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Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy.

Lek A, Zhang Y, Woodman KG, Huang S, DeSimone AM, Cohen J, Ho V, Conner J, Mead L, Kodani A, Pakula A, Sanjana N, King OD, Jones PL, Wagner KR, Lek M, Kunkel LM.

Sci Transl Med. 2020 Mar 25;12(536). pii: eaay0271. doi: 10.1126/scitranslmed.aay0271.


Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B.

Batista AR, King OD, Reardon CP, Davis C, Shankaracharya, Philip V, Gray-Edwards H, Aronin N, Lutz C, Landers J, Sena-Esteves M.

Hum Gene Ther. 2020 Jan;31(1-2):90-102. doi: 10.1089/hum.2019.186. Epub 2019 Dec 13.


Precise therapeutic gene correction by a simple nuclease-induced double-stranded break.

Iyer S, Suresh S, Guo D, Daman K, Chen JCJ, Liu P, Zieger M, Luk K, Roscoe BP, Mueller C, King OD, Emerson CP Jr, Wolfe SA.

Nature. 2019 Apr;568(7753):561-565. doi: 10.1038/s41586-019-1076-8. Epub 2019 Apr 3.


A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia.

Picariello T, Brown JM, Hou Y, Swank G, Cochran DA, King OD, Lechtreck K, Pazour GJ, Witman GB.

J Cell Sci. 2019 Feb 11;132(3). pii: jcs220749. doi: 10.1242/jcs.220749.


Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.

Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J.

Cell. 2018 Apr 19;173(3):677-692.e20. doi: 10.1016/j.cell.2018.03.002.


Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.

Chen JC, King OD, Zhang Y, Clayton NP, Spencer C, Wentworth BM, Emerson CP Jr, Wagner KR.

Mol Ther. 2016 Aug;24(8):1405-11. doi: 10.1038/mt.2016.111. Epub 2016 Jun 3.


Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease.

March ZM, King OD, Shorter J.

Brain Res. 2016 Sep 15;1647:9-18. doi: 10.1016/j.brainres.2016.02.037. Epub 2016 Mar 18. Review.


Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy.

Jones TI, King OD, Himeda CL, Homma S, Chen JC, Beermann ML, Yan C, Emerson CP Jr, Miller JB, Wagner KR, Jones PL.

Clin Epigenetics. 2015 Mar 29;7:37. doi: 10.1186/s13148-015-0072-6. eCollection 2015.


Identifying diagnostic DNA methylation profiles for facioscapulohumeral muscular dystrophy in blood and saliva using bisulfite sequencing.

Jones TI, Yan C, Sapp PC, McKenna-Yasek D, Kang PB, Quinn C, Salameh JS, King OD, Jones PL.

Clin Epigenetics. 2014 Oct 29;6(1):23. doi: 10.1186/1868-7083-6-23. eCollection 2014.


PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

Lancaster AK, Nutter-Upham A, Lindquist S, King OD.

Bioinformatics. 2014 Sep 1;30(17):2501-2. doi: 10.1093/bioinformatics/btu310. Epub 2014 May 13.


Human skeletal muscle xenograft as a new preclinical model for muscle disorders.

Zhang Y, King OD, Rahimov F, Jones TI, Ward CW, Kerr JP, Liu N, Emerson CP Jr, Kunkel LM, Partridge TA, Wagner KR.

Hum Mol Genet. 2014 Jun 15;23(12):3180-8. doi: 10.1093/hmg/ddu028. Epub 2014 Jan 22.


A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation.

Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A.

PLoS One. 2013 Sep 9;8(9):e74469. doi: 10.1371/journal.pone.0074469. eCollection 2013.


Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases.

Jackson WS, Borkowski AW, Watson NE, King OD, Faas H, Jasanoff A, Lindquist S.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14759-64. doi: 10.1073/pnas.1312006110. Epub 2013 Aug 19.


Exome sequencing to identify de novo mutations in sporadic ALS trios.

Chesi A, Staahl BT, Jovičić A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, Reed R, Crabtree GR, Blair IP, Glass JD, Gitler AD.

Nat Neurosci. 2013 Jul;16(7):851-5. doi: 10.1038/nn.3412. Epub 2013 May 26.


Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy.

Stadler G, Rahimov F, King OD, Chen JC, Robin JD, Wagner KR, Shay JW, Emerson CP Jr, Wright WE.

Nat Struct Mol Biol. 2013 Jun;20(6):671-8. doi: 10.1038/nsmb.2571. Epub 2013 May 5.


Stress granules as crucibles of ALS pathogenesis.

Li YR, King OD, Shorter J, Gitler AD.

J Cell Biol. 2013 Apr 29;201(3):361-72. doi: 10.1083/jcb.201302044. Review.


Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.

Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP.

Nature. 2013 Mar 28;495(7442):467-73. doi: 10.1038/nature11922. Epub 2013 Mar 3.


Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story?

Stadler G, King OD, Robin JD, Shay JW, Wright WE.

Rare Dis. 2013 Aug 14;1:e26142. doi: 10.4161/rdis.26142. eCollection 2013.


Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers.

Rahimov F, King OD, Leung DG, Bibat GM, Emerson CP Jr, Kunkel LM, Wagner KR.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16234-9. doi: 10.1073/pnas.1209508109. Epub 2012 Sep 17.


Daily scheduled high fat meals moderately entrain behavioral anticipatory activity, body temperature, and hypothalamic c-Fos activation.

Gallardo CM, Gunapala KM, King OD, Steele AD.

PLoS One. 2012;7(7):e41161. doi: 10.1371/journal.pone.0041161. Epub 2012 Jul 16.


Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis.

Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP Jr, Wagner KR, Jones PL.

Hum Mol Genet. 2012 Oct 15;21(20):4419-30. Epub 2012 Jul 13.


Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.

McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S.

ACS Chem Biol. 2012 Sep 21;7(9):1520-8. Epub 2012 Jun 22.


Food anticipatory activity behavior of mice across a wide range of circadian and non-circadian intervals.

Luby MD, Hsu CT, Shuster SA, Gallardo CM, Mistlberger RE, King OD, Steele AD.

PLoS One. 2012;7(5):e37992. doi: 10.1371/journal.pone.0037992. Epub 2012 May 25.


Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee VM, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD.

Hum Mol Genet. 2012 Jul 1;21(13):2899-911. doi: 10.1093/hmg/dds116. Epub 2012 Mar 27.


The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

King OD, Gitler AD, Shorter J.

Brain Res. 2012 Jun 26;1462:61-80. doi: 10.1016/j.brainres.2012.01.016. Epub 2012 Jan 21. Review.


Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice.

Matsumiya LC, Sorge RE, Sotocinal SG, Tabaka JM, Wieskopf JS, Zaloum A, King OD, Mogil JS.

J Am Assoc Lab Anim Sci. 2012 Jan;51(1):42-9.


An open system for automatic home-cage behavioral analysis and its application to male and female mouse models of Huntington's disease.

Zarringhalam K, Ka M, Kook YH, Terranova JI, Suh Y, King OD, Um M.

Behav Brain Res. 2012 Apr 1;229(1):216-25. doi: 10.1016/j.bbr.2012.01.015. Epub 2012 Jan 13.


A yeast functional screen predicts new candidate ALS disease genes.

Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20881-90. doi: 10.1073/pnas.1109434108. Epub 2011 Nov 7.


The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions.

Sotocinal SG, Sorge RE, Zaloum A, Tuttle AH, Martin LJ, Wieskopf JS, Mapplebeck JC, Wei P, Zhan S, Zhang S, McDougall JJ, King OD, Mogil JS.

Mol Pain. 2011 Jul 29;7:55. doi: 10.1186/1744-8069-7-55.


Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins.

Halfmann R, Alberti S, Krishnan R, Lyle N, O'Donnell CW, King OD, Berger B, Pappu RV, Lindquist S.

Mol Cell. 2011 Jul 8;43(1):72-84. doi: 10.1016/j.molcel.2011.05.013.


Gene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor.

Rahimov F, King OD, Warsing LC, Powell RE, Emerson CP Jr, Kunkel LM, Wagner KR.

