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A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.

Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB.

Elife. 2020 Jan 15;9. pii: e52656. doi: 10.7554/eLife.52656. [Epub ahead of print]


Altered dendritic spine function and integration in a mouse model of fragile X syndrome.

Booker SA, Domanski APF, Dando OR, Jackson AD, Isaac JTR, Hardingham GE, Wyllie DJA, Kind PC.

Nat Commun. 2019 Oct 23;10(1):4813. doi: 10.1038/s41467-019-11891-6.


Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.

Domanski APF, Booker SA, Wyllie DJA, Isaac JTR, Kind PC.

Nat Commun. 2019 Oct 23;10(1):4814. doi: 10.1038/s41467-019-12736-y.


Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome.

Asiminas A, Jackson AD, Louros SR, Till SM, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, Kind PC.

Sci Transl Med. 2019 May 29;11(494). pii: eaao0498. doi: 10.1126/scitranslmed.aao0498.


Decreased functional brain response to emotional arousal and increased psychiatric symptomology in FMR1 premutation carriers.

Brown SSG, Whalley HC, Kind PC, Stanfield AC.

Psychiatry Res Neuroimaging. 2019 Mar 30;285:9-17. doi: 10.1016/j.pscychresns.2019.01.011. Epub 2019 Jan 29.


GRIN2A-related disorders: genotype and functional consequence predict phenotype.

Strehlow V, Heyne HO, Vlaskamp DRM, Marwick KFM, Rudolf G, de Bellescize J, Biskup S, Brilstra EH, Brouwer OF, Callenbach PMC, Hentschel J, Hirsch E, Kind PC, Mignot C, Platzer K, Rump P, Skehel PA, Wyllie DJA, Hardingham GE, van Ravenswaaij-Arts CMA, Lesca G, Lemke JR; GRIN2A study group.

Brain. 2019 Jan 1;142(1):80-92. doi: 10.1093/brain/awy304.


The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.

McKay S, Ryan TJ, McQueen J, Indersmitten T, Marwick KFM, Hasel P, Kopanitsa MV, Baxter PS, Martel MA, Kind PC, Wyllie DJA, O'Dell TJ, Grant SGN, Hardingham GE, Komiyama NH.

Cell Rep. 2018 Oct 23;25(4):841-851.e4. doi: 10.1016/j.celrep.2018.09.089.


Age-related functional brain changes in FMR1 premutation carriers.

Brown SSG, Basu S, Whalley HC, Kind PC, Stanfield AC.

Neuroimage Clin. 2017 Dec 9;17:761-767. doi: 10.1016/j.nicl.2017.12.016. eCollection 2018.


C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D, Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S.

Nat Commun. 2018 Jan 24;9(1):347. doi: 10.1038/s41467-017-02729-0.


Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons.

Booker SA, Loreth D, Gee AL, Watanabe M, Kind PC, Wyllie DJA, Kulik Á, Vida I.

Cell Rep. 2018 Jan 2;22(1):36-43. doi: 10.1016/j.celrep.2017.12.021.


Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.

Thomson SR, Seo SS, Barnes SA, Louros SR, Muscas M, Dando O, Kirby C, Wyllie DJA, Hardingham GE, Kind PC, Osterweil EK.

Neuron. 2017 Aug 2;95(3):550-563.e5. doi: 10.1016/j.neuron.2017.07.013.


Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA γ2 R43Q mouse model of absence epilepsy.

Currie SP, Luz LL, Booker SA, Wyllie DJ, Kind PC, Daw MI.

Epilepsia. 2017 Apr;58(4):597-607. doi: 10.1111/epi.13693. Epub 2017 Feb 13.


Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses.

Booker SA, Campbell GR, Mysiak KS, Brophy PJ, Kind PC, Mahad DJ, Wyllie DJ.

J Physiol. 2017 Mar 15;595(6):2147-2160. doi: 10.1113/JP273581.


Characterisation of Cdkl5 transcript isoforms in rat.

Hector RD, Dando O, Ritakari TE, Kind PC, Bailey ME, Cobb SR.

Gene. 2017 Mar 1;603:21-26. doi: 10.1016/j.gene.2016.12.001. Epub 2016 Dec 7.


Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.

Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, Simpson TI, Tybulewicz VL, Wyllie DJ, Fisher EM, Lowell S, Chandran S, Hardingham GE.

