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Items: 15


T cells display mitochondria hyperpolarization in human type 1 diabetes.

Chen J, Chernatynskaya AV, Li JW, Kimbrell MR, Cassidy RJ, Perry DJ, Muir AB, Atkinson MA, Brusko TM, Mathews CE.

Sci Rep. 2017 Sep 7;7(1):10835. doi: 10.1038/s41598-017-11056-9.


Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.

Peng C, Kimbrell MR, Tian C, Pack TF, Crooks PA, Fifer EK, Papke RL.

Mol Pharmacol. 2013 Sep;84(3):459-75. doi: 10.1124/mol.113.086462. Epub 2013 Jul 9.


Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models.

Hood JD, Warshakoon HJ, Kimbrell MR, Shukla NM, Malladi SS, Wang X, David SA.

Hum Vaccin. 2010 Apr;6(4):322-35. Epub 2010 Apr 7.


Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.

Wu W, Li R, Malladi SS, Warshakoon HJ, Kimbrell MR, Amolins MW, Ukani R, Datta A, David SA.

J Med Chem. 2010 Apr 22;53(8):3198-213. doi: 10.1021/jm901839g.


Synthesis of a highly water-soluble derivative of amphotericin B with attenuated proinflammatory activity.

Adediran SA, Day TP, Sil D, Kimbrell MR, Warshakoon HJ, Malladi SS, David SA.

Mol Pharm. 2009 Sep-Oct;6(5):1582-90. doi: 10.1021/mp9001602.


Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline.

Shukla NM, Kimbrell MR, Malladi SS, David SA.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2211-4. doi: 10.1016/j.bmcl.2009.02.100. Epub 2009 Feb 28.


Potential adjuvantic properties of innate immune stimuli.

Warshakoon HJ, Hood JD, Kimbrell MR, Malladi S, Wu WY, Shukla NM, Agnihotri G, Sil D, David SA.

Hum Vaccin. 2009 Jun;5(6):381-94. Epub 2009 Jun 16. Review.


Structure-activity relationships of lipopolysaccharide sequestration in guanylhydrazone-bearing lipopolyamines.

Wu W, Sil D, Szostak ML, Malladi SS, Warshakoon HJ, Kimbrell MR, Cromer JR, David SA.

Bioorg Med Chem. 2009 Jan 15;17(2):709-15. doi: 10.1016/j.bmc.2008.11.051. Epub 2008 Nov 24.


Comparison of the immunostimulatory and proinflammatory activities of candidate Gram-positive endotoxins, lipoteichoic acid, peptidoglycan, and lipopeptides, in murine and human cells.

Kimbrell MR, Warshakoon H, Cromer JR, Malladi S, Hood JD, Balakrishna R, Scholdberg TA, David SA.

Immunol Lett. 2008 Jun 30;118(2):132-41. doi: 10.1016/j.imlet.2008.03.009. Epub 2008 Apr 18.


Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide.

Nguyen TB, Adisechan AK, Suresh Kumar EV, Balakrishna R, Kimbrell MR, Miller KA, Datta A, David SA.

Bioorg Med Chem. 2007 Sep 1;15(17):5694-709. Epub 2007 Jun 10.


Bound to shock: protection from lethal endotoxemic shock by a novel, nontoxic, alkylpolyamine lipopolysaccharide sequestrant.

Sil D, Shrestha A, Kimbrell MR, Nguyen TB, Adisechan AK, Balakrishna R, Abbo BG, Malladi S, Miller KA, Short S, Cromer JR, Arora S, Datta A, David SA.

Antimicrob Agents Chemother. 2007 Aug;51(8):2811-9. Epub 2007 Jun 4.


Polycationic sulfonamides for the sequestration of endotoxin.

Burns MR, Jenkins SA, Kimbrell MR, Balakrishna R, Nguyen TB, Abbo BG, David SA.

J Med Chem. 2007 Feb 22;50(4):877-88. Epub 2007 Jan 26.


Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs.

Burns MR, Jenkins SA, Vermeulen NM, Balakrishna R, Nguyen TB, Kimbrell MR, David SA.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6209-12. Epub 2006 Sep 28.


Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds.

Khownium K, Wood SJ, Miller KA, Balakrishna R, Nguyen TB, Kimbrell MR, Georg GI, David SA.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1305-8. Epub 2006 Jan 11.


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