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Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors.

Karamitros D, Patmanidi AL, Kotantaki P, Potocnik AJ, Bähr-Ivacevic T, Benes V, Lygerou Z, Kioussis D, Taraviras S.

Development. 2015 Jan 1;142(1):70-81. doi: 10.1242/dev.109454.


Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems.

Patel A, Harker N, Moreira-Santos L, Ferreira M, Alden K, Timmis J, Foster K, Garefalaki A, Pachnis P, Andrews P, Enomoto H, Milbrandt J, Pachnis V, Coles MC, Kioussis D, Veiga-Fernandes H.

Sci Signal. 2012 Jul 31;5(235):ra55. doi: 10.1126/scisignal.2002734.


Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression.

Tanaka Y, Kawahashi K, Katagiri Z, Nakayama Y, Mahajan M, Kioussis D.

PLoS One. 2011;6(11):e28171. doi: 10.1371/journal.pone.0028171. Epub 2011 Nov 28.


Modulation of the murine CD8 gene complex following the targeted integration of human CD2-locus control region sequences.

Menzel U, Kosteas T, Tolaini M, Killeen N, Roderick K, Kioussis D.

J Immunol. 2011 Oct 1;187(7):3712-20. doi: 10.4049/jimmunol.1100709. Epub 2011 Aug 31.


T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin.

Karamitros D, Kotantaki P, Lygerou Z, Kioussis D, Taraviras S.

Crit Rev Immunol. 2011;31(3):209-31. Review.


Geminin regulates cortical progenitor proliferation and differentiation.

Spella M, Kyrousi C, Kritikou E, Stathopoulou A, Guillemot F, Kioussis D, Pachnis V, Lygerou Z, Taraviras S.

Stem Cells. 2011 Aug;29(8):1269-82. doi: 10.1002/stem.678.


Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development.

Harker N, Garefalaki A, Menzel U, Ktistaki E, Naito T, Georgopoulos K, Kioussis D.

J Immunol. 2011 Jun 1;186(11):6368-77. doi: 10.4049/jimmunol.1003567. Epub 2011 Apr 22.


Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages.

Menzel U, Ktistaki E, Tolaini M, Veiga-Fernandes H, Kioussis D.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16928-33. doi: 10.1073/pnas.1010317107. Epub 2010 Sep 13.


Cellular and molecular requirements in lymph node and Peyer's patch development.

Coles M, Kioussis D, Veiga-Fernandes H.

Prog Mol Biol Transl Sci. 2010;92:177-205. doi: 10.1016/S1877-1173(10)92008-5. Review.


Commentary on "lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses".

Coles M, Kioussis D, Veiga-Fernandes H.

Prog Mol Biol Transl Sci. 2010;92:175-6. doi: 10.1016/S1877-1173(10)92016-4. No abstract available.


Life without geminin.

Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, Kioussis D, Taraviras S.

Cell Cycle. 2010 Aug 15;9(16):3181-5. doi: 10.4161/cc.9.16.12554. Epub 2010 Aug 28.


EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.

Foster KE, Gordon J, Cardenas K, Veiga-Fernandes H, Makinen T, Grigorieva E, Wilkinson DG, Blackburn CC, Richie E, Manley NR, Adams RH, Kioussis D, Coles MC.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13414-9. doi: 10.1073/pnas.1003747107. Epub 2010 Jul 8.


CD8 locus nuclear dynamics during thymocyte development.

Ktistaki E, Garefalaki A, Williams A, Andrews SR, Bell DM, Foster KE, Spilianakis CG, Flavell RA, Kosyakova N, Trifonov V, Liehr T, Kioussis D.

J Immunol. 2010 May 15;184(10):5686-95. doi: 10.4049/jimmunol.1000170. Epub 2010 Apr 19.


Visualisation of lymphoid organ development.

Veiga-Fernandes H, Foster K, Patel A, Coles M, Kioussis D.

Methods Mol Biol. 2010;616:161-79. doi: 10.1007/978-1-60761-461-6_11.


Natural killer receptors: the burden of a name.

Veiga-Fernandes H, Kioussis D, Coles M.

J Exp Med. 2010 Feb 15;207(2):269-72. doi: 10.1084/jem.20100105. Epub 2010 Feb 8.


Differential geminin requirement for proliferation of thymocytes and mature T cells.

Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, Kioussis D, Taraviras S.

J Immunol. 2010 Mar 1;184(5):2432-41. doi: 10.4049/jimmunol.0901983. Epub 2010 Jan 27.