Elife. 2016 Oct 1;5. pii: e20337. doi: 10.7554/eLife.20337.


Altered thalamocortical development in the SAP102 knockout model of intellectual disability.

Crocker-Buque A, Currie SP, Luz LL, Grant SG, Duffy KR, Kind PC, Daw MI.

Hum Mol Genet. 2016 Sep 15;25(18):4052-4061. doi: 10.1093/hmg/ddw244. Epub 2016 Jul 27.


Characterisation of CDKL5 Transcript Isoforms in Human and Mouse.

Hector RD, Dando O, Landsberger N, Kilstrup-Nielsen C, Kind PC, Bailey ME, Cobb SR.

PLoS One. 2016 Jun 17;11(6):e0157758. doi: 10.1371/journal.pone.0157758. eCollection 2016.


Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling.

Márkus NM, Hasel P, Qiu J, Bell KF, Heron S, Kind PC, Dando O, Simpson TI, Hardingham GE.

PLoS One. 2016 Feb 1;11(2):e0148164. doi: 10.1371/journal.pone.0148164. eCollection 2016.


Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes.

Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC, Hardingham GE, Wyllie DJ, Chandran S.

Stem Cells. 2016 Apr;34(4):1040-53. doi: 10.1002/stem.2273. Epub 2016 Jan 13.


Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.

Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ.

J Neurosci. 2015 Nov 11;35(45):15073-81. doi: 10.1523/JNEUROSCI.1087-15.2015.


Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS.

Till SM, Asiminas A, Jackson AD, Katsanevaki D, Barnes SA, Osterweil EK, Bear MF, Chattarji S, Wood ER, Wyllie DJ, Kind PC.

Hum Mol Genet. 2015 Nov 1;24(21):5977-84. doi: 10.1093/hmg/ddv299. Epub 2015 Aug 4.


Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.

James OT, Livesey MR, Qiu J, Dando O, Bilican B, Haghi G, Rajan R, Burr K, Hardingham GE, Chandran S, Kind PC, Wyllie DJ.

J Physiol. 2014 Oct 1;592(19):4353-63. doi: 10.1113/jphysiol.2014.278994. Epub 2014 Aug 28.


Stimulated emission depletion (STED) microscopy reveals nanoscale defects in the developmental trajectory of dendritic spine morphogenesis in a mouse model of fragile X syndrome.

Wijetunge LS, Angibaud J, Frick A, Kind PC, Nägerl UV.

J Neurosci. 2014 Apr 30;34(18):6405-12. doi: 10.1523/JNEUROSCI.5302-13.2014. Erratum in: J Neurosci. 2014 Aug 13;34(33):11173.


Experience-Dependent, Layer-Specific Development of Divergent Thalamocortical Connectivity.

Crocker-Buque A, Brown SM, Kind PC, Isaac JT, Daw MI.

Cereb Cortex. 2015 Aug;25(8):2255-66. doi: 10.1093/cercor/bhu031. Epub 2014 Mar 7.


Fragile X syndrome: from targets to treatments.

Wijetunge LS, Chattarji S, Wyllie DJ, Kind PC.

Neuropharmacology. 2013 May;68:83-96. doi: 10.1016/j.neuropharm.2012.11.028. Epub 2012 Dec 17. Review.


Lifting the mood on treating fragile X.

Osterweil EK, Kind PC, Bear MF.

Biol Psychiatry. 2012 Dec 1;72(11):895-7. doi: 10.1016/j.biopsych.2012.09.017. No abstract available.


Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

Henderson C, Wijetunge L, Kinoshita MN, Shumway M, Hammond RS, Postma FR, Brynczka C, Rush R, Thomas A, Paylor R, Warren ST, Vanderklish PW, Kind PC, Carpenter RL, Bear MF, Healy AM.

Sci Transl Med. 2012 Sep 19;4(152):152ra128.


SynGAP isoforms exert opposing effects on synaptic strength.

McMahon AC, Barnett MW, O'Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC.

Nat Commun. 2012 Jun 12;3:900. doi: 10.1038/ncomms1900.


The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.

Martel MA, Ryan TJ, Bell KF, Fowler JH, McMahon A, Al-Mubarak B, Komiyama NH, Horsburgh K, Kind PC, Grant SG, Wyllie DJ, Hardingham GE.

Neuron. 2012 May 10;74(3):543-56. doi: 10.1016/j.neuron.2012.03.021.


