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Items: 1 to 50 of 122

1.

Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response.

Crawford G, Hayes MD, Seoane RC, Ward S, Dalessandri T, Lai C, Healy E, Kipling D, Proby C, Moyes C, Green K, Best K, Haniffa M, Botto M, Dunn-Walters D, Strid J.

Nat Immunol. 2018 Jul 16. doi: 10.1038/s41590-018-0161-8. [Epub ahead of print]

PMID:
30013146
2.

Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells.

Alimbetov D, Askarova S, Umbayev B, Davis T, Kipling D.

Int J Mol Sci. 2018 Jun 6;19(6). pii: E1690. doi: 10.3390/ijms19061690. Review.

3.

Development and Characterisation of a Human Chronic Skin Wound Cell Line-Towards an Alternative for Animal Experimentation.

Caley M, Wall IB, Peake M, Kipling D, Giles P, Thomas DW, Stephens P.

Int J Mol Sci. 2018 Mar 27;19(4). pii: E1001. doi: 10.3390/ijms19041001.

4.

CD1d-mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis.

Sáez de Guinoa J, Jimeno R, Gaya M, Kipling D, Garzón MJ, Dunn-Walters D, Ubeda C, Barral P.

EMBO J. 2018 Mar 1;37(5). pii: e97537. doi: 10.15252/embj.201797537. Epub 2018 Jan 29.

5.

Reduced immunoglobulin gene diversity in patients with Cornelia de Lange syndrome.

Björkman A, Du L, van der Burg M, Cormier-Daire V, Borck G, Pié J, Anderlid BM, Hammarström L, Ström L, de Villartay JP, Kipling D, Dunn Walters D, Pan-Hammarström Q.

J Allergy Clin Immunol. 2018 Jan;141(1):408-411.e8. doi: 10.1016/j.jaci.2017.06.043. Epub 2017 Aug 5. No abstract available.

6.

Transitional B Cells in Early Human B Cell Development - Time to Revisit the Paradigm?

Martin VG, Wu YB, Townsend CL, Lu GH, O'Hare JS, Mozeika A, Coolen AC, Kipling D, Fraternali F, Dunn-Walters DK.

Front Immunol. 2016 Dec 2;7:546. eCollection 2016.

7.

Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions.

Townsend CL, Laffy JM, Wu YB, Silva O'Hare J, Martin V, Kipling D, Fraternali F, Dunn-Walters DK.

Front Immunol. 2016 Sep 27;7:388. eCollection 2016.

8.

Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts.

Davis T, Brook AJ, Rokicki MJ, Bagley MC, Kipling D.

Pharmaceuticals (Basel). 2016 Apr 28;9(2). pii: E23. doi: 10.3390/ph9020023.

9.

The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.

Bagley MC, Dwyer JE, Baashen M, Dix MC, Murziani PG, Rokicki MJ, Kipling D, Davis T.

Org Biomol Chem. 2016 Jan 21;14(3):947-56. doi: 10.1039/c5ob02229k. Epub 2015 Nov 27.

PMID:
26611938
10.

Assessment of B Cell Repertoire in Humans.

Wu YC, Kipling D, Dunn-Walters D.

Methods Mol Biol. 2015;1343:199-218. doi: 10.1007/978-1-4939-2963-4_16.

PMID:
26420719
11.

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.

Alimbetov D, Davis T, Brook AJ, Cox LS, Faragher RG, Nurgozhin T, Zhumadilov Z, Kipling D.

Biogerontology. 2016 Apr;17(2):305-15. doi: 10.1007/s10522-015-9610-z. Epub 2015 Sep 23.

12.

A Reassessment of IgM Memory Subsets in Humans.

Bagnara D, Squillario M, Kipling D, Mora T, Walczak AM, Da Silva L, Weller S, Dunn-Walters DK, Weill JC, Reynaud CA.

J Immunol. 2015 Oct 15;195(8):3716-24. doi: 10.4049/jimmunol.1500753. Epub 2015 Sep 9.

13.

