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Items: 1 to 50 of 106

1.

Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells.

D'Aiuto L, Bloom DC, Naciri JN, Smith A, Edwards TG, McClain L, Callio JA, Jessup M, Wood J, Chowdari K, Demers M, Abrahamson EE, Ikonomovic MD, Viggiano L, De Zio R, Watkins S, Kinchington PR, Nimgaonkar VL.

J Virol. 2019 Apr 17;93(9). pii: e00111-19. doi: 10.1128/JVI.00111-19. Print 2019 May 1.

2.

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27.

Tiwari A, Swamynathan S, Alexander N, Gnalian J, Tian S, Kinchington PR, Swamynathan SK.

Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):731-740. doi: 10.1167/iovs.18-26423.

3.

Corrigendum: Aromatase Derived Estradiol Within the Thalamus Modulates Pain Induced by Varicella Zoster Virus.

Kramer PR, Rao M, Stinson C, Bellinger LL, Kinchington PR, Yee MB.

Front Integr Neurosci. 2019 Jan 31;12:66. doi: 10.3389/fnint.2018.00066. eCollection 2018.

4.

Aromatase Derived Estradiol Within the Thalamus Modulates Pain Induced by Varicella Zoster Virus.

Kramer P, Rao M, Stinson C, Bellinger LL, Kinchington PR, Yee MB.

Front Integr Neurosci. 2018 Oct 12;12:46. doi: 10.3389/fnint.2018.00046. eCollection 2018. Erratum in: Front Integr Neurosci. 2019 Jan 31;12:66.

5.

Bacteria induce autophagy in a human ocular surface cell line.

Brothers KM, Kowalski RP, Tian S, Kinchington PR, Shanks RMQ.

Exp Eye Res. 2018 Mar;168:12-18. doi: 10.1016/j.exer.2017.12.010. Epub 2017 Dec 27.

6.

Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells.

Treat BR, Bidula SM, Ramachandran S, St Leger AJ, Hendricks RL, Kinchington PR.

PLoS Pathog. 2017 Dec 4;13(12):e1006732. doi: 10.1371/journal.ppat.1006732. eCollection 2017 Dec.

7.

Role for the Ventral Posterior Medial/Posterior Lateral Thalamus and Anterior Cingulate Cortex in Affective/Motivation Pain Induced by Varicella Zoster Virus.

Kramer PR, Strand J, Stinson C, Bellinger LL, Kinchington PR, Yee MB, Umorin M, Peng YB.

Front Integr Neurosci. 2017 Oct 16;11:27. doi: 10.3389/fnint.2017.00027. eCollection 2017.

8.

Varicella-Zoster Virus Expresses Multiple Small Noncoding RNAs.

Markus A, Golani L, Ojha NK, Borodiansky-Shteinberg T, Kinchington PR, Goldstein RS.

J Virol. 2017 Nov 30;91(24). pii: e01710-17. doi: 10.1128/JVI.01710-17. Print 2017 Dec 15.

9.

Lateral thalamic control of nociceptive response after whisker pad injection of varicella zoster virus.

Kramer PR, Stinson C, Umorin M, Deng M, Rao M, Bellinger LL, Yee MB, Kinchington PR.

Neuroscience. 2017 Jul 25;356:207-216. doi: 10.1016/j.neuroscience.2017.05.030. Epub 2017 May 24.

10.

Sex differences underlying orofacial varicella zoster associated pain in rats.

Stinson C, Deng M, Yee MB, Bellinger LL, Kinchington PR, Kramer PR.

BMC Neurol. 2017 May 17;17(1):95. doi: 10.1186/s12883-017-0882-6.

11.

Comparison of three cell-based drug screening platforms for HSV-1 infection.

D'Aiuto L, Williamson K, Dimitrion P, McNulty J, Brown CE, Dokuburra CB, Nielsen AJ, Lin WJ, Piazza P, Schurdak ME, Wood J, Yolken RH, Kinchington PR, Bloom DC, Nimgaonkar VL.

Antiviral Res. 2017 Jun;142:136-140. doi: 10.1016/j.antiviral.2017.03.016. Epub 2017 Mar 23.

12.

Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells.

Tanaka M, Tashiro H, Omer B, Lapteva N, Ando J, Ngo M, Mehta B, Dotti G, Kinchington PR, Leen AM, Rossig C, Rooney CM.

Clin Cancer Res. 2017 Jul 15;23(14):3499-3509. doi: 10.1158/1078-0432.CCR-16-2138. Epub 2017 Feb 9.

13.

Subclinical Herpes Simplex Virus Type 1 Infections Provide Site-Specific Resistance to an Unrelated Pathogen.

