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A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.

Mathur D, Root AR, Bugaj-Gaweda B, Bisulco S, Tan X, Fang W, Kearney JC, Lucas J, Guffroy M, Golas J, Rohde CM, Stevens C, Kamperschroer C, Kelleher K, Lawrence-Henderson RF, Upeslacis E, Yao J, Narula J, LaVallie ER, Fernandez DR, Buetow BS, Rosfjord E, Bloom L, King LE, Tchistiakova L, Nguyen A, Sapra P.

Clin Cancer Res. 2020 Jan 29. doi: 10.1158/1078-0432.CCR-19-3275. [Epub ahead of print]


Optimizing Flux Capacity of Dead-end Filtration Membranes by Controlling Flow with Pulse Width Modulated Periodic Backflush.

Enten AC, Leipner MPI, Bellavia MC, King LE, Sulchek TA.

Sci Rep. 2020 Jan 21;10(1):896. doi: 10.1038/s41598-020-57649-9.


Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization.

Kuwana T, King LE, Cosentino K, Suess J, Garcia-Saez AJ, Gilmore AP, Newmeyer DD.

J Biol Chem. 2020 Feb 7;295(6):1623-1636. doi: 10.1074/jbc.RA119.011635. Epub 2020 Jan 3.


A dual role of prestimulus spontaneous neural activity in visual object recognition.

Podvalny E, Flounders MW, King LE, Holroyd T, He BJ.

Nat Commun. 2019 Sep 2;10(1):3910. doi: 10.1038/s41467-019-11877-4.


A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.

Jones HM, Zhang Z, Jasper P, Luo H, Avery LB, King LE, Neubert H, Barton HA, Betts AM, Webster R.

CPT Pharmacometrics Syst Pharmacol. 2019 Oct;8(10):738-747. doi: 10.1002/psp4.12461. Epub 2019 Sep 23.


Mice with an autosomal dominant Charcot-Marie-Tooth type 2O disease mutation in both dynein alleles display severe moto-sensory phenotypes.

Nandini S, Conley Calderon JL, Sabblah TT, Love R, King LE, King SJ.

Sci Rep. 2019 Aug 19;9(1):11979. doi: 10.1038/s41598-019-48431-7.


A novel mouse model carrying a human cytoplasmic dynein mutation shows motor behavior deficits consistent with Charcot-Marie-Tooth type 2O disease.

Sabblah TT, Nandini S, Ledray AP, Pasos J, Calderon JLC, Love R, King LE, King SJ.

Sci Rep. 2018 Jan 29;8(1):1739. doi: 10.1038/s41598-018-20081-1.


Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias.

Sundberg JP, Hordinsky MK, Bergfeld W, Lenzy YM, McMichael AJ, Christiano AM, McGregor T, Stenn KS, Sivamani RK, Pratt CH, King LE Jr.

Exp Dermatol. 2018 Mar;27(3):302-310. doi: 10.1111/exd.13495.


E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.

Vuillier C, Lohard S, Fétiveau A, Allègre J, Kayaci C, King LE, Braun F, Barillé-Nion S, Gautier F, Dubrez L, Gilmore AP, Juin PP, Maillet L.

EMBO Rep. 2018 Feb;19(2):234-243. doi: 10.15252/embr.201744046. Epub 2017 Dec 12.


Phytogeographic patterns and cryptic diversity in an aposematic toad from NW Argentina.

Clemente-Carvalho RB, Vaira M, King LE, Koscinski D, Bonansea MI, Lougheed SC.

Mol Phylogenet Evol. 2017 Nov;116:248-256. doi: 10.1016/j.ympev.2017.07.013. Epub 2017 Jul 24.


Erratum to: Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.

Zhang J, Gambin T, Yuan B, Szafranski P, Rosenfeld JA, Balwi MA, Alswaid A, Al-Gazali L, Shamsi AMA, Komara M, Ali BR, Roeder E, McAuley L, Roy DS, Manchester DK, Magoulas P, King LE, Hannig V, Bonneau D, Denommé-Pichon AS, Charif M, Besnard T, Bézieau S, Cogné B, Andrieux J, Zhu W, He W, Vetrini F, Ward PA, Cheung SW, Bi W, Eng CM, Lupski JR, Yang Y, Patel A, Lalani SR, Xia F, Stankiewicz P.

Hum Genet. 2017 Aug;136(8):1009-1011. doi: 10.1007/s00439-017-1828-1. No abstract available.


Alopecia areata.

Pratt CH, King LE Jr, Messenger AG, Christiano AM, Sundberg JP.

