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Items: 1 to 50 of 564

1.

Integration of Consortia Recommendations for Justification of Animal Use Within Current and Future Drug Development Paradigms.

Prior H, Monticello T, Boulifard V, Brennan FR, Kimber I.

Int J Toxicol. 2019 Jun 20:1091581819852922. doi: 10.1177/1091581819852922. [Epub ahead of print]

PMID:
31220983
2.

Using problem formulation to clarify the meaning of weight of evidence and biological relevance in environmental risk assessments for genetically modified crops.

Raybould A, Holt K, Kimber I.

GM Crops Food. 2019;10(2):63-76. doi: 10.1080/21645698.2019.1621615. Epub 2019 Jun 11.

PMID:
31184249
3.

A response to Professor Steinemann.

Basketter D, Huggard J, Kimber I.

Regul Toxicol Pharmacol. 2019 Aug;106:351. doi: 10.1016/j.yrtph.2019.05.006. Epub 2019 May 11. No abstract available.

PMID:
31085252
4.

Fragrance inhalation and adverse health effects: The question of causation.

Basketter DA, Huggard J, Kimber I.

Regul Toxicol Pharmacol. 2019 Jun;104:151-156. doi: 10.1016/j.yrtph.2019.03.011. Epub 2019 Mar 21. Review.

PMID:
30904429
5.

Proteomic and Bioinformatic Analyses for the Identification of Proteins With Low Allergenic Potential for Hazard Assessment.

Krutz NL, Winget J, Ryan CA, Wimalasena R, Maurer-Stroh S, Dearman RJ, Kimber I, Gerberick GF.

Toxicol Sci. 2019 Jul 1;170(1):210-222. doi: 10.1093/toxsci/kfz078.

PMID:
30903174
6.

The activity of methacrylate esters in skin sensitisation test methods: A review.

Kimber I.

Regul Toxicol Pharmacol. 2019 Jun;104:14-20. doi: 10.1016/j.yrtph.2019.02.014. Epub 2019 Feb 28. Review.

7.

T lymphocyte phenotype of contact-allergic patients: experience with nickel and p-phenylenediamine.

Wicks K, Stretton C, Popple A, Beresford L, Williams J, Maxwell G, Gosling JP, Kimber I, Dearman RJ.

Contact Dermatitis. 2019 Jul;81(1):43-53. doi: 10.1111/cod.13246. Epub 2019 Apr 8.

8.

Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies.

Rane SS, Dearman RJ, Kimber I, Uddin S, Bishop S, Shah M, Podmore A, Pluen A, Derrick JP.

Pharm Res. 2019 Feb 15;36(4):51. doi: 10.1007/s11095-019-2586-7.

9.

Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals.

Prior H, Casey W, Kimber I, Whelan M, Sewell F.

Regul Toxicol Pharmacol. 2019 Mar;102:30-33. doi: 10.1016/j.yrtph.2018.12.008. Epub 2018 Dec 20.

10.

Identification of B cell epitopes enhanced by protein unfolding and aggregation.

Eyes TJ, Austerberry JI, Dearman RJ, Johannissen LO, Kimber I, Smith N, Thistlethwaite A, Derrick JP.

Mol Immunol. 2019 Jan;105:181-189. doi: 10.1016/j.molimm.2018.11.020. Epub 2018 Dec 11.

11.

Skin sensitization: Uncertainties, challenges, and opportunities for improved risk assessment.

Gilmour N, Kimber I, Williams J, Maxwell G.

Contact Dermatitis. 2019 Mar;80(3):195-200. doi: 10.1111/cod.13167. Epub 2018 Dec 7.

12.

Are skin sensitisation test methods relevant for proteins?

Basketter DA, Kimber I.

Regul Toxicol Pharmacol. 2018 Nov;99:244-248. doi: 10.1016/j.yrtph.2018.09.028. Epub 2018 Sep 27. Review.

PMID:
30268830
13.

Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway.

Kimber I, Poole A, Basketter DA.

Toxicol Res (Camb). 2018 Jan 26;7(4):586-605. doi: 10.1039/c7tx00272f. eCollection 2018 Jul 1. Review.

14.

Keratinocytes derived from late-onset-psoriasis skin do not impair Langerhans cell migration.

Eaton LH, Dearman RJ, Kimber I, Griffiths CEM.

