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Development of Zinc Chelating Resin Polymer Beads for the Removal of Cell-Free Hemoglobin.

Simms K, Rebholz E, Mayberry RM, Basu S, Perlegas A, Guthold M, Kim-Shapiro DB, Rahbar E.

Ann Biomed Eng. 2019 Jun;47(6):1470-1478. doi: 10.1007/s10439-019-02249-6. Epub 2019 Mar 27.


Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.

Sun CW, Yang J, Kleschyov AL, Zhuge Z, Carlström M, Pernow J, Wajih N, Isbell TS, Oh JY, Cabrales P, Tsai AG, Townes T, Kim-Shapiro DB, Patel RP, Lundberg JO.

Circulation. 2019 Jun 4;139(23):2654-2663. doi: 10.1161/CIRCULATIONAHA.118.039284. Epub 2019 Mar 25.


Effects of acute dietary nitrate supplementation on aortic blood pressures and pulse wave characteristics in post-menopausal women.

Kim DJ, Roe CA, Somani YB, Moore DJ, Barrett MA, Flanagan M, Kim-Shapiro DB, Basu S, Muller MD, Proctor DN.

Nitric Oxide. 2019 Apr 1;85:10-16. doi: 10.1016/j.niox.2019.01.008. Epub 2019 Jan 19.


Erythrocytic bioactivation of nitrite and its potentiation by far-red light.

Wajih N, Basu S, Ucer KB, Rigal F, Shakya A, Rahbar E, Vachharajani V, Guthold M, Gladwin MT, Smith LM, Kim-Shapiro DB.

Redox Biol. 2019 Jan;20:442-450. doi: 10.1016/j.redox.2018.11.001. Epub 2018 Nov 3.


Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival.

Blaine KP, Cortés-Puch I, Sun J, Wang D, Solomon SB, Feng J, Gladwin MT, Kim-Shapiro DB, Basu S, Perlegas A, West K, Klein HG, Natanson C.

Transfusion. 2019 Jan;59(1):347-358. doi: 10.1111/trf.14997. Epub 2018 Nov 1.


Haptoglobin improves shock, lung injury, and survival in canine pneumonia.

Remy KE, Cortés-Puch I, Solomon SB, Sun J, Pockros BM, Feng J, Lertora JJ, Hantgan RR, Liu X, Perlegas A, Warren HS, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C.

JCI Insight. 2018 Sep 20;3(18). pii: 123013. doi: 10.1172/jci.insight.123013. eCollection 2018 Sep 20.


Nitrite and nitrate chemical biology and signalling.

DeMartino AW, Kim-Shapiro DB, Patel RP, Gladwin MT.

Br J Pharmacol. 2019 Jan;176(2):228-245. doi: 10.1111/bph.14484. Epub 2018 Oct 3. Review.


Nitric oxide pathology and therapeutics in sickle cell disease.

Kim-Shapiro DB, Gladwin MT.

Clin Hemorheol Microcirc. 2018;68(2-3):223-237. doi: 10.3233/CH-189009.


Erythrocytes and Vascular Function: Oxygen and Nitric Oxide.

Helms CC, Gladwin MT, Kim-Shapiro DB.

Front Physiol. 2018 Feb 22;9:125. doi: 10.3389/fphys.2018.00125. eCollection 2018. Review.


Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT.

Hypertension. 2017 Sep;70(3):634-644. doi: 10.1161/HYPERTENSIONAHA.117.09016.


Parenteral irons versus transfused red blood cells for treatment of anemia during canine experimental bacterial pneumonia.

Suffredini DA, Xu W, Sun J, Barea-Mendoza J, Solomon SB, Brashears SL, Perlegas A, Kim-Shapiro DB, Klein HG, Natanson C, Cortés-Puch I.

Transfusion. 2017 Oct;57(10):2338-2347. doi: 10.1111/trf.14214. Epub 2017 Jun 27.


Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.

Shaltout HA, Eggebeen J, Marsh AP, Brubaker PH, Laurienti PJ, Burdette JH, Basu S, Morgan A, Dos Santos PC, Norris JL, Morgan TM, Miller GD, Rejeski WJ, Hawfield AT, Diz DI, Becton JT, Kim-Shapiro DB, Kitzman DW.

