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Structurally Modified Cyclopenta[b]benzofuran Analogues Isolated from Aglaia perviridis.

Agarwal G, Wilson JR, Kurina SJ, Anaya-Eugenio GD, Ninh TN, Burdette JE, Soejarto DD, Cheng X, Carcache de Blanco EJ, Rakotondraibe LH, Kinghorn AD.

J Nat Prod. 2019 Oct 17. doi: 10.1021/acs.jnatprod.9b00631. [Epub ahead of print]


α-Pyrone and Sterol Constituents of Penicillium aurantiacobrunneum, a Fungal Associate of the Lichen Niebla homalea.

Tan CY, Wang F, Anaya-Eugenio GD, Gallucci JC, Goughenour KD, Rappleye CA, Spjut RW, Carcache de Blanco EJ, Kinghorn AD, Rakotondraibe LH.

J Nat Prod. 2019 Sep 27;82(9):2529-2536. doi: 10.1021/acs.jnatprod.9b00340. Epub 2019 Aug 29.


Highly sweet compounds of plant origin: From ethnobotanical observations to wide utilization.

Soejarto DD, Addo EM, Kinghorn AD.

J Ethnopharmacol. 2019 Oct 28;243:112056. doi: 10.1016/j.jep.2019.112056. Epub 2019 Jul 3. Review.


Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas.

Anaya-Eugenio GD, Addo EM, Ezzone N, Henkin JM, Ninh TN, Ren Y, Soejarto DD, Kinghorn AD, Carcache de Blanco EJ.

J Nat Prod. 2019 Jun 28;82(6):1645-1655. doi: 10.1021/acs.jnatprod.9b00140. Epub 2019 May 23.


Potential Anticancer Agents Characterized from Selected Tropical Plants.

Ren Y, de Blanco EJC, Fuchs JR, Soejarto DD, Burdette JE, Swanson SM, Kinghorn AD.

J Nat Prod. 2019 Mar 22;82(3):657-679. doi: 10.1021/acs.jnatprod.9b00018. Epub 2019 Mar 4.


Bioactivity-Guided Isolation of Totarane-Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3-Deoxy-2α-hydroxynagilactone E.

Benatrehina PA, Chen WL, Czarnecki AA, Kurina S, Chai HB, Lantvit DD, Ninh TN, Zhang X, Soejarto DD, Burdette JE, Kinghorn AD, Rakotondraibe LH.

Nat Prod Bioprospect. 2019 Apr;9(2):157-163. doi: 10.1007/s13659-019-0198-x. Epub 2019 Feb 19.


Changes for Volume 82.

Kinghorn AD.

J Nat Prod. 2019 Jan 25;82(1):1. doi: 10.1021/acs.jnatprod.8b01055. No abstract available.


Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity.

Ren Y, Kinghorn AD.

Planta Med. 2019 Aug;85(11-12):802-814. doi: 10.1055/a-0832-2383. Epub 2019 Jan 18. Review.


Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.


Current status and contemporary approaches to the discovery of antitumor agents from higher plants.

Agarwal G, Carcache PJB, Addo EM, Kinghorn AD.

Biotechnol Adv. 2019 Jan 8. pii: S0734-9750(19)30004-7. doi: 10.1016/j.biotechadv.2019.01.004. [Epub ahead of print] Review.


Non-Destructive Chemical Analysis of a Garcinia mangostana L. (Mangosteen) Herbarium Voucher Specimen.

Kao D, Henkin JM, Soejarto DD, Kinghorn AD, Oberlies NH.

Phytochem Lett. 2018 Dec;28:124-129. doi: 10.1016/j.phytol.2018.10.001. Epub 2018 Oct 12.


The Search for Anticancer Agents from Tropical Plants.

Henkin JM, Ren Y, Soejarto DD, Kinghorn AD.

Prog Chem Org Nat Prod. 2018;107:1-94. doi: 10.1007/978-3-319-93506-5_1. Review.


A Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma via Toll-Like Receptor-Mediated NF-κB and STAT3 Signaling Pathways.

Yi L, Chen L, Guo X, Lu T, Wang H, Ji X, Zhang J, Ren Y, Pan P, Kinghorn AD, Huang X, Wang LS, Fan Z, Caligiuri MA, Yu J.

