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Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial.

Mora JS, Genge A, Chio A, Estol CJ, Chaverri D, Hernández M, Marín S, Mascias J, Rodriguez GE, Povedano M, Paipa A, Dominguez R, Gamez J, Salvado M, Lunetta C, Ballario C, Riva N, Mandrioli J, Moussy A, Kinet JP, Auclair C, Dubreuil P, Arnold V, Mansfield CD, Hermine O; AB10015 STUDY GROUP.

Amyotroph Lateral Scler Frontotemporal Degener. 2019 Jul 7:1-10. doi: 10.1080/21678421.2019.1632346. [Epub ahead of print]


Calcium signalling in T cells.

Trebak M, Kinet JP.

Nat Rev Immunol. 2019 Mar;19(3):154-169. doi: 10.1038/s41577-018-0110-7. Review.


Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells.

Shi J, Miralles F, Kinet JP, Birnbaumer L, Large WA, Albert AP.

Channels (Austin). 2017 Jul 4;11(4):329-339. doi: 10.1080/19336950.2017.1303025. Epub 2017 Mar 16.


Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study.

Lortholary O, Chandesris MO, Bulai Livideanu C, Paul C, Guillet G, Jassem E, Niedoszytko M, Barete S, Verstovsek S, Grattan C, Damaj G, Canioni D, Fraitag S, Lhermitte L, Georgin Lavialle S, Frenzel L, Afrin LB, Hanssens K, Agopian J, Gaillard R, Kinet JP, Auclair C, Mansfield C, Moussy A, Dubreuil P, Hermine O.

Lancet. 2017 Feb 11;389(10069):612-620. doi: 10.1016/S0140-6736(16)31403-9. Epub 2017 Jan 7.


Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles.

Wang H, Zhang X, Xue L, Xing J, Jouvin MH, Putney JW, Anderson MP, Trebak M, Kinet JP.

Immunity. 2016 Apr 19;44(4):782-94. doi: 10.1016/j.immuni.2016.01.015. Epub 2016 Mar 29.


T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels.

Matza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, Kinet JP, Peled A, Shapira OM, Kaczmarek LK, Flavell RA.

PLoS One. 2016 Jan 27;11(1):e0147379. doi: 10.1371/journal.pone.0147379. eCollection 2016.


Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.

Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet JP, Maurer D, Baron RM, Blumberg RS, Fiebiger E.

Mucosal Immunol. 2015 May;8(3):516-32. doi: 10.1038/mi.2014.85. Epub 2014 Sep 17.


Serum IgE clearance is facilitated by human FcεRI internalization.

Greer AM, Wu N, Putnam AL, Woodruff PG, Wolters P, Kinet JP, Shin JS.

J Clin Invest. 2014 Mar;124(3):1187-98. doi: 10.1172/JCI68964. Epub 2014 Feb 24.


Pillars article: Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity. 1996. 4: 77-85.

Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet JP, Long EO.

J Immunol. 2013 Oct 1;191(7):3491-9. No abstract available.


The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.

Kraft S, Jouvin MH, Kulkarni N, Kissing S, Morgan ES, Dvorak AM, Schröder B, Saftig P, Kinet JP.

J Immunol. 2013 Sep 15;191(6):2871-8. doi: 10.4049/jimmunol.1202323. Epub 2013 Aug 14.


A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT.

Gomez-Ospina N, Panagiotakos G, Portmann T, Pasca SP, Rabah D, Budzillo A, Kinet JP, Dolmetsch RE.

PLoS One. 2013 Apr 16;8(4):e60526. doi: 10.1371/journal.pone.0060526. Print 2013.


The TRPM4 channel controls monocyte and macrophage, but not neutrophil, function for survival in sepsis.

Serafini N, Dahdah A, Barbet G, Demion M, Attout T, Gautier G, Arcos-Fajardo M, Souchet H, Jouvin MH, Vrtovsnik F, Kinet JP, Benhamou M, Monteiro RC, Launay P.

J Immunol. 2012 Oct 1;189(7):3689-99. Epub 2012 Aug 29.


Trichuris suis ova: testing a helminth-based therapy as an extension of the hygiene hypothesis.

Jouvin MH, Kinet JP.

J Allergy Clin Immunol. 2012 Jul;130(1):3-10; quiz 11-2. doi: 10.1016/j.jaci.2012.05.028. Review.


Repression of floral meristem fate is crucial in shaping tomato inflorescence.

Thouet J, Quinet M, Lutts S, Kinet JM, Périlleux C.

PLoS One. 2012;7(2):e31096. doi: 10.1371/journal.pone.0031096. Epub 2012 Feb 7.


Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria.

Porcherie A, Mathieu C, Peronet R, Schneider E, Claver J, Commere PH, Kiefer-Biasizzo H, Karasuyama H, Milon G, Dy M, Kinet JP, Louis J, Blank U, Mécheri S.

