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Items: 27


Thy1-Targeted Microbubbles for Ultrasound Molecular Imaging of Pancreatic Ductal Adenocarcinoma.

Abou-Elkacem L, Wang H, Chowdhury SM, Kimura RH, Bachawal SV, Gambhir SS, Tian L, Willmann JK.

Clin Cancer Res. 2018 Apr 1;24(7):1574-1585. doi: 10.1158/1078-0432.CCR-17-2057. Epub 2018 Jan 4.


Development and Preclinical Validation of a Cysteine Knottin Peptide Targeting Integrin αvβ6 for Near-infrared Fluorescent-guided Surgery in Pancreatic Cancer.

Tummers WS, Kimura RH, Abou-Elkacem L, Beinat C, Vahrmeijer AL, Swijnenburg RJ, Willmann JK, Gambhir SS.

Clin Cancer Res. 2018 Apr 1;24(7):1667-1676. doi: 10.1158/1078-0432.CCR-17-2491. Epub 2018 Jan 3.


Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2.

Park SH, Park S, Kim DY, Pyo A, Kimura RH, Sathirachinda A, Choy HE, Min JJ, Gambhir SS, Hong Y.

PLoS One. 2015 Jul 15;10(7):e0132976. doi: 10.1371/journal.pone.0132976. eCollection 2015.


64Cu-Labeled Divalent Cystine Knot Peptide for Imaging Carotid Atherosclerotic Plaques.

Jiang L, Tu Y, Kimura RH, Habte F, Chen H, Cheng K, Shi H, Gambhir SS, Cheng Z.

J Nucl Med. 2015 Jun;56(6):939-44. doi: 10.2967/jnumed.115.155176. Epub 2015 Apr 23.


A radiofluorinated divalent cystine knot peptide for tumor PET imaging.

Jiang L, Kimura RH, Ma X, Tu Y, Miao Z, Shen B, Chin FT, Shi H, Gambhir SS, Cheng Z.

Mol Pharm. 2014 Nov 3;11(11):3885-92. doi: 10.1021/mp500018s. Epub 2014 Apr 28.


99mTc-labeled cystine knot peptide targeting integrin αvβ6 for tumor SPECT imaging.

Zhu X, Li J, Hong Y, Kimura RH, Ma X, Liu H, Qin C, Hu X, Hayes TR, Benny P, Gambhir SS, Cheng Z.

Mol Pharm. 2014 Apr 7;11(4):1208-17. doi: 10.1021/mp400683q. Epub 2014 Feb 24.


18F-fluorobenzoate-labeled cystine knot peptides for PET imaging of integrin αvβ6.

Hackel BJ, Kimura RH, Miao Z, Liu H, Sathirachinda A, Cheng Z, Chin FT, Gambhir SS.

J Nucl Med. 2013 Jul;54(7):1101-5. doi: 10.2967/jnumed.112.110759. Epub 2013 May 13.


111In-labeled cystine-knot peptides based on the Agouti-related protein for targeting tumor angiogenesis.

Jiang L, Miao Z, Kimura RH, Silverman AP, Ren G, Liu H, Lu H, Cochran JR, Cheng Z.

J Biomed Biotechnol. 2012;2012:368075. doi: 10.1155/2012/368075. Epub 2012 Apr 11.


Use of (64)Cu-labeled fibronectin domain with EGFR-overexpressing tumor xenograft: molecular imaging.

Hackel BJ, Kimura RH, Gambhir SS.

Radiology. 2012 Apr;263(1):179-88. doi: 10.1148/radiol.12111504. Epub 2012 Feb 17.


PET Imaging of Integrin Positive Tumors Using F Labeled Knottin Peptides.

Liu S, Liu H, Ren G, Kimura RH, Cochran JR, Cheng Z.

Theranostics. 2011;1:403-12. Epub 2011 Dec 21.


Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer.

Kimura RH, Teed R, Hackel BJ, Pysz MA, Chuang CZ, Sathirachinda A, Willmann JK, Gambhir SS.

Clin Cancer Res. 2012 Feb 1;18(3):839-49. doi: 10.1158/1078-0432.CCR-11-1116. Epub 2011 Dec 15.


Functional mutation of multiple solvent-exposed loops in the Ecballium elaterium trypsin inhibitor-II cystine knot miniprotein.

