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Items: 13


A Randomized, Controlled Trial of the Analytic and Diagnostic Performance of Singleton and Trio, Rapid Genome and Exome Sequencing in Ill Infants.

Kingsmore SF, Cakici JA, Clark MM, Gaughran M, Feddock M, Batalov S, Bainbridge MN, Carroll J, Caylor SA, Clarke C, Ding Y, Ellsworth K, Farnaes L, Hildreth A, Hobbs C, James K, Kint CI, Lenberg J, Nahas S, Prince L, Reyes I, Salz L, Sanford E, Schols P, Sweeney N, Tokita M, Veeraraghavan N, Watkins K, Wigby K, Wong T, Chowdhury S, Wright MS, Dimmock D; RCIGM Investigators.

Am J Hum Genet. 2019 Oct 3;105(4):719-733. doi: 10.1016/j.ajhg.2019.08.009. Epub 2019 Sep 26.


Biochemical determinants of ObgE-mediated persistence.

Verstraeten N, Gkekas S, Kint CI, Deckers B, Van den Bergh B, Herpels P, Louwagie E, Knapen W, Wilmaerts D, Dewachter L, Fauvart M, Singh RK, Michiels J, Versées W.

Mol Microbiol. 2019 Nov;112(5):1593-1608. doi: 10.1111/mmi.14382. Epub 2019 Sep 18.


Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation.

Clark MM, Hildreth A, Batalov S, Ding Y, Chowdhury S, Watkins K, Ellsworth K, Camp B, Kint CI, Yacoubian C, Farnaes L, Bainbridge MN, Beebe C, Braun JJA, Bray M, Carroll J, Cakici JA, Caylor SA, Clarke C, Creed MP, Friedman J, Frith A, Gain R, Gaughran M, George S, Gilmer S, Gleeson J, Gore J, Grunenwald H, Hovey RL, Janes ML, Lin K, McDonagh PD, McBride K, Mulrooney P, Nahas S, Oh D, Oriol A, Puckett L, Rady Z, Reese MG, Ryu J, Salz L, Sanford E, Stewart L, Sweeney N, Tokita M, Van Der Kraan L, White S, Wigby K, Williams B, Wong T, Wright MS, Yamada C, Schols P, Reynders J, Hall K, Dimmock D, Veeraraghavan N, Defay T, Kingsmore SF.

Sci Transl Med. 2019 Apr 24;11(489). pii: eaat6177. doi: 10.1126/scitranslmed.aat6177.


A Single-Amino-Acid Substitution in Obg Activates a New Programmed Cell Death Pathway in Escherichia coli.

Dewachter L, Verstraeten N, Monteyne D, Kint CI, Versées W, Pérez-Morga D, Michiels J, Fauvart M.

mBio. 2015 Dec 22;6(6):e01935-15. doi: 10.1128/mBio.01935-15.


Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance.

Verstraeten N, Knapen WJ, Kint CI, Liebens V, Van den Bergh B, Dewachter L, Michiels JE, Fu Q, David CC, Fierro AC, Marchal K, Beirlant J, Versées W, Hofkens J, Jansen M, Fauvart M, Michiels J.

Mol Cell. 2015 Jul 2;59(1):9-21. doi: 10.1016/j.molcel.2015.05.011. Epub 2015 Jun 4.


New-found fundamentals of bacterial persistence.

Kint CI, Verstraeten N, Fauvart M, Michiels J.

Trends Microbiol. 2012 Dec;20(12):577-85. doi: 10.1016/j.tim.2012.08.009. Epub 2012 Sep 5. Review.


The Escherichia coli GTPase ObgE modulates hydroxyl radical levels in response to DNA replication fork arrest.

Kint CI, Verstraeten N, Wens I, Liebens VR, Hofkens J, Versées W, Fauvart M, Michiels J.

FEBS J. 2012 Oct;279(19):3692-3704. doi: 10.1111/j.1742-4658.2012.08731.x. Epub 2012 Aug 31.


Elucidating the structure-function relationship of a bacterial GTPase in DNA replication through random mutagenesis.

Kint CI, Wens I, Verstraeten N, Liebens VR, Fauvart M, Michiels J.

Commun Agric Appl Biol Sci. 2011;76(1):231-4. No abstract available.


Cell surface properties determine persistence of Pseudomonas aeruginosa.

Liebens VR, De Groote VN, Fauvart M, Kint CI, Jans A, Vercruysse M, Verstraeten N, Michiels J.

Commun Agric Appl Biol Sci. 2011;76(1):193-6. No abstract available.


Single-cell level decision-making between growth and dormancy.

Verstraeten N, Kint CI, Liebens VR, Fauvart M, Michiels J.

Commun Agric Appl Biol Sci. 2011;76(1):57-60. No abstract available.


Pseudomonas aeruginosa fosfomycin resistance mechanisms affect non-inherited fluoroquinolone tolerance.

De Groote VN, Fauvart M, Kint CI, Verstraeten N, Jans A, Cornelis P, Michiels J.

J Med Microbiol. 2011 Mar;60(Pt 3):329-36. doi: 10.1099/jmm.0.019703-0. Epub 2011 Jan 6.


Novel persistence genes in Pseudomonas aeruginosa identified by high-throughput screening.

De Groote VN, Verstraeten N, Fauvart M, Kint CI, Verbeeck AM, Beullens S, Cornelis P, Michiels J.

FEMS Microbiol Lett. 2009 Aug;297(1):73-9. doi: 10.1111/j.1574-6968.2009.01657.x. Epub 2009 May 21.


Identification of novel persistence genes in Pseudomonas aeruginosa in the combat against emerging antimicrobial resistance.

De Groote VN, Verstraeten N, Fauvart M, Kint CI, Cornelis P, Michiels J.

Commun Agric Appl Biol Sci. 2009;74(4):51-6. No abstract available.


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