Nitric Oxide. 2017 Sep 30;69:78-90. doi: 10.1016/j.niox.2017.05.005. Epub 2017 May 23.


Potential therapeutic action of nitrite in sickle cell disease.

Wajih N, Basu S, Jailwala A, Kim HW, Ostrowski D, Perlegas A, Bolden CA, Buechler NL, Gladwin MT, Caudell DL, Rahbar E, Alexander-Miller MA, Vachharajani V, Kim-Shapiro DB.

Redox Biol. 2017 Aug;12:1026-1039. doi: 10.1016/j.redox.2017.05.006. Epub 2017 May 10.


Stored blood: how old is too old?

Lee JS, Kim-Shapiro DB.

J Clin Invest. 2017 Jan 3;127(1):100-102. doi: 10.1172/JCI91309. Epub 2016 Dec 12.


Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.

Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT.

Sci Transl Med. 2016 Dec 7;8(368):368ra173.


Reactions between nitrosopersulfide and heme proteins.

Bolden C, King SB, Kim-Shapiro DB.

Free Radic Biol Med. 2016 Oct;99:418-425. doi: 10.1016/j.freeradbiomed.2016.09.005. Epub 2016 Sep 5.


Exposure of fibrinogen and thrombin to nitric oxide donor ProliNONOate affects fibrin clot properties.

Helms CC, Kapadia S, Gilmore AC, Lu Z, Basu S, Kim-Shapiro DB.

Blood Coagul Fibrinolysis. 2017 Jul;28(5):356-364. doi: 10.1097/MBC.0000000000000602.


Recent insights into nitrite signaling processes in blood.

Helms CC, Liu X, Kim-Shapiro DB.

Biol Chem. 2017 Mar;398(3):319-329. doi: 10.1515/hsz-2016-0263.


Rainbow of hemolysis associated with acquired thrombotic thrombocytopenic purpura.

Raval JS, Mazepa MA, Kim-Shapiro DB, Basu S, Kasthuri RS, Whinna HC, Park YA.

J Clin Apher. 2017 Aug;32(4):274-275. doi: 10.1002/jca.21487. Epub 2016 Aug 17. No abstract available.


Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice.

Osei-Hwedieh DO, Kanias T, Croix CS, Jessup M, Xiong Z, Sinchar D, Franks J, Xu Q, M Novelli E, Sertorio JT, Potoka K, Binder RJ, Basu S, Belanger AM, Kim-Shapiro DB, Triulzi D, Lee JS, Gladwin MT.

EBioMedicine. 2016 Sep;11:239-248. doi: 10.1016/j.ebiom.2016.08.006. Epub 2016 Aug 4.


Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells.

Corti P, Xue J, Tejero J, Wajih N, Sun M, Stolz DB, Tsang M, Kim-Shapiro DB, Gladwin MT.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8538-43. doi: 10.1073/pnas.1522670113. Epub 2016 Jul 12.


Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop.

Ahluwalia A, Gladwin M, Coleman GD, Hord N, Howard G, Kim-Shapiro DB, Lajous M, Larsen FJ, Lefer DJ, McClure LA, Nolan BT, Pluta R, Schechter A, Wang CY, Ward MH, Harman JL.

J Am Heart Assoc. 2016 Jul 6;5(7). pii: e003402. doi: 10.1161/JAHA.116.003402. No abstract available.


Compartmentalization Is Key in Limiting Nitric Oxide Scavenging by Cell-Free Hemoglobin.

Kim-Shapiro DB, Patel RP.

Am J Respir Crit Care Med. 2016 May 15;193(10):1072-4. doi: 10.1164/rccm.201512-2481ED. No abstract available.


The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose.

Wajih N, Liu X, Shetty P, Basu S, Wu H, Hogg N, Patel RP, Furdui CM, Kim-Shapiro DB.

Redox Biol. 2016 Aug;8:415-21. doi: 10.1016/j.redox.2016.04.004. Epub 2016 Apr 30.


One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction.

Eggebeen J, Kim-Shapiro DB, Haykowsky M, Morgan TM, Basu S, Brubaker P, Rejeski J, Kitzman DW.

JACC Heart Fail. 2016 Jun;4(6):428-37. doi: 10.1016/j.jchf.2015.12.013. Epub 2016 Feb 10.


