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Proton beam therapy for recurrent ovarian carcinoma: A case report.

Kino T, Ando N, Ogawara Y, Shigeta H.

J Obstet Gynaecol Res. 2019 Sep;45(9):1952-1956. doi: 10.1111/jog.14036. Epub 2019 Jul 22.


Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice.

Arakawa K, Ishigami T, Nakai-Sugiyama M, Chen L, Doi H, Kino T, Minegishi S, Saigoh-Teranaka S, Sasaki-Nakashima R, Hibi K, Kimura K, Tamura K.

PLoS One. 2019 Jun 17;14(6):e0218096. doi: 10.1371/journal.pone.0218096. eCollection 2019.


A prospective cohort for the investigation of alteration in temporal transcriptional and microbiome trajectories preceding preterm birth: a study protocol.

Brummaier T, Syed Ahamed Kabeer B, Lindow S, Konje JC, Pukrittayaamee S, Utzinger J, Toufiq M, Antoniou A, Marr AK, Suriyakan S, Kino T, Al Khodor S, Terranegra A, Nosten F, Paris DH, McGready R, Chaussabel D.

BMJ Open. 2019 Jan 15;9(1):e023417. doi: 10.1136/bmjopen-2018-023417.


Prediction of risk of falls based on handgrip strength in chronic liver disease patients living independently.

Hiraoka A, Tamura R, Oka M, Izumoto H, Ueki H, Tsuruta M, Yoshino T, Ono A, Aibiki T, Okudaira T, Yamago H, Suga Y, Iwasaki R, Mori K, Miyata H, Tsubouchi E, Kishida M, Ninomiya T, Hirooka M, Abe M, Matsuura B, Hiasa Y, Kino T, Yamamoto K, Michitaka K.

Hepatol Res. 2019 Jul;49(7):823-829. doi: 10.1111/hepr.13322. Epub 2019 Mar 19.


C2H2-Type Zinc Finger Proteins: Evolutionarily Old and New Partners of the Nuclear Hormone Receptors.

Mackeh R, Marr AK, Fadda A, Kino T.

Nucl Recept Signal. 2018 Oct 24;15:1550762918801071. doi: 10.1177/1550762918801071. eCollection 2018. Review.


Adverse pregnancy outcomes related to preterm cesarean delivery.

Kino T, Yamamoto Y, Saigusa Y, Aoki S, Miyagi E.

Eur J Obstet Gynecol Reprod Biol. 2019 Mar;234:89-91. doi: 10.1016/j.ejogrb.2018.12.033. Epub 2019 Jan 9.


Labor may mask a symptom of the rupture of ovarian endometrial cyst: a case report.

Kino T, Obata S, Osanai N, Hashimoto A, Okada Y, Aoki S, Miyagi E.

Clin Case Rep. 2018 Apr 26;6(6):1128-1131. doi: 10.1002/ccr3.1554. eCollection 2018 Jun.


Single Nucleotide Variations of the Human GR Gene Manifested as Pathologic Mutations or Polymorphisms.

Kino T.

Endocrinology. 2018 Jul 1;159(7):2506-2519. doi: 10.1210/en.2017-03254. Review.


New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis.

Doi H, Ishigami T, Nakashima-Sasaki R, Kino T, Chen L, Arakawa K, Teranaka S, Minegishi S, Abe K, Ishikawa T, Sugano T, Tamura K.

Clin Exp Hypertens. 2018 May 8:1-7. doi: 10.1080/10641963.2018.1465072. [Epub ahead of print]


Highly Diastereoselective Synthesis of 2-(1-N-Boc-aminoalkyl)thiazole-5-carboxylates by Reduction of tert-Butylsulfinyl Ketimines.

Magata T, Hirokawa Y, Furokawa A, Takeuchi K, Ohtomo Y, Kino T, Kominami J, Nakai Y, Kitamura M, Maezaki N.

Chem Pharm Bull (Tokyo). 2018;66(4):416-422. doi: 10.1248/cpb.c17-00907.


