and leukocyte subpopulations in whole blood.

Konstandin MH, Wabnitz GH, Aksoy H, Kirchgessner H, Dengler TJ, Samstag Y.

J Immunol Methods. 2007 Oct 31;327(1-2):30-9. Epub 2007 Aug 13.


The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B.

J Exp Med. 2001 Jun 4;193(11):1269-84.


Molecular alterations of the Fyn-complex occur as late events of human T cell activation.

Marie-Cardine A, Kirchgessner H, Schraven B.

Eur J Immunol. 1999 Apr;29(4):1175-87.


SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.

Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B.

J Exp Med. 1999 Apr 19;189(8):1181-94.


T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.

Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B.

J Exp Med. 1998 Aug 3;188(3):561-75.


Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes.

Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B.

J Biol Chem. 1997 Jun 27;272(26):16077-80.


Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.

Bruyns E, Mincheva A, Bruyns RM, Kirchgessner H, Weitz S, Lichter P, Meuer S, Schraven B.

Genomics. 1996 Nov 15;38(1):79-83.


Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase.

Marie-Cardine A, Kirchgessner H, Eckerskorn C, Meuer SC, Schraven B.

Eur J Immunol. 1995 Dec;25(12):3290-7.


LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes.

Schraven B, Schoenhaut D, Bruyns E, Koretzky G, Eckerskorn C, Wallich R, Kirchgessner H, Sakorafas P, Labkovsky B, Ratnofsky S, et al.

J Biol Chem. 1994 Nov 18;269(46):29102-11.


Identification of a novel dimeric phosphoprotein (PP29/30) associated with signaling receptors in human T lymphocytes and natural killer cells.

Schraven B, Ratnofsky S, Gaumont Y, Lindegger H, Kirchgessner H, Bruyns E, Moebius U, Meuer SC.

J Exp Med. 1994 Sep 1;180(3):897-906.


Alterations of CD2 association with T cell receptor signaling molecules in "CD2 unresponsive" human T lymphocytes.

Schraven B, Wild M, Kirchgessner H, Siebert B, Wallich R, Henning S, Samstag Y, Meuer SC.

Eur J Immunol. 1993 Jan;23(1):119-23.


Four CD45/P56lck-associated phosphorproteins (pp29-pp32) undergo alterations in human T cell activation.

Schraven B, Schirren A, Kirchgessner H, Siebert B, Meuer SC.

Eur J Immunol. 1992 Jul;22(7):1857-63.


Melanoma targeting with a cocktail of monoclonal antibodies to distinct determinants of the human HMW-MAA.

Matzku S, Kirchgessner H, Schmid U, Temponi M, Ferrone S.

J Nucl Med. 1989 Mar;30(3):390-7.


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