Br J Dermatol. 2018 Nov;179(5):1208-1209. doi: 10.1111/bjd.16896. Epub 2018 Sep 25. No abstract available.

PMID:
29923325
15.

Langerhans cells express human β-defensin 3: relevance for immunity during skin ageing.

Pilkington SM, Dearman RJ, Kimber I, Griffiths CEM.

Br J Dermatol. 2018 Nov;179(5):1170-1171. doi: 10.1111/bjd.16770. Epub 2018 Sep 12. No abstract available.

PMID:
29758092
16.

The future trajectory of adverse outcome pathways: a commentary.

Sewell F, Gellatly N, Beaumont M, Burden N, Currie R, de Haan L, Hutchinson TH, Jacobs M, Mahony C, Malcomber I, Mehta J, Whale G, Kimber I.

Arch Toxicol. 2018 Apr;92(4):1657-1661. doi: 10.1007/s00204-018-2183-2. Epub 2018 Mar 16.

17.

Skin sensitization quantitative risk assessment for occupational exposure of hairdressers to hair dye ingredients.

Goebel C, Diepgen TL, Blömeke B, Gaspari AA, Schnuch A, Fuchs A, Schlotmann K, Krasteva M, Kimber I.

Regul Toxicol Pharmacol. 2018 Jun;95:124-132. doi: 10.1016/j.yrtph.2018.03.006. Epub 2018 Mar 9.

PMID:
29530615
18.

Azodicarbonamide (ADCA): A reconsideration of classification as a respiratory sensitiser.

Arts J, Kimber I.

Regul Toxicol Pharmacol. 2018 Apr;94:332-333. doi: 10.1016/j.yrtph.2018.01.011. Epub 2018 Jan 17. No abstract available.

PMID:
29353066
19.

Impaired Langerhans cell migration in psoriasis is due to an altered keratinocyte phenotype induced by interleukin-17.

Eaton LH, Mellody KT, Pilkington SM, Dearman RJ, Kimber I, Griffiths CEM.

Br J Dermatol. 2018 Jun;178(6):1364-1372. doi: 10.1111/bjd.16172. Epub 2018 Mar 31.

PMID:
29194565
20.

Bisphenol A and immunotoxic potential: A commentary.

Kimber I.

Regul Toxicol Pharmacol. 2017 Nov;90:358-363. doi: 10.1016/j.yrtph.2017.08.022. Epub 2017 Sep 15. Review.

21.

Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin.

Pilkington SM, Ogden S, Eaton LH, Dearman RJ, Kimber I, Griffiths CEM.

Immunology. 2018 Jan;153(1):60-70. doi: 10.1111/imm.12810. Epub 2017 Aug 31.

22.

Lack of immunotoxic effects of repeated exposure to atrazine associated with the adaptation of adrenal gland activation.

Foradori CD, Zimmerman AD, Coder PS, Peachee VL, Handa RJ, Kimber I, Pruett SB, Breckenridge CB.

Regul Toxicol Pharmacol. 2017 Oct;89:200-214. doi: 10.1016/j.yrtph.2017.07.017. Epub 2017 Jul 20.

23.

Azodicarbonamide (ADCA): A reconsideration of classification as a respiratory sensitiser.

Arts J, Kimber I.

Regul Toxicol Pharmacol. 2017 Oct;89:268-278. doi: 10.1016/j.yrtph.2017.07.018. Epub 2017 Jul 20.

24.

Surrogate CD16-expressing effector cell lines for determining the bioactivity of therapeutic monoclonal antibodies.

Gurjar SA, Derrick JP, Dearman RJ, Thorpe R, Hufton S, Kimber I, Wadhwa M.

J Pharm Biomed Anal. 2017 Sep 5;143:188-198. doi: 10.1016/j.jpba.2017.06.004. Epub 2017 Jun 9.

25.

A primer on systematic reviews in toxicology.

Hoffmann S, de Vries RBM, Stephens ML, Beck NB, Dirven HAAM, Fowle JR 3rd, Goodman JE, Hartung T, Kimber I, Lalu MM, Thayer K, Whaley P, Wikoff D, Tsaioun K.

Arch Toxicol. 2017 Jul;91(7):2551-2575. doi: 10.1007/s00204-017-1980-3. Epub 2017 May 13. Review.

26.

Behaviour of chemical respiratory allergens in novel predictive methods for skin sensitisation.

Basketter D, Poole A, Kimber I.

