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Items: 14

1.

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.

Lopez CK, Noguera E, Stavropoulou V, Robert E, Aid Z, Ballerini P, Bilhou-Nabera C, Lapillonne H, Boudia F, Thirant C, Fagnan A, Arcangeli ML, Kinston SJ, Diop M, Job B, Lecluse Y, Brunet E, Babin L, Villeval JL, Delabesse E, Peters AHFM, Vainchenker W, Gaudry M, Masetti R, Locatelli F, Malinge S, Nerlov C, Droin N, Lobry C, Godin I, Bernard OA, Göttgens B, Petit A, Pflumio F, Schwaller J, Mercher T.

Cancer Discov. 2019 Dec;9(12):1736-1753. doi: 10.1158/2159-8290.CD-18-1463. Epub 2019 Oct 29.

PMID:
31662298
2.

Reconstructing blood stem cell regulatory network models from single-cell molecular profiles.

Hamey FK, Nestorowa S, Kinston SJ, Kent DG, Wilson NK, Göttgens B.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):5822-5829. doi: 10.1073/pnas.1610609114.

3.

An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability.

Schütte J, Wang H, Antoniou S, Jarratt A, Wilson NK, Riepsaame J, Calero-Nieto FJ, Moignard V, Basilico S, Kinston SJ, Hannah RL, Chan MC, Nürnberg ST, Ouwehand WH, Bonzanni N, de Bruijn MF, Göttgens B.

Elife. 2016 Feb 22;5:e11469. doi: 10.7554/eLife.11469.

4.

ConBind: motif-aware cross-species alignment for the identification of functional transcription factor binding sites.

Lelieveld SH, Schütte J, Dijkstra MJ, Bawono P, Kinston SJ, Göttgens B, Heringa J, Bonzanni N.

Nucleic Acids Res. 2016 May 5;44(8):e72. doi: 10.1093/nar/gkv1518. Epub 2015 Dec 31.

5.

Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia.

Sive JI, Basilico S, Hannah R, Kinston SJ, Calero-Nieto FJ, Göttgens B.

Leukemia. 2016 Jan;30(1):14-23. doi: 10.1038/leu.2015.172. Epub 2015 Jul 1.

6.

Constrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cells.

Ng FS, Schütte J, Ruau D, Diamanti E, Hannah R, Kinston SJ, Göttgens B.

Nucleic Acids Res. 2014 Dec 16;42(22):13513-24. doi: 10.1093/nar/gku1254. Epub 2014 Nov 26.

7.

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.

Goldberg L, Tijssen MR, Birger Y, Hannah RL, Kinston SJ, Schütte J, Beck D, Knezevic K, Schiby G, Jacob-Hirsch J, Biran A, Kloog Y, Marcucci G, Bloomfield CD, Aplan PD, Pimanda JE, Göttgens B, Izraeli S.

Blood. 2013 Oct 10;122(15):2694-703. doi: 10.1182/blood-2013-01-477133. Epub 2013 Aug 23.

8.

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes.

Beck D, Thoms JA, Perera D, Schütte J, Unnikrishnan A, Knezevic K, Kinston SJ, Wilson NK, O'Brien TA, Göttgens B, Wong JW, Pimanda JE.

Blood. 2013 Oct 3;122(14):e12-22. doi: 10.1182/blood-2013-03-490425. Epub 2013 Aug 23.

PMID:
23974199
9.

Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia.

Oram SH, Thoms J, Sive JI, Calero-Nieto FJ, Kinston SJ, Schütte J, Knezevic K, Lock RB, Pimanda JE, Göttgens B.

Leukemia. 2013 Jun;27(6):1348-57. doi: 10.1038/leu.2013.2. Epub 2013 Jan 10.

10.

Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain.

Follows GA, Ferreira R, Janes ME, Spensberger D, Cambuli F, Chaney AF, Kinston SJ, Landry JR, Green AR, Göttgens B.

PLoS One. 2012;7(3):e31484. doi: 10.1371/journal.pone.0031484. Epub 2012 Mar 1.

11.

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.

Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE.

Blood. 2011 Jun 30;117(26):7079-89. doi: 10.1182/blood-2010-12-317990. Epub 2011 May 2.

PMID:
21536859
12.

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.

Oram SH, Thoms JA, Pridans C, Janes ME, Kinston SJ, Anand S, Landry JR, Lock RB, Jayaraman PS, Huntly BJ, Pimanda JE, Göttgens B.

Oncogene. 2010 Oct 28;29(43):5796-808. doi: 10.1038/onc.2010.320. Epub 2010 Aug 2.

PMID:
20676125
13.

Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.

Wilson NK, Timms RT, Kinston SJ, Cheng YH, Oram SH, Landry JR, Mullender J, Ottersbach K, Gottgens B.

Mol Cell Biol. 2010 Aug;30(15):3853-63. doi: 10.1128/MCB.00032-10. Epub 2010 Jun 1.

14.

Disruption of the talin gene arrests mouse development at the gastrulation stage.

Monkley SJ, Zhou XH, Kinston SJ, Giblett SM, Hemmings L, Priddle H, Brown JE, Pritchard CA, Critchley DR, Fässler R.

Dev Dyn. 2000 Dec;219(4):560-74.

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