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Ensemble of Convolutional Neural Networks Improves Automated Segmentation of Acute Ischemic Lesions Using Multiparametric Diffusion-Weighted MRI.

Winzeck S, Mocking SJT, Bezerra R, Bouts MJRJ, McIntosh EC, Diwan I, Garg P, Chutinet A, Kimberly WT, Copen WA, Schaefer PW, Ay H, Singhal AB, Kamnitsas K, Glocker B, Sorensen AG, Wu O.

AJNR Am J Neuroradiol. 2019 Jun;40(6):938-945. doi: 10.3174/ajnr.A6077. Epub 2019 May 30.


Intermittent CSF drainage and rapid EVD weaning approach after subarachnoid hemorrhage: association with fewer VP shunts and shorter length of stay.

Rao SS, Chung DY, Wolcott Z, Sheriff F, Khawaja AM, Lee H, Guanci MM, Leslie-Mazwi TM, Kimberly WT, Patel AB, Rordorf GA.

J Neurosurg. 2019 Apr 26:1-6. doi: 10.3171/2019.1.JNS182702. [Epub ahead of print]


Succinate links atrial dysfunction and cardioembolic stroke.

Nelson SE, Ament Z, Wolcott Z, Gerszten RE, Kimberly WT.

Neurology. 2019 Feb 19;92(8):e802-e810. doi: 10.1212/WNL.0000000000006957. Epub 2019 Jan 23.


Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial.

Kimberly WT, Bevers MB, von Kummer R, Demchuk AM, Romero JM, Elm JJ, Hinson HE, Molyneaux BJ, Simard JM, Sheth KN.

Neurology. 2018 Dec 4;91(23):e2163-e2169. doi: 10.1212/WNL.0000000000006618. Epub 2018 Nov 16.


Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date.

King ZA, Sheth KN, Kimberly WT, Simard JM.

Drug Des Devel Ther. 2018 Aug 15;12:2539-2552. doi: 10.2147/DDDT.S150043. eCollection 2018. Review.


Comparative Analysis of Markers of Mass Effect after Ischemic Stroke.

Ostwaldt AC, Battey TWK, Irvine HJ, Campbell BCV, Davis SM, Donnan GA, Kimberly WT.

J Neuroimaging. 2018 Sep;28(5):530-534. doi: 10.1111/jon.12525. Epub 2018 May 24.


Long-Term Outcomes in Patients Aged ≤70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis.

Sheth KN, Petersen NH, Cheung K, Elm JJ, Hinson HE, Molyneaux BJ, Beslow LA, Sze GK, Simard JM, Kimberly WT.

Stroke. 2018 Jun;49(6):1457-1463. doi: 10.1161/STROKEAHA.117.020365. Epub 2018 May 22.


Apparent Diffusion Coefficient Signal Intensity Ratio Predicts the Effect of Revascularization on Ischemic Cerebral Edema.

Bevers MB, Battey TWK, Ostwaldt AC, Jahan R, Saver JL, Kimberly WT, Kidwell CS.

Cerebrovasc Dis. 2018;45(3-4):93-100. doi: 10.1159/000487406. Epub 2018 Mar 13.


Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke: A Secondary Analysis of the MR CLEAN Trial.

Kimberly WT, Dutra BG, Boers AMM, Alves HCBR, Berkhemer OA, van den Berg L, Sheth KN, Roos YBWEM, van der Lugt A, Beenen LFM, Dippel DWJ, van Zwam WH, van Oostenbrugge RJ, Lingsma HF, Marquering H, Majoie CBLM; MR CLEAN Investigators.

JAMA Neurol. 2018 Apr 1;75(4):453-461. doi: 10.1001/jamaneurol.2017.5162.


Cerebral Edema After Cardiopulmonary Resuscitation: A Therapeutic Target Following Cardiac Arrest?

Hayman EG, Patel AP, Kimberly WT, Sheth KN, Simard JM.

Neurocrit Care. 2018 Jun;28(3):276-287. doi: 10.1007/s12028-017-0474-8.


Soluble ST2 predicts outcome and hemorrhagic transformation after acute stroke.

Wolcott Z, Batra A, Bevers MB, Sastre C, Khoury J, Sperling M, Meyer BC, Walsh KB, Adeoye O, Broderick JP, Kimberly WT.

Ann Clin Transl Neurol. 2017 Jul 5;4(8):553-563. doi: 10.1002/acn3.435. eCollection 2017 Aug.


Reperfusion after ischemic stroke is associated with reduced brain edema.

Irvine HJ, Ostwaldt AC, Bevers MB, Dixon S, Battey TW, Campbell BC, Davis SM, Donnan GA, Sheth KN, Jahan R, Saver JL, Kidwell CS, Kimberly WT.

