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Items: 1 to 50 of 135

1.

Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency.

Abdul-Razak HH, Rocca CJ, Howe SJ, Alonso-Ferrero ME, Wang J, Gabriel R, Bartholomae CC, Gan CHV, Garín MI, Roberts A, Blundell MP, Prakash V, Molina-Estevez FJ, Pantoglou J, Guenechea G, Holmes MC, Gregory PD, Kinnon C, von Kalle C, Schmidt M, Bueren JA, Thrasher AJ, Yáñez-Muñoz RJ.

Sci Rep. 2018 May 29;8(1):8214. doi: 10.1038/s41598-018-26439-9.

2.

Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors.

Alonso-Ferrero ME, van Til NP, Bartolovic K, Mata MF, Wagemaker G, Moulding D, Williams DA, Kinnon C, Waddington SN, Milsom MD, Howe SJ.

Exp Hematol. 2018 Jan;57:21-29. doi: 10.1016/j.exphem.2017.09.003. Epub 2017 Sep 11.

3.

HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.

Hughes DI, Boyle KA, Kinnon CM, Bilsland C, Quayle JA, Callister RJ, Graham BA.

Neuroscience. 2013 May 1;237:7-18. doi: 10.1016/j.neuroscience.2013.01.028. Epub 2013 Jan 26.

4.

Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn.

Hughes DI, Sikander S, Kinnon CM, Boyle KA, Watanabe M, Callister RJ, Graham BA.

J Physiol. 2012 Aug 15;590(16):3927-51. doi: 10.1113/jphysiol.2012.235655. Epub 2012 Jun 6.

5.

The gene involved in X-linked agammaglobulinaemia is a member of the Src family of protein-tyrosine kinases. 1993.

Vetrie D, Vořechovský I, Sideras P, Holland J, Davies A, Flinter F, Hammarström L, Kinnon C, Levinsky R, Bobrow M, Smith CI, Bentley DR.

J Immunol. 2012 Apr 1;188(7):2948-55. No abstract available.

6.

Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction.

Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Zhang F, Adams S, Bjorkegren E, Bayford J, Brown L, Davies EG, Veys P, Fairbanks L, Bordon V, Petropoulou T, Kinnon C, Thrasher AJ.

Sci Transl Med. 2011 Aug 24;3(97):97ra80. doi: 10.1126/scitranslmed.3002716. Erratum in: Sci Transl Med. 2013 Jan 16;5(168):168er1. Petropolou, Theoni [corrected to Petropoulou, Theoni].

7.

Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency.

Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Adams S, Howe SJ, Al Ghonaium A, Bayford J, Brown L, Davies EG, Kinnon C, Thrasher AJ.

Sci Transl Med. 2011 Aug 24;3(97):97ra79. doi: 10.1126/scitranslmed.3002715.

8.

Bone morphogenetic protein-4 (BMP4) up regulates key haematopoietic genes in differentiating embryonic stem cells treated with BMP4 short hairpin RNA.

Abeyewickreme A, Thrasher AJ, Kinnon C.

Br J Haematol. 2011 Dec;155(5):638-41. doi: 10.1111/j.1365-2141.2011.08759.x. Epub 2011 Jul 12. No abstract available.

PMID:
21749358
9.

Codon optimization of human factor VIII cDNAs leads to high-level expression.

Ward NJ, Buckley SM, Waddington SN, Vandendriessche T, Chuah MK, Nathwani AC, McIntosh J, Tuddenham EG, Kinnon C, Thrasher AJ, McVey JH.

Blood. 2011 Jan 20;117(3):798-807. doi: 10.1182/blood-2010-05-282707. Epub 2010 Nov 1.

PMID:
21041718
10.

Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.

Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, Haria S, Parsley KL, Kinnon C, Malech HL, Bueren JA, Grez M, Thrasher AJ.

Mol Ther. 2011 Jan;19(1):122-32. doi: 10.1038/mt.2010.226. Epub 2010 Oct 26.

11.

Phosphorylation of WASp is a key regulator of activity and stability in vivo.

Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15738-43. doi: 10.1073/pnas.0904346106. Epub 2009 Sep 1.

12.

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.

Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, Brugman MH, Pike-Overzet K, Chatters SJ, de Ridder D, Gilmour KC, Adams S, Thornhill SI, Parsley KL, Staal FJ, Gale RE, Linch DC, Bayford J, Brown L, Quaye M, Kinnon C, Ancliff P, Webb DK, Schmidt M, von Kalle C, Gaspar HB, Thrasher AJ.

J Clin Invest. 2008 Sep;118(9):3143-50. doi: 10.1172/JCI35798.

13.

Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy.

Blundell MP, Bouma G, Calle Y, Jones GE, Kinnon C, Thrasher AJ.

Mol Ther. 2008 May;16(5):836-44. doi: 10.1038/mt.2008.43. Epub 2008 Mar 18.

14.