Rowe AM, Yun H, Treat BR, Kinchington PR, Hendricks RL.

J Immunol. 2017 Feb 15;198(4):1706-1717. doi: 10.4049/jimmunol.1601310. Epub 2017 Jan 6.

14.

Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79.

Bowen CD, Renner DW, Shreve JT, Tafuri Y, Payne KM, Dix RD, Kinchington PR, Gatherer D, Szpara ML.

Virology. 2016 May;492:179-86. doi: 10.1016/j.virol.2016.02.013. Epub 2016 Mar 21.

15.

iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.

McNulty J, D'Aiuto L, Zhi Y, McClain L, Zepeda-Velázquez C, Ler S, Jenkins HA, Yee MB, Piazza P, Yolken RH, Kinchington PR, Nimgaonkar VL.

ACS Med Chem Lett. 2015 Nov 19;7(1):46-50. doi: 10.1021/acsmedchemlett.5b00318. eCollection 2016 Jan 14.

16.

Broad-spectrum non-nucleoside inhibitors of human herpesviruses.

McClain L, Zhi Y, Cheng H, Ghosh A, Piazza P, Yee MB, Kumar S, Milosevic J, Bloom DC, Arav-Boger R, Kinchington PR, Yolken R, Nimgaonkar V, D'Aiuto L.

Antiviral Res. 2015 Sep;121:16-23. doi: 10.1016/j.antiviral.2015.06.005. Epub 2015 Jun 12.

17.

An in vitro model of latency and reactivation of varicella zoster virus in human stem cell-derived neurons.

Markus A, Lebenthal-Loinger I, Yang IH, Kinchington PR, Goldstein RS.

PLoS Pathog. 2015 Jun 4;11(6):e1004885. doi: 10.1371/journal.ppat.1004885. eCollection 2015 Jun.

18.

Direct transfer of viral and cellular proteins from varicella-zoster virus-infected non-neuronal cells to human axons.

Grigoryan S, Yee MB, Glick Y, Gerber D, Kepten E, Garini Y, Yang IH, Kinchington PR, Goldstein RS.

PLoS One. 2015 May 14;10(5):e0126081. doi: 10.1371/journal.pone.0126081. eCollection 2015.

19.

Current gene therapy using viral vectors for chronic pain.

Guedon JM, Wu S, Zheng X, Churchill CC, Glorioso JC, Liu CH, Liu S, Vulchanova L, Bekker A, Tao YX, Kinchington PR, Goins WF, Fairbanks CA, Hao S.

Mol Pain. 2015 May 13;11:27. doi: 10.1186/s12990-015-0018-1. Review.

20.

Neuronal changes induced by Varicella Zoster Virus in a rat model of postherpetic neuralgia.

Guedon JM, Yee MB, Zhang M, Harvey SA, Goins WF, Kinchington PR.

Virology. 2015 Aug;482:167-80. doi: 10.1016/j.virol.2015.03.046. Epub 2015 Apr 11.

21.

Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation.

D'Aiuto L, Zhi Y, Kumar Das D, Wilcox MR, Johnson JW, McClain L, MacDonald ML, Di Maio R, Schurdak ME, Piazza P, Viggiano L, Sweet R, Kinchington PR, Bhattacharjee AG, Yolken R, Nimgaonkar VL.

Organogenesis. 2014;10(4):365-77. doi: 10.1080/15476278.2015.1011921. Erratum in: Organogenesis. 2015;11(2):93. Nimgaonka, Vishwajit L [Corrected to Nimgaonkar, Vishwajit L].

22.

Human trophoblasts confer resistance to viruses implicated in perinatal infection.

Bayer A, Delorme-Axford E, Sleigher C, Frey TK, Trobaugh DW, Klimstra WB, Emert-Sedlak LA, Smithgall TE, Kinchington PR, Vadia S, Seveau S, Boyle JP, Coyne CB, Sadovsky Y.

Am J Obstet Gynecol. 2015 Jan;212(1):71.e1-71.e8. doi: 10.1016/j.ajog.2014.07.060. Epub 2014 Aug 6.

23.

Relief of pain induced by varicella-zoster virus in a rat model of post-herpetic neuralgia using a herpes simplex virus vector expressing enkephalin.

Guedon JM, Zhang M, Glorioso JC, Goins WF, Kinchington PR.

Gene Ther. 2014 Jul;21(7):694-702. doi: 10.1038/gt.2014.43. Epub 2014 May 15.

24.

Cellular transcriptome analysis reveals differential expression of pro- and antiapoptosis genes by varicella-zoster virus-infected neurons and fibroblasts.

