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Items: 10

1.

Correction: Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities.

Fordyce EAF, Fraser Hunt S, Crepin D, Onions ST, Parra GF, Sleigh CJ, King-Underwood J, Finch H, Murray J.

Medchemcomm. 2018 Mar 26;9(4):746. doi: 10.1039/c8md90016g. eCollection 2018 Apr 1.

2.

Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities.

Fordyce EAF, Fraser Hunt S, Crepin D, Onions ST, Parra GF, Sleigh CJ, King-Underwood J, Finch H, Murray J.

Medchemcomm. 2018 Feb 20;9(3):583-589. doi: 10.1039/c8md00033f. eCollection 2018 Mar 1. Erratum in: Medchemcomm. 2018 Mar 26;9(4):746.

3.

Synthesis and Activity of a Novel Autotaxin Inhibitor-Icodextrin Conjugate.

Fisher N, Edwards MG, Hemming R, Allin SM, Wallis JD, Bulman Page PC, Mckenzie MJ, Jones SM, Elsegood MRJ, King-Underwood J, Richardson A.

J Med Chem. 2018 Sep 13;61(17):7942-7951. doi: 10.1021/acs.jmedchem.8b00935. Epub 2018 Aug 15.

PMID:
30059212
4.

In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May.

5.

Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus.

Fordyce EAF, Brookes DW, Lise-Ciana C, Coates MS, Hunt SF, Ito K, King-Underwood J, Onions ST, Parra GF, Rapeport G, Sherbukhin V, Stockwell JA, Strong P, Thomas JC, Murray J.

Bioorg Med Chem Lett. 2017 May 15;27(10):2201-2206. doi: 10.1016/j.bmcl.2017.03.053. Epub 2017 Mar 23.

PMID:
28372911
6.

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.

Colley T, Alanio A, Kelly SL, Sehra G, Kizawa Y, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Anderson-Dring L, Nakaoki T, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, Cooke M, Bretagne S, King-Underwood J, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. doi: 10.1128/AAC.02280-16. Print 2017 May.

7.

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.

Onions ST, Ito K, Charron CE, Brown RJ, Colucci M, Frickel F, Hardy G, Joly K, King-Underwood J, Kizawa Y, Knowles I, Murray PJ, Novak A, Rani A, Rapeport G, Smith A, Strong P, Taddei DM, Williams JG.

J Med Chem. 2016 Mar 10;59(5):1727-46. doi: 10.1021/acs.jmedchem.5b01029. Epub 2016 Feb 4.

PMID:
26800309
8.

Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction.

Farinha CM, King-Underwood J, Sousa M, Correia AR, Henriques BJ, Roxo-Rosa M, Da Paula AC, Williams J, Hirst S, Gomes CM, Amaral MD.

Chem Biol. 2013 Jul 25;20(7):943-55. doi: 10.1016/j.chembiol.2013.06.004.

9.

The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.

Bennett JM, Campbell AD, Campbell AJ, Carr MG, Dunsdon RM, Greening JR, Hurst DN, Jennings NS, Jones PS, Jordan S, Kay PB, O'Brien MA, King-Underwood J, Raynham TM, Wilkinson CS, Wilkinson TC, Wilson FX.

Bioorg Med Chem Lett. 2001 Feb 12;11(3):355-7.

PMID:
11212109
10.

The design and synthesis of potent inhibitors of hepatitis C virus NS3-4A proteinase.

Attwood MR, Bennett JM, Campbell AD, Canning GG, Carr MG, Conway E, Dunsdon RM, Greening JR, Jones PS, Kay PB, Handa BK, Hurst DN, Jennings NS, Jordan S, Keech E, O'Brien MA, Overton HA, King-Underwood J, Raynham TM, Stenson KP, Wilkinson CS, Wilkinson TC, Wilson FX.

Antivir Chem Chemother. 1999 Sep;10(5):259-73.

PMID:
10574181

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