Ageing of the B-cell repertoire.

Martin V, Bryan Wu YC, Kipling D, Dunn-Walters D.

Philos Trans R Soc Lond B Biol Sci. 2015 Sep 5;370(1676). pii: 20140237. doi: 10.1098/rstb.2014.0237.

14.

Age-related aspects of human IgM(+) B cell heterogeneity.

Martin V, Wu YC, Kipling D, Dunn-Walters DK.

Ann N Y Acad Sci. 2015 Dec;1362:153-63. doi: 10.1111/nyas.12823. Epub 2015 Jul 7.

15.

Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells.

Bagley MC, Baashen M, Chuckowree I, Dwyer JE, Kipling D, Davis T.

Pharmaceuticals (Basel). 2015 Jun 3;8(2):257-76. doi: 10.3390/ph8020257.

16.

Monoclonal paraprotein influences baseline B-cell repertoire diversity and perturbates influenza vaccination-induced B-cell response.

Tete SM, Kipling D, Westra J, de Haan A, Bijl M, Dunn-Walters DK, Sahota SS, Bos NA.

Exp Hematol. 2015 Jun;43(6):439-47.e1. doi: 10.1016/j.exphem.2015.02.005. Epub 2015 Mar 18.

PMID:
25795522
17.

Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus.

Hehle V, Fraser LD, Tahir R, Kipling D, Wu YC, Lutalo PM, Cason J, Choong L, D'Cruz DP, Cope AP, Dunn-Walters DK, Spencer J.

Mol Immunol. 2015 Jun;65(2):215-23. doi: 10.1016/j.molimm.2015.01.017. Epub 2015 Feb 17.

PMID:
25700344
18.

Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBN(p70) protein undergo p38/MK2-dependent premature senescence.

Davis T, Tivey HS, Brook AJ, Kipling D.

Biogerontology. 2015 Feb;16(1):43-51. doi: 10.1007/s10522-014-9530-3. Epub 2014 Sep 12.

19.

Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis.

Wu YC, James LK, Vander Heiden JA, Uduman M, Durham SR, Kleinstein SH, Kipling D, Gould HJ.

J Allergy Clin Immunol. 2014 Sep;134(3):604-12. doi: 10.1016/j.jaci.2014.07.010.

20.

Identification of a transcriptional signature for the wound healing continuum.

Peake MA, Caley M, Giles PJ, Wall I, Enoch S, Davies LC, Kipling D, Thomas DW, Stephens P.

Wound Repair Regen. 2014 May-Jun;22(3):399-405. doi: 10.1111/wrr.12170.

21.

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12.

22.

Differential expression of cysteine dioxygenase 1 in complex karyotype liposarcomas.

Shaker M, Pascarelli KM, Plantinga MJ, Love MA, Lazar AJ, Ingram DR, von Mehren M, Lev D, Kipling D, Broccoli D.

Biomark Cancer. 2014 Apr 6;6:1-10. doi: 10.4137/BIC.S14683. eCollection 2014.

23.

DNA repair genes are selectively mutated in diffuse large B cell lymphomas.

de Miranda NF, Peng R, Georgiou K, Wu C, Falk Sörqvist E, Berglund M, Chen L, Gao Z, Lagerstedt K, Lisboa S, Roos F, van Wezel T, Teixeira MR, Rosenquist R, Sundström C, Enblad G, Nilsson M, Zeng Y, Kipling D, Pan-Hammarström Q.

J Exp Med. 2013 Aug 26;210(9):1729-42. doi: 10.1084/jem.20122842. Epub 2013 Aug 19.

24.

Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts.

Tivey HS, Rokicki MJ, Barnacle JR, Rogers MJ, Bagley MC, Kipling D, Davis T.

J Gerontol A Biol Sci Med Sci. 2013 Sep;68(9):1001-9. doi: 10.1093/gerona/gls336. Epub 2013 Feb 11.

25.

The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome.

Davis T, Rokicki MJ, Bagley MC, Kipling D.

