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Items: 38


De novo design of tunable, pH-driven conformational changes.

Boyken SE, Benhaim MA, Busch F, Jia M, Bick MJ, Choi H, Klima JC, Chen Z, Walkey C, Mileant A, Sahasrabuddhe A, Wei KY, Hodge EA, Byron S, Quijano-Rubio A, Sankaran B, King NP, Lippincott-Schwartz J, Wysocki VH, Lee KK, Baker D.

Science. 2019 May 17;364(6441):658-664. doi: 10.1126/science.aav7897.


Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus.

Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee KK, Veesler D, Correnti CE, Stewart LJ, Baker D, Loré K, Perez L, King NP.

Cell. 2019 Mar 7;176(6):1420-1431.e17. doi: 10.1016/j.cell.2019.01.046.


New Vaccine Design and Delivery Technologies.

Kanekiyo M, Ellis D, King NP.

J Infect Dis. 2019 Apr 8;219(Supplement_1):S88-S96. doi: 10.1093/infdis/jiy745.


Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS.

Sahasrabuddhe A, Hsia Y, Busch F, Sheffler W, King NP, Baker D, Wysocki VH.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1268-1273. doi: 10.1073/pnas.1713646115. Epub 2018 Jan 19.


Evolution of a designed protein assembly encapsulating its own RNA genome.

Butterfield GL, Lajoie MJ, Gustafson HH, Sellers DL, Nattermann U, Ellis D, Bale JB, Ke S, Lenz GH, Yehdego A, Ravichandran R, Pun SH, King NP, Baker D.

Nature. 2017 Dec 21;552(7685):415-420. doi: 10.1038/nature25157. Epub 2017 Dec 13.


Multivalent Display of Antifreeze Proteins by Fusion to Self-Assembling Protein Cages Enhances Ice-Binding Activities.

Phippen SW, Stevens CA, Vance TD, King NP, Baker D, Davies PL.

Biochemistry. 2016 Dec 13;55(49):6811-6820. Epub 2016 Nov 29.


Designed proteins induce the formation of nanocage-containing extracellular vesicles.

Votteler J, Ogohara C, Yi S, Hsia Y, Nattermann U, Belnap DM, King NP, Sundquist WI.

Nature. 2016 Dec 8;540(7632):292-295. doi: 10.1038/nature20607. Epub 2016 Nov 30.


Corrigendum: Design of a hyperstable 60-subunit protein icosahedron.

Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D.

Nature. 2016 Dec 1;540(7631):150. doi: 10.1038/nature20108. Epub 2016 Oct 19. No abstract available.


Accurate design of megadalton-scale two-component icosahedral protein complexes.

Bale JB, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates TO, Gonen T, King NP, Baker D.

Science. 2016 Jul 22;353(6297):389-94. doi: 10.1126/science.aaf8818.


Design of a hyperstable 60-subunit protein dodecahedron. [corrected].

Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D.

Nature. 2016 Jul 7;535(7610):136-9. doi: 10.1038/nature18010. Epub 2016 Jun 15. Erratum in: Nature. 2016 Dec 1;540(7631):150.


Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM.

Heinze K, Sasaki E, King NP, Baker D, Hilvert D, Wuite GJ, Roos WH.

J Phys Chem B. 2016 Jul 7;120(26):5945-52. doi: 10.1021/acs.jpcb.6b01464. Epub 2016 May 17.


Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae.

Ipe DS, Ben Zakour NL, Sullivan MJ, Beatson SA, Ulett KB, Benjamin WH Jr, Davies MR, Dando SJ, King NP, Cripps AW, Schembri MA, Dougan G, Ulett GC.

Infect Immun. 2015 Nov 9;84(1):307-19. doi: 10.1128/IAI.00938-15. Print 2016 Jan.


Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression.

Bale JB, Park RU, Liu Y, Gonen S, Gonen T, Cascio D, King NP, Yeates TO, Baker D.

