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Items: 1 to 50 of 109


Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy.

Kim JK, Cho J, Kim SH, Kang HC, Kim DS, Kim VN, Lee JH.

J Clin Invest. 2019 Oct 1;129(10):4207-4223. doi: 10.1172/JCI127032.


Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development.

Kang D, Shin J, Cho Y, Kim HS, Gu YR, Kim H, You KT, Chang MJ, Chang CB, Kang SB, Kim JS, Kim VN, Kim JH.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaar6659. doi: 10.1126/scitranslmed.aar6659.


Deuterium-Free, Three-Plexed Peptide Diethylation for Highly Accurate Quantitative Proteomics.

Jung J, Jeong K, Choi Y, Kim SA, Kim H, Lee JW, Kim VN, Kim KP, Kim JS.

J Proteome Res. 2019 Mar 1;18(3):1078-1087. doi: 10.1021/acs.jproteome.8b00775. Epub 2019 Jan 29.


Bias-minimized quantification of microRNA reveals widespread alternative processing and 3' end modification.

Kim H, Kim J, Kim K, Chang H, You K, Kim VN.

Nucleic Acids Res. 2019 Mar 18;47(5):2630-2640. doi: 10.1093/nar/gky1293.


Molecular Basis for the Single-Nucleotide Precision of Primary microRNA Processing.

Kwon SC, Baek SC, Choi YG, Yang J, Lee YS, Woo JS, Kim VN.

Mol Cell. 2019 Feb 7;73(3):505-518.e5. doi: 10.1016/j.molcel.2018.11.005. Epub 2018 Dec 13.


U-tail as a guardian against invading RNAs.

Yeo J, Kim VN.

Nat Struct Mol Biol. 2018 Oct;25(10):903-905. doi: 10.1038/s41594-018-0139-0. No abstract available.


PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs.

Kim Y, Park J, Kim S, Kim M, Kang MG, Kwak C, Kang M, Kim B, Rhee HW, Kim VN.

Mol Cell. 2018 Sep 20;71(6):1051-1063.e6. doi: 10.1016/j.molcel.2018.07.029. Epub 2018 Aug 30.


Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation.

Lim J, Kim D, Lee YS, Ha M, Lee M, Yeo J, Chang H, Song J, Ahn K, Kim VN.

Science. 2018 Aug 17;361(6403):701-704. doi: 10.1126/science.aam5794. Epub 2018 Jul 19.


PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay.

Yi H, Park J, Ha M, Lim J, Chang H, Kim VN.

Mol Cell. 2018 Jun 21;70(6):1081-1088.e5. doi: 10.1016/j.molcel.2018.05.009.


fCLIP-seq for transcriptomic footprinting of dsRNA-binding proteins: Lessons from DROSHA.

Kim B, Kim VN.

Methods. 2019 Jan 1;152:3-11. doi: 10.1016/j.ymeth.2018.06.004. Epub 2018 Jun 12.


Microprocessor depends on hemin to recognize the apical loop of primary microRNA.

Nguyen TA, Park J, Dang TL, Choi YG, Kim VN.

Nucleic Acids Res. 2018 Jun 20;46(11):5726-5736. doi: 10.1093/nar/gky248.


PARN and TOE1 Constitute a 3' End Maturation Module for Nuclear Non-coding RNAs.

Son A, Park JE, Kim VN.

Cell Rep. 2018 Apr 17;23(3):888-898. doi: 10.1016/j.celrep.2018.03.089.


Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos.

Chang H, Yeo J, Kim JG, Kim H, Lim J, Lee M, Kim HH, Ohk J, Jeon HY, Lee H, Jung H, Kim KW, Kim VN.

Mol Cell. 2018 Apr 5;70(1):72-82.e7. doi: 10.1016/j.molcel.2018.03.004.


RNA-targeting CRISPR comes of age.

Kim VN.

Nat Biotechnol. 2018 Jan 10;36(1):44-45. doi: 10.1038/nbt.4054. No abstract available.


Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates.

Kim B, Jeong K, Kim VN.

Mol Cell. 2017 Apr 20;66(2):258-269.e5. doi: 10.1016/j.molcel.2017.03.013.


MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis.

Choi J, Kim YK, Park K, Nah J, Yoon SS, Kim DW, Kim VN, Seong RH.

Blood. 2016 Oct 27;128(17):2117-2129. Epub 2016 Sep 7.


mTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development.

Lim J, Lee M, Son A, Chang H, Kim VN.

Genes Dev. 2016 Jul 15;30(14):1671-82. doi: 10.1101/gad.284802.116. Epub 2016 Jul 21.


Gastric Carcinogenesis in the miR-222/221 Transgenic Mouse Model.