Chem Cent J. 2013 Jan 29;7(1):18. doi: 10.1186/1752-153X-7-18.

26.

Biomarkers, interventions and healthy ageing.

Kenessary A, Zhumadilov Z, Nurgozhin T, Kipling D, Yeoman M, Cox L, Ostler E, Faragher R.

N Biotechnol. 2013 May 25;30(4):373-7. doi: 10.1016/j.nbt.2012.11.018. Epub 2012 Nov 29. Review.

PMID:
23201073
27.

p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes.

Tivey HS, Brook AJ, Rokicki MJ, Kipling D, Davis T.

Biogerontology. 2013 Feb;14(1):47-62. doi: 10.1007/s10522-012-9407-2. Epub 2012 Oct 31.

28.

Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund-Thomson syndrome.

Davis T, Tivey HS, Brook AJ, Grimstead JW, Rokicki MJ, Kipling D.

Age (Dordr). 2013 Oct;35(5):1767-83. doi: 10.1007/s11357-012-9476-9. Epub 2012 Sep 22.

29.

Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination.

Wu YC, Kipling D, Dunn-Walters DK.

Front Immunol. 2012 Jul 9;3:193. doi: 10.3389/fimmu.2012.00193. eCollection 2012.

30.

Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors.

Davis T, Dix MC, Rokicki MJ, Brook AJ, Widdowson CS, Kipling D, Bagley MC.

Chem Cent J. 2011 Dec 8;5(1):83. doi: 10.1186/1752-153X-5-83.

31.

Characterization of cellular senescence mechanisms in human corneal endothelial cells.

Sheerin AN, Smith SK, Jennert-Burston K, Brook AJ, Allen MC, Ibrahim B, Jones D, Wallis C, Engelmann K, Rhys-Williams W, Faragher RG, Kipling D.

Aging Cell. 2012 Apr;11(2):234-40. doi: 10.1111/j.1474-9726.2011.00776.x. Epub 2011 Dec 29.

32.

Reversible senescence in human CD4+CD45RA+CD27- memory T cells.

Di Mitri D, Azevedo RI, Henson SM, Libri V, Riddell NE, Macaulay R, Kipling D, Soares MV, Battistini L, Akbar AN.

J Immunol. 2011 Sep 1;187(5):2093-100. doi: 10.4049/jimmunol.1100978. Epub 2011 Jul 25.

33.

Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages.

Ademokun A, Wu YC, Martin V, Mitra R, Sack U, Baxendale H, Kipling D, Dunn-Walters DK.

Aging Cell. 2011 Dec;10(6):922-30. doi: 10.1111/j.1474-9726.2011.00732.x. Epub 2011 Aug 10.

34.

Validating a gene expression signature proposed to differentiate liposarcomas that use different telomere maintenance mechanisms.

Doyle KR, Mitchell MA, Roberts CL, James S, Johnson JE, Zhou Y, von Mehren M, Lev D, Kipling D, Broccoli D.

Oncogene. 2012 Jan 12;31(2):265-6; author reply 267-8. doi: 10.1038/onc.2011.225. Epub 2011 Jun 27. No abstract available.

35.

Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells.

Bagley MC, Davis T, Dix MC, Murziani PG, Rokicki MJ, Kipling D.

Future Med Chem. 2010 Feb;2(2):203-13. doi: 10.4155/fmc.09.160.

PMID:
21426187
36.

Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.

Bagley MC, Davis T, Rokicki MJ, Widdowson CS, Kipling D.

Future Med Chem. 2010 Feb;2(2):193-201. doi: 10.4155/fmc.09.163. Erratum in: Future Med Chem. 2011 Jan;3(1):138.

PMID:
21426186
37.

Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome.

Bagley MC, Davis T, Dix MC, Fusillo V, Pigeaux M, Rokicki MJ, Kipling D.

Future Med Chem. 2010 Sep;2(9):1417-27. doi: 10.4155/fmc.10.217.

PMID:
21426137
38.

The relationship between CD27 negative and positive B cell populations in human peripheral blood.