Detecting and monitoring NO, SNO and nitrite in vivo.

Bellavia L, Kim-Shapiro DB, King SB.

Future Sci OA. 2015;1(1). pii: FSO36.


Beet Root Juice: An Ergogenic Aid for Exercise and the Aging Brain.

Petrie M, Rejeski WJ, Basu S, Laurienti PJ, Marsh AP, Norris JL, Kim-Shapiro DB, Burdette JH.

J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1284-1289. doi: 10.1093/gerona/glw219.


In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome.

Cortés-Puch I, Remy KE, Solomon SB, Sun J, Wang D, Al-Hamad M, Kelly SM, Sinchar D, Bellavia L, Kanias T, Popovsky MA, Kim-Shapiro DB, Klein HG, Natanson C.

Transfusion. 2015 Nov;55(11):2564-75. doi: 10.1111/trf.13275. Epub 2015 Sep 7.


Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function.

Risbano MG, Kanias T, Triulzi D, Donadee C, Barge S, Badlam J, Jain S, Belanger AM, Kim-Shapiro DB, Gladwin MT.

Am J Respir Crit Care Med. 2015 Nov 15;192(10):1223-33. doi: 10.1164/rccm.201501-0145OC.


Transfused older stored red blood cells improve the clinical course and outcome in a canine lethal hemorrhage and reperfusion model.

Solomon SB, Cortés-Puch I, Sun J, Remy KE, Wang D, Feng J, Khan SS, Sinchar D, Kim-Shapiro DB, Klein HG, Natanson C.

Transfusion. 2015 Nov;55(11):2552-63. doi: 10.1111/trf.13213. Epub 2015 Jul 15.


Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients.

Dahan I, Farber E, Thauho N, Nakhoul N, Francis A, Awawde M, Levy AP, Kim-Shapiro DB, Basu S, Nakhoul F.

J Diabetes Res. 2015;2015:613860. doi: 10.1155/2015/613860. Epub 2015 Jun 11.


Effects of nitric oxide and its congeners on sickle red blood cell deformability.

Belanger AM, Keggi C, Kanias T, Gladwin MT, Kim-Shapiro DB.

Transfusion. 2015 Oct;55(10):2464-72. doi: 10.1111/trf.13134. Epub 2015 Apr 23.


The relationship between plasma and salivary NOx.

Clodfelter WH, Basu S, Bolden C, Dos Santos PC, King SB, Kim-Shapiro DB.

Nitric Oxide. 2015 May 1;47:85-90. doi: 10.1016/j.niox.2015.04.003. Epub 2015 Apr 21.


Acute dietary nitrate supplementation does not augment submaximal forearm exercise hyperemia in healthy young men.

Kim JK, Moore DJ, Maurer DG, Kim-Shapiro DB, Basu S, Flanagan MP, Skulas-Ray AC, Kris-Etherton P, Proctor DN.

Appl Physiol Nutr Metab. 2015 Feb;40(2):122-8. doi: 10.1139/apnm-2014-0228. Epub 2014 Oct 15.


Mechanisms of human erythrocytic bioactivation of nitrite.

Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, Kim-Shapiro DB.

J Biol Chem. 2015 Jan 9;290(2):1281-94. doi: 10.1074/jbc.M114.609222. Epub 2014 Dec 3.


Loving-kindness meditation's effects on nitric oxide and perceived well-being: a pilot study in experienced and inexperienced meditators.

Kemper KJ, Powell D, Helms CC, Kim-Shapiro DB.

Explore (NY). 2015 Jan-Feb;11(1):32-9. doi: 10.1016/j.explore.2014.10.002. Epub 2014 Oct 23.


Pitfalls in measuring NO bioavailability using NOx.

Kim-Shapiro DB, Gladwin MT.

Nitric Oxide. 2015 Jan 30;44:1-2. doi: 10.1016/j.niox.2014.10.003. Epub 2014 Oct 22. No abstract available.


Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia.

Wang D, Cortés-Puch I, Sun J, Solomon SB, Kanias T, Remy KE, Feng J, Alimchandani M, Quezado M, Helms C, Perlegas A, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C.

Transfusion. 2014 Jul;54(7):1712-24. doi: 10.1111/trf.12607. Epub 2014 Mar 3.