GR-regulating Serine/Threonine Kinases: New Physiologic and Pathologic Implications.

Kino T.

Trends Endocrinol Metab. 2018 Apr;29(4):260-270. doi: 10.1016/j.tem.2018.01.010. Epub 2018 Feb 28. Review.


Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals.

Mackeh R, Marr AK, Dargham SR, Syed N, Fakhro KA, Kino T.

J Endocr Soc. 2017 Dec 4;2(1):77-90. doi: 10.1210/js.2017-00406. eCollection 2018 Jan 1.


Effect of N-arachidonoyl-l-serine on human cerebromicrovascular endothelium.

Kino T, Tomori T, Abutarboush R, Castri P, Chen Y, Lenz FA, McCarron RM, Spatz M.

Biochem Biophys Rep. 2016 Sep 21;8:254-260. doi: 10.1016/j.bbrep.2016.09.002. eCollection 2016 Dec.


SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity.

Suzuki S, Iben JR, Coon SL, Kino T.

Mol Cell Endocrinol. 2018 Feb 5;461:178-187. doi: 10.1016/j.mce.2017.09.012. Epub 2017 Sep 18.


The Role of S-Palmitoylation of the Human Glucocorticoid Receptor (hGR) in Mediating the Nongenomic Glucocorticoid Actions.

Nicolaides NC, Kino T, Roberts ML, Katsantoni E, Sertedaki A, Moutsatsou P, Psarra AG, Chrousos GP, Charmandari E.

J Mol Biochem. 2017;6(1):3-12. Epub 2017 Apr 15.


An Isoform of Nedd4-2 Plays a Pivotal Role in Electrophysiological Cardiac Abnormalities.

Minegishi S, Ishigami T, Kawamura H, Kino T, Chen L, Nakashima-Sasaki R, Doi H, Azushima K, Wakui H, Chiba Y, Tamura K.

Int J Mol Sci. 2017 Jun 14;18(6). pii: E1268. doi: 10.3390/ijms18061268.


Eplerenone-Resistant Salt-Sensitive Hypertension in Nedd4-2 C2 KO Mice.

Kino T, Ishigami T, Murata T, Doi H, Nakashima-Sasaki R, Chen L, Sugiyama M, Azushima K, Wakui H, Minegishi S, Tamura K.

Int J Mol Sci. 2017 Jun 11;18(6). pii: E1250. doi: 10.3390/ijms18061250.


Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on Health.

Nicolaides NC, Charmandari E, Kino T, Chrousos GP.

Front Endocrinol (Lausanne). 2017 Apr 28;8:70. doi: 10.3389/fendo.2017.00070. eCollection 2017. Review.


Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells.

Tsubaki M, Takeda T, Kino T, Sakai K, Itoh T, Imano M, Nakayama T, Nishio K, Satou T, Nishida S.

Oncotarget. 2017 Jun 13;8(24):38717-38730. doi: 10.18632/oncotarget.16314.


Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor.

Fadda A, Syed N, Mackeh R, Papadopoulou A, Suzuki S, Jithesh PV, Kino T.

Sci Rep. 2017 Jan 31;7:41598. doi: 10.1038/srep41598.


Commensal Microbe-specific Activation of B2 Cell Subsets Contributes to Atherosclerosis Development Independently of Lipid Metabolism.

Chen L, Ishigami T, Nakashima-Sasaki R, Kino T, Doi H, Minegishi S, Umemura S.

EBioMedicine. 2016 Nov;13:237-247. doi: 10.1016/j.ebiom.2016.10.030. Epub 2016 Oct 20.


The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways.

Tsubaki M, Fujiwara D, Takeda T, Kino T, Tomonari Y, Itoh T, Imano M, Satou T, Sakaguchi K, Nishida S.

Clin Exp Pharmacol Physiol. 2017 Feb;44(2):222-234. doi: 10.1111/1440-1681.12690.


AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.