Wu YC, Kipling D, Dunn-Walters DK.

Front Immunol. 2011 Dec 26;2:81. doi: 10.3389/fimmu.2011.00081. eCollection 2011.

39.

'Young' oral fibroblasts are geno/phenotypically distinct.

Enoch S, Peake MA, Wall I, Davies L, Farrier J, Giles P, Kipling D, Price P, Moseley R, Thomas D, Stephens P.

J Dent Res. 2010 Dec;89(12):1407-13. doi: 10.1177/0022034510377796.

PMID:
21098492
40.

Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts.

Davis T, Bachler MA, Wyllie FS, Bagley MC, Kipling D.

Ann N Y Acad Sci. 2010 Jun;1197:45-8. doi: 10.1111/j.1749-6632.2010.05195.x. Review.

PMID:
20536832
41.

Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.

Bagley MC, Davis T, Murziani PG, Widdowson CS, Kipling D.

Pharmaceuticals (Basel). 2010 Jun 4;3(6):1842-1872. Review.

42.

High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations.

Wu YC, Kipling D, Leong HS, Martin V, Ademokun AA, Dunn-Walters DK.

Blood. 2010 Aug 19;116(7):1070-8. doi: 10.1182/blood-2010-03-275859. Epub 2010 May 10.

43.

Doxorubicin resistance in a novel in vitro model of human pleomorphic liposarcoma associated with alternative lengthening of telomeres.

Mitchell MA, Johnson JE, Pascarelli K, Beeharry N, Chiourea M, Gagos S, Lev D, von Mehren M, Kipling D, Broccoli D.

Mol Cancer Ther. 2010 Mar;9(3):682-92. doi: 10.1158/1535-7163.MCT-09-0705. Epub 2010 Mar 2.

44.

Modelling p-value distributions to improve theme-driven survival analysis of cancer transcriptome datasets.

Czwan E, Brors B, Kipling D.

BMC Bioinformatics. 2010 Jan 11;11:19. doi: 10.1186/1471-2105-11-19.

45.

Increased oral fibroblast lifespan is telomerase-independent.

Enoch S, Wall I, Peake M, Davies L, Farrier J, Giles P, Baird D, Kipling D, Price P, Moseley R, Thomas D, Stephens P.

J Dent Res. 2009 Oct;88(10):916-21. doi: 10.1177/0022034509342979.

PMID:
19783799
46.

Microwave-assisted Ullmann C-S bond formation: synthesis of the P38alpha MAPK clinical candidate VX-745.

Bagley MC, Davis T, Dix MC, Fusillo V, Pigeaux M, Rokicki MJ, Kipling D.

J Org Chem. 2009 Nov 6;74(21):8336-42. doi: 10.1021/jo9017155.

PMID:
19778055
47.

Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification.

Burton DG, Giles PJ, Sheerin AN, Smith SK, Lawton JJ, Ostler EL, Rhys-Williams W, Kipling D, Faragher RG.

Exp Gerontol. 2009 Oct;44(10):659-65. doi: 10.1016/j.exger.2009.07.004. Epub 2009 Jul 23.

PMID:
19631729
48.

Mechanisms of immunosenescence.

Caruso C, Buffa S, Candore G, Colonna-Romano G, Dunn-Walters D, Kipling D, Pawelec G.

Immun Ageing. 2009 Jul 22;6:10. doi: 10.1186/1742-4933-6-10.

49.

Text-based over-representation analysis of microarray gene lists with annotation bias.

Leong HS, Kipling D.

Nucleic Acids Res. 2009 Jun;37(11):e79. doi: 10.1093/nar/gkp310. Epub 2009 May 8.

50.

A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence.

Kipling D, Jones DL, Smith SK, Giles PJ, Jennert-Burston K, Ibrahim B, Sheerin AN, Evans AJ, Rhys-Willams W, Faragher RG.

Exp Eye Res. 2009 Feb;88(2):277-85. doi: 10.1016/j.exer.2008.11.030. Epub 2008 Dec 13.

PMID:
19087878

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