Front Immunol. 2018 Jul 18;9:1509. doi: 10.3389/fimmu.2018.01509. eCollection 2018.


Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.

Ren Y, Anaya-Eugenio GD, Czarnecki AA, Ninh TN, Yuan C, Chai HB, Soejarto DD, Burdette JE, de Blanco EJC, Kinghorn AD.

Bioorg Med Chem. 2018 Aug 15;26(15):4452-4460. doi: 10.1016/j.bmc.2018.07.025. Epub 2018 Jul 17.


Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition.

Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H, Swanson SM, Kinghorn AD, Zhang X, Phelps MA, Aldrich LN, Fuchs JR, Burdette JE.

Mol Cancer Ther. 2018 Oct;17(10):2123-2135. doi: 10.1158/1535-7163.MCT-17-1195. Epub 2018 Jul 17.


Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States.

Benatrehina PA, Pan L, Naman CB, Li J, Kinghorn AD.

J Tradit Complement Med. 2018 Mar 2;8(2):267-277. doi: 10.1016/j.jtcme.2018.01.006. eCollection 2018 Apr. Review.


Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

Woodard JL, Huntsman AC, Patel PA, Chai HB, Kanagasabai R, Karmahapatra S, Young AN, Ren Y, Cole MS, Herrera D, Yalowich JC, Kinghorn AD, Burdette JE, Fuchs JR.

Bioorg Med Chem. 2018 May 15;26(9):2354-2364. doi: 10.1016/j.bmc.2018.03.033. Epub 2018 Mar 23.


Changes for Volume 81.

Kinghorn AD.

J Nat Prod. 2018 Jan 26;81(1):1. doi: 10.1021/acs.jnatprod.7b01078. No abstract available.


Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.

Ren Y, Gallucci JC, Li X, Chen L, Yu J, Kinghorn AD.

J Nat Prod. 2018 Mar 23;81(3):554-561. doi: 10.1021/acs.jnatprod.7b01079. Epub 2018 Jan 19.


Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents.

Henkin JM, Sydara K, Xayvue M, Souliya O, Kinghorn AD, Burdette JE, Chen WL, Elkington BG, Soejarto DD.

J Med Plant Res. 2017 Oct;11(40):621-634. Epub 2017 Oct 25.


Bioassay-Guided Isolation of Antioxidant and Cytoprotective Constituents from a Maqui Berry (Aristotelia chilensis) Dietary Supplement Ingredient As Markers for Qualitative and Quantitative Analysis.

Li J, Yuan C, Pan L, Benatrehina PA, Chai H, Keller WJ, Naman CB, Kinghorn AD.

J Agric Food Chem. 2017 Oct 4;65(39):8634-8642. doi: 10.1021/acs.jafc.7b03261. Epub 2017 Sep 26.


Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

Oghumu S, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR.

J Nat Prod. 2017 Sep 22;80(9):2515-2523. doi: 10.1021/acs.jnatprod.7b00445. Epub 2017 Sep 6.


Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation.

Oblinger JL, Burns SS, Huang J, Pan L, Ren Y, Shen R, Kinghorn AD, Welling DB, Chang LS.

Exp Neurol. 2018 Jan;299(Pt B):299-307. doi: 10.1016/j.expneurol.2017.06.015. Epub 2017 Jun 10.


An Intramolecular CAr-H•••O=C Hydrogen Bond and the Configuration of Rotenoids.

Ren Y, Gallucci JC, Kinghorn AD.

Planta Med. 2017 Oct;83(14-15):1194-1199. doi: 10.1055/s-0043-108910. Epub 2017 Apr 20.


(+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks.

Chen WL, Ren Y, Ren J, Erxleben C, Johnson ME, Gentile S, Kinghorn AD, Swanson SM, Burdette JE.

J Nat Prod. 2017 Mar 24;80(3):659-669. doi: 10.1021/acs.jnatprod.6b01150. Epub 2017 Feb 24.


Changes for Volume 80.

Kinghorn AD.

J Nat Prod. 2017 Jan 27;80(1):1. doi: 10.1021/acs.jnatprod.6b01155. No abstract available.


Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.

Ren Y, Chen WL, Lantvit DD, Sass EJ, Shriwas P, Ninh TN, Chai HB, Zhang X, Soejarto DD, Chen X, Lucas DM, Swanson SM, Burdette JE, Kinghorn AD.

