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Items: 1 to 50 of 87

1.

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem.

Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH.

J Cell Biol. 2019 Jun 3;218(6):1799-1809. doi: 10.1083/jcb.201810061. Epub 2019 Apr 15.

PMID:
30988001
2.

IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala.

Patel RR, Khom S, Steinman MQ, Varodayan FP, Kiosses WB, Hedges DM, Vlkolinsky R, Nadav T, Polis I, Bajo M, Roberts AJ, Roberto M.

Brain Behav Immun. 2019 Jan;75:208-219. doi: 10.1016/j.bbi.2018.10.009. Epub 2018 Oct 26.

PMID:
30791967
3.

The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration.

Ramadass M, Johnson JL, Marki A, Zhang J, Wolf D, Kiosses WB, Pestonjamasp K, Ley K, Catz SD.

J Leukoc Biol. 2019 Jun;105(6):1209-1224. doi: 10.1002/JLB.1VMA0818-320R. Epub 2019 Feb 12.

PMID:
30748033
4.

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.

Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N.

J Clin Invest. 2019 Mar 1;129(3):1193-1210. doi: 10.1172/JCI123267. Epub 2019 Feb 11.

5.

High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis.

Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, Arnaout MA, Gutierrez E, Groisman A, Ginsberg MH, Ley K.

Cell Rep. 2019 Jan 2;26(1):119-130.e5. doi: 10.1016/j.celrep.2018.12.038.

6.

Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.

Chandra S, Gray J, Kiosses WB, Khurana A, Hitomi K, Crosby CM, Chawla A, Fu Z, Zhao M, Veerapen N, Richardson SK, Porcelli SA, Besra G, Howell AR, Sharma S, Peters B, Kronenberg M.

Nat Commun. 2018 Oct 15;9(1):4279. doi: 10.1038/s41467-018-06646-8.

7.

Delineating the Cellular Mechanisms Associated with Skin Electroporation.

Schultheis K, Smith TRF, Kiosses WB, Kraynyak KA, Wong A, Oh J, Broderick KE.

Hum Gene Ther Methods. 2018 Aug;29(4):177-188. doi: 10.1089/hgtb.2017.105. Epub 2018 Aug 10.

8.

The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation.

Miles LA, Baik N, Bai H, Makarenkova HP, Kiosses WB, Krajewski S, Castellino FJ, Valenzuela A, Varki NM, Mueller BM, Parmer RJ.

J Thromb Haemost. 2018 May;16(5):919-932. doi: 10.1111/jth.13988. Epub 2018 Apr 1.

9.

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV Jr, Cravatt BF.

Biochemistry. 2018 Feb 6;57(5):827-838. doi: 10.1021/acs.biochem.7b01028. Epub 2017 Dec 26.

10.

Adipose tissue: a new target for electroporation-enhanced DNA vaccines.

Fisher PD, Brambila CJ, McCoy JR, Kiosses WB, Mendoza JM, Oh J, Yung BS, Schultheis K, Smith TRF, Broderick KE.

Gene Ther. 2017 Dec;24(12):757-767. doi: 10.1038/gt.2017.96. Epub 2017 Nov 6.

11.

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.

Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N.

Nat Commun. 2017 Oct 20;8(1):1060. doi: 10.1038/s41467-017-01168-1.

12.

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice.

Meckes JK, Caramés B, Olmer M, Kiosses WB, Grogan SP, Lotz MK, D'Lima DD.

Osteoarthritis Cartilage. 2017 Nov;25(11):1880-1889. doi: 10.1016/j.joca.2017.07.023. Epub 2017 Aug 8.

13.

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

Zhang J, Johnson JL, He J, Napolitano G, Ramadass M, Rocca C, Kiosses WB, Bucci C, Xin Q, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD.

J Biol Chem. 2017 Jun 23;292(25):10328-10346. doi: 10.1074/jbc.M116.764076. Epub 2017 May 2.

14.

Intratumoral Cancer Cell Intravasation Can Occur Independent of Invasion into the Adjacent Stroma.

Deryugina EI, Kiosses WB.

Cell Rep. 2017 Apr 18;19(3):601-616. doi: 10.1016/j.celrep.2017.03.064.

15.

Macrophages form functional vascular mimicry channels in vivo.

Barnett FH, Rosenfeld M, Wood M, Kiosses WB, Usui Y, Marchetti V, Aguilar E, Friedlander M.