J Exp Med. 2011 Oct 24;208(11):2225-36. doi: 10.1084/jem.20110845. Epub 2011 Oct 3.


Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial.

Piette F, Belmin J, Vincent H, Schmidt N, Pariel S, Verny M, Marquis C, Mely J, Hugonot-Diener L, Kinet JP, Dubreuil P, Moussy A, Hermine O.

Alzheimers Res Ther. 2011 Apr 19;3(2):16. doi: 10.1186/alzrt75.


Flowering response of the uniflora:blind:self-pruning and jointless:uniflora:self-pruning tomato (Solanum lycopersicum) triple mutants.

Quinet M, Kinet JM, Lutts S.

Physiol Plant. 2011 Feb;141(2):166-76. doi: 10.1111/j.1399-3054.2010.01426.x. Epub 2010 Nov 26.


Evaluation of 12- and 24-month survival rates after treatment with masitinib in dogs with nonresectable mast cell tumors.

Hahn KA, Legendre AM, Shaw NG, Phillips B, Ogilvie GK, Prescott DM, Atwater SW, Carreras JK, Lana SE, Ladue T, Rusk A, Kinet JP, Dubreuil P, Moussy A, Hermine O.

Am J Vet Res. 2010 Nov;71(11):1354-61. doi: 10.2460/ajvr.71.11.1354. Erratum in: Am J Vet Res. 2011 Feb;72(2):247.


Safety and activity of masitinib in combination with gemcitabine in patients with advanced pancreatic cancer.

Mitry E, Hammel P, Deplanque G, Mornex F, Levy P, Seitz JF, Moussy A, Kinet JP, Hermine O, Rougier P, Raymond E.

Cancer Chemother Pharmacol. 2010 Jul;66(2):395-403. doi: 10.1007/s00280-010-1299-8. Epub 2010 Apr 4.


Phase II study of oral masitinib mesilate in imatinib-naïve patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST).

Le Cesne A, Blay JY, Bui BN, Bouché O, Adenis A, Domont J, Cioffi A, Ray-Coquard I, Lassau N, Bonvalot S, Moussy A, Kinet JP, Hermine O.

Eur J Cancer. 2010 May;46(8):1344-51. doi: 10.1016/j.ejca.2010.02.014. Epub 2010 Mar 6.


Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC.

Jeon D, Kim S, Chetana M, Jo D, Ruley HE, Lin SY, Rabah D, Kinet JP, Shin HS.

Nat Neurosci. 2010 Apr;13(4):482-8. doi: 10.1038/nn.2504. Epub 2010 Feb 28.


Calcium signaling in immune cells.

Vig M, Kinet JP.

Nat Immunol. 2009 Jan;10(1):21-7. doi: 10.1038/ni.f.220. Review. Erratum in: Nat Immunol. 2009 Feb;10(2):223.


Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.

Calloway N, Vig M, Kinet JP, Holowka D, Baird B.

Mol Biol Cell. 2009 Jan;20(1):389-99. doi: 10.1091/mbc.E07-11-1132. Epub 2008 Nov 5.


Masitinib is safe and effective for the treatment of canine mast cell tumors.

Hahn KA, Ogilvie G, Rusk T, Devauchelle P, Leblanc A, Legendre A, Powers B, Leventhal PS, Kinet JP, Palmerini F, Dubreuil P, Moussy A, Hermine O.

J Vet Intern Med. 2008 Nov-Dec;22(6):1301-9. doi: 10.1111/j.1939-1676.2008.0190.x. Epub 2008 Sep 24. Erratum in: J Vet Intern Med. 2009 Jan-Feb;23(1):224. Oglivie, G [corrected to Ogilvie, G].


Revisiting the involvement of SELF-PRUNING in the sympodial growth of tomato.

Thouet J, Quinet M, Ormenese S, Kinet JM, Périlleux C.

Plant Physiol. 2008 Sep;148(1):61-4. doi: 10.1104/pp.108.124164. No abstract available.


Morphology of nectaries and biology of nectar production in the distylous species Fagopyrum esculentum.

Cawoy V, Kinet JM, Jacquemart AL.

Ann Bot. 2008 Nov;102(5):675-84. doi: 10.1093/aob/mcn150. Epub 2008 Sep 2.


The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells.

Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P.

Nat Immunol. 2008 Oct;9(10):1148-56. doi: 10.1038/ni.1648. Epub 2008 Aug 31.


Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors.

Letard S, Yang Y, Hanssens K, Palmérini F, Leventhal PS, Guéry S, Moussy A, Kinet JP, Hermine O, Dubreuil P.

Mol Cancer Res. 2008 Jul;6(7):1137-45. doi: 10.1158/1541-7786.MCR-08-0067.


Case-control cohort study of patients' perceptions of disability in mastocytosis.