Generalized immune activation as a direct result of activated CD4+ T cell killing.

Marques R, Williams A, Eksmond U, Wullaert A, Killeen N, Pasparakis M, Kioussis D, Kassiotis G.

J Biol. 2009;8(10):93. doi: 10.1186/jbiol194.


Immune and nervous systems: more than just a superficial similarity?

Kioussis D, Pachnis V.

Immunity. 2009 Nov 20;31(5):705-10. doi: 10.1016/j.immuni.2009.09.009.


The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.

Gascoyne DM, Long E, Veiga-Fernandes H, de Boer J, Williams O, Seddon B, Coles M, Kioussis D, Brady HJ.

Nat Immunol. 2009 Oct;10(10):1118-24. doi: 10.1038/ni.1787. Epub 2009 Sep 13. Erratum in: Nat Immunol. 2010 Jun;11(6):543.


Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes.

Woodward MJ, de Boer J, Heidorn S, Hubank M, Kioussis D, Williams O, Brady HJ.

Cell Death Differ. 2010 Feb;17(2):316-23. doi: 10.1038/cdd.2009.125. Epub 2009 Sep 4.


An essential role for the stalk region of CD8 beta in the coreceptor function of CD8.

Rettig L, McNeill L, Sarner N, Guillaume P, Luescher I, Tolaini M, Kioussis D, Zamoyska R.

J Immunol. 2009 Jan 1;182(1):121-9.


Rac GTPases play critical roles in early T-cell development.

Dumont C, Corsoni-Tadrzak A, Ruf S, de Boer J, Williams A, Turner M, Kioussis D, Tybulewicz VL.

Blood. 2009 Apr 23;113(17):3990-8. doi: 10.1182/blood-2008-09-181180. Epub 2008 Dec 16.


HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions.

Aucott R, Bullwinkel J, Yu Y, Shi W, Billur M, Brown JP, Menzel U, Kioussis D, Wang G, Reisert I, Weimer J, Pandita RK, Sharma GG, Pandita TK, Fundele R, Singh PB.

J Cell Biol. 2008 Nov 17;183(4):597-606. doi: 10.1083/jcb.200804041.


Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease.

Zhu B, Symonds AL, Martin JE, Kioussis D, Wraith DC, Li S, Wang P.

J Exp Med. 2008 Sep 29;205(10):2295-307. doi: 10.1084/jem.20080187. Epub 2008 Sep 8.


The relative efficiency of acquisition of MHC:peptide complexes and cross-presentation depends on dendritic cell type.

Smyth LA, Harker N, Turnbull W, El-Doueik H, Klavinskis L, Kioussis D, Lombardi G, Lechler R.

J Immunol. 2008 Sep 1;181(5):3212-20.


Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

McMahon KA, Hiew SY, Hadjur S, Veiga-Fernandes H, Menzel U, Price AJ, Kioussis D, Williams O, Brady HJ.

Cell Stem Cell. 2007 Sep 13;1(3):338-45. doi: 10.1016/j.stem.2007.07.002.


Position effect variegation and imprinting of transgenes in lymphocytes.

Williams A, Harker N, Ktistaki E, Veiga-Fernandes H, Roderick K, Tolaini M, Norton T, Williams K, Kioussis D.

Nucleic Acids Res. 2008 Apr;36(7):2320-9. doi: 10.1093/nar/gkn085. Epub 2008 Feb 22.


Contribution of neural crest-derived cells in the embryonic and adult thymus.

Foster K, Sheridan J, Veiga-Fernandes H, Roderick K, Pachnis V, Adams R, Blackburn C, Kioussis D, Coles M.

J Immunol. 2008 Mar 1;180(5):3183-9.


Regulation of early T cell development by the PHD finger of histone lysine methyltransferase ASH1.

Tanaka Y, Nakayama Y, Taniguchi M, Kioussis D.

Biochem Biophys Res Commun. 2008 Jan 18;365(3):589-94. Epub 2007 Nov 5.


Epigenetic flexibility underlying lineage choices in the adaptive immune system.

Kioussis D, Georgopoulos K.

Science. 2007 Aug 3;317(5838):620-2.


Trithorax-group protein ASH1 methylates histone H3 lysine 36.

Tanaka Y, Katagiri Z, Kawahashi K, Kioussis D, Kitajima S.

Gene. 2007 Aug 1;397(1-2):161-8. Epub 2007 May 1.


Noncontact optical imaging in mice with full angular coverage and automatic surface extraction.