J Nat Prod. 2017 Mar 24;80(3):648-658. doi: 10.1021/acs.jnatprod.6b00924. Epub 2016 Dec 16.


Discovery of Anticancer Agents of Diverse Natural Origin.

Kinghorn AD, DE Blanco EJ, Lucas DM, Rakotondraibe HL, Orjala J, Soejarto DD, Oberlies NH, Pearce CJ, Wani MC, Stockwell BR, Burdette JE, Swanson SM, Fuchs JR, Phelps MA, Xu L, Zhang X, Shen YY.

Anticancer Res. 2016 Nov;36(11):5623-5637. Review.


Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure-activity relationship of anabaenopeptin protease inhibitors.

Harms H, Kurita KL, Pan L, Wahome PG, He H, Kinghorn AD, Carter GT, Linington RG.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):4960-4965. doi: 10.1016/j.bmcl.2016.09.008. Epub 2016 Sep 6.


A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Gupta G, Peine KJ, Abdelhamid D, Snider H, Shelton AB, Rao L, Kotha SR, Huntsman AC, Varikuti S, Oghumu S, Naman CB, Pan L, Parinandi NL, Papenfuss TL, Kinghorn AD, Bachelder EM, Ainslie KM, Fuchs JR, Satoskar AR.

ACS Infect Dis. 2015 Oct 9;1(10):497-506. doi: 10.1021/acsinfecdis.5b00081. Epub 2015 Sep 21.


Isolation of Bioactive Rotenoids and Isoflavonoids from the Fruits of Millettia caerulea.

Ren Y, Benatrehina PA, Muñoz Acuña U, Yuan C, Chai HB, Ninh TN, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD.

Planta Med. 2016 Jul;82(11-12):1096-104. doi: 10.1055/s-0042-108059. Epub 2016 Jun 9.


Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones.

Ren Y, Yu J, Kinghorn AD.

Curr Med Chem. 2016;23(23):2397-420. Review.


Cyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa.

Othman N, Pan L, Mejin M, Voong JC, Chai HB, Pannell CM, Kinghorn AD, Yeo TC.

J Nat Prod. 2016 Apr 22;79(4):784-91. doi: 10.1021/acs.jnatprod.5b00810. Epub 2016 Mar 14.


Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas.

Oblinger JL, Burns SS, Akhmametyeva EM, Huang J, Pan L, Ren Y, Shen R, Miles-Markley B, Moberly AC, Kinghorn AD, Welling DB, Chang LS.

Neuro Oncol. 2016 Sep;18(9):1265-77. doi: 10.1093/neuonc/now032. Epub 2016 Mar 6.


Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.

Naman CB, Gromovsky AD, Vela CM, Fletcher JN, Gupta G, Varikuti S, Zhu X, Zywot EM, Chai H, Werbovetz KA, Satoskar AR, Kinghorn AD.

J Nat Prod. 2016 Mar 25;79(3):598-606. doi: 10.1021/acs.jnatprod.5b01131. Epub 2016 Feb 23.


Changes for Volume 79.

Kinghorn AD.

J Nat Prod. 2016 Jan 22;79(1):1. doi: 10.1021/acs.jnatprod.5b01136. No abstract available.


Silvestrol induces early autophagy and apoptosis in human melanoma cells.

Chen WL, Pan L, Kinghorn AD, Swanson SM, Burdette JE.

BMC Cancer. 2016 Jan 13;16:17. doi: 10.1186/s12885-015-1988-0.


A Symposium in Honor of Richard G. Powell, a Long-Time Associate Editor of the Journal of Natural Products.

Horwitz SB, Kinghorn AD.

J Nat Prod. 2015 Oct 23;78(10):2317-8. doi: 10.1021/acs.jnatprod.5b00856. Epub 2015 Oct 1. No abstract available.


Cytotoxic Barrigenol-like Triterpenoids from an Extract of Cyrilla racemiflora Housed in a Repository.

Ren Y, VanSchoiack A, Chai HB, Goetz M, Kinghorn AD.

J Nat Prod. 2015 Oct 23;78(10):2440-6. doi: 10.1021/acs.jnatprod.5b00532. Epub 2015 Sep 30.