Nat Rev Dis Primers. 2017 Mar 16;3:17011. doi: 10.1038/nrdp.2017.11. Review.


Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.

Zhang J, Gambin T, Yuan B, Szafranski P, Rosenfeld JA, Balwi MA, Alswaid A, Al-Gazali L, Shamsi AMA, Komara M, Ali BR, Roeder E, McAuley L, Roy DS, Manchester DK, Magoulas P, King LE, Hannig V, Bonneau D, Denommé-Pichon AS, Charif M, Besnard T, Bézieau S, Cogné B, Andrieux J, Zhu W, He W, Vetrini F, Ward PA, Cheung SW, Bi W, Eng CM, Lupski JR, Yang Y, Patel A, Lalani SR, Xia F, Stankiewicz P.

Hum Genet. 2017 Apr;136(4):377-386. doi: 10.1007/s00439-017-1763-1. Epub 2017 Mar 1. Erratum in: Hum Genet. 2017 Jun 28;:.


Beehive fences as a multidimensional conflict-mitigation tool for farmers coexisting with elephants.

King LE, Lala F, Nzumu H, Mwambingu E, Douglas-Hamilton I.

Conserv Biol. 2017 Aug;31(4):743-752. doi: 10.1111/cobi.12898. Epub 2017 Feb 21.


The effects of pharmaceuticals on a unionid mussel (Lampsilis siliquoidea): An examination of acute and chronic endpoints of toxicity across life stages.

Gilroy ÈAM, Gillis PL, King LE, Bendo NA, Salerno J, Giacomin M, de Solla SR.

Environ Toxicol Chem. 2017 Jun;36(6):1572-1583. doi: 10.1002/etc.3683. Epub 2017 Jan 17.


Parallelism experiments in biomarker ligand-binding assays to assess immunological similarity.

King LE.

Bioanalysis. 2016 Dec;8(23):2387-2391. No abstract available.


Perfluoroalkylphosphinic Acids in Northern Pike (Esox lucius), Double-Crested Cormorants (Phalacrocorax auritus), and Bottlenose Dolphins (Tursiops truncatus) in Relation to Other Perfluoroalkyl Acids.

De Silva AO, Spencer C, Ho KC, Al Tarhuni M, Go C, Houde M, de Solla SR, Lavoie RA, King LE, Muir DC, Fair PA, Wells RS, Bossart GD.

Environ Sci Technol. 2016 Oct 18;50(20):10903-10913. Epub 2016 Sep 28.


Feasibility of Singlet Analysis for Ligand Binding Assays: a Retrospective Examination of Data Generated Using the Gyrolab Platform.

Clark TH, Yates PD, Chunyk AG, Joyce AP, Wu A, Pop-Damkov P, Zhang Y, Dreher EA, Tylaska LA, Wentland JA, Pelletier KB, King LE, Ray CA.

AAPS J. 2016 Sep;18(5):1300-1308. doi: 10.1208/s12248-016-9944-8. Epub 2016 Jul 11.


DermO; an ontology for the description of dermatologic disease.

Fisher HM, Hoehndorf R, Bazelato BS, Dadras SS, King LE Jr, Gkoutos GV, Sundberg JP, Schofield PN.

J Biomed Semantics. 2016 Jun 13;7:38. doi: 10.1186/s13326-016-0085-x.


Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin.

Betts AM, Haddish-Berhane N, Tolsma J, Jasper P, King LE, Sun Y, Chakrapani S, Shor B, Boni J, Johnson TR.

AAPS J. 2016 Sep;18(5):1101-1116. doi: 10.1208/s12248-016-9929-7. Epub 2016 May 19.


Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening.

Sundberg JP, Silva KA, King LE Jr, Pratt CH.

Methods Mol Biol. 2016;1438:199-224. doi: 10.1007/978-1-4939-3661-8_12.


Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1).

Singh AP, Maass KF, Betts AM, Wittrup KD, Kulkarni C, King LE, Khot A, Shah DK.

AAPS J. 2016 Jul;18(4):861-75. doi: 10.1208/s12248-016-9904-3. Epub 2016 Mar 30.


Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells.

King LE, Love CG, Sieber OM, Faux MC, Burgess AW.

Genom Data. 2016 Feb 3;7:293-6. doi: 10.1016/j.gdata.2016.02.001. eCollection 2016 Mar.


Dermal lymphatic dilation in a mouse model of alopecia areata.

Sundberg JP, Pratt CH, Silva KA, Kennedy VE, Stearns TM, Sundberg BA, King LE, HogenEsch H.