Sci Rep. 2016 Nov 11;6:36659. doi: 10.1038/srep36659.

16.

Mitochondrial dysfunction in an Opa1(Q285STOP) mouse model of dominant optic atrophy results from Opa1 haploinsufficiency.

Kushnareva Y, Seong Y, Andreyev AY, Kuwana T, Kiosses WB, Votruba M, Newmeyer DD.

Cell Death Dis. 2016 Jul 28;7:e2309. doi: 10.1038/cddis.2016.160.

17.

Pro-apoptotic Bax molecules densely populate the edges of membrane pores.

Kuwana T, Olson NH, Kiosses WB, Peters B, Newmeyer DD.

Sci Rep. 2016 Jun 3;6:27299. doi: 10.1038/srep27299.

18.

S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.

Teijaro JR, Studer S, Leaf N, Kiosses WB, Nguyen N, Matsuki K, Negishi H, Taniguchi T, Oldstone MB, Rosen H.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1351-6. doi: 10.1073/pnas.1525356113. Epub 2016 Jan 19.

19.

Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.

Johnson JL, He J, Ramadass M, Pestonjamasp K, Kiosses WB, Zhang J, Catz SD.

J Biol Chem. 2016 Feb 12;291(7):3423-38. doi: 10.1074/jbc.M115.705871. Epub 2015 Dec 4.

20.

Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction.

Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown JH, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ.

Mol Pharmacol. 2016 Jan;89(1):176-86. doi: 10.1124/mol.115.100222. Epub 2015 Oct 22.

21.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.

22.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

23.

The relationship of autophagy defects to cartilage damage during joint aging in a mouse model.

Caramés B, Olmer M, Kiosses WB, Lotz MK.

Arthritis Rheumatol. 2015 Jun;67(6):1568-76. doi: 10.1002/art.39073.

24.

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.

Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N.

Ann Rheum Dis. 2016 Jan;75(1):295-302. doi: 10.1136/annrheumdis-2014-205790. Epub 2014 Nov 6.

25.

DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response.

Smith TR, Schultheis K, Kiosses WB, Amante DH, Mendoza JM, Stone JC, McCoy JR, Sardesai NY, Broderick KE.

Mol Ther Methods Clin Dev. 2014 Dec 3;1:14054. doi: 10.1038/mtm.2014.54. eCollection 2014.

26.

A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress.

Liu Y, Collins C, Kiosses WB, Murray AM, Joshi M, Shepherd TR, Fuentes EJ, Tzima E.

J Cell Biol. 2013 Jun 10;201(6):863-73. doi: 10.1083/jcb.201207115. Epub 2013 Jun 3.

27.

Glucosamine activates autophagy in vitro and in vivo.

Caramés B, Kiosses WB, Akasaki Y, Brinson DC, Eap W, Koziol J, Lotz MK.

Arthritis Rheum. 2013 Jul;65(7):1843-52. doi: 10.1002/art.37977.

28.

Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.

Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N.

Arthritis Rheum. 2013 May;65(5):1171-80. doi: 10.1002/art.37872.

29.

Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation.

Mendoza JM, Amante DH, Kichaev G, Knott CL, Kiosses WB, Smith TR, Sardesai NY, Broderick KE.

Vaccines (Basel). 2013 Aug 28;1(3):384-97. doi: 10.3390/vaccines1030384.

30.

The plasminogen receptor, Plg-R(KT), and macrophage function.

Miles LA, Lighvani S, Baik N, Andronicos NM, Chen EI, Parmer CM, Khaldoyanidi S, Diggs JE, Kiosses WB, Kamps MP, Yates JR 3rd, Parmer RJ.

J Biomed Biotechnol. 2012;2012:250464. doi: 10.1155/2012/250464. Epub 2012 Oct 14. Review.

31.

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.

Johnson JL, Monfregola J, Napolitano G, Kiosses WB, Catz SD.

Mol Biol Cell. 2012 May;23(10):1902-16. doi: 10.1091/mbc.E11-12-1001. Epub 2012 Mar 21.

32.

The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release.

Bai H, Baik N, Kiosses WB, Krajewski S, Miles LA, Parmer RJ.

J Biol Chem. 2011 Sep 23;286(38):33125-33. doi: 10.1074/jbc.M111.218693. Epub 2011 Jul 27.

33.

A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy.

Coppieters K, Martinic MM, Kiosses WB, Amirian N, von Herrath M.

PLoS One. 2010 Dec 23;5(12):e15732. doi: 10.1371/journal.pone.0015732.