Physiol Genomics. 2011 Apr 27;43(8):398-407. doi: 10.1152/physiolgenomics.00223.2010. Epub 2011 Jan 25.


Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.

Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP.

Nat Methods. 2011 Feb;8(2):159-64. doi: 10.1038/nmeth.1550. Epub 2011 Jan 9.


Prion-like disorders: blurring the divide between transmissibility and infectivity.

Cushman M, Johnson BS, King OD, Gitler AD, Shorter J.

J Cell Sci. 2010 Apr 15;123(Pt 8):1191-201. doi: 10.1242/jcs.051672.


Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice.

Jackson WS, Borkowski AW, Faas H, Steele AD, King OD, Watson N, Jasanoff A, Lindquist S.

Neuron. 2009 Aug 27;63(4):438-50. doi: 10.1016/j.neuron.2009.07.026.


Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.

Yeger-Lotem E, Riva L, Su LJ, Gitler AD, Cashikar AG, King OD, Auluck PK, Geddie ML, Valastyan JS, Karger DR, Lindquist S, Fraenkel E.

Nat Genet. 2009 Mar;41(3):316-23. doi: 10.1038/ng.337. Epub 2009 Feb 22.


Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.

Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A, Lindquist S.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13626-31. doi: 10.1073/pnas.0806319105. Epub 2008 Aug 29.


Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function.

Tian W, Zhang LV, Taşan M, Gibbons FD, King OD, Park J, Wunderlich Z, Cherry JM, Roth FP.

Genome Biol. 2008;9 Suppl 1:S7. doi: 10.1186/gb-2008-9-s1-s7. Epub 2008 Jun 27.


Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo.

Steele AD, King OD, Jackson WS, Hetz CA, Borkowski AW, Thielen P, Wollmann R, Lindquist S.

J Neurosci. 2007 Nov 21;27(47):13022-7.


The evolution of bet-hedging adaptations to rare scenarios.

King OD, Masel J.

Theor Popul Biol. 2007 Dec;72(4):560-75. Epub 2007 Aug 31.


The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases.

Steele AD, Jackson WS, King OD, Lindquist S.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1983-8. Epub 2007 Jan 29.


The loss of adaptive plasticity during long periods of environmental stasis.

Masel J, King OD, Maughan H.

Am Nat. 2007 Jan;169(1):38-46. Epub 2006 Nov 28.


Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network.

Zhang LV, King OD, Wong SL, Goldberg DS, Tong AH, Lesage G, Andrews B, Bussey H, Boone C, Roth FP.

J Biol. 2005;4(2):6. Epub 2005 Jun 1.


Comment on "Subgraphs in random networks".

King OD.

Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Nov;70(5 Pt 2):058101; author reply 058102. Epub 2004 Nov 18.


Combining biological networks to predict genetic interactions.

Wong SL, Zhang LV, Tong AH, Li Z, Goldberg DS, King OD, Lesage G, Vidal M, Andrews B, Bussey H, Boone C, Roth FP.

Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15682-7. Epub 2004 Oct 20.


Predicting protein complex membership using probabilistic network reliability.

Asthana S, King OD, Gibbons FD, Roth FP.

Genome Res. 2004 Jun;14(6):1170-5. Epub 2004 May 12.


Predicting co-complexed protein pairs using genomic and proteomic data integration.

Zhang LV, Wong SL, King OD, Roth FP.

BMC Bioinformatics. 2004 Apr 16;5:38.


Intensity-based protein identification by machine learning from a library of tandem mass spectra.

Elias JE, Gibbons FD, King OD, Roth FP, Gygi SP.

Nat Biotechnol. 2004 Feb;22(2):214-9. Epub 2004 Jan 18.


Characterizing gene sets with FuncAssociate.

Berriz GF, King OD, Bryant B, Sander C, Roth FP.

Bioinformatics. 2003 Dec 12;19(18):2502-4.


A non-parametric model for transcription factor binding sites.

King OD, Roth FP.

Nucleic Acids Res. 2003 Oct 1;31(19):e116.


Predicting phenotype from patterns of annotation.

King OD, Lee JC, Dudley AM, Janse DM, Church GM, Roth FP.

Bioinformatics. 2003;19 Suppl 1:i183-9.


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