Meyer H, Garofalakis A, Zacharakis G, Psycharakis S, Mamalaki C, Kioussis D, Economou EN, Ntziachristos V, Ripoll J.

Appl Opt. 2007 Jun 10;46(17):3617-27.


Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography.

Garofalakis A, Zacharakis G, Meyer H, Economou EN, Mamalaki C, Papamatheakis J, Kioussis D, Ntziachristos V, Ripoll J.

Mol Imaging. 2007 Mar-Apr;6(2):96-107.


Aiolos: an ungrateful member of the Ikaros family.

Kioussis D.

Immunity. 2007 Mar;26(3):275-7. Review.


Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.

Veiga-Fernandes H, Coles MC, Foster KE, Patel A, Williams A, Natarajan D, Barlow A, Pachnis V, Kioussis D.

Nature. 2007 Mar 29;446(7135):547-51. Epub 2007 Feb 25.


TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL.

Morrow M, Samanta A, Kioussis D, Brady HJ, Williams O.

Oncogene. 2007 Jun 28;26(30):4404-14. Epub 2007 Jan 22.


Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.

Coles MC, Veiga-Fernandes H, Foster KE, Norton T, Pagakis SN, Seddon B, Kioussis D.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13457-62. Epub 2006 Aug 24.


ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.

Papoutsopoulou S, Symons A, Tharmalingham T, Belich MP, Kaiser F, Kioussis D, O'Garra A, Tybulewicz V, Ley SC.

Nat Immunol. 2006 Jun;7(6):606-15. Epub 2006 Apr 23.


Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.

Horton SJ, Grier DG, McGonigle GJ, Thompson A, Morrow M, De Silva I, Moulding DA, Kioussis D, Lappin TR, Brady HJ, Williams O.

Cancer Res. 2005 Oct 15;65(20):9245-52.


Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation.

Sekkali B, Szabat E, Ktistaki E, Tolaini M, Roderick K, Harker N, Patel A, Williams K, Norton T, Kioussis D.

J Immunol. 2005 Oct 15;175(8):5203-12.


Identification of a macrophage-specific chromatin signature in the IL-10 locus.

Saraiva M, Christensen JR, Tsytsykova AV, Goldfeld AE, Ley SC, Kioussis D, O'Garra A.

J Immunol. 2005 Jul 15;175(2):1041-6.


Gene regulation: kissing chromosomes.

Kioussis D.

Nature. 2005 Jun 2;435(7042):579-80. No abstract available.


The AXH domain adopts alternative folds the solution structure of HBP1 AXH.

de Chiara C, Menon RP, Adinolfi S, de Boer J, Ktistaki E, Kelly G, Calder L, Kioussis D, Pastore A.

Structure. 2005 May;13(5):743-53.


Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance.

Stephens R, Albano FR, Quin S, Pascal BJ, Harrison V, Stockinger B, Kioussis D, Weltzien HU, Langhorne J.

Blood. 2005 Sep 1;106(5):1676-84. Epub 2005 May 12.


The European dimension for the mouse genome mutagenesis program.

Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, de Angelis MH, Jackson I, Kioussis D, Kollias G, Lathrop M, Lendahl U, Malumbres M, von Melchner H, Müller W, Partanen J, Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B, Stewart AF, Thornton J, Tocchini-Valentini G, Wagner E, Wahli W, Wurst W.

Nat Genet. 2004 Sep;36(9):925-7. Erratum in: Nat Genet. 2004 Nov;36(11):1238.


Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice.

Quaratino S, Badami E, Pang YY, Bartok I, Dyson J, Kioussis D, Londei M, Maiuri L.

Nat Med. 2004 Sep;10(9):920-6. Epub 2004 Aug 15.


Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.

Li L, Grønning LM, Anderson PO, Li S, Edvardsen K, Johnston J, Kioussis D, Shepherd PR, Wang P.

J Biol Chem. 2004 Aug 13;279(33):34107-14. Epub 2004 Apr 27.


Shh! Shh! It's, oh, so quiet.

Kioussis D.

Nat Immunol. 2004 Apr;5(4):353-4. No abstract available.


TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity.

Morrow M, Horton S, Kioussis D, Brady HJ, Williams O.

Blood. 2004 May 15;103(10):3890-6. Epub 2004 Jan 15.


L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes.

Galkina E, Tanousis K, Preece G, Tolaini M, Kioussis D, Florey O, Haskard DO, Tedder TF, Ager A.

J Exp Med. 2003 Nov 3;198(9):1323-35.

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