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Items: 23


CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation.

Kimura MY, Igi A, Hayashizaki K, Mita Y, Shinzawa M, Kadakia T, Endo Y, Ogawa S, Yagi R, Motohashi S, Singer A, Nakayama T.

Nat Commun. 2018 Sep 14;9(1):3749. doi: 10.1038/s41467-018-06283-1.


Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells.

Mita Y, Kimura MY, Hayashizaki K, Koyama-Nasu R, Ito T, Motohashi S, Okamoto Y, Nakayama T.

Int Immunol. 2018 Nov 14;30(12):559-567. doi: 10.1093/intimm/dxy050.


Use of remote control in the intraoperative telemetry of cochlear implant: multicentric study.

Tanamati LF, Muniz LF, Samuel PA, Goffi-Gomez MVS, Wiemes GRM, Lima DP, Curi SB, Onuki LC, Queiroz CF, Capistrano AKB, Moret ALM, Kimura MYT, Oyanguren V, Mauch H.

Braz J Otorhinolaryngol. 2018 May 18. pii: S1808-8694(18)30227-1. doi: 10.1016/j.bjorl.2018.04.003. [Epub ahead of print]


Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation.

Hayashizaki K, Kimura MY, Tokoyoda K, Hosokawa H, Shinoda K, Hirahara K, Ichikawa T, Onodera A, Hanazawa A, Iwamura C, Kakuta J, Muramoto K, Motohashi S, Tumes DJ, Iinuma T, Yamamoto H, Ikehara Y, Okamoto Y, Nakayama T.

Sci Immunol. 2016 Sep 16;1(3):eaaf9154. doi: 10.1126/sciimmunol.aaf9154. Epub 2016 Sep 16.


Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation.

Kimura MY, Hayashizaki K, Tokoyoda K, Takamura S, Motohashi S, Nakayama T.

Immunol Rev. 2017 Jul;278(1):87-100. doi: 10.1111/imr.12559. Review.


Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.

Kimura MY, Thomas J, Tai X, Guinter TI, Shinzawa M, Etzensperger R, Li Z, Love P, Nakayama T, Singer A.

Nat Immunol. 2016 Dec;17(12):1415-1423. doi: 10.1038/ni.3560. Epub 2016 Sep 26.


Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells.

Hosokawa H, Kato M, Tohyama H, Tamaki Y, Endo Y, Kimura MY, Tumes DJ, Motohashi S, Matsumoto M, Nakayama KI, Tanaka T, Nakayama T.

J Biol Chem. 2015 May 22;290(21):13095-103. doi: 10.1074/jbc.M114.621524. Epub 2015 Apr 10.


Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.

Pobezinsky LA, Etzensperger R, Jeurling S, Alag A, Kadakia T, McCaughtry TM, Kimura MY, Sharrow SO, Guinter TI, Feigenbaum L, Singer A.

Nat Immunol. 2015 May;16(5):517-24. doi: 10.1038/ni.3146. Epub 2015 Apr 6.


The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.

Luckey MA, Kimura MY, Waickman AT, Feigenbaum L, Singer A, Park JH.

Nat Immunol. 2014 Jul;15(7):638-45. doi: 10.1038/ni.2917. Epub 2014 Jun 1.


Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.

Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A.

Cell. 2013 Sep 12;154(6):1326-41. doi: 10.1016/j.cell.2013.08.009.


IL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death.

Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.

Nat Immunol. 2013 Feb;14(2):143-51. doi: 10.1038/ni.2494. Epub 2012 Dec 16.


Memory Th1/Th2 cell generation controlled by Schnurri-2.

Nakayama T, Kimura MY.

Adv Exp Med Biol. 2010;684:1-10.


Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung.

Suzuki A, Iwamura C, Shinoda K, Tumes DJ, Kimura MY, Hosokawa H, Endo Y, Horiuchi S, Tokoyoda K, Koseki H, Yamashita M, Nakayama T.

J Immunol. 2010 Apr 15;184(8):4510-20. doi: 10.4049/jimmunol.0903426. Epub 2010 Mar 17.


Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L, Singer A.

Nat Immunol. 2010 Mar;11(3):257-64. doi: 10.1038/ni.1840. Epub 2010 Jan 31.


Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness.

Iwamura C, Kimura MY, Shinoda K, Endo Y, Hasegawa A, Yamashita M, Nakayama T.

Int Immunol. 2007 Jun;19(6):755-62. Epub 2007 May 9.


Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo.

Kimura MY, Iwamura C, Suzuki A, Miki T, Hasegawa A, Sugaya K, Yamashita M, Ishii S, Nakayama T.

J Immunol. 2007 Apr 15;178(8):4926-36.


Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells.

Kaneko T, Hosokawa H, Yamashita M, Wang CR, Hasegawa A, Kimura MY, Kitajiama M, Kimura F, Miyazaki M, Nakayama T.

Mol Immunol. 2007 Mar;44(9):2249-56. Epub 2006 Dec 12.


Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.

Hosokawa H, Kimura MY, Shinnakasu R, Suzuki A, Miki T, Koseki H, van Lohuizen M, Yamashita M, Nakayama T.

J Immunol. 2006 Dec 1;177(11):7656-64.


Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice.

Tenda Y, Yamashita M, Kimura MY, Hasegawa A, Shimizu C, Kitajima M, Onodera A, Suzuki A, Seki N, Nakayama T.

J Allergy Clin Immunol. 2006 Sep;118(3):725-33. Epub 2006 Jul 28.


Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.

Yamashita M, Hirahara K, Shinnakasu R, Hosokawa H, Norikane S, Kimura MY, Hasegawa A, Nakayama T.

Immunity. 2006 May;24(5):611-22.


Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.

Hasegawa A, Miki T, Hosokawa H, Hossain MB, Shimizu C, Hashimoto K, Kimura MY, Yamashita M, Nakayama T.

J Immunol. 2006 Feb 15;176(4):2546-54.


Differentiation of NK1 and NK2 cells.

Kimura MY, Nakayama T.

Crit Rev Immunol. 2005;25(5):361-74. Review.


Regulation of T helper type 2 cell differentiation by murine Schnurri-2.

Kimura MY, Hosokawa H, Yamashita M, Hasegawa A, Iwamura C, Watarai H, Taniguchi M, Takagi T, Ishii S, Nakayama T.

J Exp Med. 2005 Feb 7;201(3):397-408.

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