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Items: 1 to 50 of 281

1.

Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.

Gordin D, Shah H, Shinjo T, St-Louis R, Qi W, Park K, Paniagua SM, Pober DM, Wu IH, Bahnam V, Brissett MJ, Tinsley LJ, Dreyfuss JM, Pan H, Dong Y, Niewczas MA, Amenta P, Sadowski T, Kannt A, Keenan HA, King GL.

Diabetes Care. 2019 Jul;42(7):1263-1273. doi: 10.2337/dc18-2585. Epub 2019 May 10.

PMID:
31076418
2.

Characterization of periodontitis in people with type 1 diabetes of 50 years or longer duration.

Shinjo T, Ishikado A, Hasturk H, Pober DM, Paniagua SM, Shah H, Wu IH, Tinsley LJ, Matsumoto M, Keenan HA, Van Dyke TE, Genco RJ, King GL.

J Periodontol. 2019 Apr 26. doi: 10.1002/JPER.18-0735. [Epub ahead of print]

PMID:
31026349
3.

System for Scoring Severity of Acute Radiation Syndrome Response in Rhesus Macaques (Macaca mulatta).

King GL, Sandgren DJ, Mitchell JM, Bolduc DL, Blakely WF.

Comp Med. 2018 Dec 1;68(6):474-488. doi: 10.30802/AALAS-CM-17-000106. Epub 2018 Oct 10.

5.

Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications.

Musen G, Tinsley LJ, Marcinkowski KA, Pober D, Sun JK, Khatri M, Huynh R, Lu A, King GL, Keenan HA.

Diabetes Care. 2018 Aug;41(8):1749-1756. doi: 10.2337/dc17-1955. Epub 2018 Jun 5.

PMID:
29871904
6.

Obesity-associated glomerular inflammation increases albuminuria without renal histological changes.

Mima A, Yasuzawa T, King GL, Ueshima S.

FEBS Open Bio. 2018 Feb 26;8(4):664-670. doi: 10.1002/2211-5463.12400. eCollection 2018 Apr.

7.

Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism.

Qi W, Li Q, Gordin D, King GL.

J Mol Med (Berl). 2018 May;96(5):373-381. doi: 10.1007/s00109-018-1630-0. Epub 2018 Mar 24. Review.

PMID:
29574544
8.

Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.

Roshandel D, Gubitosi-Klug R, Bull SB, Canty AJ, Pezzolesi MG, King GL, Keenan HA, Snell-Bergeon JK, Maahs DM, Klein R, Klein BEK, Orchard TJ, Costacou T, Weedon MN; DCCT/EDIC Research Group, Oram RA, Paterson AD.

Diabetologia. 2018 May;61(5):1098-1111. doi: 10.1007/s00125-018-4555-9. Epub 2018 Feb 5.

9.

Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes.

Gordin D, Harjutsalo V, Tinsley L, Fickweiler W, Sun JK, Forsblom C, Amenta PS, Pober D, D'Eon S, Khatri M, Stillman IE, Groop PH, Keenan HA, King GL.

Diabetes Care. 2018 Apr;41(4):815-822. doi: 10.2337/dc17-2250. Epub 2018 Jan 31.

10.

Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function.

Park K, Li Q, Evcimen ND, Rask-Madsen C, Maeda Y, Maddaloni E, Yokomizo H, Shinjo T, St-Louis R, Fu J, Gordin D, Khamaisi M, Pober D, Keenan H, King GL.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):92-101. doi: 10.1161/ATVBAHA.117.310291. Epub 2017 Nov 21.

11.

Diabetic Microvascular Disease: An Endocrine Society Scientific Statement.

Barrett EJ, Liu Z, Khamaisi M, King GL, Klein R, Klein BEK, Hughes TM, Craft S, Freedman BI, Bowden DW, Vinik AI, Casellini CM.

J Clin Endocrinol Metab. 2017 Dec 1;102(12):4343-4410. doi: 10.1210/jc.2017-01922. Review.