Kimura RH, Jones DS, Jiang L, Miao Z, Cheng Z, Cochran JR.

PLoS One. 2011 Feb 18;6(2):e16112. doi: 10.1371/journal.pone.0016112.


Preliminary evaluation of (177)Lu-labeled knottin peptides for integrin receptor-targeted radionuclide therapy.

Jiang L, Miao Z, Kimura RH, Liu H, Cochran JR, Culter CS, Bao A, Li P, Cheng Z.

Eur J Nucl Med Mol Imaging. 2011 Apr;38(4):613-22. doi: 10.1007/s00259-010-1684-x. Epub 2010 Dec 10.


PET imaging of tumor neovascularization in a transgenic mouse model with a novel 64Cu-DOTA-knottin peptide.

Nielsen CH, Kimura RH, Withofs N, Tran PT, Miao Z, Cochran JR, Cheng Z, Felsher D, Kjær A, Willmann JK, Gambhir SS.

Cancer Res. 2010 Nov 15;70(22):9022-30. doi: 10.1158/0008-5472.CAN-10-1338. Epub 2010 Nov 9.


Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides.

Willmann JK, Kimura RH, Deshpande N, Lutz AM, Cochran JR, Gambhir SS.

J Nucl Med. 2010 Mar;51(3):433-40. doi: 10.2967/jnumed.109.068007. Epub 2010 Feb 11.


A dual-labeled knottin peptide for PET and near-infrared fluorescence imaging of integrin expression in living subjects.

Kimura RH, Miao Z, Cheng Z, Gambhir SS, Cochran JR.

Bioconjug Chem. 2010 Mar 17;21(3):436-44. doi: 10.1021/bc9003102. Epub 2010 Feb 4.


Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.

Jiang L, Kimura RH, Miao Z, Silverman AP, Ren G, Liu H, Li P, Gambhir SS, Cochran JR, Cheng Z.

J Nucl Med. 2010 Feb;51(2):251-258. doi: 10.2967/jnumed.109.069831.


An engineered knottin peptide labeled with 18F for PET imaging of integrin expression.

Miao Z, Ren G, Liu H, Kimura RH, Jiang L, Cochran JR, Gambhir SS, Cheng Z.

Bioconjug Chem. 2009 Dec;20(12):2342-7. doi: 10.1021/bc900361g.


In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1.

Austin J, Kimura RH, Woo YH, Camarero JA.

Amino Acids. 2010 May;38(5):1313-22. doi: 10.1007/s00726-009-0338-4. Epub 2009 Aug 14.


Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.

Kimura RH, Levin AM, Cochran FV, Cochran JR.

Proteins. 2009 Nov 1;77(2):359-69. doi: 10.1002/prot.22441.


Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects.

Kimura RH, Cheng Z, Gambhir SS, Cochran JR.

Cancer Res. 2009 Mar 15;69(6):2435-42. doi: 10.1158/0008-5472.CAN-08-2495. Epub 2009 Mar 10.


Biosynthesis of a fully functional cyclotide inside living bacterial cells.

Camarero JA, Kimura RH, Woo YH, Shekhtman A, Cantor J.

Chembiochem. 2007 Aug 13;8(12):1363-6. No abstract available.


Development of a cell-based fluorescence resonance energy transfer reporter for Bacillus anthracis lethal factor protease.

Kimura RH, Steenblock ER, Camarero JA.

Anal Biochem. 2007 Oct 1;369(1):60-70. Epub 2007 May 18.


Biosynthesis of the cyclotide Kalata B1 by using protein splicing.

Kimura RH, Tran AT, Camarero JA.

Angew Chem Int Ed Engl. 2006 Jan 30;45(6):973-6. No abstract available.


Selective stimulation of translational expression by Alu RNA.

Rubin CM, Kimura RH, Schmid CW.

Nucleic Acids Res. 2002 Jul 15;30(14):3253-61.


Stress induction of Bm1 RNA in silkworm larvae: SINEs, an unusual class of stress genes.

Kimura RH, Choudary PV, Stone KK, Schmid CW.

Cell Stress Chaperones. 2001 Jul;6(3):263-72.


Silk worm Bm1 SINE RNA increases following cellular insults.

Kimura RH, Choudary PV, Schmid CW.

Nucleic Acids Res. 1999 Aug 15;27(16):3380-7.

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