J Cereb Blood Flow Metab. 2018 Oct;38(10):1807-1817. doi: 10.1177/0271678X17720559. Epub 2017 Jul 21.


Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis.

Kimberly WT, O'Sullivan JF, Nath AK, Keyes M, Shi X, Larson MG, Yang Q, Long MT, Vasan R, Peterson RT, Wang TJ, Corey KE, Gerszten RE.

JCI Insight. 2017 May 4;2(9). pii: 92989. doi: 10.1172/jci.insight.92989. eCollection 2017 May 4.


Critical Care Management of Acute Ischemic Stroke.

Bevers MB, Kimberly WT.

Curr Treat Options Cardiovasc Med. 2017 Jun;19(6):41. doi: 10.1007/s11936-017-0542-6. Review.


Today's Approach to Treating Brain Swelling in the Neuro Intensive Care Unit.

Shah S, Kimberly WT.

Semin Neurol. 2016 Dec;36(6):502-507. Epub 2016 Dec 1. Review.


Perihematomal Edema Expansion Rates and Patient Outcomes in Deep and Lobar Intracerebral Hemorrhage.

Grunwald Z, Beslow LA, Urday S, Vashkevich A, Ayres A, Greenberg SM, Goldstein JN, Leasure A, Shi FD, Kahle KT, Battey TW, Simard JM, Rosand J, Kimberly WT, Sheth KN.

Neurocrit Care. 2017 Apr;26(2):205-212. doi: 10.1007/s12028-016-0321-3.


Hyperglycemia is associated with more severe cytotoxic injury after stroke.

Bevers MB, Vaishnav NH, Pham L, Battey TW, Kimberly WT.

J Cereb Blood Flow Metab. 2017 Jul;37(7):2577-2583. doi: 10.1177/0271678X16671730. Epub 2016 Jan 1.


Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial.

Sheth KN, Elm JJ, Molyneaux BJ, Hinson H, Beslow LA, Sze GK, Ostwaldt AC, Del Zoppo GJ, Simard JM, Jacobson S, Kimberly WT.

Lancet Neurol. 2016 Oct;15(11):1160-9. doi: 10.1016/S1474-4422(16)30196-X. Epub 2016 Aug 23.


Rate of perihaematomal oedema expansion is associated with poor clinical outcomes in intracerebral haemorrhage.

Murthy SB, Urday S, Beslow LA, Dawson J, Lees K, Kimberly WT, Iadecola C, Kamel H, Hanley DF, Sheth KN, Ziai WC; VISTA ICH Collaborators.

J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1169-1173. doi: 10.1136/jnnp-2016-313653. Epub 2016 Jul 27.


Early neurological stability predicts adverse outcome after acute ischemic stroke.

Irvine HJ, Battey TW, Ostwaldt AC, Campbell BC, Davis SM, Donnan GA, Sheth KN, Kimberly WT.

Int J Stroke. 2016 Oct;11(8):882-889. doi: 10.1177/1747493016654484. Epub 2016 Jul 9.


Treatment of Edema Associated With Intracerebral Hemorrhage.

Leasure A, Kimberly WT, Sansing LH, Kahle KT, Kronenberg G, Kunte H, Simard JM, Sheth KN.

Curr Treat Options Neurol. 2016 Feb;18(2):9. doi: 10.1007/s11940-015-0392-z.


Forced Expiratory Volume in the First Second and Aldosterone as Mediators of Smoking Effect on Stroke in African Americans: The Jackson Heart Study.

Wang W, Shen G, Shahar E, Bidulescu A, Kimberly WT, Sheth KN, Campbell BW, Horbal S, Correa A, Griswold ME.

J Am Heart Assoc. 2016 Jan 27;5(1). pii: e002689. doi: 10.1161/JAHA.115.002689.


Rate of Perihematomal Edema Expansion Predicts Outcome After Intracerebral Hemorrhage.

Urday S, Beslow LA, Dai F, Zhang F, Battey TW, Vashkevich A, Ayres AM, Leasure AC, Selim MH, Simard JM, Rosand J, Kimberly WT, Sheth KN.

Crit Care Med. 2016 Apr;44(4):790-7. doi: 10.1097/CCM.0000000000001553.


ATS Core Curriculum 2015: Part IV. Adult Critical Care Medicine.

Poston JT, McSparron JI, Hayes MM, Damm T, Patel JJ, Decker BK, Attia EF, Çoruh B, Cai X, Kimberly WT, Poisson SN, Sokol S, Csikesz N, Levinson AT, Thomson CC, Luks AM.

Ann Am Thorac Soc. 2015 Dec;12(12):1864-72. doi: 10.1513/AnnalsATS.201508-528CME. Review. No abstract available.


Novel Imaging Markers of Ischemic Cerebral Edema and Its Association with Neurological Outcome.