Regul Toxicol Pharmacol. 2017 Jun;86:101-106. doi: 10.1016/j.yrtph.2017.03.002. Epub 2017 Mar 6.

27.

The T Cell Response to the Contact Sensitizer Paraphenylenediamine Is Characterized by a Polyclonal Diverse Repertoire of Antigen-Specific Receptors.

Oakes T, Popple AL, Williams J, Best K, Heather JM, Ismail M, Maxwell G, Gellatly N, Dearman RJ, Kimber I, Chain B.

Front Immunol. 2017 Feb 16;8:162. doi: 10.3389/fimmu.2017.00162. eCollection 2017.

28.

Quantitative risk assessment for skin sensitization: Success or failure?

Kimber I, Gerberick GF, Basketter DA.

Regul Toxicol Pharmacol. 2017 Feb;83:104-108. doi: 10.1016/j.yrtph.2016.11.020. Epub 2016 Nov 18. Review.

PMID:
27871868
29.

Influence of Escherichia coli chaperone DnaK on protein immunogenicity.

Ratanji KD, Derrick JP, Kimber I, Thorpe R, Wadhwa M, Dearman RJ.

Immunology. 2017 Mar;150(3):343-355. doi: 10.1111/imm.12689. Epub 2016 Dec 7.

30.

Data on the histological and immune cell response in the popliteal lymph node in mice following exposure to metal particles and ions.

Winans B, Tvermoes BE, Unice KM, Kovochich M, Fung ES, Christian WV, Donovan E, Finley BL, Kimber I, Paustenbach DJ.

Data Brief. 2016 Aug 27;9:388-97. doi: 10.1016/j.dib.2016.08.037. eCollection 2016 Dec.

31.

A preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay.

Tvermoes BE, Unice KM, Winans B, Kovochich M, Christian WV, Donovan E, Fung ES, Finley BL, Kimber I, Paustenbach DJ.

Toxicol Appl Pharmacol. 2016 Oct 1;308:77-90. doi: 10.1016/j.taap.2016.07.020. Epub 2016 Jul 28.

PMID:
27478144
32.

Developing a framework for assessing chemical respiratory sensitization: A workshop report.

North CM, Ezendam J, Hotchkiss JA, Maier C, Aoyama K, Enoch S, Goetz A, Graham C, Kimber I, Karjalainen A, Pauluhn J, Roggen EL, Selgrade M, Tarlo SM, Chen CL.

Regul Toxicol Pharmacol. 2016 Oct;80:295-309. doi: 10.1016/j.yrtph.2016.06.006. Epub 2016 Jul 7.

PMID:
27396307
33.

Editor's Highlight: Subvisible Aggregates of Immunogenic Proteins Promote a Th1-Type Response.

Ratanji KD, Dearman RJ, Kimber I, Thorpe R, Wadhwa M, Derrick JP.

Toxicol Sci. 2016 Oct;153(2):258-70. doi: 10.1093/toxsci/kfw121. Epub 2016 Jun 30.

34.

Current challenges facing the assessment of the allergenic capacity of food allergens in animal models.

Bøgh KL, van Bilsen J, Głogowski R, López-Expósito I, Bouchaud G, Blanchard C, Bodinier M, Smit J, Pieters R, Bastiaan-Net S, de Wit N, Untersmayr E, Adel-Patient K, Knippels L, Epstein MM, Noti M, Nygaard UC, Kimber I, Verhoeckx K, O'Mahony L.

Clin Transl Allergy. 2016 Jun 16;6:21. doi: 10.1186/s13601-016-0110-2. eCollection 2016. Review.

35.

Phthalic anhydride: Illustrating a conundrum in chemical allergy.

Basketter DA, Kimber I.

J Immunotoxicol. 2016 Nov;13(6):767-769. Epub 2016 May 26. Review.

PMID:
27230707
36.

T lymphocyte dynamics in methylisothiazolinone-allergic patients.

Popple A, Williams J, Maxwell G, Gellatly N, Dearman RJ, Kimber I.

Contact Dermatitis. 2016 Jul;75(1):1-13. doi: 10.1111/cod.12600. Epub 2016 May 3.

PMID:
27145152
37.

Interleukin-17 and interleukin-23 regulate Langerhans cell migration.

Eaton LH, Dearman RJ, Kimber I, Griffiths CE.