Habib T, Sadoun A, Nader N, Suzuki S, Liu W, Jithesh PV, Kino T.

Mol Cell Endocrinol. 2017 Jan 5;439:431-443. doi: 10.1016/j.mce.2016.10.002. Epub 2016 Oct 4.


Successful prediction of cardiovascular risk by new non-invasive vascular indexes using suprasystolic cuff oscillometric waveform analysis.

Sasaki-Nakashima R, Kino T, Chen L, Doi H, Minegishi S, Abe K, Sugano T, Taguri M, Ishigami T.

J Cardiol. 2017 Jan;69(1):30-37. doi: 10.1016/j.jjcc.2016.06.004. Epub 2016 Aug 31.


Posterior reversible encephalopathy syndrome after iron administration in a patient with chronic severe anemia.

Ono K, Murata K, Arai T, Kino T, Onaka K, Takahashi S, Sato H, Kuwahara H.

J Neurol Sci. 2016 Aug 15;367:333-4. doi: 10.1016/j.jns.2016.06.042. Epub 2016 Jun 21. No abstract available.


A curated transcriptome dataset collection to investigate the development and differentiation of the human placenta and its associated pathologies.

Marr AK, Boughorbel S, Presnell S, Quinn C, Chaussabel D, Kino T.

Version 2. F1000Res. 2016 Mar 9 [revised 2016 Jan 1];5:305. doi: 10.12688/f1000research.8210.2. eCollection 2016.


An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice.

Minegishi S, Ishigami T, Kino T, Chen L, Nakashima-Sasaki R, Araki N, Yatsu K, Fujita M, Umemura S.

Sci Rep. 2016 Jun 3;6:27137. doi: 10.1038/srep27137.


Differential Expression of Glucocorticoid Receptor Noncoding RNA Repressor Gas5 in Autoimmune and Inflammatory Diseases.

Mayama T, Marr AK, Kino T.

Horm Metab Res. 2016 Aug;48(8):550-7. doi: 10.1055/s-0042-106898. Epub 2016 May 23.


Infusion of solutions of pre-irradiated components in rats.

Pappas G, Arnaud F, Haque A, Kino T, Facemire P, Carroll E, Auker C, McCarron R, Scultetus A.

Exp Toxicol Pathol. 2016 Jun;68(6):355-63. doi: 10.1016/j.etp.2016.05.004. Epub 2016 May 19.


Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway.

Takeda T, Tsubaki M, Kino T, Kawamura A, Isoyama S, Itoh T, Imano M, Tanabe G, Muraoka O, Matsuda H, Satou T, Nishida S.

Int J Oncol. 2016 Jun;48(6):2704-12. doi: 10.3892/ijo.2016.3470. Epub 2016 Apr 1.


Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase.

Takeda T, Tsubaki M, Kino T, Yamagishi M, Iida M, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S.

Chem Biol Interact. 2016 May 5;251:26-33. doi: 10.1016/j.cbi.2016.03.018. Epub 2016 Mar 17.


Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells.

Tsubaki M, Mashimo K, Takeda T, Kino T, Fujita A, Itoh T, Imano M, Sakaguchi K, Satou T, Nishida S.

Biomed Pharmacother. 2016 Mar;78:23-29. doi: 10.1016/j.biopha.2015.12.017. Epub 2016 Jan 8.


Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains.

Hurt DE, Suzuki S, Mayama T, Charmandari E, Kino T.

Mol Endocrinol. 2016 Feb;30(2):173-88. doi: 10.1210/me.2015-1177. Epub 2016 Jan 8.


Statins improve survival by inhibiting spontaneous metastasis and tumor growth in a mouse melanoma model.

Tsubaki M, Takeda T, Kino T, Obata N, Itoh T, Imano M, Mashimo K, Fujiwara D, Sakaguchi K, Satou T, Nishida S.

Am J Cancer Res. 2015 Sep 15;5(10):3186-97. eCollection 2015.