Markus A, Waldman Ben-Asher H, Kinchington PR, Goldstein RS.

J Virol. 2014 Jul;88(13):7674-7. doi: 10.1128/JVI.00500-14. Epub 2014 Apr 16.

25.

Persistent infection by HSV-1 is associated with changes in functional architecture of iPSC-derived neurons and brain activation patterns underlying working memory performance.

D'Aiuto L, Prasad KM, Upton CH, Viggiano L, Milosevic J, Raimondi G, McClain L, Chowdari K, Tischfield J, Sheldon M, Moore JC, Yolken RH, Kinchington PR, Nimgaonkar VL.

Schizophr Bull. 2015 Jan;41(1):123-32. doi: 10.1093/schbul/sbu032. Epub 2014 Mar 12.

26.

Varicella-zoster virus and herpes simplex virus 1 can infect and replicate in the same neurons whether co- or superinfected.

Sloutskin A, Yee MB, Kinchington PR, Goldstein RS.

J Virol. 2014 May;88(9):5079-86. doi: 10.1128/JVI.00252-14. Epub 2014 Feb 26.

27.

RNA-seq analysis of host and viral gene expression highlights interaction between varicella zoster virus and keratinocyte differentiation.

Jones M, Dry IR, Frampton D, Singh M, Kanda RK, Yee MB, Kellam P, Hollinshead M, Kinchington PR, O'Toole EA, Breuer J.

PLoS Pathog. 2014 Jan 30;10(1):e1003896. doi: 10.1371/journal.ppat.1003896. eCollection 2014 Jan. Erratum in: PLoS Pathog. 2014 Jul;10(7):e1004313.

28.

Targeting host pathways to block HSV-1 at the cornea.

Kinchington PR.

Invest Ophthalmol Vis Sci. 2014 Feb 3;55(2):716. doi: 10.1167/iovs.14-13879. No abstract available.

PMID:
24492207
29.

Deep sequencing of viral genomes provides insight into the evolution and pathogenesis of varicella zoster virus and its vaccine in humans.

Depledge DP, Kundu S, Jensen NJ, Gray ER, Jones M, Steinberg S, Gershon A, Kinchington PR, Schmid DS, Balloux F, Nichols RA, Breuer J.

Mol Biol Evol. 2014 Feb;31(2):397-409. doi: 10.1093/molbev/mst210. Epub 2013 Oct 25.

30.

Productive vs non-productive infection by cell-free varicella zoster virus of human neurons derived from embryonic stem cells is dependent upon infectious viral dose.

Sloutskin A, Kinchington PR, Goldstein RS.

Virology. 2013 Sep 1;443(2):285-93. doi: 10.1016/j.virol.2013.05.021. Epub 2013 Jun 12.

31.

Retrograde axonal transport of VZV: kinetic studies in hESC-derived neurons.

Grigoryan S, Kinchington PR, Yang IH, Selariu A, Zhu H, Yee M, Goldstein RS.

J Neurovirol. 2012 Dec;18(6):462-70. doi: 10.1007/s13365-012-0124-z. Epub 2012 Aug 24.

32.

Herpes simplex virus and varicella zoster virus, the house guests who never leave.

Kinchington PR, Leger AJ, Guedon JM, Hendricks RL.

Herpesviridae. 2012 Jun 12;3(1):5. doi: 10.1186/2042-4280-3-5.

33.

Varicella-zoster virus infects human embryonic stem cell-derived neurons and neurospheres but not pluripotent embryonic stem cells or early progenitors.

Dukhovny A, Sloutskin A, Markus A, Yee MB, Kinchington PR, Goldstein RS.

J Virol. 2012 Mar;86(6):3211-8. doi: 10.1128/JVI.06810-11. Epub 2012 Jan 11.

34.

Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models.

Kinchington PR, Goins WF.

J Neurovirol. 2011 Dec;17(6):590-9. doi: 10.1007/s13365-011-0069-7. Epub 2011 Dec 28.

35.

Varicella-zoster virus inhibition of the NF-κB pathway during infection of human dendritic cells: role for open reading frame 61 as a modulator of NF-κB activity.

Sloan E, Henriquez R, Kinchington PR, Slobedman B, Abendroth A.

J Virol. 2012 Jan;86(2):1193-202. doi: 10.1128/JVI.06400-11. Epub 2011 Nov 16.

36.

Varicella-zoster virus (VZV) infection of neurons derived from human embryonic stem cells: direct demonstration of axonal infection, transport of VZV, and productive neuronal infection.

Markus A, Grigoryan S, Sloutskin A, Yee MB, Zhu H, Yang IH, Thakor NV, Sarid R, Kinchington PR, Goldstein RS.

