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Items: 1 to 50 of 191

1.

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR.

Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207. Epub 2013 Nov 6.

2.

SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.

Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 1;305(9):L615-24. doi: 10.1152/ajplung.00249.2012. Epub 2013 Sep 13.

3.

Environmental exposure as an independent risk factor of chronic bronchitis in northwest Russia.

Nieminen P, Panychev D, Lyalyushkin S, Komarov G, Nikanov A, Borisenko M, Kinnula VL, Toljamo T.

Int J Circumpolar Health. 2013;72. doi: 10.3402/ijch.v72i0.19742. Epub 2013 Feb 22.

4.

Successful Smoking Cessation in COPD: Association with Comorbidities and Mortality.

Kupiainen H, Kinnula VL, Lindqvist A, Postma DS, Boezen HM, Laitinen T, Kilpeläinen M.

Pulm Med. 2012;2012:725024. doi: 10.1155/2012/725024. Epub 2012 Nov 14.

5.

Peroxiredoxins and their expression in ependymomas.

Haapasalo T, Nordfors K, Järvelä S, Kok E, Sallinen P, Kinnula VL, Haapasalo HK, Soini Y.

J Clin Pathol. 2013 Jan;66(1):12-7. doi: 10.1136/jclinpath-2012-201048. Epub 2012 Oct 16.

PMID:
23076395
6.

Distribution and levels of alpha-1-antitrypsin in the lung and plasma in smokers and chronic obstructive pulmonary disease.

Linja-aho A, Mazur W, Toljamo T, Nieminen P, Ohlmeier S, Rönty M, Kinnula VL.

APMIS. 2013 Jan;121(1):11-21. doi: 10.1111/j.1600-0463.2012.02936.x. Epub 2012 Jun 28.

PMID:
23030783
7.

Dual use of cigarettes and Swedish snuff (snus) among young adults in Northern Finland.

Hamari AK, Toljamo TI, Kinnula VL, Nieminen PA.

Eur J Public Health. 2013 Oct;23(5):768-71. doi: 10.1093/eurpub/cks131. Epub 2012 Sep 22.

PMID:
23002233
8.

High association of peroxiredoxins with lung cancer.

Soini Y, Kinnula VL.

Lung Cancer. 2012 Nov;78(2):167. doi: 10.1016/j.lungcan.2012.08.013. Epub 2012 Sep 14. No abstract available.

PMID:
22981900
9.

Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer.

Hartikainen JM, Tengström M, Kosma VM, Kinnula VL, Mannermaa A, Soini Y.

Cancer Res. 2012 Nov 1;72(21):5537-46. doi: 10.1158/0008-5472.CAN-12-1474. Epub 2012 Sep 10. Erratum in: Cancer Res. 2015 Apr 1;75(7):1538.

11.

Young male daily smokers are nicotine dependent and experience several unsuccessful quit attempts.

Toljamo T, Hamari A, Nieminen P, Kinnula VL.

Scand J Prim Health Care. 2012 Sep;30(3):183-8. doi: 10.3109/02813432.2012.704809. Epub 2012 Jul 25.

12.

Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.

Rahman I, Kinnula VL.

Expert Rev Clin Pharmacol. 2012 May;5(3):293-309. doi: 10.1586/ecp.12.16. Review.

13.

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I.

J Clin Invest. 2012 Jun;122(6):2032-45. doi: 10.1172/JCI60132. Epub 2012 May 1.

14.

Chronic smoke exposure induces rheumatoid factor and anti-heat shock protein 70 autoantibodies in susceptible mice and humans with lung disease.

Newkirk MM, Mitchell S, Procino M, Li Z, Cosio M, Mazur W, Kinnula VL, Hudson M, Baron M, Fritzler MJ, El-Gabalawy HS.

Eur J Immunol. 2012 Apr;42(4):1051-61. doi: 10.1002/eji.201141856.

15.

Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lung.

Leppäranta O, Sens C, Salmenkivi K, Kinnula VL, Keski-Oja J, Myllärniemi M, Koli K.

Cell Tissue Res. 2012 Jun;348(3):491-503. doi: 10.1007/s00441-012-1385-9. Epub 2012 Mar 22.

PMID:
22434388
16.

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation.

COPDGene CT Workshop Group, Barr RG, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, MacNee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD Jr, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, van Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG.

COPD. 2012 Apr;9(2):151-9. doi: 10.3109/15412555.2012.654923. Epub 2012 Mar 19.

17.

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease.

Rahman I, Kinnula VL, Gorbunova V, Yao H.

Prev Med. 2012 May;54 Suppl:S20-8. doi: 10.1016/j.ypmed.2011.11.014. Epub 2011 Dec 8. Review.

18.

Sputum proteomics identifies elevated PIGR levels in smokers and mild-to-moderate COPD.

Ohlmeier S, Mazur W, Linja-Aho A, Louhelainen N, Rönty M, Toljamo T, Bergmann U, Kinnula VL.