New Bioactive Lupane Triterpene Coumaroyl Esters Isolated from Buxus cochinchinensis.

Pan L, Muñoz Acuña U, Chai H, Park HY, Ninh TN, Thanh BV, Merino EF, Cassera MB, Rakotondraibe LH, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD.

Planta Med. 2015 Aug;81(12-13):1133-40. doi: 10.1055/s-0035-1546118. Epub 2015 Jul 1.


Computer-Assisted Structure Elucidation of Black Chokeberry (Aronia melanocarpa) Fruit Juice Isolates with a New Fused Pentacyclic Flavonoid Skeleton.

Naman CB, Li J, Moser A, Hendrycks JM, Benatrehina PA, Chai H, Yuan C, Keller WJ, Kinghorn AD.

Org Lett. 2015 Jun 19;17(12):2988-91. doi: 10.1021/acs.orglett.5b01284. Epub 2015 Jun 1.


Northalrugosidine is a bisbenzyltetrahydroisoquinoline alkaloid from Thalictrum alpinum with in vivo antileishmanial activity.

Naman CB, Gupta G, Varikuti S, Chai H, Doskotch RW, Satoskar AR, Kinghorn AD.

J Nat Prod. 2015 Mar 27;78(3):552-6. doi: 10.1021/np501028u. Epub 2015 Jan 28.


Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.

Ren Y, Yuan C, Deng Y, Kanagasabai R, Ninh TN, Tu VT, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Kinghorn AD.

Phytochemistry. 2015 Mar;111:132-40. doi: 10.1016/j.phytochem.2014.12.014. Epub 2015 Jan 14.


Bioactive indole alkaloids isolated from Alstonia angustifolia.

Pan L, Terrazas C, Muñoz Acuña U, Ninh TN, Chai H, Carcache de Blanco EJ, Soejarto DD, Satoskar AR, Kinghorn AD.

Phytochem Lett. 2014 Dec;10:54-59.


Investigation of Vietnamese plants for potential anticancer agents.

Pérez LB, Still PC, Naman CB, Ren Y, Pan L, Chai HB, Carcache de Blanco EJ, Ninh TN, Van Thanh B, Swanson SM, Soejarto DD, Kinghorn AD.

Phytochem Rev. 2014 Dec;13(4):727-739.


The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease.

Patton JT, Lustberg ME, Lozanski G, Garman SL, Towns WH, Drohan CM, Lehman A, Zhang X, Bolon B, Pan L, Kinghorn AD, Grever MR, Lucas DM, Baiocchi RA.

Oncotarget. 2015 Feb 20;6(5):2693-708.


The natural product phyllanthusmin C enhances IFN-γ production by human NK cells through upregulation of TLR-mediated NF-κB signaling.

Deng Y, Chu J, Ren Y, Fan Z, Ji X, Mundy-Bosse B, Yuan S, Hughes T, Zhang J, Cheema B, Camardo AT, Xia Y, Wu LC, Wang LS, He X, Kinghorn AD, Li X, Caligiuri MA, Yu J.

J Immunol. 2014 Sep 15;193(6):2994-3002. doi: 10.4049/jimmunol.1302600. Epub 2014 Aug 13.


Assay development for the discovery of semaphorin 3B inducing agents from natural product sources.

Yong Y, Pan L, Ren Y, Fatima N, Ahmed S, Chang LC, Zhang X, Kinghorn AD, Swanson SM, Carcache de Blanco EJ.

Fitoterapia. 2014 Oct;98:184-91. doi: 10.1016/j.fitote.2014.07.004. Epub 2014 Jul 10.


In vitro evaluation of potential bitterness-masking terpenoids from the Canada goldenrod (Solidago canadensis).

Li J, Pan L, Fletcher JN, Lv W, Deng Y, Vincent MA, Slack JP, McCluskey TS, Jia Z, Cushman M, Kinghorn AD.

J Nat Prod. 2014 Jul 25;77(7):1739-43. doi: 10.1021/np5001413. Epub 2014 Jul 7.


Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.

Ren Y, Lantvit DD, Deng Y, Kanagasabai R, Gallucci JC, Ninh TN, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Swanson SM, Kinghorn AD.

J Nat Prod. 2014 Jun 27;77(6):1494-504. doi: 10.1021/np5002785. Epub 2014 Jun 12.

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