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Items: 38


CB1 positive allosteric modulation attenuates Δ9-THC withdrawal and NSAID-induced gastric inflammation.

Trexler KR, Eckard ML, Kinsey SG.

Pharmacol Biochem Behav. 2019 Feb;177:27-33. doi: 10.1016/j.pbb.2018.12.009. Epub 2018 Dec 28.


Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice.

Trexler KR, Nass SR, Crowe MS, Gross JD, Jones MS, McKitrick AW, Siderovski DP, Kinsey SG.

Drug Alcohol Depend. 2018 Oct 1;191:14-24. doi: 10.1016/j.drugalcdep.2018.05.029. Epub 2018 Jul 7.


Selective and Context-Dependent Social and Behavioral Effects of Δ9-Tetrahydrocannabinol in Weakly Electric Fish.

Neeley B, Overholt T, Artz E, Kinsey SG, Marsat G.

Brain Behav Evol. 2018;91(4):214-227. doi: 10.1159/000490171. Epub 2018 Jul 25.


The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.

Crowe MS, Wilson CD, Leishman E, Prather PL, Bradshaw HB, Banks ML, Kinsey SG.

Br J Pharmacol. 2017 Dec;174(23):4523-4539. doi: 10.1111/bph.14055. Epub 2017 Nov 20.


The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.

Donvito G, Nass SR, Wilkerson JL, Curry ZA, Schurman LD, Kinsey SG, Lichtman AH.

Neuropsychopharmacology. 2018 Jan;43(1):52-79. doi: 10.1038/npp.2017.204. Epub 2017 Aug 31. Review.


MAGL inhibition modulates gastric secretion and motility following NSAID exposure in mice.

Crowe MS, Kinsey SG.

Eur J Pharmacol. 2017 Jul 15;807:198-204. doi: 10.1016/j.ejphar.2017.05.006. Epub 2017 May 3.


Diacylglycerol lipase β inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain.

Wilkerson JL, Ghosh S, Bagdas D, Mason BL, Crowe MS, Hsu KL, Wise LE, Kinsey SG, Damaj MI, Cravatt BF, Lichtman AH.

Br J Pharmacol. 2016 May;173(10):1678-92. doi: 10.1111/bph.13469. Epub 2016 Apr 8.


Effects of a single night of postpartum sleep on childless women's daytime functioning.

McBean AL, Kinsey SG, Montgomery-Downs HE.

Physiol Behav. 2016 Mar 15;156:137-47. doi: 10.1016/j.physbeh.2016.01.014. Epub 2016 Jan 15.


Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice.

Ghosh S, Kinsey SG, Liu QS, Hruba L, McMahon LR, Grim TW, Merritt CR, Wise LE, Abdullah RA, Selley DE, Sim-Selley LJ, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2015 Aug;354(2):111-20. doi: 10.1124/jpet.115.222851. Epub 2015 May 21.


Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge.

Nass SR, Long JZ, Schlosburg JE, Cravatt BF, Lichtman AH, Kinsey SG.

J Neuroimmune Pharmacol. 2015 Jun;10(2):364-70. doi: 10.1007/s11481-015-9593-1. Epub 2015 Feb 27.


Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice.

Crowe MS, Leishman E, Banks ML, Gujjar R, Mahadevan A, Bradshaw HB, Kinsey SG.

Br J Pharmacol. 2015 Apr;172(7):1700-12. doi: 10.1111/bph.13012. Epub 2015 Jan 20.


Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models.

Grim TW, Ghosh S, Hsu KL, Cravatt BF, Kinsey SG, Lichtman AH.

Pharmacol Biochem Behav. 2014 Sep;124:405-11. doi: 10.1016/j.pbb.2014.07.008. Epub 2014 Jul 21.


The endocannabinoid system modulates stress, emotionality, and inflammation.

Crowe MS, Nass SR, Gabella KM, Kinsey SG.

Brain Behav Immun. 2014 Nov;42:1-5. doi: 10.1016/j.bbi.2014.06.007. Epub 2014 Jun 19. Review.


Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice.

Schlosburg JE, Kinsey SG, Ignatowska-Jankowska B, Ramesh D, Abdullah RA, Tao Q, Booker L, Long JZ, Selley DE, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2014 Aug;350(2):196-204. doi: 10.1124/jpet.114.212753. Epub 2014 May 21.


In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects.

Ignatowska-Jankowska BM, Ghosh S, Crowe MS, Kinsey SG, Niphakis MJ, Abdullah RA, Tao Q, O' Neal ST, Walentiny DM, Wiley JL, Cravatt BF, Lichtman AH.

Br J Pharmacol. 2014 Mar;171(6):1392-407. doi: 10.1111/bph.12298.


Acute Δ(9)-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice.

Kinsey SG, Cole EC.

Eur J Pharmacol. 2013 Sep 5;715(1-3):111-6. doi: 10.1016/j.ejphar.2013.06.001. Epub 2013 Jun 11.


Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.

