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Interactions of the super complexes: When mTORC1 meets the proteasome.

Adegoke OAJ, Beatty BE, Kimball SR, Wing SS.

Int J Biochem Cell Biol. 2019 Dec;117:105638. doi: 10.1016/j.biocel.2019.105638. Epub 2019 Oct 31. Review.


Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.

Buj R, Chen CW, Dahl ES, Leon KE, Kuskovsky R, Maglakelidze N, Navaratnarajah M, Zhang G, Doan MT, Jiang H, Zaleski M, Kutzler L, Lacko H, Lu Y, Mills GB, Gowda R, Robertson GP, Warrick JI, Herlyn M, Imamura Y, Kimball SR, DeGraff DJ, Snyder NW, Aird KM.

Cell Rep. 2019 Aug 20;28(8):1971-1980.e8. doi: 10.1016/j.celrep.2019.07.084.


Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.

Xu D, Shimkus KL, Lacko HA, Kutzler L, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E817-E828. doi: 10.1152/ajpendo.00522.2018. Epub 2019 Mar 5.


O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina.

Dierschke SK, Miller WP, Favate JS, Shah P, Imamura Kawasawa Y, Salzberg AC, Kimball SR, Jefferson LS, Dennis MD.

J Biol Chem. 2019 Apr 5;294(14):5508-5520. doi: 10.1074/jbc.RA119.007494. Epub 2019 Feb 7.


Palmitate- and C6 ceramide-induced Tnnt3 pre-mRNA alternative splicing occurs in a PP2A dependent manner.

Black AJ, Schilder RJ, Kimball SR.

Nutr Metab (Lond). 2018 Dec 17;15:87. doi: 10.1186/s12986-018-0326-3. eCollection 2018.


Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.

Shimkus KL, Jefferson LS, Gordon BS, Kimball SR.

Physiol Rep. 2018 Oct;6(20):e13891. doi: 10.14814/phy2.13891.


Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model.

El-Kadi SW, Boutry C, Suryawan A, Gazzaneo MC, Orellana RA, Srivastava N, Nguyen HV, Kimball SR, Fiorotto ML, Davis TA.

Am J Clin Nutr. 2018 Oct 1;108(4):830-841. doi: 10.1093/ajcn/nqy133.


Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol.

Kimball SR, Lang CH.

Annu Rev Nutr. 2018 Aug 21;38:197-217. doi: 10.1146/annurev-nutr-071816-064642.


Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.

Dai W, Miller WP, Toro AL, Black AJ, Dierschke SK, Feehan RP, Kimball SR, Dennis MD.

FASEB J. 2018 Jun 19:fj201800413RR. doi: 10.1096/fj.201800413RR. [Epub ahead of print]


A Unique ISR Program Determines Cellular Responses to Chronic Stress.

Guan BJ, van Hoef V, Jobava R, Elroy-Stein O, Valasek LS, Cargnello M, Gao XH, Krokowski D, Merrick WC, Kimball SR, Komar AA, Koromilas AE, Wynshaw-Boris A, Topisirovic I, Larsson O, Hatzoglou M.

Mol Cell. 2017 Dec 7;68(5):885-900.e6. doi: 10.1016/j.molcel.2017.11.007.


Leucine-Induced Upregulation of Terminal Oligopyrimidine mRNA Translation in Skeletal Muscle: Just the Tip of the Iceberg?

Kimball SR.

J Nutr. 2017 Sep;147(9):1603-1604. doi: 10.3945/jn.117.256289. Epub 2017 Aug 2. No abstract available.


Dietary Fat Quantity and Type Induce Transcriptome-Wide Effects on Alternative Splicing of Pre-mRNA in Rat Skeletal Muscle.

Black AJ, Ravi S, Jefferson LS, Kimball SR, Schilder RJ.

J Nutr. 2017 Sep;147(9):1648-1657. doi: 10.3945/jn.117.254482. Epub 2017 Aug 2.


Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice.

Pettit AP, Jonsson WO, Bargoud AR, Mirek ET, Peelor FF 3rd, Wang Y, Gettys TW, Kimball SR, Miller BF, Hamilton KL, Wek RC, Anthony TG.

J Nutr. 2017 Jun;147(6):1031-1040. doi: 10.3945/jn.116.246710. Epub 2017 Apr 26. Erratum in: J Nutr. 2017 Sep;147(9):1826.


Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum.

Black AJ, Gordon BS, Dennis MD, Jefferson LS, Kimball SR.

Biochem Biophys Rep. 2016 Dec;8:296-301. doi: 10.1016/j.bbrep.2016.10.003. Epub 2016 Oct 8.