Kimberly WT, Battey TW, Wu O, Singhal AB, Campbell BC, Davis SM, Donnan GA, Sheth KN.

Acta Neurochir Suppl. 2016;121:223-6. doi: 10.1007/978-3-319-18497-5_40.


Human Data Supporting Glyburide in Ischemic Stroke.

Sheth KN, Simard JM, Elm J, Kronenberg G, Kunte H, Kimberly WT.

Acta Neurochir Suppl. 2016;121:13-8. doi: 10.1007/978-3-319-18497-5_3. Review.


Ventriculostomy-related infections: The performance of different definitions for diagnosing infection.

Lewis A, Wahlster S, Karinja S, Czeisler BM, Kimberly WT, Lord AS.

Br J Neurosurg. 2016;30(1):49-56. doi: 10.3109/02688697.2015.1080222. Epub 2015 Sep 15.


TURN Score Predicts 24-Hour Cerebral Edema After IV Thrombolysis.

Asuzu D, Nyström K, Sreekrishnan A, Schindler J, Wira C, Greer D, Halliday J, Kimberly WT, Sheth KN.

Neurocrit Care. 2016 Jun;24(3):381-8. doi: 10.1007/s12028-015-0198-6.


Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial: Rationale and Design.

Sheth KN, Elm JJ, Beslow LA, Sze GK, Kimberly WT.

Neurocrit Care. 2016 Feb;24(1):132-9. doi: 10.1007/s12028-015-0189-7.


Measurement of perihematomal edema in intracerebral hemorrhage.

Urday S, Beslow LA, Goldstein DW, Vashkevich A, Ayres AM, Battey TW, Selim MH, Kimberly WT, Rosand J, Sheth KN.

Stroke. 2015 Apr;46(4):1116-9. doi: 10.1161/STROKEAHA.114.007565. Epub 2015 Feb 26.


Targeting secondary injury in intracerebral haemorrhage--perihaematomal oedema.

Urday S, Kimberly WT, Beslow LA, Vortmeyer AO, Selim MH, Rosand J, Simard JM, Sheth KN.

Nat Rev Neurol. 2015 Feb;11(2):111-22. doi: 10.1038/nrneurol.2014.264. Epub 2015 Jan 27. Review.


Brain edema predicts outcome after nonlacunar ischemic stroke.

Battey TW, Karki M, Singhal AB, Wu O, Sadaghiani S, Campbell BC, Davis SM, Donnan GA, Sheth KN, Kimberly WT.

Stroke. 2014 Dec;45(12):3643-8. doi: 10.1161/STROKEAHA.114.006884. Epub 2014 Oct 21.


Predictors for delayed ventriculoperitoneal shunt placement after external ventricular drain removal in patients with subarachnoid hemorrhage.

Lewis A, Irvine H, Ogilvy C, Kimberly WT.

Br J Neurosurg. 2015 Apr;29(2):219-24. doi: 10.3109/02688697.2014.967753. Epub 2014 Oct 9.


Case scenario: power of positive end-expiratory pressure: use of esophageal manometry to illustrate pulmonary physiology in an obese patient.

Stahl DL, North CM, Lewis A, Kimberly WT, Hess DR.

Anesthesiology. 2014 Dec;121(6):1320-6. doi: 10.1097/ALN.0000000000000377. No abstract available.


Low neurologic intensive care unit hemoglobin as a predictor for intra-arterial vasospasm therapy and poor discharge modified Rankin Scale in aneurysmal subarachnoid haemorrhage-induced cerebral vasospasm.

Bell DL, Kimberly WT, Yoo AJ, Leslie-Mazwi TM, Rabinov JD, Bell JE, Mehta BP, Hirsch JA.

J Neurointerv Surg. 2015 Jun;7(6):438-42. doi: 10.1136/neurintsurg-2014-011164. Epub 2014 May 9.


Exploratory analysis of glyburide as a novel therapy for preventing brain swelling.

Sheth KN, Kimberly WT, Elm JJ, Kent TA, Yoo AJ, Thomalla G, Campbell B, Donnan GA, Davis SM, Albers GW, Jacobson S, del Zoppo G, Simard JM, Stern BJ, Mandava P.

Neurocrit Care. 2014 Aug;21(1):43-51. doi: 10.1007/s12028-014-9970-2.


Fluid-attenuated inversion recovery hyperintensity correlates with matrix metalloproteinase-9 level and hemorrhagic transformation in acute ischemic stroke.

Jha R, Battey TW, Pham L, Lorenzano S, Furie KL, Sheth KN, Kimberly WT.

Stroke. 2014 Apr;45(4):1040-5. doi: 10.1161/STROKEAHA.113.004627. Epub 2014 Mar 11.


Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare professionals from the American Heart Association/American Stroke Association.

Wijdicks EF, Sheth KN, Carter BS, Greer DM, Kasner SE, Kimberly WT, Schwab S, Smith EE, Tamargo RJ, Wintermark M; American Heart Association Stroke Council.

Stroke. 2014 Apr;45(4):1222-38. doi: 10.1161/01.str.0000441965.15164.d6. Epub 2014 Jan 30.


Pilot study of intravenous glyburide in patients with a large ischemic stroke.

Sheth KN, Kimberly WT, Elm JJ, Kent TA, Mandava P, Yoo AJ, Thomalla G, Campbell B, Donnan GA, Davis SM, Albers GW, Jacobson S, Simard JM, Stern BJ.

Stroke. 2014 Jan;45(1):281-3. doi: 10.1161/STROKEAHA.113.003352. Epub 2013 Nov 5.


Glibenclamide in cerebral ischemia and stroke.

Simard JM, Sheth KN, Kimberly WT, Stern BJ, del Zoppo GJ, Jacobson S, Gerzanich V.

Neurocrit Care. 2014 Apr;20(2):319-33. doi: 10.1007/s12028-013-9923-1. Review.


Tracheostomy after severe ischemic stroke: a population-based study.

Walcott BP, Kamel H, Castro B, Kimberly WT, Sheth KN.

J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):1024-9. doi: 10.1016/j.jstrokecerebrovasdis.2013.08.019. Epub 2013 Oct 6.


Glyburide is associated with attenuated vasogenic edema in stroke patients.

Kimberly WT, Battey TW, Pham L, Wu O, Yoo AJ, Furie KL, Singhal AB, Elm JJ, Stern BJ, Sheth KN.

Neurocrit Care. 2014 Apr;20(2):193-201. doi: 10.1007/s12028-013-9917-z.


Outcomes in severe middle cerebral artery ischemic stroke.

Walcott BP, Miller JC, Kwon CS, Sheth SA, Hiller M, Cronin CA, Schwamm LH, Simard JM, Kahle KT, Kimberly WT, Sheth KN.

Neurocrit Care. 2014 Aug;21(1):20-6. doi: 10.1007/s12028-013-9838-x.


Computed tomography angiography spot sign does not predict case fatality in aneurysmal subarachnoid hemorrhage with intraparenchymal extension.

Brouwers HB, Backes D, Kimberly WT, Schwab K, Romero JM, Velthuis BK, Klijn CJ, Ogilvy CS, Regli L, Greenberg SM, Rosand J, Rinkel GJ, Goldstein JN.

Stroke. 2013 Jun;44(6):1590-4. doi: 10.1161/STROKEAHA.111.000586. Epub 2013 Apr 9.


Metabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke.

Kimberly WT, Wang Y, Pham L, Furie KL, Gerszten RE.

Stroke. 2013 May;44(5):1389-95. doi: 10.1161/STROKEAHA.111.000397. Epub 2013 Mar 21.


Sex differences and hemoglobin levels in relation to stroke outcomes.

Kimberly WT, Lima FO, O'Connor S, Furie KL.

Neurology. 2013 Feb 19;80(8):719-24. doi: 10.1212/WNL.0b013e31828250ff. Epub 2013 Jan 30.


Postoperative intensive care unit requirements after elective craniotomy.

Hanak BW, Walcott BP, Nahed BV, Muzikansky A, Mian MK, Kimberly WT, Curry WT.

World Neurosurg. 2014 Jan;81(1):165-72. doi: 10.1016/j.wneu.2012.11.068. Epub 2012 Nov 24.


Does inhibiting Sur1 complement rt-PA in cerebral ischemia?

Simard JM, Geng Z, Silver FL, Sheth KN, Kimberly WT, Stern BJ, Colucci M, Gerzanich V.

Ann N Y Acad Sci. 2012 Sep;1268:95-107. doi: 10.1111/j.1749-6632.2012.06705.x. Review.


Process improvement methods increase the efficiency, accuracy, and utility of a neurocritical care research repository.

O'Connor S, Ayres A, Cortellini L, Rosand J, Rosenthal E, Kimberly WT.

Neurocrit Care. 2012 Aug;17(1):90-6. doi: 10.1007/s12028-012-9689-x.


Validating imaging biomarkers of cerebral edema in patients with severe ischemic stroke.

Yoo AJ, Sheth KN, Kimberly WT, Chaudhry ZA, Elm JJ, Jacobson S, Davis SM, Donnan GA, Albers GW, Stern BJ, González RG.

J Stroke Cerebrovasc Dis. 2013 Aug;22(6):742-9. doi: 10.1016/j.jstrokecerebrovasdis.2012.01.002. Epub 2012 Feb 9.

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