Hermine O, Lortholary O, Leventhal PS, Catteau A, Soppelsa F, Baude C, Cohen-Akenine A, Palmérini F, Hanssens K, Yang Y, Sobol H, Fraytag S, Ghez D, Suarez F, Barete S, Casassus P, Sans B, Arock M, Kinet JP, Dubreuil P, Moussy A.

PLoS One. 2008 May 28;3(5):e2266. doi: 10.1371/journal.pone.0002266.


Resource availability regulates reproductive meristem activity, development of reproductive structures and seed set in buckwheat (Fagopyrum esculentum).

Cawoy V, Lutts S, Ledent JF, Kinet JM.

Physiol Plant. 2007 Oct;131(2):341-53. doi: 10.1111/j.1399-3054.2007.00963.x.


Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI.

Hartman ML, Lin SY, Jouvin MH, Kinet JP.

Mol Immunol. 2008 Apr;45(8):2307-11. doi: 10.1016/j.molimm.2007.11.017. Epub 2008 Jan 7.


Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels.

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP.

Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.


The long and arduous road to CRAC.

Vig M, Kinet JP.

Cell Calcium. 2007 Aug;42(2):157-62. Epub 2007 May 22. Review.


The essential role of mast cells in orchestrating inflammation.

Kinet JP.

Immunol Rev. 2007 Jun;217:5-7. Review. No abstract available.


New developments in FcepsilonRI regulation, function and inhibition.

Kraft S, Kinet JP.

Nat Rev Immunol. 2007 May;7(5):365-78. doi: 10.1038/nri2072. Review.


CRACM1 multimers form the ion-selective pore of the CRAC channel.

Vig M, Beck A, Billingsley JM, Lis A, Parvez S, Peinelt C, Koomoa DL, Soboloff J, Gill DL, Fleig A, Kinet JP, Penner R.

Curr Biol. 2006 Oct 24;16(20):2073-9. Epub 2006 Sep 14.


TRPM4 controls insulin secretion in pancreatic beta-cells.

Cheng H, Beck A, Launay P, Gross SA, Stokes AJ, Kinet JP, Fleig A, Penner R.

Cell Calcium. 2007 Jan;41(1):51-61. Epub 2006 Jun 27.


Amplification of CRAC current by STIM1 and CRACM1 (Orai1).

Peinelt C, Vig M, Koomoa DL, Beck A, Nadler MJ, Koblan-Huberson M, Lis A, Fleig A, Penner R, Kinet JP.

Nat Cell Biol. 2006 Jul;8(7):771-3. Epub 2006 May 30.


Genetic interactions in the control of flowering time and reproductive structure development in tomato (Solanum lycopersicum).

Quinet M, Dielen V, Batoko H, Boutry M, Havelange A, Kinet JM.

New Phytol. 2006;170(4):701-10.


CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.

Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP.

Science. 2006 May 26;312(5777):1220-3. Epub 2006 Apr 27.


Characterization of tomato (Solanum lycopersicum L.) mutants affected in their flowering time and in the morphogenesis of their reproductive structure.

Quinet M, Dubois C, Goffin MC, Chao J, Dielen V, Batoko H, Boutry M, Kinet JM.

J Exp Bot. 2006;57(6):1381-90. Epub 2006 Mar 17.


A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.

Takezawa R, Cheng H, Beck A, Ishikawa J, Launay P, Kubota H, Kinet JP, Fleig A, Yamada T, Penner R.

Mol Pharmacol. 2006 Apr;69(4):1413-20. Epub 2006 Jan 11.


NaCl alleviates polyethylene glycol-induced water stress in the halophyte species Atriplex halimus L.

Martínez JP, Kinet JM, Bajji M, Lutts S.

J Exp Bot. 2005 Sep;56(419):2421-31. Epub 2005 Jul 25.


A new strategy to counter allergy.

Kinet JP.

N Engl J Med. 2005 Jul 21;353(3):310-2. No abstract available.


Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo.

Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz P, Kinet JP.

J Exp Med. 2005 Feb 7;201(3):385-96. Epub 2005 Jan 31.


Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors.

Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL.

J Exp Med. 2005 Jan 17;201(2):267-77. Epub 2005 Jan 10.


TRPM4 regulates calcium oscillations after T cell activation.

Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP.

Science. 2004 Nov 19;306(5700):1374-7.


Is osmotic adjustment required for water stress resistance in the Mediterranean shrub Atriplex halimus L?

Martìnez JP, Lutts S, Schanck A, Bajji M, Kinet JM.

J Plant Physiol. 2004 Sep;161(9):1041-51.


Molecular dissection of the FcRbeta signaling amplifier.

On M, Billingsley JM, Jouvin MH, Kinet JP.

J Biol Chem. 2004 Oct 29;279(44):45782-90. Epub 2004 Aug 30.


The role of the FcepsilonRI beta-chain in allergic diseases.

Kraft S, Rana S, Jouvin MH, Kinet JP.

Int Arch Allergy Immunol. 2004 Sep;135(1):62-72. Epub 2004 Aug 13. Review.


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