Exp Mol Pathol. 2016 Apr;100(2):332-6. doi: 10.1016/j.yexmp.2016.03.001. Epub 2016 Mar 6.


Bioaccumulation of pharmaceuticals and personal care products in the unionid mussel Lasmigona costata in a river receiving wastewater effluent.

de Solla SR, Gilroy ÈA, Klinck JS, King LE, McInnis R, Struger J, Backus SM, Gillis PL.

Chemosphere. 2016 Mar;146:486-96. doi: 10.1016/j.chemosphere.2015.12.022. Epub 2015 Dec 30.


Excavating the Genome: Large-Scale Mutagenesis Screening for the Discovery of New Mouse Models.

Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Murray SA, Denegre JM, Schofield PN, King LE Jr, Wiles MV, Pratt CH.

J Investig Dermatol Symp Proc. 2015 Nov;17(2):27-9. doi: 10.1038/jidsymp.2015.36. Review.


Animal Models for Alopecia Areata: What and Where?

Sundberg JP, McElwee K, Brehm MA, Su L, King LE Jr.

J Investig Dermatol Symp Proc. 2015 Nov;17(2):23-6. doi: 10.1038/jidsymp.2015.35. Review.


Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging.

Morgan CD, Zuckerman SL, King LE, Beaird SE, Sills AK, Solomon GS.

Childs Nerv Syst. 2015 Dec;31(12):2305-9. doi: 10.1007/s00381-015-2916-y. Epub 2015 Sep 29.


Antibody-drug conjugates nonclinical support: from early to late nonclinical bioanalysis using ligand-binding assays.

Kumar S, King LE, Clark TH, Gorovits B.

Bioanalysis. 2015;7(13):1605-17. doi: 10.4155/bio.15.107.


Resolution of chronic ocular sarcoidosis with antimycobacterial therapy.

Richmond BW, Richter K, King LE, Drake WP.

Case Rep Intern Med. 2014;1(2). pii: 5042.


Crisp1 and alopecia areata in C3H/HeJ mice.

Sundberg JP, Awgulewitsch A, Pruett ND, Potter CS, Silva KA, Stearns TM, Sundberg BA, Muñoz MW, Cuasnicu PS, King LE Jr, Rice RH.

Exp Mol Pathol. 2014 Dec;97(3):525-8. doi: 10.1016/j.yexmp.2014.10.010. Epub 2014 Oct 29.


Contamination of mercury during the wintering period influences concentrations at breeding sites in two migratory piscivorous birds.

Lavoie RA, Baird CJ, King LE, Kyser TK, Friesen VL, Campbell LM.

Environ Sci Technol. 2014 Dec 2;48(23):13694-702. doi: 10.1021/es502746z. Epub 2014 Nov 19.


Microsatellite DNA mutations in double-crested cormorants (Phalacrocorax auritus) associated with exposure to PAH-containing industrial air pollution.

King LE, de Solla SR, Small JM, Sverko E, Quinn JS.

Environ Sci Technol. 2014 Oct 7;48(19):11637-45. doi: 10.1021/es502720a. Epub 2014 Sep 15.


Characterization of selenium in ambient aerosols and primary emission sources.

De Santiago A, Longo AF, Ingall ED, Diaz JM, King LE, Lai B, Weber RJ, Russell AG, Oakes M.

Environ Sci Technol. 2014 Aug 19;48(16):8988-94. doi: 10.1021/es500379y. Epub 2014 Aug 7.


Ligand binding assay critical reagents and their stability: recommendations and best practices from the Global Bioanalysis Consortium Harmonization Team.

King LE, Farley E, Imazato M, Keefe J, Khan M, Ma M, Pihl KS, Sriraman P.

AAPS J. 2014 May;16(3):504-15. doi: 10.1208/s12248-014-9583-x. Epub 2014 Apr 1.


African elephant alarm calls distinguish between threats from humans and bees.

Soltis J, King LE, Douglas-Hamilton I, Vollrath F, Savage A.

PLoS One. 2014 Feb 26;9(2):e89403. doi: 10.1371/journal.pone.0089403. eCollection 2014.


A priori prediction of tumor payload concentrations: preclinical case study with an auristatin-based anti-5T4 antibody-drug conjugate.

Shah DK, King LE, Han X, Wentland JA, Zhang Y, Lucas J, Haddish-Berhane N, Betts A, Leal M.

AAPS J. 2014 May;16(3):452-63. doi: 10.1208/s12248-014-9576-9. Epub 2014 Mar 1.