Protein Sci. 2015 Oct;24(10):1695-701. doi: 10.1002/pro.2748. Epub 2015 Aug 6.


Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector.

King NP, Newton P, Schuelein R, Brown DL, Petru M, Zarsky V, Dolezal P, Luo L, Bugarcic A, Stanley AC, Murray RZ, Collins BM, Teasdale RD, Hartland EL, Stow JL.

Cell Microbiol. 2015 Jun;17(6):767-84. doi: 10.1111/cmi.12405. Epub 2015 Jan 24.


Accurate design of co-assembling multi-component protein nanomaterials.

King NP, Bale JB, Sheffler W, McNamara DE, Gonen S, Gonen T, Yeates TO, Baker D.

Nature. 2014 Jun 5;510(7503):103-8. doi: 10.1038/nature13404. Epub 2014 May 25.


Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry.

Luo L, King NP, Yeo JC, Jones A, Stow JL.

Proteomics. 2014 Jan;14(1):19-23. doi: 10.1002/pmic.201300315.


Practical approaches to designing novel protein assemblies.

King NP, Lai YT.

Curr Opin Struct Biol. 2013 Aug;23(4):632-8. doi: 10.1016/ Epub 2013 Jul 1. Review.


Structural and functional characterization of ScsC, a periplasmic thioredoxin-like protein from Salmonella enterica serovar Typhimurium.

Shepherd M, Heras B, Achard ME, King GJ, Argente MP, Kurth F, Taylor SL, Howard MJ, King NP, Schembri MA, McEwan AG.

Antioxid Redox Signal. 2013 Nov 1;19(13):1494-506. doi: 10.1089/ars.2012.4939. Epub 2013 Aug 9.


Principles for designing ordered protein assemblies.

Lai YT, King NP, Yeates TO.

Trends Cell Biol. 2012 Dec;22(12):653-61. doi: 10.1016/j.tcb.2012.08.004. Epub 2012 Sep 10. Review.


Computational design of self-assembling protein nanomaterials with atomic level accuracy.

King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, André I, Gonen T, Yeates TO, Baker D.

Science. 2012 Jun 1;336(6085):1171-4. doi: 10.1126/science.1219364.


Molecular characterization of the EhaG and UpaG trimeric autotransporter proteins from pathogenic Escherichia coli.

Totsika M, Wells TJ, Beloin C, Valle J, Allsopp LP, King NP, Ghigo JM, Schembri MA.

Appl Environ Microbiol. 2012 Apr;78(7):2179-89. doi: 10.1128/AEM.06680-11. Epub 2012 Jan 27.


Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance.

King NP, Sakinç T, Ben Zakour NL, Totsika M, Heras B, Simerska P, Shepherd M, Gatermann SG, Beatson SA, Schembri MA.

BMC Microbiol. 2012 Jan 15;12:8. doi: 10.1186/1471-2180-12-8.


Protein stabilization in a highly knotted protein polymer.

Sayre TC, Lee TM, King NP, Yeates TO.

Protein Eng Des Sel. 2011 Aug;24(8):627-30. doi: 10.1093/protein/gzr024. Epub 2011 Jun 13.


UafB is a serine-rich repeat adhesin of Staphylococcus saprophyticus that mediates binding to fibronectin, fibrinogen and human uroepithelial cells.

King NP, Beatson SA, Totsika M, Ulett GC, Alm RA, Manning PA, Schembri MA.

Microbiology. 2011 Apr;157(Pt 4):1161-75. doi: 10.1099/mic.0.047639-0. Epub 2011 Jan 20.


Structure and folding of a designed knotted protein.

King NP, Jacobitz AW, Sawaya MR, Goldschmidt L, Yeates TO.

Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20732-7. doi: 10.1073/pnas.1007602107. Epub 2010 Nov 10.


Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.