Activation of the Stress Response Kinase JNK (c-Jun N-terminal Kinase) Attenuates Insulin Action in Retina through a p70S6K1-dependent Mechanism.

Miller WP, Ravi S, Martin TD, Kimball SR, Dennis MD.

J Biol Chem. 2017 Feb 3;292(5):1591-1602. doi: 10.1074/jbc.M116.760868. Epub 2016 Dec 13.


Loss of REDD1 augments the rate of the overload-induced increase in muscle mass.

Gordon BS, Liu C, Steiner JL, Nader GA, Jefferson LS, Kimball SR.

Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R545-57. doi: 10.1152/ajpregu.00159.2016. Epub 2016 Jul 27.


Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblasts.

Grainger DL, Kutzler L, Rannels SL, Kimball SR.

F1000Res. 2016 Mar 1;5:250. doi: 10.12688/f1000research.7691.1. eCollection 2016.


Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism.

Gordon BS, Steiner JL, Williamson DL, Lang CH, Kimball SR.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E157-74. doi: 10.1152/ajpendo.00059.2016. Epub 2016 May 17. Review.


Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.

Kimball SR, Gordon BS, Moyer JE, Dennis MD, Jefferson LS.

Cell Signal. 2016 Aug;28(8):896-906. doi: 10.1016/j.cellsig.2016.03.008. Epub 2016 Mar 21.


The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction.

Miller WP, Mihailescu ML, Yang C, Barber AJ, Kimball SR, Jefferson LS, Dennis MD.

Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1327-37. doi: 10.1167/iovs.15-18719.


Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs.

Boutry C, El-Kadi SW, Suryawan A, Steinhoff-Wagner J, Stoll B, Orellana RA, Nguyen HV, Kimball SR, Fiorotto ML, Davis TA.

Am J Physiol Endocrinol Metab. 2016 Apr 15;310(8):E699-E713. doi: 10.1152/ajpendo.00479.2015. Epub 2016 Feb 16.


Effects of age and hindlimb immobilization and remobilization on fast troponin T precursor mRNA alternative splicing in rat gastrocnemius muscle.

Ravi S, Schilder RJ, Berg AS, Kimball SR.

Appl Physiol Nutr Metab. 2016 Feb;41(2):142-9. doi: 10.1139/apnm-2015-0381. Epub 2015 Oct 16.


Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle.

Steiner JL, Crowell KT, Kimball SR, Lang CH.

Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E981-94. doi: 10.1152/ajpendo.00264.2015. Epub 2015 Oct 20.


Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.

Kimball SR, Ravi S, Gordon BS, Dennis MD, Jefferson LS.

J Nutr. 2015 Nov;145(11):2496-502. doi: 10.3945/jn.115.215491. Epub 2015 Sep 23.


Acute Alcohol-Induced Decrease in Muscle Protein Synthesis in Female Mice Is REDD-1 and mTOR-Independent.

Steiner JL, Kimball SR, Lang CH.

Alcohol Alcohol. 2016 May;51(3):242-50. doi: 10.1093/alcalc/agv105. Epub 2015 Sep 22.


Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover.

Lynch CJ, Kimball SR, Xu Y, Salzberg AC, Kawasawa YI.

Physiol Genomics. 2015 Nov;47(11):569-80. doi: 10.1152/physiolgenomics.00055.2015. Epub 2015 Sep 8.


Influence of ageing and essential amino acids on quantitative patterns of troponin T alternative splicing in human skeletal muscle.

Coble J, Schilder RJ, Berg A, Drummond MJ, Rasmussen BB, Kimball SR.

Appl Physiol Nutr Metab. 2015 Aug;40(8):788-796. doi: 10.1139/apnm-2014-0568. Epub 2015 Mar 23.


IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis.

So JS, Cho S, Min SH, Kimball SR, Lee AH.

Mol Cell Biol. 2015 Aug;35(16):2761-70. doi: 10.1128/MCB.00215-15. Epub 2015 Jun 1.


Role of precursor mRNA splicing in nutrient-induced alterations in gene expression and metabolism.

Ravi S, Schilder RJ, Kimball SR.

J Nutr. 2015 May;145(5):841-6. doi: 10.3945/jn.114.203216. Epub 2015 Mar 11. Review.


Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.

Gordon BS, Williamson DL, Lang CH, Jefferson LS, Kimball SR.

J Nutr. 2015 Apr;145(4):708-13. doi: 10.3945/jn.114.207621. Epub 2015 Feb 25.


Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents.

Dennis MD, Kimball SR, Fort PE, Jefferson LS.

