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Items: 7

1.

Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.

Hambleton M, Hahn H, Pleger ST, Kuhn MC, Klevitsky R, Carr AN, Kimball TF, Hewett TE, Dorn GW 2nd, Koch WJ, Molkentin JD.

Circulation. 2006 Aug 8;114(6):574-82. Epub 2006 Jul 31.

2.

PKC-alpha regulates cardiac contractility and propensity toward heart failure.

Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD.

Nat Med. 2004 Mar;10(3):248-54. Epub 2004 Feb 15.

3.

Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.

Kaiser RA, Bueno OF, Lips DJ, Doevendans PA, Jones F, Kimball TF, Molkentin JD.

J Biol Chem. 2004 Apr 9;279(15):15524-30. Epub 2004 Jan 28.

4.

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling.

Braz JC, Bueno OF, Liang Q, Wilkins BJ, Dai YS, Parsons S, Braunwart J, Glascock BJ, Klevitsky R, Kimball TF, Hewett TE, Molkentin JD.

J Clin Invest. 2003 May;111(10):1475-86.

5.

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth.

Wilkins BJ, De Windt LJ, Bueno OF, Braz JC, Glascock BJ, Kimball TF, Molkentin JD.

Mol Cell Biol. 2002 Nov;22(21):7603-13.

6.

Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice.

Bueno OF, Wilkins BJ, Tymitz KM, Glascock BJ, Kimball TF, Lorenz JN, Molkentin JD.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4586-91. Epub 2002 Mar 19.

7.

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo.

De Windt LJ, Lim HW, Bueno OF, Liang Q, Delling U, Braz JC, Glascock BJ, Kimball TF, del Monte F, Hajjar RJ, Molkentin JD.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3322-7.

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