12.

Association of Glycemic Control With Reduced Risk for Large-Vessel Disease After More Than 50 Years of Type 1 Diabetes.

Tinsley LJ, Kupelian V, D'Eon SA, Pober D, Sun JK, King GL, Keenan HA.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3704-3711. doi: 10.1210/jc.2017-00589.

13.

High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes.

Maddaloni E, Xia Y, Park K, D'Eon S, Tinsley LJ, St-Louis R, Khamaisi M, Li Q, King GL, Keenan HA.

Cardiovasc Diabetol. 2017 Sep 16;16(1):116. doi: 10.1186/s12933-017-0599-2.

14.

Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCδ Isoform Activation.

Li Q, Park K, Xia Y, Matsumoto M, Qi W, Fu J, Yokomizo H, Khamaisi M, Wang X, Rask-Madsen C, King GL.

Circ Res. 2017 Oct 27;121(10):1153-1167. doi: 10.1161/CIRCRESAHA.117.311606. Epub 2017 Aug 30.

15.

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.

Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL.

Nat Med. 2017 Jun;23(6):753-762. doi: 10.1038/nm.4328. Epub 2017 Apr 24.

16.

Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications.

Noh H, Yu MR, Kim HJ, Lee JH, Park BW, Wu IH, Matsumoto M, King GL.

Kidney Int. 2017 Jul;92(1):101-113. doi: 10.1016/j.kint.2017.02.013. Epub 2017 Apr 7.

17.

Letter by Rask-Madsen et al Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop".

Rask-Madsen C, Park K, Li Q, King GL.

Circ Res. 2017 Feb 17;120(4):e2-e3. doi: 10.1161/CIRCRESAHA.116.310491. No abstract available.

18.

SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes.

Qi W, Li Q, Liew CW, Rask-Madsen C, Lockhart SM, Rasmussen LM, Xia Y, Wang X, Khamaisi M, Croce K, King GL.

Diabetologia. 2017 Mar;60(3):585-596. doi: 10.1007/s00125-016-4159-1. Epub 2016 Dec 9.

19.

Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.

Alavi M, Song M, King GL, Gillis T, Propst R, Lamanuzzi M, Bousum A, Miller A, Allen R, Kidd T.

PLoS Biol. 2016 Sep 21;14(9):e1002560. doi: 10.1371/journal.pbio.1002560. eCollection 2016 Sep.

20.
21.

Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance.

Katagiri S, Park K, Maeda Y, Rao TN, Khamaisi M, Li Q, Yokomizo H, Mima A, Lancerotto L, Wagers A, Orgill DP, King GL.

Diabetes. 2016 Sep;65(9):2760-71. doi: 10.2337/db15-1721. Epub 2016 May 23.

22.

Insulin decreases atherosclerosis by inducing endothelin receptor B expression.

Park K, Mima A, Li Q, Rask-Madsen C, He P, Mizutani K, Katagiri S, Maeda Y, Wu IH, Khamaisi M, Preil SR, Maddaloni E, Sørensen D, Rasmussen LM, Huang PL, King GL.

JCI Insight. 2016 May 5;1(6). pii: e86574.

23.

PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts.

Khamaisi M, Katagiri S, Keenan H, Park K, Maeda Y, Li Q, Qi W, Thomou T, Eschuk D, Tellechea A, Veves A, Huang C, Orgill DP, Wagers A, King GL.

J Clin Invest. 2016 Mar 1;126(3):837-53. doi: 10.1172/JCI82788. Epub 2016 Jan 25.

24.

Associations between metabolic dysregulation and circulating biomarkers of fibrosis: the Cardiovascular Health Study.

Agarwal I, Glazer NL, Barasch E, Djousse L, Gottdiener JS, Ix JH, Kizer JR, Rimm EB, Siscovick DS, King GL, Mukamal KJ.

