Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 40

1.

A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function.

Koltes JE, Arora I, Gupta R, Nguyen DC, Schaid M, Kim JA, Kimple ME, Bhatnagar S.

Sci Rep. 2019 Jul 12;9(1):10119. doi: 10.1038/s41598-019-46219-3.

2.

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.

De Leon ER, Brinkman JA, Fenske RJ, Gregg T, Schmidt BA, Sherman DS, Cummings NE, Peter DC, Kimple ME, Lamming DW, Merrins MJ.

Sci Rep. 2018 Dec 13;8(1):17814. doi: 10.1038/s41598-018-36289-0.

3.

Complement 1q-like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein-coupled receptor BAI3.

Gupta R, Nguyen DC, Schaid MD, Lei X, Balamurugan AN, Wong GW, Kim JA, Koltes JE, Kimple ME, Bhatnagar S.

J Biol Chem. 2018 Nov 23;293(47):18086-18098. doi: 10.1074/jbc.RA118.005403. Epub 2018 Sep 18.

4.

Targeting dysfunctional beta-cell signaling for the potential treatment of type 1 diabetes mellitus.

Fenske RJ, Kimple ME.

Exp Biol Med (Maywood). 2018 Mar;243(6):586-591. doi: 10.1177/1535370218761662. Epub 2018 Mar 4. Review.

5.

Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.

Yu D, Yang SE, Miller BR, Wisinski JA, Sherman DS, Brinkman JA, Tomasiewicz JL, Cummings NE, Kimple ME, Cryns VL, Lamming DW.

FASEB J. 2018 Jun;32(6):3471-3482. doi: 10.1096/fj.201701211R. Epub 2018 Jan 30.

6.

Restoration of metabolic health by decreased consumption of branched-chain amino acids.

Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, Poudel C, Sherman DS, Yu D, Arriola Apelo SI, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, Matkowskyj KA, Kimple ME, Alexander CM, Merrins MJ, Lamming DW.

J Physiol. 2018 Feb 15;596(4):623-645. doi: 10.1113/JP275075. Epub 2017 Dec 27.

7.

EPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP.

Rodríguez CI, Castro-Pérez E, Prabhakar K, Block L, Longley BJ, Wisinski JA, Kimple ME, Setaluri V.

Mol Cancer Res. 2017 Dec;15(12):1792-1802. doi: 10.1158/1541-7786.MCR-17-0067. Epub 2017 Aug 29.

8.

The EP3 Receptor/Gz Signaling Axis as a Therapeutic Target for Diabetes and Cardiovascular Disease.

Schaid MD, Wisinski JA, Kimple ME.

AAPS J. 2017 Sep;19(5):1276-1283. doi: 10.1208/s12248-017-0097-1. Epub 2017 Jun 5. Review.

PMID:
28584908
9.

Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferation.

Carboneau BA, Allan JA, Townsend SE, Kimple ME, Breyer RM, Gannon M.

Mol Metab. 2017 Apr 5;6(6):548-559. doi: 10.1016/j.molmet.2017.04.002. eCollection 2017 Jun.

10.

Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.

Hernandez R, Graves SA, Gregg T, VanDeusen HR, Fenske RJ, Wienkes HN, England CG, Valdovinos HF, Jeffery JJ, Barnhart TE, Severin GW, Nickles RJ, Kimple ME, Merrins MJ, Cai W.

Diabetes. 2017 Aug;66(8):2163-2174. doi: 10.2337/db16-1285. Epub 2017 May 17.

11.

Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes pathophysiology, prevention, and treatment.

Neuman JC, Fenske RJ, Kimple ME.

Nutr Healthy Aging. 2017 Mar 31;4(2):127-140. doi: 10.3233/NHA-160004. Review. No abstract available.

12.

The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice.