J Proteome Res. 2012 Feb 3;11(2):599-608. doi: 10.1021/pr2006395. Epub 2011 Nov 18.

PMID:
22053820
19.

Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer.

Merikallio H, Pääkkö P, Kinnula VL, Harju T, Soini Y.

Hum Pathol. 2012 Apr;43(4):577-84. doi: 10.1016/j.humpath.2011.05.024. Epub 2011 Sep 23.

PMID:
21943684
20.

NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.

Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I.

PLoS One. 2011;6(8):e23488. doi: 10.1371/journal.pone.0023488. Epub 2011 Aug 24.

21.

FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease.

Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I.

J Immunol. 2011 Jul 15;187(2):987-98. doi: 10.4049/jimmunol.1001861. Epub 2011 Jun 20.

22.

Diffuse alveolar damage: a common phenomenon in progressive interstitial lung disorders.

Kaarteenaho R, Kinnula VL.

Pulm Med. 2011;2011:531302. doi: 10.1155/2011/531302. Epub 2010 Nov 2.

23.

Smoking and COPD increase sputum levels of extracellular superoxide dismutase.

Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL.

Free Radic Biol Med. 2011 Aug 1;51(3):726-32. doi: 10.1016/j.freeradbiomed.2011.05.008. Epub 2011 May 14.

PMID:
21621610
24.

Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma.

Ishikawa N, Mazur W, Toljamo T, Vuopala K, Rönty M, Horimasu Y, Kohno N, Kinnula VL.

BMC Pulm Med. 2011 May 11;11:22. doi: 10.1186/1471-2466-11-22.

25.

Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction.

Ilumets H, Mazur W, Toljamo T, Louhelainen N, Nieminen P, Kobayashi H, Ishikawa N, Kinnula VL.

BMC Pulm Med. 2011 Apr 19;11:19. doi: 10.1186/1471-2466-11-19.

26.

Levels of surfactant proteins A and D and KL-6 are elevated in the induced sputum of chronic obstructive pulmonary disease patients: a sequential sputum analysis.

Ishikawa N, Hattori N, Tanaka S, Horimasu Y, Haruta Y, Yokoyama A, Kohno N, Kinnula VL.

Respiration. 2011;82(1):10-8. doi: 10.1159/000324539. Epub 2011 Apr 7.

27.

The 10-year COPD Programme in Finland: effects on quality of diagnosis, smoking, prevalence, hospital admissions and mortality.

Kinnula VL, Vasankari T, Kontula E, Sovijarvi A, Saynajakangas O, Pietinalho A.

Prim Care Respir J. 2011 Jun;20(2):178-83. doi: 10.4104/pcrj.2011.00024.

28.

Overlap syndrome of asthma and COPD predicts low quality of life.

Kauppi P, Kupiainen H, Lindqvist A, Tammilehto L, Kilpeläinen M, Kinnula VL, Haahtela T, Laitinen T.

J Asthma. 2011 Apr;48(3):279-85. doi: 10.3109/02770903.2011.555576. Epub 2011 Feb 17.

PMID:
21323613
29.

Elevation of surfactant protein A in plasma and sputum in cigarette smokers.

Mazur W, Toljamo T, Ohlmeier S, Vuopala K, Nieminen P, Kobayashi H, Kinnula VL.

Eur Respir J. 2011 Aug;38(2):277-84. doi: 10.1183/09031936.00110510. Epub 2011 Jan 27.

30.

A novel screening method detects herpesviral DNA in the idiopathic pulmonary fibrosis lung.

Pulkkinen V, Salmenkivi K, Kinnula VL, Sutinen E, Halme M, Hodgson U, Lehto J, Jääskeläinen A, Piiparinen H, Kere J, Lautenschlager I, Lappalainen M, Myllärniemi M.

Ann Med. 2012 Mar;44(2):178-86. doi: 10.3109/07853890.2010.532151. Epub 2011 Jan 24.

PMID:
21254895
31.

Comparison between the disease-specific Airways Questionnaire 20 and the generic 15D instruments in COPD.

Mazur W, Kupiainen H, Pitkäniemi J, Kilpeläinen M, Sintonen H, Lindqvist A, Kinnula VL, Laitinen T.

Health Qual Life Outcomes. 2011 Jan 16;9:4. doi: 10.1186/1477-7525-9-4.

32.

Proteomic studies on receptor for advanced glycation end product variants in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.

Ohlmeier S, Mazur W, Salmenkivi K, Myllärniemi M, Bergmann U, Kinnula VL.

Proteomics Clin Appl. 2010 Jan;4(1):97-105. doi: 10.1002/prca.200900128. Epub 2010 Jan 7.

PMID:
21137019
33.

Variability in the precursor proteins of collagen I and III in different stages of COPD.

Harju T, Kinnula VL, Pääkkö P, Salmenkivi K, Risteli J, Kaarteenaho R.

Respir Res. 2010 Nov 30;11:165. doi: 10.1186/1465-9921-11-165.