Br J Dermatol. 2016 Sep;175(3):622-4. doi: 10.1111/bjd.14541. Epub 2016 Jul 5. No abstract available.

PMID:
26972796
38.

Mannosylation Allows for Synergic (CD44/C-Type Lectin) Uptake of Hyaluronic Acid Nanoparticles in Dendritic Cells, but Only upon Correct Ligand Presentation.

Gennari A, Pelliccia M, Donno R, Kimber I, Tirelli N.

Adv Healthc Mater. 2016 Apr 20;5(8):966-76. doi: 10.1002/adhm.201500941. Epub 2016 Feb 10.

PMID:
26865006
39.

Oral exposure to mineral oils: Is there an association with immune perturbation and autoimmunity?

Kimber I, Carrillo JC.

Toxicology. 2016 Feb 17;344-346:19-25. doi: 10.1016/j.tox.2016.01.008. Epub 2016 Jan 25. Review.

PMID:
26821245
40.

Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.

Chapman VL, Terranova R, Moggs JG, Kimber I, Dearman RJ.

Toxicology. 2016 Jan 18;340:17-26. doi: 10.1016/j.tox.2015.12.003. Epub 2015 Dec 28.

PMID:
26732893
41.

Skin sensitization: Implications for integration of clinical data into hazard identification and risk assessment.

Basketter DA, White IR, McFadden JP, Kimber I.

Hum Exp Toxicol. 2015 Dec;34(12):1222-30. doi: 10.1177/0960327115601760. Review.

PMID:
26614809
42.

Setting Occupational Exposure Limits for Chemical Allergens--Understanding the Challenges.

Dotson GS, Maier A, Siegel PD, Anderson SE, Green BJ, Stefaniak AB, Codispoti CD, Kimber I.

J Occup Environ Hyg. 2015;12 Suppl 1:S82-98. doi: 10.1080/15459624.2015.1072277.

43.

Respiratory allergenic potential of plant-derived proteins: Understanding the relationship between exposure and potency for risk assessments.

Blackburn K, N'jai AU, Dearman RJ, Kimber I, Gerberick GF.

Crit Rev Toxicol. 2015;45(9):799-811. doi: 10.3109/10408444.2015.1067876. Epub 2015 Nov 13. Review.

PMID:
26565768
44.

Anti-hapten antibodies in response to skin sensitization.

Singleton H, Popple A, Gellatly N, Maxwell G, Williams J, Friedmann PS, Kimber I, Dearman RJ.

Contact Dermatitis. 2016 Apr;74(4):197-204. doi: 10.1111/cod.12486. Epub 2015 Nov 11. Review.

PMID:
26560413
45.

Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin.

Ainscough JS, Gerberick GF, Kimber I, Dearman RJ.

J Biol Chem. 2015 Dec 25;290(52):31151-61. doi: 10.1074/jbc.M115.680694. Epub 2015 Nov 11.

46.

A fresh look at T cells in psoriasis.

Eaton LH, Kimber I, Griffiths CE.

Br J Dermatol. 2015 Oct;173(4):891-2. doi: 10.1111/bjd.14099. No abstract available.

PMID:
26511827
47.

Fragrance sensitisers: Is inhalation an allergy risk?

Basketter D, Kimber I.

Regul Toxicol Pharmacol. 2015 Dec;73(3):897-902. doi: 10.1016/j.yrtph.2015.09.031. Epub 2015 Oct 6. Review.

PMID:
26433121
48.

The European Long-range Research Initiative (LRI): A decade of contributions to human health protection, exposure modelling and environmental integrity.

de Boer J, Fritsche E, Schoeters G, Kimber I.

Toxicology. 2015 Nov 4;337:83-90. doi: 10.1016/j.tox.2015.09.003. Epub 2015 Sep 24. Review.

PMID:
26388043
49.

A Review on the Potential Role of Basement Membrane Laminin in the Pathogenesis of Psoriasis.

McFadden JP, Kimber I.

Scand J Immunol. 2016 Jan;83(1):3-9. doi: 10.1111/sji.12384. Review.

50.

An in vitro human skin test for assessing sensitization potential.

Ahmed SS, Wang XN, Fielding M, Kerry A, Dickinson I, Munuswamy R, Kimber I, Dickinson AM.

J Appl Toxicol. 2016 May;36(5):669-84. doi: 10.1002/jat.3197. Epub 2015 Aug 7.

PMID:
26251951

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