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Items: 12


Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.

Buchler I, Akuma D, Au V, Carr G, de León P, DePasquale M, Ernst G, Huang Y, Kimos M, Kolobova A, Poslusney M, Wei H, Swinnen D, Montel F, Moureau F, Jigorel E, Schulze MED, Wood M, Barrow JC.

J Med Chem. 2018 Nov 8;61(21):9647-9665. doi: 10.1021/acs.jmedchem.8b01126. Epub 2018 Oct 19.


Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity.

Wormald M, Liao G, Kimos M, Barrow J, Wei H.

PLoS One. 2017 Nov 29;12(11):e0188852. doi: 10.1371/journal.pone.0188852. eCollection 2017.


Development of an HTRF Assay for the Detection and Characterization of Inhibitors of Catechol-O-Methyltransferase.

Kimos M, Burton M, Urbain D, Caudron D, Martini M, Famelart M, Gillard M, Barrow J, Wood M.

J Biomol Screen. 2016 Jun;21(5):490-5. doi: 10.1177/1087057115616793. Epub 2015 Nov 18.


L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy.

Meng H, Matthaei M, Ramanan N, Grebe R, Chakravarti S, Speck CL, Kimos M, Vij N, Eberhart CG, Jun AS.

Invest Ophthalmol Vis Sci. 2013 Mar 28;54(3):1887-97. doi: 10.1167/iovs.12-11021.


An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis.

Jun AS, Meng H, Ramanan N, Matthaei M, Chakravarti S, Bonshek R, Black GC, Grebe R, Kimos M.

Hum Mol Genet. 2012 Jan 15;21(2):384-93. doi: 10.1093/hmg/ddr473. Epub 2011 Oct 14.


Aging changes of mouse corneal endothelium and Descemet's membrane.

Jun AS, Chakravarti S, Edelhauser HF, Kimos M.

Exp Eye Res. 2006 Oct;83(4):890-6. Epub 2006 Jun 13.


Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression.

Kimos MC, Wang S, Borkowski A, Yang GY, Yang CS, Perry K, Olaru A, Deacu E, Sterian A, Cottrell J, Papadimitriou J, Sisodia L, Selaru FM, Mori Y, Xu Y, Yin J, Abraham JM, Meltzer SJ.

Int J Cancer. 2004 Sep 1;111(3):415-7.


Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors.

Olaru A, Mori Y, Yin J, Wang S, Kimos MC, Perry K, Xu Y, Sato F, Selaru FM, Deacu E, Sterian A, Shibata D, Abraham JM, Meltzer SJ.

Lab Invest. 2003 Dec;83(12):1867-71.


An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma.

Wang S, Mori Y, Sato F, Yin J, Xu Y, Zou TT, Olaru A, Kimos MC, Perry K, Selaru FM, Deacu E, Sun M, Shi YC, Shibata D, Abraham JM, Greenwald BD, Meltzer SJ.

Oncogene. 2003 Jan 23;22(3):467-70.


Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma.

Sato F, Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru A, Deacu E, Selaru FM, Kimos MC, Hytiroglou P, Young J, Leggett B, Gazdar AF, Toyooka S, Abraham JM, Meltzer SJ.

Cancer Res. 2002 Dec 1;62(23):6820-2.


Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers.

Mori Y, Sato F, Selaru FM, Olaru A, Perry K, Kimos MC, Tamura G, Matsubara N, Wang S, Xu Y, Yin J, Zou TT, Leggett B, Young J, Nukiwa T, Stine OC, Abraham JM, Shibata D, Meltzer SJ.

Cancer Res. 2002 Jul 1;62(13):3641-5.


Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer.

Xu Y, Selaru FM, Yin J, Zou TT, Shustova V, Mori Y, Sato F, Liu TC, Olaru A, Wang S, Kimos MC, Perry K, Desai K, Greenwald BD, Krasna MJ, Shibata D, Abraham JM, Meltzer SJ.

Cancer Res. 2002 Jun 15;62(12):3493-7.

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