34.

Latent TGF-β binding proteins (LTBPs) 1 and 3 differentially regulate transforming growth factor-β activity in malignant mesothelioma.

Vehviläinen P, Koli K, Myllärniemi M, Lindholm P, Soini Y, Salmenkivi K, Kinnula VL, Keski-Oja J.

Hum Pathol. 2011 Feb;42(2):269-78. doi: 10.1016/j.humpath.2010.07.005. Epub 2010 Nov 24.

PMID:
21106222
35.

Expression of Transcription Factor GATA-6 in Alveolar Epithelial Cells Is Linked to Neonatal Lung Disease.

Vähätalo R, Asikainen TM, Karikoski R, Kinnula VL, White CW, Andersson S, Heikinheimo M, Myllärniemi M.

Neonatology. 2011;99(3):231-40. doi: 10.1159/000317827. Epub 2010 Nov 12.

36.

Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury.

Sundar IK, Chung S, Hwang JW, Arunachalam G, Cook S, Yao H, Mazur W, Kinnula VL, Fisher AB, Rahman I.

Exp Lung Res. 2010 Oct;36(8):451-62. doi: 10.3109/01902141003754128.

37.

Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD.

Ishikawa N, Ohlmeier S, Salmenkivi K, Myllärniemi M, Rahman I, Mazur W, Kinnula VL.

Respir Res. 2010 Sep 13;11:123. doi: 10.1186/1465-9921-11-123.

38.

Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia.

Mazur W, Lindholm P, Vuorinen K, Myllärniemi M, Salmenkivi K, Kinnula VL.

APMIS. 2010 Sep 1;118(9):703-12. doi: 10.1111/j.1600-0463.2010.02646.x.

PMID:
20718723
39.

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM.

Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15571-6. doi: 10.1073/pnas.1007625107. Epub 2010 Aug 16.

40.

Attitudes to new smoking restrictions and second-hand smoke among young Finnish males.

Nieminen P, Toljamo T, Hamari A, Kinnula VL.

Scand J Public Health. 2010 Dec;38(8):817-25. doi: 10.1177/1403494810379892. Epub 2010 Aug 5.

PMID:
20688794
41.

High frequency of chronic cough and sputum production with lowered exercise capacity in young smokers.

Hamari A, Toljamo T, Nieminen P, Kinnula VL.

Ann Med. 2010 Oct;42(7):512-20. doi: 10.3109/07853890.2010.505933.

PMID:
20662762
42.

Early detection of COPD combined with individualized counselling for smoking cessation: a two-year prospective study.

Toljamo T, Kaukonen M, Nieminen P, Kinnula VL.

Scand J Prim Health Care. 2010 Mar;28(1):41-6. doi: 10.3109/02813431003630105.

43.

Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors.

Järvelä S, Rantala I, Rodriguez A, Kallio H, Parkkila S, Kinnula VL, Soini Y, Haapasalo H.

BMC Cancer. 2010 Mar 22;10:104. doi: 10.1186/1471-2407-10-104.

44.

Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: a research study.

Louhelainen N, Stark H, Mazur W, Rytilä P, Djukanovic R, Kinnula VL.

BMC Pulm Med. 2010 Mar 14;10:13. doi: 10.1186/1471-2466-10-13.

45.

ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses.

Pulkkinen V, Bruce S, Rintahaka J, Hodgson U, Laitinen T, Alenius H, Kinnula VL, Myllärniemi M, Matikainen S, Kere J.

FASEB J. 2010 Apr;24(4):1167-77. doi: 10.1096/fj.09-138545. Epub 2009 Dec 4.

PMID:
19966137
46.

Proteomic approaches for studying human parenchymal lung diseases.

Kinnula VL, Ishikawa N, Bergmann U, Ohlmeier S.

Expert Rev Proteomics. 2009 Dec;6(6):619-29. doi: 10.1586/epr.09.80.

PMID:
19929608
47.

Extracellular superoxide dismutase and risk of COPD.

Oberley-Deegan RE, Regan EA, Kinnula VL, Crapo JD.

COPD. 2009 Aug;6(4):307-12. Review.

48.

Real-world clinical data identifies gender-related profiles in chronic obstructive pulmonary disease.

Laitinen T, Hodgson U, Kupiainen H, Tammilehto L, Haahtela T, Kilpeläinen M, Lindqvist A, Kinnula VL.

COPD. 2009 Aug;6(4):256-62.

PMID:
19811384
49.

Reduced phosphorylation of the TGF-Beta signal transducer Smad2 in emphysematous human lung.

Leppäranta O, Myllärniemi M, Salmenkivi K, Kinnula VL, Keski-Oja J, Koli K.

COPD. 2009 Aug;6(4):234-41.

PMID:
19811381
50.

Smoking and COPD-mechanisms and prevention.

Kinnula VL, Crapo JD.

COPD. 2009 Aug;6(4):231-3. No abstract available.

PMID:
19811380

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