Witherington J, Abberley L, Bellenie BR, Boatman R, Collis K, Dean DK, Gaiba A, King NP, Shuker N, Steadman JG, Takle AK, Sanger G, Butler S, McKay F, Muir A, Winborn K, Ward RW, Heightman TD.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):684-7. doi: 10.1016/j.bmcl.2008.12.042. Epub 2008 Dec 14.


Structures and functional implications of an AMP-binding cystathionine beta-synthase domain protein from a hyperthermophilic archaeon.

King NP, Lee TM, Sawaya MR, Cascio D, Yeates TO.

J Mol Biol. 2008 Jun 27;380(1):181-92. doi: 10.1016/j.jmb.2008.04.073. Epub 2008 May 7.


Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.

Witherington J, Abberley L, Briggs MA, Collis K, Dean DK, Gaiba A, King NP, Kraus H, Shuker N, Steadman JG, Takle AK, Sanger G, Wadsworth G, Butler S, McKay F, Muir A, Winborn K, Heightman TD.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2203-5. doi: 10.1016/j.bmcl.2007.12.021. Epub 2007 Dec 15.


Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.

Young RJ, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chan C, Charbaut M, Convery MA, Diallo H, Hortense E, Irving WR, Kelly HA, King NP, Kleanthous S, Mason AM, Pateman AJ, Patikis AN, Pinto IL, Pollard DR, Senger S, Shah GP, Toomey JR, Watson NS, Weston HE, Zhou P.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):28-33. Epub 2007 Nov 13.


Knotted and topologically complex proteins as models for studying folding and stability.

Yeates TO, Norcross TS, King NP.

Curr Opin Chem Biol. 2007 Dec;11(6):595-603. Epub 2007 Nov 9. Review.


Identification of rare slipknots in proteins and their implications for stability and folding.

King NP, Yeates EO, Yeates TO.

J Mol Biol. 2007 Oct 12;373(1):153-66. Epub 2007 Aug 2.


Silyl-modified Bellus-Claisen rearrangement.

Craig D, King NP, Mountford DM.

Chem Commun (Camb). 2007 Mar 14;(10):1077-9. Epub 2006 Dec 21.


Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.

Young RJ, Campbell M, Borthwick AD, Brown D, Burns-Kurtis CL, Chan C, Convery MA, Crowe MC, Dayal S, Diallo H, Kelly HA, King NP, Kleanthous S, Mason AM, Mordaunt JE, Patel C, Pateman AJ, Senger S, Shah GP, Smith PW, Watson NS, Weston HE, Zhou P.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):5953-7. Epub 2006 Sep 18.


Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.

Watson NS, Brown D, Campbell M, Chan C, Chaudry L, Convery MA, Fenwick R, Hamblin JN, Haslam C, Kelly HA, King NP, Kurtis CL, Leach AR, Manchee GR, Mason AM, Mitchell C, Patel C, Patel VK, Senger S, Shah GP, Weston HE, Whitworth C, Young RJ.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3784-8. Epub 2006 May 11.


Synthesis of homoallylic sulfones through a decarboxylative claisen rearrangement reaction.

Bourgeois D, Craig D, King NP, Mountford DM.

Angew Chem Int Ed Engl. 2005 Jan 14;44(4):618-21. No abstract available.


Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.

Nicolaou KC, Hepworth D, King NP, Finlay MR, Scarpelli R, Pereira MM, Bollbuck B, Bigot A, Werschkun B, Winssinger N.

Chemistry. 2000 Aug 4;6(15):2783-800.


Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy.

Nicolaou KC, King NP, Finlay MR, He Y, Roschangar F, Vourloumis D, Vallberg H, Sarabia F, Ninkovic S, Hepworth D.

Bioorg Med Chem. 1999 May;7(5):665-97.


Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones.

Nicolaou KC, Finlay MR, Ninkovic S, King NP, He Y, Li T, Sarabia F, Vourloumis D.

Chem Biol. 1998 Jul;5(7):365-72.

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