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Integrated actions of mTOR complexes 1 and 2 for growth and development of Dictyostelium.

Jaiswal P, Majithia AR, Rosel D, Liao XH, Khurana T, Kimmel AR.

Int J Dev Biol. 2019;63(8-9-10):521-527. doi: 10.1387/ijdb.190245ak.


DPF is a cell-density sensing factor, with cell-autonomous and non-autonomous functions during Dictyostelium growth and development.

Meena NP, Jaiswal P, Chang FS, Brzostowski J, Kimmel AR.

BMC Biol. 2019 Dec 2;17(1):97. doi: 10.1186/s12915-019-0714-9.


mTORC1/AMPK responses define a core gene set for developmental cell fate switching.

Jaiswal P, Kimmel AR.

BMC Biol. 2019 Jul 18;17(1):58. doi: 10.1186/s12915-019-0673-1.


Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart.

Mardani I, Tomas Dalen K, Drevinge C, Miljanovic A, Ståhlman M, Klevstig M, Scharin Täng M, Fogelstrand P, Levin M, Ekstrand M, Nair S, Redfors B, Omerovic E, Andersson L, Kimmel AR, Borén J, Levin MC.

Sci Rep. 2019 May 6;9(1):6909. doi: 10.1038/s41598-019-43335-y.


An ERK Phosphoproteome Expands Chemotactic Signaling in Dictyostelium.

Kimmel AR.

Dev Cell. 2019 Feb 25;48(4):421-422. doi: 10.1016/j.devcel.2019.02.006.


Quantification of Live Bacterial Sensing for Chemotaxis and Phagocytosis and of Macropinocytosis.

Meena NP, Kimmel AR.

Front Cell Infect Microbiol. 2018 Mar 2;8:62. doi: 10.3389/fcimb.2018.00062. eCollection 2018.


Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation.

Lee YK, Sohn JH, Han JS, Park YJ, Jeon YG, Ji Y, Dalen KT, Sztalryd C, Kimmel AR, Kim JB.

Diabetes. 2018 May;67(5):791-804. doi: 10.2337/db17-0983. Epub 2018 Feb 13.


Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation.

Feng YZ, Lund J, Li Y, Knabenes IK, Bakke SS, Kase ET, Lee YK, Kimmel AR, Thoresen GH, Rustan AC, Dalen KT.

J Lipid Res. 2017 Nov;58(11):2147-2161. doi: 10.1194/jlr.M079764. Epub 2017 Aug 19.


Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.

Andersson L, Drevinge C, Mardani I, Dalen KT, Ståhlman M, Klevstig M, Lundqvist A, Haugen F, Adiels M, Fogelstrand P, Asin-Cayuela J, Hultén LM, Levin M, Ehrenborg E, Lee YK, Kimmel AR, Borén J, Levin MC.

Int J Biochem Cell Biol. 2017 Oct;91(Pt A):9-13. doi: 10.1016/j.biocel.2017.07.021. Epub 2017 Aug 12.


Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing.

Meena NP, Kimmel AR.

Elife. 2017 May 25;6. pii: e24627. doi: 10.7554/eLife.24627.


Regulation of nucleosome positioning by a CHD Type III chromatin remodeler and its relationship to developmental gene expression in Dictyostelium.

Platt JL, Kent NA, Kimmel AR, Harwood AJ.

Genome Res. 2017 Apr;27(4):591-600. doi: 10.1101/gr.216309.116. Epub 2017 Mar 22.


A Unique High-Throughput Assay to Identify Novel Small Molecule Inhibitors of Chemotaxis and Migration.

Liao XH, Kimmel AR.

Curr Protoc Cell Biol. 2017 Mar 3;74:12.11.1-12.11.13. doi: 10.1002/cpcb.17.


The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis.

Kimmel AR, Sztalryd C.

Annu Rev Nutr. 2016 Jul 17;36:471-509. doi: 10.1146/annurev-nutr-071813-105410. Review.


Perilipin 5 is protective in the ischemic heart.

Drevinge C, Dalen KT, Mannila MN, Täng MS, Ståhlman M, Klevstig M, Lundqvist A, Mardani I, Haugen F, Fogelstrand P, Adiels M, Asin-Cayuela J, Ekestam C, Gådin JR, Lee YK, Nebb H, Svedlund S, Johansson BR, Hultén LM, Romeo S, Redfors B, Omerovic E, Levin M, Gan LM, Eriksson P, Andersson L, Ehrenborg E, Kimmel AR, Borén J, Levin MC.

Int J Cardiol. 2016 Sep 15;219:446-54. doi: 10.1016/j.ijcard.2016.06.037. Epub 2016 Jun 16.


Biochemical Responses to Chemically Distinct Chemoattractants During the Growth and Development of Dictyostelium.

Meena NP, Kimmel AR.

Methods Mol Biol. 2016;1407:141-51. doi: 10.1007/978-1-4939-3480-5_11.


A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration.

Liao XH, Meena NP, Southall N, Liu L, Swaroop M, Zhang AL, Xiang JJ, Parent CA, Zheng W, Kimmel AR.

Sci Rep. 2016 Mar 9;6:22273. doi: 10.1038/srep22273.


Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization.

Kimmel AR, Sztalryd C.

Curr Opin Lipidol. 2014 Apr;25(2):110-7. doi: 10.1097/MOL.0000000000000057. Review.


An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.

Ludtmann MH, Otto GP, Schilde C, Chen ZH, Allan CY, Brace S, Beesley PW, Kimmel AR, Fisher P, Killick R, Williams RS.