Gene therapy of inherited immunodeficiencies.

Santilli G, Thornhill SI, Kinnon C, Thrasher AJ.

Expert Opin Biol Ther. 2008 Apr;8(4):397-407. doi: 10.1517/14712598.8.4.397 . Review.

PMID:
18352845
15.

Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.

Thornhill SI, Schambach A, Howe SJ, Ulaganathan M, Grassman E, Williams D, Schiedlmeier B, Sebire NJ, Gaspar HB, Kinnon C, Baum C, Thrasher AJ.

Mol Ther. 2008 Mar;16(3):590-8. doi: 10.1038/sj.mt.6300393. Epub 2008 Jan 8.

16.
17.

Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.

Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, Jones GE, Thrasher AJ.

J Exp Med. 2007 Sep 3;204(9):2213-24. Epub 2007 Aug 27.

18.

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.

Schwarzwaelder K, Howe SJ, Schmidt M, Brugman MH, Deichmann A, Glimm H, Schmidt S, Prinz C, Wissler M, King DJ, Zhang F, Parsley KL, Gilmour KC, Sinclair J, Bayford J, Peraj R, Pike-Overzet K, Staal FJ, de Ridder D, Kinnon C, Abel U, Wagemaker G, Gaspar HB, Thrasher AJ, von Kalle C.

J Clin Invest. 2007 Aug;117(8):2241-9.

19.

Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12.

Barker SE, Grosse SM, Siapati EK, Kritz A, Kinnon C, Thrasher AJ, Hart SL.

Br J Cancer. 2007 Jul 16;97(2):210-7. Epub 2007 Jun 26.

20.
21.

Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.

Zhang F, Thornhill SI, Howe SJ, Ulaganathan M, Schambach A, Sinclair J, Kinnon C, Gaspar HB, Antoniou M, Thrasher AJ.

Blood. 2007 Sep 1;110(5):1448-57. Epub 2007 Apr 24.

22.

Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction.

Qasim W, Mackey T, Sinclair J, Chatziandreou I, Kinnon C, Thrasher AJ, Gaspar HB.

Mol Ther. 2007 Feb;15(2):355-60.

23.

Capture and generation of adenovirus specific T cells for adoptive immunotherapy.

Chatziandreou I, Gilmour KC, McNicol AM, Costabile M, Sinclair J, Cubitt D, Campbell JD, Kinnon C, Qasim W, Gaspar HB.

Br J Haematol. 2007 Jan;136(1):117-26. Epub 2006 Nov 8.

PMID:
17092305
24.

Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning.

Gaspar HB, Bjorkegren E, Parsley K, Gilmour KC, King D, Sinclair J, Zhang F, Giannakopoulos A, Adams S, Fairbanks LD, Gaspar J, Henderson L, Xu-Bayford JH, Davies EG, Veys PA, Kinnon C, Thrasher AJ.

Mol Ther. 2006 Oct;14(4):505-13. Epub 2006 Aug 14.

25.

Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia.

Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, Hann IM, Gale RE, Linch DC, Thrasher AJ.

Blood. 2006 Oct 1;108(7):2182-9. Epub 2006 Jun 27.

PMID:
16804117
26.

Gene therapy: has it delivered what it promised?

Kinnon C.

Br J Hosp Med (Lond). 2006 May;67(5):228-9. No abstract available.

PMID:
16729623
27.

Effective gene therapy with nonintegrating lentiviral vectors.

Yáñez-Muñoz RJ, Balaggan KS, MacNeil A, Howe SJ, Schmidt M, Smith AJ, Buch P, MacLaren RE, Anderson PN, Barker SE, Duran Y, Bartholomae C, von Kalle C, Heckenlively JR, Kinnon C, Ali RR, Thrasher AJ.

Nat Med. 2006 Mar;12(3):348-53. Epub 2006 Feb 19.

PMID:
16491086
28.

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector.

Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J, Brouns G, Schmidt M, Von Kalle C, Barington T, Jakobsen MA, Christensen HO, Al Ghonaium A, White HN, Smith JL, Levinsky RJ, Ali RR, Kinnon C, Thrasher AJ.

Lancet. 2004 Dec 18-31;364(9452):2181-7.

PMID:
15610804
29.

Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein.

de Noronha S, Hardy S, Sinclair J, Blundell MP, Strid J, Schulz O, Zwirner J, Jones GE, Katz DR, Kinnon C, Thrasher AJ.

Blood. 2005 Feb 15;105(4):1590-7. Epub 2004 Oct 19.

PMID:
15494425
30.

Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD.

Schwickerath O, Brouns G, Thrasher A, Kinnon C, Roes J, Casimir C.

J Gene Med. 2004 Jun;6(6):603-15.

PMID:
15170731
31.

SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease.

Sharifi R, Sinclair JC, Gilmour KC, Arkwright PD, Kinnon C, Thrasher AJ, Gaspar HB.