Mechanism of faster NO scavenging by older stored red blood cells.

Liu C, Liu X, Janes J, Stapley R, Patel RP, Gladwin MT, Kim-Shapiro DB.

Redox Biol. 2014 Jan 10;2:211-9. doi: 10.1016/j.redox.2013.12.014. eCollection 2014.


Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia.

Cortés-Puch I, Wang D, Sun J, Solomon SB, Remy KE, Fernandez M, Feng J, Kanias T, Bellavia L, Sinchar D, Perlegas A, Solomon MA, Kelley WE, Popovsky MA, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C.

Blood. 2014 Feb 27;123(9):1403-11. doi: 10.1182/blood-2013-11-539353. Epub 2013 Dec 23.


Mechanisms of nitrite bioactivation.

Kim-Shapiro DB, Gladwin MT.

Nitric Oxide. 2014 Apr 30;38:58-68. doi: 10.1016/j.niox.2013.11.002. Epub 2013 Dec 6. Review.


Mechanisms of hemolysis-associated platelet activation.

Helms CC, Marvel M, Zhao W, Stahle M, Vest R, Kato GJ, Lee JS, Christ G, Gladwin MT, Hantgan RR, Kim-Shapiro DB.

J Thromb Haemost. 2013 Dec;11(12):2148-54. doi: 10.1111/jth.12422.


Nitric oxide scavenging by red cell microparticles.

Liu C, Zhao W, Christ GJ, Gladwin MT, Kim-Shapiro DB.

Free Radic Biol Med. 2013 Dec;65:1164-1173. doi: 10.1016/j.freeradbiomed.2013.09.002. Epub 2013 Sep 16.


Direct and nitroxyl (HNO)-mediated reactions of acyloxy nitroso compounds with the thiol-containing proteins glyceraldehyde 3-phosphate dehydrogenase and alkyl hydroperoxide reductase subunit C.

Mitroka S, Shoman ME, DuMond JF, Bellavia L, Aly OM, Abdel-Aziz M, Kim-Shapiro DB, King SB.

J Med Chem. 2013 Sep 12;56(17):6583-92. doi: 10.1021/jm400057r. Epub 2013 Aug 26.


Magnetic and electric fields induce directional responses in Steinernema carpocapsae.

Ilan T, Kim-Shapiro DB, Bock CH, Shapiro-Ilan DI.

Int J Parasitol. 2013 Sep;43(10):781-4. doi: 10.1016/j.ijpara.2013.05.007. Epub 2013 Jun 20.


Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction.

Raat NJ, Tabima DM, Specht PA, Tejero J, Champion HC, Kim-Shapiro DB, Baust J, Mik EG, Hildesheim M, Stasch JP, Becker EM, Truebel H, Gladwin MT.

Antioxid Redox Signal. 2013 Dec 20;19(18):2232-43. doi: 10.1089/ars.2013.5181. Epub 2013 Jul 9.


Hemoglobin-mediated nitric oxide signaling.

Helms C, Kim-Shapiro DB.

Free Radic Biol Med. 2013 Aug;61:464-72. doi: 10.1016/j.freeradbiomed.2013.04.028. Epub 2013 Apr 26. Review.


Nitroxyl accelerates the oxidation of oxyhemoglobin by nitrite.

Bellavia L, DuMond JF, Perlegas A, Bruce King S, Kim-Shapiro DB.

Nitric Oxide. 2013 May 31;31:38-47. doi: 10.1016/j.niox.2013.03.006. Epub 2013 Mar 30.


In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines.

Wang D, Piknova B, Solomon SB, Cortes-Puch I, Kern SJ, Sun J, Kanias T, Gladwin MT, Helms C, Kim-Shapiro DB, Schechter AN, Natanson C.

Transfusion. 2013 Dec;53(12):3149-63. doi: 10.1111/trf.12162. Epub 2013 Mar 14.


Estrogen therapy, independent of timing, improves cardiac structure and function in oophorectomized mRen2.Lewis rats.

Jessup JA, Wang H, MacNamara LM, Presley TD, Kim-Shapiro DB, Zhang L, Chen AF, Groban L.

Menopause. 2013 Aug;20(8):860-8. doi: 10.1097/GME.0b013e318280589a.

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