Kinsey SG, Wise LE, Ramesh D, Abdullah R, Selley DE, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2013 Jun;345(3):492-501. doi: 10.1124/jpet.112.201426. Epub 2013 Feb 14.


Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation.

Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF.

Science. 2011 Nov 11;334(6057):809-13. doi: 10.1126/science.1209200. Epub 2011 Oct 20.


Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.

Kinsey SG, Naidu PS, Cravatt BF, Dudley DT, Lichtman AH.

Pharmacol Biochem Behav. 2011 Oct;99(4):718-25. doi: 10.1016/j.pbb.2011.06.022. Epub 2011 Jun 29.


Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice.

Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH.

J Pharmacol Exp Ther. 2011 Oct;339(1):173-85. doi: 10.1124/jpet.111.181370. Epub 2011 Jun 30.


Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice.

Kinsey SG, Nomura DK, O'Neal ST, Long JZ, Mahadevan A, Cravatt BF, Grider JR, Lichtman AH.

J Pharmacol Exp Ther. 2011 Sep;338(3):795-802. doi: 10.1124/jpet.110.175778. Epub 2011 Jun 9.


The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice.

Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH.

Br J Pharmacol. 2012 Apr;165(8):2485-96. doi: 10.1111/j.1476-5381.2011.01445.x.


Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.

Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL.

J Med Chem. 2011 Apr 28;54(8):2805-22. doi: 10.1021/jm101597x. Epub 2011 Mar 23.


Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.

Kinsey SG, O'Neal ST, Long JZ, Cravatt BF, Lichtman AH.

Pharmacol Biochem Behav. 2011 Mar;98(1):21-7. doi: 10.1016/j.pbb.2010.12.002. Epub 2010 Dec 8.


The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects.

Kinsey SG, Mahadevan A, Zhao B, Sun H, Naidu PS, Razdan RK, Selley DE, Imad Damaj M, Lichtman AH.

Neuropharmacology. 2011 Feb-Mar;60(2-3):244-51. doi: 10.1016/j.neuropharm.2010.09.004. Epub 2010 Sep 16.


Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.

Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF.

Nat Neurosci. 2010 Sep;13(9):1113-9. doi: 10.1038/nn.2616. Epub 2010 Aug 22.


Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.

Kinsey SG, Long JZ, Cravatt BF, Lichtman AH.

J Pain. 2010 Dec;11(12):1420-8. doi: 10.1016/j.jpain.2010.04.001. Epub 2010 Jun 16.


Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase.

Naidu PS, Kinsey SG, Guo TL, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2010 Jul;334(1):182-90. doi: 10.1124/jpet.109.164806. Epub 2010 Apr 7.


Social stress enhances IL-1beta and TNF-alpha production by Porphyromonas gingivalis lipopolysaccharide-stimulated CD11b+ cells.

Bailey MT, Kinsey SG, Padgett DA, Sheridan JF, Leblebicioglu B.

Physiol Behav. 2009 Sep 7;98(3):351-8. doi: 10.1016/j.physbeh.2009.06.013. Epub 2009 Jun 26.


Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.

Kinsey SG, Long JZ, O'Neal ST, Abdullah RA, Poklis JL, Boger DL, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2009 Sep;330(3):902-10. doi: 10.1124/jpet.109.155465. Epub 2009 Jun 5.


Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production.

Bailey MT, Kierstein S, Sharma S, Spaits M, Kinsey SG, Tliba O, Amrani Y, Sheridan JF, Panettieri RA, Haczku A.

J Immunol. 2009 Jun 15;182(12):7888-96. doi: 10.4049/jimmunol.0800891. Erratum in: J Immunol. 2009 Sep 1;183(5):3551. Amrani, Yassine [added].


Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation.

Schlosburg JE, Kinsey SG, Lichtman AH.

AAPS J. 2009 Mar;11(1):39-44. doi: 10.1208/s12248-008-9075-y. Epub 2009 Jan 29. Review.


Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.

Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pavón FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, Cravatt BF.

Nat Chem Biol. 2009 Jan;5(1):37-44. doi: 10.1038/nchembio.129. Epub 2008 Nov 23.


The inflammatory response to social defeat is increased in older mice.

Kinsey SG, Bailey MT, Sheridan JF, Padgett DA.

Physiol Behav. 2008 Feb 27;93(3):628-36. Epub 2007 Nov 9.


Subordinate social status modulates the vulnerability to the immunological effects of social stress.

Avitsur R, Kinsey SG, Bidor K, Bailey MT, Padgett DA, Sheridan JF.

Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):1097-105. Epub 2007 Oct 22.


Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice.

Kinsey SG, Bailey MT, Sheridan JF, Padgett DA, Avitsur R.

Brain Behav Immun. 2007 May;21(4):458-66. Epub 2006 Dec 18.


Photoperiod and stress affect wound healing in Siberian hamsters.

Kinsey SG, Prendergast BJ, Nelson RJ.

Physiol Behav. 2003 Feb;78(2):205-11.


Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia.

Prendergast BJ, Hotchkiss AK, Bilbo SD, Kinsey SG, Nelson RJ.

J Biol Rhythms. 2003 Feb;18(1):51-62.


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