Experience-dependent regulation of functional maps and synaptic protein expression in the cat visual cortex.

Jaffer S, Vorobyov V, Kind PC, Sengpiel F.

Eur J Neurosci. 2012 Apr;35(8):1281-94. doi: 10.1111/j.1460-9568.2012.08044.x.


The development and activity-dependent expression of aggrecan in the cat visual cortex.

Kind PC, Sengpiel F, Beaver CJ, Crocker-Buque A, Kelly GM, Matthews RT, Mitchell DE.

Cereb Cortex. 2013 Feb;23(2):349-60. doi: 10.1093/cercor/bhs015. Epub 2012 Feb 23.


Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome.

Till SM, Wijetunge LS, Seidel VG, Harlow E, Wright AK, Bagni C, Contractor A, Gillingwater TH, Kind PC.

Hum Mol Genet. 2012 May 15;21(10):2143-56. doi: 10.1093/hmg/dds030. Epub 2012 Feb 9.


Phospholipase C-beta1 signaling affects reproductive behavior, ovulation, and implantation.

Filis P, Lannagan T, Thomson A, Murray AA, Kind PC, Spears N.

Endocrinology. 2009 Jul;150(7):3259-66. doi: 10.1210/en.2009-0214. Epub 2009 Apr 2.


Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex.

Thomson RE, Kind PC, Graham NA, Etherson ML, Kennedy J, Fernandes AC, Marques CS, Hevner RF, Iwata T.

Neural Dev. 2009 Feb 3;4:4. doi: 10.1186/1749-8104-4-4.


mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex.

Wijetunge LS, Till SM, Gillingwater TH, Ingham CA, Kind PC.

J Neurosci. 2008 Dec 3;28(49):13028-37. doi: 10.1523/JNEUROSCI.2600-08.2008.


Involvement of protein kinase A in patterning of the mouse somatosensory cortex.

Watson RF, Abdel-Majid RM, Barnett MW, Willis BS, Katsnelson A, Gillingwater TH, McKnight GS, Kind PC, Neumann PE.

J Neurosci. 2006 May 17;26(20):5393-401.


Short periods of concordant binocular vision prevent the development of deprivation amblyopia.

Mitchell DE, Kind PC, Sengpiel F, Murphy K.

Eur J Neurosci. 2006 May;23(9):2458-66.


Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice.

Barnett MW, Watson RF, Vitalis T, Porter K, Komiyama NH, Stoney PN, Gillingwater TH, Grant SG, Kind PC.

J Neurosci. 2006 Feb 1;26(5):1355-65.


Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling.

Spires TL, Molnár Z, Kind PC, Cordery PM, Upton AL, Blakemore C, Hannan AJ.

Cereb Cortex. 2005 Apr;15(4):385-93.


Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development.

Porter K, Komiyama NH, Vitalis T, Kind PC, Grant SG.

Eur J Neurosci. 2005 Jan;21(2):351-62.


NMDA receptors: neural map designers and refiners?

Dickson KS, Kind PC.

Curr Biol. 2003 Dec 2;13(23):R920-2. Review. No abstract available.


Brief daily periods of binocular vision prevent deprivation-induced acuity loss.

Mitchell DE, Kind PC, Sengpiel F, Murphy K.

Curr Biol. 2003 Sep 30;13(19):1704-8.


The role of activity in development of the visual system.

Sengpiel F, Kind PC.

Curr Biol. 2002 Dec 10;12(23):R818-26. Review.


Correlated binocular activity guides recovery from monocular deprivation.

Kind PC, Mitchell DE, Ahmed B, Blakemore C, Bonhoeffer T, Sengpiel F.

Nature. 2002 Mar 28;416(6879):430-3.


Neural activity: sculptor of 'barrels' in the neocortex.

Erzurumlu RS, Kind PC.

Trends Neurosci. 2001 Oct;24(10):589-95. Review.


Plasticity: downstream of glutamate.

Kind PC, Neumann PE.

Trends Neurosci. 2001 Oct;24(10):553-5. Review.


Initial recovery of vision after early monocular deprivation in kittens is faster when both eyes are open.

Mitchell DE, Gingras G, Kind PC.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11662-7.


PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex.

Hannan AJ, Blakemore C, Katsnelson A, Vitalis T, Huber KM, Bear M, Roder J, Kim D, Shin HS, Kind PC.

Nat Neurosci. 2001 Mar;4(3):282-8.


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