34.

Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils.

Johnson JL, Hong H, Monfregola J, Kiosses WB, Catz SD.

J Biol Chem. 2011 Feb 18;286(7):5647-56. doi: 10.1074/jbc.M110.184762. Epub 2010 Dec 9.

35.

Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo.

Kemball CC, Alirezaei M, Flynn CT, Wood MR, Harkins S, Kiosses WB, Whitton JL.

J Virol. 2010 Dec;84(23):12110-24. doi: 10.1128/JVI.01417-10. Epub 2010 Sep 22.

36.

A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS.

Tabor-Godwin JM, Ruller CM, Bagalso N, An N, Pagarigan RR, Harkins S, Gilbert PE, Kiosses WB, Gude NA, Cornell CT, Doran KS, Sussman MA, Whitton JL, Feuer R.

J Neurosci. 2010 Jun 23;30(25):8676-91. doi: 10.1523/JNEUROSCI.1860-10.2010.

37.

Short-term fasting induces profound neuronal autophagy.

Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB.

Autophagy. 2010 Aug;6(6):702-10. Epub 2010 Aug 14.

38.

OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.

Hong Y, Fink E, Hu QY, Kiosses WB, Elder JH.

J Virol. 2010 Jul;84(14):7225-32. doi: 10.1128/JVI.00434-10. Epub 2010 May 12.

39.

Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality.

Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL.

Nat Struct Mol Biol. 2010 Jan;17(1):57-61. doi: 10.1038/nsmb.1706. Epub 2009 Dec 13.

40.

Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation.

Andronicos NM, Chen EI, Baik N, Bai H, Parmer CM, Kiosses WB, Kamps MP, Yates JR 3rd, Parmer RJ, Miles LA.

Blood. 2010 Feb 18;115(7):1319-30. doi: 10.1182/blood-2008-11-188938. Epub 2009 Nov 6.

41.

Retraction for "S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF".

Gon Y, Wood MR, Kiosses WB, Jo E, Sanna MG, Chun J, Rosen H.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12561. doi: 10.1073/pnas.0906977106. Epub 2009 Jul 9. No abstract available.

42.

Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period.

Feuer R, Ruller CM, An N, Tabor-Godwin JM, Rhoades RE, Maciejewski S, Pagarigan RR, Cornell CT, Crocker SJ, Kiosses WB, Pham-Mitchell N, Campbell IL, Whitton JL.

J Virol. 2009 Sep;83(18):9356-69. doi: 10.1128/JVI.02382-07. Epub 2009 Jul 1.

43.

Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene.

Makarenkova HP, Gonzalez KN, Kiosses WB, Meech R.

J Biol Chem. 2009 May 29;284(22):14866-74. doi: 10.1074/jbc.M807208200. Epub 2009 Mar 5.

44.

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis.

Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ.

Autophagy. 2009 Feb;5(2):152-8. Epub 2009 Feb 5.

45.

The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.

Brzezinska AA, Johnson JL, Munafo DB, Crozat K, Beutler B, Kiosses WB, Ellis BA, Catz SD.

Traffic. 2008 Dec;9(12):2151-64. doi: 10.1111/j.1600-0854.2008.00838.x. Epub 2008 Oct 30.

46.

Decreased neuronal autophagy in HIV dementia: a mechanism of indirect neurotoxicity.

Alirezaei M, Kiosses WB, Fox HS.

Autophagy. 2008 Oct;4(7):963-6. Epub 2008 Oct 18.

47.

Disruption of neuronal autophagy by infected microglia results in neurodegeneration.

Alirezaei M, Kiosses WB, Flynn CT, Brady NR, Fox HS.

PLoS One. 2008 Aug 6;3(8):e2906. doi: 10.1371/journal.pone.0002906.

48.

Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment.

Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH.

Circ Res. 2008 Jul 18;103(2):177-85. doi: 10.1161/CIRCRESAHA.108.176354. Epub 2008 Jun 26.

49.

Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events.

Mullick AE, Soldau K, Kiosses WB, Bell TA 3rd, Tobias PS, Curtiss LK.

J Exp Med. 2008 Feb 18;205(2):373-83. doi: 10.1084/jem.20071096. Epub 2008 Feb 4.

50.

Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine.

Zhou Q, Kiosses WB, Liu J, Schimmel P.

Methods. 2008 Feb;44(2):190-5. doi: 10.1016/j.ymeth.2007.10.004.

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