Transplantable malignant melanoma in LT.B6 congenic mice resembling pigmented epithelioid melanocytoma in humans.

Dadras SS, Silva KA, King LE Jr, Sundberg JP.

J Invest Dermatol. 2014 Jun;134(6):1772-1775. doi: 10.1038/jid.2014.47. Epub 2014 Jan 29. No abstract available.


Development of a calibration methodology for large-volume, solid ⁶⁸Ge phantoms for traceable measurements in positron emission tomography.

Zimmerman BE, Pibida L, King LE, Bergeron DE, Cessna JT, Mille MM.

Appl Radiat Isot. 2014 May;87:5-9. doi: 10.1016/j.apradiso.2013.11.049. Epub 2013 Nov 27.


Alopecia areata: updates from the mouse perspective.

Sundberg JP, Berndt A, Silva KA, Kennedy VE, Sundberg BA, Everts HB, Rice RH, King LE Jr.

J Investig Dermatol Symp Proc. 2013 Dec;16(1):S23-4. doi: 10.1038/jidsymp.2013.6. Review.


What causes alopecia areata?

McElwee KJ, Gilhar A, Tobin DJ, Ramot Y, Sundberg JP, Nakamura M, Bertolini M, Inui S, Tokura Y, King LE Jr, Duque-Estrada B, Tosti A, Keren A, Itami S, Shoenfeld Y, Zlotogorski A, Paus R.

Exp Dermatol. 2013 Sep;22(9):609-26. doi: 10.1111/exd.12209. Review.


Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study.

Drake WP, Oswald-Richter K, Richmond BW, Isom J, Burke VE, Algood H, Braun N, Taylor T, Pandit KV, Aboud C, Yu C, Kaminski N, Boyd AS, King LE.

JAMA Dermatol. 2013 Sep;149(9):1040-9. doi: 10.1001/jamadermatol.2013.4646.


Discovery fit-for-purpose ligand-binding PK assays: what's really important?

King LE, Leung S, Ray C.

Bioanalysis. 2013 Jun;5(12):1463-6. doi: 10.4155/bio.13.122. No abstract available.


Mouse alopecia areata and heart disease: know your mouse!

Sundberg JP, Chevallier L, Silva KA, Kennedy VE, Sundberg BA, Li Q, Uitto J, King LE Jr, Berndt A.

J Invest Dermatol. 2014 Jan;134(1):279-281. doi: 10.1038/jid.2013.273. Epub 2013 Jun 17. No abstract available.


Lack of response to laser comb in spontaneous and graft-induced alopecia areata in C3H/HeJ mice.

King LE Jr, Silva KA, Kennedy VE, Sundberg JP.

J Invest Dermatol. 2014 Jan;134(1):264-266. doi: 10.1038/jid.2013.252. Epub 2013 Jun 10. No abstract available.


Feasibility study on the spatial and temporal movement of Samburu's cattle and wildlife in Kenya using GPS radio-tracking, remote sensing and GIS.

Raizman EA, Rasmussen HB, King LE, Ihwagi FW, Douglas-Hamilton I.

Prev Vet Med. 2013 Aug 1;111(1-2):76-80. doi: 10.1016/j.prevetmed.2013.04.007. Epub 2013 May 25.


Theoretical considerations and practical approaches to address the effect of anti-drug antibody (ADA) on quantification of biotherapeutics in circulation.

Kelley M, Ahene AB, Gorovits B, Kamerud J, King LE, McIntosh T, Yang J.

AAPS J. 2013 Jul;15(3):646-58. doi: 10.1208/s12248-013-9468-4. Epub 2013 Mar 30. Review.


Poorly differentiated squamous cell carcinoma arising from an intraepidermal epithelioma.

Boyd AS, King LE Jr.

Pathol Res Pract. 2013 Apr;209(4):260-3. doi: 10.1016/j.prp.2013.01.011. Epub 2013 Mar 11.


Calibration of Traceable Solid Mock (131)I Phantoms Used in an International SPECT Image Quantification Comparison.

Zimmerman BE, Pibida L, King LE, Bergeron DE, Cessna JT, Mille MM.

J Res Natl Inst Stand Technol. 2013 Aug 15;118:359-74. doi: 10.6028/jres.118.017. eCollection 2013.


Pulmonary function abnormalities in children with active Crohn's disease.

Welsh L, Haller W, King LE, Soto-Martinez M, Oliver M, Catto-Smith A, Robinson PJ.

Am J Respir Crit Care Med. 2012 Nov 15;186(10):1060-1. No abstract available.


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