J Biol Chem. 2015 Feb 6;290(6):3865-74. doi: 10.1074/jbc.M114.623058. Epub 2014 Dec 29.


REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization.

Kelleher AR, Pereira SL, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E122-9. doi: 10.1152/ajpendo.00341.2014. Epub 2014 Nov 18.


ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.

Wang L, Liu X, Nie J, Zhang J, Kimball SR, Zhang H, Zhang WJ, Jefferson LS, Cheng Z, Ji Q, Shi Y.

Hepatology. 2015 Feb;61(2):486-96. doi: 10.1002/hep.27420.


Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction.

Gordon BS, Steiner JL, Lang CH, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E703-11. doi: 10.1152/ajpendo.00250.2014. Epub 2014 Aug 26.


REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR.

Sci Signal. 2014 Jul 22;7(335):ra68. doi: 10.1126/scisignal.2005103. Erratum in: Sci Signal. 2015 Mar 17;8(368):er4.


Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.

Steiner JL, Pruznak AM, Deiter G, Navaratnarajah M, Kutzler L, Kimball SR, Lang CH.

PLoS One. 2014 Jun 19;9(6):e99582. doi: 10.1371/journal.pone.0099582. eCollection 2014.


Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.

Williamson DL, Li Z, Tuder RM, Feinstein E, Kimball SR, Dungan CM.

J Appl Physiol (1985). 2014 Aug 1;117(3):246-56. doi: 10.1152/japplphysiol.01350.2013. Epub 2014 May 29.


mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.

Martin TD, Dennis MD, Gordon BS, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1397-405. doi: 10.1152/ajpendo.00064.2014. Epub 2014 May 6.


Changes in REDD1, REDD2, and atrogene mRNA expression are prevented in skeletal muscle fixed in a stretched position during hindlimb immobilization.

Kelleher AR, Gordon BS, Kimball SR, Jefferson LS.

Physiol Rep. 2014 Feb 25;2(2):e00246. doi: 10.1002/phy2.246. eCollection 2014 Feb 1.


mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes.

Fort PE, Losiewicz MK, Pennathur S, Jefferson LS, Kimball SR, Abcouwer SF, Gardner TW.

Diabetes. 2014 Sep;63(9):3077-90. doi: 10.2337/db14-0235. Epub 2014 Apr 16.


Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.

Guan BJ, Krokowski D, Majumder M, Schmotzer CL, Kimball SR, Merrick WC, Koromilas AE, Hatzoglou M.

J Biol Chem. 2014 May 2;289(18):12593-611. doi: 10.1074/jbc.M113.543215. Epub 2014 Mar 19.


RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.


Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle.

Kimball SR.

Am J Clin Nutr. 2014 Jan;99(1):237S-242S. doi: 10.3945/ajcn.113.068387. Epub 2013 Nov 27. Review.


SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling.

Nie J, Liu X, Lilley BN, Zhang H, Pan YA, Kimball SR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X, Shi Y.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13857-62. doi: 10.1073/pnas.1307698110. Epub 2013 Aug 6.


Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs.

Boutry C, El-Kadi SW, Suryawan A, Wheatley SM, Orellana RA, Kimball SR, Nguyen HV, Davis TA.

Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E620-31. doi: 10.1152/ajpendo.00135.2013. Epub 2013 Jul 9.


Regulation of muscle protein synthesis and the effects of catabolic states.

Gordon BS, Kelleher AR, Kimball SR.

Int J Biochem Cell Biol. 2013 Oct;45(10):2147-57. doi: 10.1016/j.biocel.2013.05.039. Epub 2013 Jun 12. Review.


Viscera and muscle protein synthesis in neonatal pigs is increased more by intermittent bolus than by continuous feeding.

El-Kadi SW, Gazzaneo MC, Suryawan A, Orellana RA, Torrazza RM, Srivastava N, Kimball SR, Nguyen HV, Fiorotto ML, Davis TA.

Pediatr Res. 2013 Aug;74(2):154-62. doi: 10.1038/pr.2013.89. Epub 2013 Jun 4.


Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon.

Tuckow AP, Kazi AA, Kimball SR, Jefferson LS.

Biochem Biophys Res Commun. 2013 Jun 21;436(1):41-6. doi: 10.1016/j.bbrc.2013.05.053. Epub 2013 May 21.


A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.

Krokowski D, Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Bröer S, Arvan P, Tchórzewski M, Snider MD, Puchowicz M, Croniger CM, Kimball SR, Pan T, Koromilas AE, Kaufman RJ, Hatzoglou M.

J Biol Chem. 2013 Jun 14;288(24):17202-13. doi: 10.1074/jbc.M113.466920. Epub 2013 May 3.

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