Fenske RJ, Cadena MT, Harenda QE, Wienkes HN, Carbajal K, Schaid MD, Laundre E, Brill AL, Truchan NA, Brar H, Wisinski J, Cai J, Graham TE, Engin F, Kimple ME.

Endocrinology. 2017 Jun 1;158(6):1645-1658. doi: 10.1210/en.2016-1700.

13.

Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-Cell Function.

Neuman JC, Schaid MD, Brill AL, Fenske RJ, Kibbe CR, Fontaine DA, Sdao SM, Brar HK, Connors KM, Wienkes HN, Eliceiri KW, Merrins MJ, Davis DB, Kimple ME.

Diabetes. 2017 Jun;66(6):1572-1585. doi: 10.2337/db16-1362. Epub 2017 Feb 13.

14.

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health.

Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ, Alexander CM, Kimple ME, Lamming DW.

Cell Rep. 2016 Jul 12;16(2):520-530. doi: 10.1016/j.celrep.2016.05.092. Epub 2016 Jun 23.

15.

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.

Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ.

Diabetes. 2016 Sep;65(9):2700-10. doi: 10.2337/db16-0432. Epub 2016 Jun 9.

16.

Synergy Between Gαz Deficiency and GLP-1 Analog Treatment in Preserving Functional β-Cell Mass in Experimental Diabetes.

Brill AL, Wisinski JA, Cadena MT, Thompson MF, Fenske RJ, Brar HK, Schaid MD, Pasker RL, Kimple ME.

Mol Endocrinol. 2016 May;30(5):543-56. doi: 10.1210/me.2015-1164. Epub 2016 Apr 6.

17.

The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma.

Weeks AC, Kimple ME, Davis DB.

J Investig Med High Impact Case Rep. 2015 Sep 19;3(3):2324709615607062. doi: 10.1177/2324709615607062. eCollection 2015 Jul-Sep.

18.

Spontaneous Tumor Lysis Syndrome: A Case Report and Critical Evaluation of Current Diagnostic Criteria and Optimal Treatment Regimens.

Weeks AC, Kimple ME.

J Investig Med High Impact Case Rep. 2015 Aug 25;3(3):2324709615603199. doi: 10.1177/2324709615603199. eCollection 2015 Jul-Sep.

19.

Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes.

Wisinski JA, Kimple ME.

Diabetes. 2016 Feb;65(2):349-51. doi: 10.2337/dbi15-0032. No abstract available.

20.

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.

Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW.

Aging Cell. 2016 Feb;15(1):28-38. doi: 10.1111/acel.12405. Epub 2015 Oct 13.

21.

A single-islet microplate assay to measure mouse and human islet insulin secretion.

Truchan NA, Brar HK, Gallagher SJ, Neuman JC, Kimple ME.

Islets. 2015;7(3):e1076607. doi: 10.1080/19382014.2015.1076607.

22.

The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition.

Pierre JF, Neuman JC, Brill AL, Brar HK, Thompson MF, Cadena MT, Connors KM, Busch RA, Heneghan AF, Cham CM, Jones EK, Kibbe CR, Davis DB, Groblewski GE, Kudsk KA, Kimple ME.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G431-42. doi: 10.1152/ajpgi.00072.2015. Epub 2015 Jul 16.

23.

Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.

Oropeza D, Jouvet N, Budry L, Campbell JE, Bouyakdan K, Lacombe J, Perron G, Bergeron V, Neuman JC, Brar HK, Fenske RJ, Meunier C, Sczelecki S, Kimple ME, Drucker DJ, Screaton RA, Poitout V, Ferron M, Alquier T, Estall JL.

Diabetes. 2015 Nov;64(11):3798-807. doi: 10.2337/db15-0272. Epub 2015 Jul 7.

24.

Glucagon-Like Peptide-1 Regulates Cholecystokinin Production in β-Cells to Protect From Apoptosis.

Linnemann AK, Neuman JC, Battiola TJ, Wisinski JA, Kimple ME, Davis DB.