Metabolism. 2015 Oct;64(10):1316-23. doi: 10.1016/j.metabol.2015.07.013. Epub 2015 Jul 21.

25.

Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes.

Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN.

Cell Metab. 2015 Aug 4;22(2):239-52. doi: 10.1016/j.cmet.2015.07.015.

26.

Cardiovascular disease protection in long-duration type 1 diabetes and sex differences.

He ZH, D'Eon SA, Tinsley LJ, Fitzgerald S, Hastings SM, Khamaisi M, Sun JK, Turek SJ, Schaefer EJ, King GL, Keenan HA.

Diabetes Care. 2015 May;38(5):e73-4. doi: 10.2337/dc15-0017. No abstract available.

27.

PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis.

Durpès MC, Morin C, Paquin-Veillet J, Beland R, Paré M, Guimond MO, Rekhter M, King GL, Geraldes P.

Cardiovasc Res. 2015 May 1;106(2):303-13. doi: 10.1093/cvr/cvv107. Epub 2015 Mar 24.

28.

Improvement of insulin sensitivity by isoenergy high carbohydrate traditional Asian diet: a randomized controlled pilot feasibility study.

Hsu WC, Lau KH, Matsumoto M, Moghazy D, Keenan H, King GL.

PLoS One. 2014 Sep 16;9(9):e106851. doi: 10.1371/journal.pone.0106851. eCollection 2014.

29.

A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study.

Kondo K, Ishikado A, Morino K, Nishio Y, Ugi S, Kajiwara S, Kurihara M, Iwakawa H, Nakao K, Uesaki S, Shigeta Y, Imanaka H, Yoshizaki T, Sekine O, Makino T, Maegawa H, King GL, Kashiwagi A.

Nutr Res. 2014 Jun;34(6):491-8. doi: 10.1016/j.nutres.2014.06.001. Epub 2014 Jun 11.

PMID:
25026916
30.

Characterization of circulating and endothelial progenitor cells in patients with extreme-duration type 1 diabetes.

Hernandez SL, Gong JH, Chen L, Wu IH, Sun JK, Keenan HA, King GL.

Diabetes Care. 2014 Aug;37(8):2193-201. doi: 10.2337/dc13-2547. Epub 2014 Apr 29.

31.

Obesity-associated Gingival Vascular Inflammation and Insulin Resistance.

Mizutani K, Park K, Mima A, Katagiri S, King GL.

J Dent Res. 2014 Jun;93(6):596-601. doi: 10.1177/0022034514532102. Epub 2014 Apr 17.

32.

Effects of solar particle event proton radiation on parameters related to ferret emesis.

Sanzari JK, Wan XS, Krigsfeld GS, King GL, Miller A, Mick R, Gridley DS, Wroe AJ, Rightnar S, Dolney D, Kennedy AR.

Radiat Res. 2013 Aug;180(2):166-76. doi: 10.1667/RR3173.1. Epub 2013 Jul 24.

33.

Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes.

Turek SJ, Hastings SM, Sun JK, King GL, Keenan HA.

Diabetes Care. 2013 Oct;36(10):3222-6. doi: 10.2337/dc13-0294. Epub 2013 Jun 18.

34.

Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.

Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL.

Mol Cell Biol. 2013 Aug;33(16):3227-41. doi: 10.1128/MCB.00506-13. Epub 2013 Jun 17.

35.

Characterization of factors affecting attainment of glycemic control in Asian Americans with diabetes in a culturally specific program.

Le H, Wong S, Iftikar T, Keenan H, King GL, Hsu WC.

Diabetes Educ. 2013 Jul-Aug;39(4):468-77. doi: 10.1177/0145721713492217. Epub 2013 Jun 14.

36.

Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium.

Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL.

Circ Res. 2013 Aug 2;113(4):418-27. doi: 10.1161/CIRCRESAHA.113.301074. Epub 2013 Jun 11.

37.

SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.