J Virol. 2011 Jul;85(13):6220-33. doi: 10.1128/JVI.02396-10. Epub 2011 Apr 27.

37.

A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitro.

Bertke AS, Swanson SM, Chen J, Imai Y, Kinchington PR, Margolis TP.

J Virol. 2011 Jul;85(13):6669-77. doi: 10.1128/JVI.00204-11. Epub 2011 Apr 20.

38.

The capacity of UL49.5 proteins to inhibit TAP is widely distributed among members of the genus Varicellovirus.

Verweij MC, Lipinska AD, Koppers-Lalic D, van Leeuwen WF, Cohen JI, Kinchington PR, Messaoudi I, Bienkowska-Szewczyk K, Ressing ME, Rijsewijk FA, Wiertz EJ.

J Virol. 2011 Mar;85(5):2351-63. doi: 10.1128/JVI.01621-10. Epub 2010 Dec 15.

39.

The alphaherpesvirus US3/ORF66 protein kinases direct phosphorylation of the nuclear matrix protein matrin 3.

Erazo A, Yee MB, Banfield BW, Kinchington PR.

J Virol. 2011 Jan;85(1):568-81. doi: 10.1128/JVI.01611-10. Epub 2010 Oct 20.

40.

Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases.

Walters MS, Kinchington PR, Banfield BW, Silverstein S.

J Virol. 2010 Oct;84(19):9666-76. doi: 10.1128/JVI.00981-10. Epub 2010 Jul 21.

41.

Delaying the expression of herpes simplex virus type 1 glycoprotein B (gB) to a true late gene alters neurovirulence and inhibits the gB-CD8+ T-cell response in the trigeminal ganglion.

Ramachandran S, Davoli KA, Yee MB, Hendricks RL, Kinchington PR.

J Virol. 2010 Sep;84(17):8811-20. doi: 10.1128/JVI.00496-10. Epub 2010 Jun 23.

42.

Varicella zoster virus immune evasion strategies.

Abendroth A, Kinchington PR, Slobedman B.

Curr Top Microbiol Immunol. 2010;342:155-71. doi: 10.1007/82_2010_41. Review.

43.

Varicella-zoster virus open reading frame 66 protein kinase and its relationship to alphaherpesvirus US3 kinases.

Erazo A, Kinchington PR.

Curr Top Microbiol Immunol. 2010;342:79-98. doi: 10.1007/82_2009_7. Review.

44.

Histone deacetylases 1 and 2 are phosphorylated at novel sites during varicella-zoster virus infection.

Walters MS, Erazo A, Kinchington PR, Silverstein S.

J Virol. 2009 Nov;83(22):11502-13. doi: 10.1128/JVI.01318-09. Epub 2009 Sep 9.

45.

Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency.

Knickelbein JE, Khanna KM, Yee MB, Baty CJ, Kinchington PR, Hendricks RL.

Science. 2008 Oct 10;322(5899):268-71. doi: 10.1126/science.1164164.

46.

Cyclin-dependent kinase 1/cyclin B1 phosphorylates varicella-zoster virus IE62 and is incorporated into virions.

Leisenfelder SA, Kinchington PR, Moffat JF.

J Virol. 2008 Dec;82(24):12116-25. doi: 10.1128/JVI.00153-08. Epub 2008 Sep 17.

47.

Development and pathogenic evaluation of recombinant herpes simplex virus type 1 expressing two fluorescent reporter genes from different lytic promoters.

Ramachandran S, Knickelbein JE, Ferko C, Hendricks RL, Kinchington PR.

Virology. 2008 Sep 1;378(2):254-64. doi: 10.1016/j.virol.2008.05.034. Epub 2008 Jul 11. Erratum in: Virology. 2013 Jan 20;435(2):504.

48.

Varicella-zoster virus open reading frame 66 protein kinase is required for efficient viral growth in primary human corneal stromal fibroblast cells.

Erazo A, Yee MB, Osterrieder N, Kinchington PR.

J Virol. 2008 Aug;82(15):7653-65. doi: 10.1128/JVI.00311-08. Epub 2008 May 21.

49.

Identification of viral antigens recognized by ocular infiltrating T cells from patients with varicella zoster virus-induced uveitis.

Milikan JC, Kinchington PR, Baarsma GS, Kuijpers RW, Osterhaus AD, Verjans GM.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3689-97.

PMID:
17652740
50.

Potential prophylactic and therapeutic vaccines for HSV infections.

Ramachandran S, Kinchington PR.

Curr Pharm Des. 2007;13(19):1965-73. Review.

PMID:
17627530

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