Blood. 2004 May 15;103(10):3821-7. Epub 2004 Jan 15.

PMID:
14726378
32.

The impact of retroviral suicide gene transduction procedures on T cells.

Qasim W, King D, Buddle J, Verfuerth S, Kinnon C, Thrasher AJ, Gaspar HB.

Br J Haematol. 2003 Nov;123(4):712-9.

PMID:
14616977
33.

Enhancement of integrin-mediated transfection of haematopoietic cells with a synthetic vector system.

Uduehi A, Mailhos C, Truman H, Thrasher AJ, Kinnon C, Hart SL.

Biotechnol Appl Biochem. 2003 Dec;38(Pt 3):201-9.

PMID:
12812522
34.

Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12.

Siapati KE, Barker S, Kinnon C, Michalski A, Anderson R, Brickell P, Thrasher AJ, Hart SL.

Br J Cancer. 2003 May 19;88(10):1641-8.

35.

T cell transduction and suicide with an enhanced mutant thymidine kinase.

Qasim W, Thrasher AJ, Buddle J, Kinnon C, Black ME, Gaspar HB.

Gene Ther. 2002 Jun;9(12):824-7.

37.

Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung.

Jenkins G, Hart SL, Hodges RJ, Meng QH, Kinnon C, Laurent GJ, McAnulty RJ.

Chest. 2002 Mar;121(3 Suppl):102S-104S. No abstract available.

PMID:
11893724
38.

Fetal haemopoietic cells display enhanced migration across endothelium.

Yong KL, Fahey A, Pahal G, Linch DC, Pizzey A, Thomas NS, Jauniaux E, Kinnon C, Thrasher AJ.

Br J Haematol. 2002 Feb;116(2):392-400.

PMID:
11841444
39.

Non-viral, integrin-mediated gene transfer into fibroblasts from patients with lysosomal storage diseases.

Estruch EJ, Hart SL, Kinnon C, Winchester BG.

J Gene Med. 2001 Sep-Oct;3(5):488-97.

PMID:
11601762
40.
41.

Protein assays for diagnosis of Wiskott-Aldrich syndrome and X-linked thrombocytopenia.

Qasim W, Gilmour KC, Heath S, Ashton E, Cranston T, Thomas A, Finn A, Davies EG, Thrasher AJ, Kinnon C, Jones A, Gaspar HB.

Br J Haematol. 2001 Jun;113(4):861-5.

PMID:
11442475
42.

Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells.

Leverrier Y, Lorenzi R, Blundell MP, Brickell P, Kinnon C, Ridley AJ, Thrasher AJ.

J Immunol. 2001 Apr 15;166(8):4831-4.

43.

Rapid protein-based assays for the diagnosis of T-B+ severe combined immunodeficiency.

Gilmour KC, Cranston T, Loughlin S, Gwyther J, Lester T, Espanol T, Hernandez M, Savoldi G, Davies EG, Abinun M, Kinnon C, Jones A, Gaspar HB.

Br J Haematol. 2001 Mar;112(3):671-6.

PMID:
11260071
44.

Normal development of human fetal hematopoiesis between eight and seventeen weeks' gestation.

Pahal GS, Jauniaux E, Kinnon C, Thrasher AJ, Rodeck CH.

Am J Obstet Gynecol. 2000 Oct;183(4):1029-34.

PMID:
11035358
45.

Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region.

Marshall CJ, Kinnon C, Thrasher AJ.

Blood. 2000 Aug 15;96(4):1591-3.

PMID:
10942412
46.

Diagnosis of X-linked lymphoproliferative disease by analysis of SLAM-associated protein expression.

Gilmour KC, Cranston T, Jones A, Davies EG, Goldblatt D, Thrasher A, Kinnon C, Nichols KE, Gaspar HB.

Eur J Immunol. 2000 Jun;30(6):1691-7.

47.

Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy.

Ali RR, Sarra GM, Stephens C, Alwis MD, Bainbridge JW, Munro PM, Fauser S, Reichel MB, Kinnon C, Hunt DM, Bhattacharya SS, Thrasher AJ.

Nat Genet. 2000 Jul;25(3):306-10.

PMID:
10888879
48.

Kinase mutant Btk results in atypical X-linked agammaglobulinaemia phenotype.

Gaspar HB, Ferrando M, Caragol I, Hernandez M, Bertran JM, De Gracia X, Lester T, Kinnon C, Ashton E, Espanol T.

Clin Exp Immunol. 2000 May;120(2):346-50.

49.

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis.

Lorenzi R, Brickell PM, Katz DR, Kinnon C, Thrasher AJ.

Blood. 2000 May 1;95(9):2943-6.

PMID:
10779443
50.

The Wiskott-Aldrich syndrome.

Thrasher AJ, Kinnon C.

Clin Exp Immunol. 2000 Apr;120(1):2-9. Review. No abstract available.

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