Fukuzawa T, Fukazawa M, Ueda O, Shimada H, Kito A, Kakefuda M, Kawase Y, Wada NA, Goto C, Fukushima N, Jishage K, Honda K, King GL, Kawabe Y.

PLoS One. 2013;8(2):e56681. doi: 10.1371/journal.pone.0056681. Epub 2013 Feb 25.

38.

Vascular complications of diabetes: mechanisms of injury and protective factors.

Rask-Madsen C, King GL.

Cell Metab. 2013 Jan 8;17(1):20-33. doi: 10.1016/j.cmet.2012.11.012. Review.

39.

Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans.

Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Keith Blackwell T, Makino T.

Free Radic Biol Med. 2013 Dec;65:1506-1515. doi: 10.1016/j.freeradbiomed.2012.12.006. Epub 2012 Dec 28.

40.

Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes.

Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL.

Invest Ophthalmol Vis Sci. 2012 Dec 19;53(13):8424-32. doi: 10.1167/iovs.12-10207.

41.

Implications of treatment that target protective mechanisms against diabetic nephropathy.

Mima A, Qi W, King GL.

Semin Nephrol. 2012 Sep;32(5):471-8. doi: 10.1016/j.semnephrol.2012.07.010. Review.

42.

Transforming growth factor beta-1 and incidence of heart failure in older adults: the Cardiovascular Health Study.

Glazer NL, Macy EM, Lumley T, Smith NL, Reiner AP, Psaty BM, King GL, Tracy RP, Siscovick DS.

Cytokine. 2012 Nov;60(2):341-5. doi: 10.1016/j.cyto.2012.07.013. Epub 2012 Aug 9.

43.

Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes.

Mima A, Hiraoka-Yamomoto J, Li Q, Kitada M, Li C, Geraldes P, Matsumoto M, Mizutani K, Park K, Cahill C, Nishikawa S, Rask-Madsen C, King GL.

Diabetes. 2012 Nov;61(11):2967-79. doi: 10.2337/db11-1824. Epub 2012 Jul 23.

44.

Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications.

Hsu WC, Boyko EJ, Fujimoto WY, Kanaya A, Karmally W, Karter A, King GL, Look M, Maskarinec G, Misra R, Tavake-Pasi F, Arakaki R.

Diabetes Care. 2012 May;35(5):1189-98. doi: 10.2337/dc12-0212. Review. No abstract available.

45.

Understanding and addressing unique needs of diabetes in Asian Americans, native Hawaiians, and Pacific Islanders.

King GL, McNeely MJ, Thorpe LE, Mau ML, Ko J, Liu LL, Sun A, Hsu WC, Chow EA.

Diabetes Care. 2012 May;35(5):1181-8. doi: 10.2337/dc12-0210. Review. No abstract available.

46.

Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy.

Mima A, Kitada M, Geraldes P, Li Q, Matsumoto M, Mizutani K, Qi W, Li C, Leitges M, Rask-Madsen C, King GL.

FASEB J. 2012 Jul;26(7):2963-74. doi: 10.1096/fj.11-202994. Epub 2012 Apr 12.

47.

Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice.

Rask-Madsen C, Buonomo E, Li Q, Park K, Clermont AC, Yerokun O, Rekhter M, King GL.

Arterioscler Thromb Vasc Biol. 2012 May;32(5):1124-31. doi: 10.1161/ATVBAHA.111.239558. Epub 2012 Mar 15.

48.

A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes.

Hsu WC, Okeke E, Cheung S, Keenan H, Tsui T, Cheng K, King GL.

PLoS One. 2011;6(12):e28311. doi: 10.1371/journal.pone.0028311. Epub 2011 Dec 2.

49.

Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K).

Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL.

J Biol Chem. 2012 Feb 10;287(7):4518-30. doi: 10.1074/jbc.M111.286591. Epub 2011 Dec 12.

50.

PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.

Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR.

J Clin Invest. 2011 Jun;121(6):2504-17. doi: 10.1172/JCI46045. Epub 2011 May 16.

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