CRTC2 Is a Coactivator of GR and Couples GR and CREB in the Regulation of Hepatic Gluconeogenesis.

Hill MJ, Suzuki S, Segars JH, Kino T.

Mol Endocrinol. 2016 Jan;30(1):104-17. doi: 10.1210/me.2015-1237. Epub 2015 Dec 10.


Transient generalized glucocorticoid hypersensitivity.

Nicolaides NC, Lamprokostopoulou A, Polyzos A, Kino T, Katsantoni E, Triantafyllou P, Christophoridis A, Katzos G, Dracopoulou M, Sertedaki A, Chrousos GP, Charmandari E.

Eur J Clin Invest. 2015 Dec;45(12):1306-15. doi: 10.1111/eci.12554. Epub 2015 Nov 20.


Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β, and RANKL through inhibiting the activation of NF-κB and ERK1/2.

Tsubaki M, Takeda T, Kino T, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S.

Am J Transl Res. 2015 Aug 15;7(8):1371-81. eCollection 2015.


Stress, glucocorticoid hormones, and hippocampal neural progenitor cells: implications to mood disorders.

Kino T.

Front Physiol. 2015 Aug 19;6:230. doi: 10.3389/fphys.2015.00230. eCollection 2015. Review.


Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression.

Papadopoulou A, Siamatras T, Delgado-Morales R, Amin ND, Shukla V, Zheng YL, Pant HC, Almeida OF, Kino T.

Transl Psychiatry. 2015 Jun 9;5:e578. doi: 10.1038/tp.2015.72.


Glucocorticoid Receptor.

Kino T.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2017 Aug 15.



Kino T.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2017 Aug 7.


Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome.

Nicolaides NC, Kino T, Chrousos G, Charmandari E.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2017 Sep 10.


Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired Osteogenesis.

Koide H, Holmbeck K, Lui JC, Guo XC, Driggers P, Chu T, Tatsuno I, Quaglieri C, Kino T, Baron J, Young MF, Robey PG, Segars JH.

J Bone Miner Res. 2015 Oct;30(10):1887-95. doi: 10.1002/jbmr.2534. Epub 2015 May 10.


Circadian endocrine rhythms: the hypothalamic-pituitary-adrenal axis and its actions.

Nicolaides NC, Charmandari E, Chrousos GP, Kino T.

Ann N Y Acad Sci. 2014 May;1318:71-80. doi: 10.1111/nyas.12464. Review.


Identification of bona fide alternative renin transcripts expressed along cortical tubules and potential roles in promoting insulin resistance in vivo without significant plasma renin activity elevation.

Ishigami T, Kino T, Chen L, Minegishi S, Araki N, Umemura M, Abe K, Sasaki R, Yamana H, Umemura S.

Hypertension. 2014 Jul;64(1):125-33. doi: 10.1161/HYPERTENSIONAHA.114.03394. Epub 2014 Apr 28.


A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities.

Nicolaides NC, Roberts ML, Kino T, Braatvedt G, Hurt DE, Katsantoni E, Sertedaki A, Chrousos GP, Charmandari E.

J Clin Endocrinol Metab. 2014 May;99(5):E902-7. doi: 10.1210/jc.2013-3005. Epub 2014 Jan 31.


HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation.

Agarwal N, Iyer D, Patel SG, Sekhar RV, Phillips TM, Schubert U, Oplt T, Buras ED, Samson SL, Couturier J, Lewis DE, Rodriguez-Barradas MC, Jahoor F, Kino T, Kopp JB, Balasubramanyam A.

Sci Transl Med. 2013 Nov 27;5(213):213ra164. doi: 10.1126/scitranslmed.3007148.


Alkalizer administration improves renal function in hyperuricemia associated with obesity.

Saito J, Matsuzawa Y, Ito H, Omura M, Kino T, Nishikawa T.

Jpn Clin Med. 2013 Feb 3;4:1-6. doi: 10.4137/JCM.S10056. eCollection 2013.

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