Mol Endocrinol. 2015 Jul;29(7):978-87. doi: 10.1210/me.2015-1030. Epub 2015 May 18.

25.

Bombesin Preserves Goblet Cell Resistin-Like Molecule β During Parenteral Nutrition but Not Other Goblet Cell Products.

Busch RA, Heneghan AF, Pierre JF, Neuman JC, Reimer CA, Wang X, Kimple ME, Kudsk KA.

JPEN J Parenter Enteral Nutr. 2016 Sep;40(7):1042-9. doi: 10.1177/0148607115585353. Epub 2015 May 1.

26.

A method for mouse pancreatic islet isolation and intracellular cAMP determination.

Neuman JC, Truchan NA, Joseph JW, Kimple ME.

J Vis Exp. 2014 Jun 25;(88):e50374. doi: 10.3791/50374.

27.

Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.

Kimple ME, Neuman JC, Linnemann AK, Casey PJ.

Exp Mol Med. 2014 Jun 20;46:e102. doi: 10.1038/emm.2014.40. Review.

28.

Overview of affinity tags for protein purification.

Kimple ME, Brill AL, Pasker RL.

Curr Protoc Protein Sci. 2013 Sep 24;73:9.9.1-9.9.23. doi: 10.1002/0471140864.ps0909s73. Review.

29.

Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line.

Krautkramer KA, Linnemann AK, Fontaine DA, Whillock AL, Harris TW, Schleis GJ, Truchan NA, Marty-Santos L, Lavine JA, Cleaver O, Kimple ME, Davis DB.

Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E600-10. doi: 10.1152/ajpendo.00147.2013. Epub 2013 Jul 16.

30.

The EP3 Receptor: Exploring a New Target for Type 2 Diabetes Therapeutics.

Neuman JC, Kimple ME.

J Endocrinol Diabetes Obes. 2013 Jul-Sep;1(1). pii: 1002. No abstract available.

31.

Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion.

Kimple ME, Keller MP, Rabaglia MR, Pasker RL, Neuman JC, Truchan NA, Brar HK, Attie AD.

Diabetes. 2013 Jun;62(6):1904-12. doi: 10.2337/db12-0769. Epub 2013 Jan 24.

32.

Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.

Kimple ME, Moss JB, Brar HK, Rosa TC, Truchan NA, Pasker RL, Newgard CB, Casey PJ.

J Biol Chem. 2012 Jun 8;287(24):20344-55. doi: 10.1074/jbc.M112.359745. Epub 2012 Mar 28.

33.

Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.

Kelly P, Bailey CL, Fueger PT, Newgard CB, Casey PJ, Kimple ME.

J Biol Chem. 2010 May 21;285(21):15777-85. doi: 10.1074/jbc.M109.069112. Epub 2010 Mar 25.

34.

Overview of affinity tags for protein purification.

Kimple ME, Sondek J.

Curr Protoc Protein Sci. 2004 Sep;Chapter 9:Unit 9.9. doi: 10.1002/0471140864.ps0909s36. Review.

PMID:
18429272
35.

Galphaz negatively regulates insulin secretion and glucose clearance.

Kimple ME, Joseph JW, Bailey CL, Fueger PT, Hendry IA, Newgard CB, Casey PJ.

J Biol Chem. 2008 Feb 22;283(8):4560-7. Epub 2007 Dec 20.

36.

A role for G(z) in pancreatic islet beta-cell biology.

Kimple ME, Nixon AB, Kelly P, Bailey CL, Young KH, Fields TA, Casey PJ.

J Biol Chem. 2005 Sep 9;280(36):31708-13. Epub 2005 Jul 6.

37.

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.

Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE.

Mol Cell. 2005 Jul 22;19(2):197-207.

38.
39.

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.

Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP.

Nature. 2002 Apr 25;416(6883):878-81.

PMID:
11976690
40.

Supplemental Content

Loading ...
Support Center