J Cell Sci. 2014 Apr 1;127(Pt 7):1576-84. doi: 10.1242/jcs.140939. Epub 2014 Jan 24.


Different CHD chromatin remodelers are required for expression of distinct gene sets and specific stages during development of Dictyostelium discoideum.

Platt JL, Rogers BJ, Rogers KC, Harwood AJ, Kimmel AR.

Development. 2013 Dec;140(24):4926-36. doi: 10.1242/dev.099879.


Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection.

Sztalryd C, Kimmel AR.

Biochimie. 2014 Jan;96:96-101. doi: 10.1016/j.biochi.2013.08.026. Epub 2013 Sep 13. Review.


Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay.

Brzostowski JA, Sawai S, Rozov O, Liao XH, Imoto D, Parent CA, Kimmel AR.

J Cell Sci. 2013 Oct 15;126(Pt 20):4614-26. doi: 10.1242/jcs.122952. Epub 2013 Jul 31.


The application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci.

Faix J, Linkner J, Nordholz B, Platt JL, Liao XH, Kimmel AR.

Methods Mol Biol. 2013;983:249-67. doi: 10.1007/978-1-62703-302-2_13.


Analysis of chromatin organization by deep sequencing technologies.

Platt JL, Kent NA, Harwood AJ, Kimmel AR.

Methods Mol Biol. 2013;983:173-83. doi: 10.1007/978-1-62703-302-2_9.


Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets.

Hsieh K, Lee YK, Londos C, Raaka BM, Dalen KT, Kimmel AR.

J Cell Sci. 2012 Sep 1;125(Pt 17):4067-76. doi: 10.1242/jcs.104943. Epub 2012 Jun 8.


TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing.

Rosel D, Khurana T, Majithia A, Huang X, Bhandari R, Kimmel AR.

J Cell Sci. 2012 Jan 1;125(Pt 1):37-48. doi: 10.1242/jcs.077040. Epub 2012 Jan 20.


Combinatorial cell-specific regulation of GSK3 directs cell differentiation and polarity in Dictyostelium.

Kim L, Brzostowski J, Majithia A, Lee NS, McMains V, Kimmel AR.

Development. 2011 Feb;138(3):421-30. doi: 10.1242/dev.055335.


An orphan nuclear receptor finds a home.

Kimmel AR.

Mol Cell. 2010 Jan 29;37(2):155-7. doi: 10.1016/j.molcel.2010.01.008.


Biochemical responses to chemoattractants in Dictyostelium: ligand-receptor interactions and downstream kinase activation.

Liao XH, Kimmel AR.

Methods Mol Biol. 2009;571:271-81. doi: 10.1007/978-1-60761-198-1_18.


Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins.

Kimmel AR, Brasaemle DL, McAndrews-Hill M, Sztalryd C, Londos C.

J Lipid Res. 2010 Mar;51(3):468-71. doi: 10.1194/jlr.R000034. Epub 2009 Jul 28. Review.


Oscillatory signaling and network responses during the development of Dictyostelium discoideum.

McMains VC, Liao XH, Kimmel AR.

Ageing Res Rev. 2008 Jul;7(3):234-48. doi: 10.1016/j.arr.2008.04.003. Epub 2008 May 4. Review.


Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism.

Liao XH, Majithia A, Huang X, Kimmel AR.

Amino Acids. 2008 Nov;35(4):761-70. doi: 10.1007/s00726-008-0100-3. Epub 2008 Jul 24. Review.


Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling.

Bokko PB, Francione L, Bandala-Sanchez E, Ahmed AU, Annesley SJ, Huang X, Khurana T, Kimmel AR, Fisher PR.

Mol Biol Cell. 2007 May;18(5):1874-86. Epub 2007 Mar 1.


GSK3 at the edge: regulation of developmental specification and cell polarization.

Kim L, Kimmel AR.

Curr Drug Targets. 2006 Nov;7(11):1411-9. Review.


Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line.

Sztalryd C, Bell M, Lu X, Mertz P, Hickenbottom S, Chang BH, Chan L, Kimmel AR, Londos C.

J Biol Chem. 2006 Nov 10;281(45):34341-8. Epub 2006 Sep 12.


Generation of multiple knockout mutants using the Cre-loxP system.

Kimmel AR, Faix J.

Methods Mol Biol. 2006;346:187-99.


Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay.

Brzostowski JA, Kimmel AR.

Mol Biol Cell. 2006 Oct;17(10):4220-7. Epub 2006 Jul 26.


The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum.

Rosel D, Kimmel AR.

Eur J Cell Biol. 2006 Sep;85(9-10):1023-34. Epub 2006 Jun 14.


Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway.

Xu G, Sztalryd C, Lu X, Tansey JT, Gan J, Dorward H, Kimmel AR, Londos C.

J Biol Chem. 2005 Dec 30;280(52):42841-7. Epub 2005 Aug 22.


A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms.

Khurana T, Brzostowski JA, Kimmel AR.

EMBO J. 2005 Jul 6;24(13):2254-64. Epub 2005 Jun 16.


Role of PAT proteins in lipid metabolism.

Londos C, Sztalryd C, Tansey JT, Kimmel AR.

Biochimie. 2005 Jan;87(1):45-9. Review.


The central role of perilipin a in lipid metabolism and adipocyte lipolysis.

Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C.

IUBMB Life. 2004 Jul;56(7):379-85. Review.


Structure of a lipid droplet protein; the PAT family member TIP47.

Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH.

Structure. 2004 Jul;12(7):1199-207.

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