Choi B, Yu J, Han TS, Kim YK, Hur K, Kang BC, Kim WH, Kim DY, Lee HJ, Kim VN, Yang HK.

Cancer Res Treat. 2017 Jan;49(1):150-160. doi: 10.4143/crt.2015.462. Epub 2016 Jun 23.


Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle.

Park JE, Yi H, Kim Y, Chang H, Kim VN.

Mol Cell. 2016 May 5;62(3):462-471. doi: 10.1016/j.molcel.2016.04.007.


Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.

Kim YK, Kim B, Kim VN.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1881-9. doi: 10.1073/pnas.1602532113. Epub 2016 Mar 14.


Structure of Human DROSHA.

Kwon SC, Nguyen TA, Choi YG, Jo MH, Hohng S, Kim VN, Woo JS.

Cell. 2016 Jan 14;164(1-2):81-90. doi: 10.1016/j.cell.2015.12.019. Epub 2015 Dec 31.


Role of the small subunit processome in the maintenance of pluripotent stem cells.

You KT, Park J, Kim VN.

Genes Dev. 2015 Oct 1;29(19):2004-9. doi: 10.1101/gad.267112.115.


Multiple repressive mechanisms in the hippocampus during memory formation.

Cho J, Yu NK, Choi JH, Sim SE, Kang SJ, Kwak C, Lee SW, Kim JI, Choi DI, Kim VN, Kaang BK.

Science. 2015 Oct 2;350(6256):82-7. doi: 10.1126/science.aac7368.


Next-generation libraries for robust RNA interference-based genome-wide screens.

Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3384-91. doi: 10.1073/pnas.1508821112. Epub 2015 Jun 15.


Temporal Landscape of MicroRNA-Mediated Host-Virus Crosstalk during Productive Human Cytomegalovirus Infection.

Kim S, Seo D, Kim D, Hong Y, Chang H, Baek D, Kim VN, Lee S, Ahn K.

Cell Host Microbe. 2015 Jun 10;17(6):838-51. doi: 10.1016/j.chom.2015.05.014.


Functional Anatomy of the Human Microprocessor.

Nguyen TA, Jo MH, Choi YG, Park J, Kwon SC, Hohng S, Kim VN, Woo JS.

Cell. 2015 Jun 4;161(6):1374-87. doi: 10.1016/j.cell.2015.05.010. Epub 2015 May 28.


TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.

Kim B, Ha M, Loeff L, Chang H, Simanshu DK, Li S, Fareh M, Patel DJ, Joo C, Kim VN.

EMBO J. 2015 Jul 2;34(13):1801-15. doi: 10.15252/embj.201590931. Epub 2015 May 15.


Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells.

Boo K, Bhin J, Jeon Y, Kim J, Shin HJ, Park JE, Kim K, Kim CR, Jang H, Kim IH, Kim VN, Hwang D, Lee H, Baek SH.

Nat Commun. 2015 Apr 10;6:6810. doi: 10.1038/ncomms7810.


Uridylation by TUT4 and TUT7 marks mRNA for degradation.

Lim J, Ha M, Chang H, Kwon SC, Simanshu DK, Patel DJ, Kim VN.

Cell. 2014 Dec 4;159(6):1365-76. doi: 10.1016/j.cell.2014.10.055.


Adenylation of maternally inherited microRNAs by Wispy.

Lee M, Choi Y, Kim K, Jin H, Lim J, Nguyen TA, Yang J, Jeong M, Giraldez AJ, Yang H, Patel DJ, Kim VN.

Mol Cell. 2014 Dec 4;56(5):696-707. doi: 10.1016/j.molcel.2014.10.011. Epub 2014 Nov 13.


Deletion of human tarbp2 reveals cellular microRNA targets and cell-cycle function of TRBP.

Kim Y, Yeo J, Lee JH, Cho J, Seo D, Kim JS, Kim VN.

Cell Rep. 2014 Nov 6;9(3):1061-74. doi: 10.1016/j.celrep.2014.09.039. Epub 2014 Oct 23.


miRseqViewer: multi-panel visualization of sequence, structure and expression for analysis of microRNA sequencing data.

Jang I, Chang H, Jun Y, Park S, Yang JO, Lee B, Kim W, Kim VN, Lee S.

Bioinformatics. 2015 Feb 15;31(4):596-8. doi: 10.1093/bioinformatics/btu676. Epub 2014 Oct 15.


Emerging roles of RNA modification: m(6)A and U-tail.

Lee M, Kim B, Kim VN.

Cell. 2014 Aug 28;158(5):980-987. doi: 10.1016/j.cell.2014.08.005. Review.


Regulation of microRNA biogenesis.

Ha M, Kim VN.

Nat Rev Mol Cell Biol. 2014 Aug;15(8):509-24. doi: 10.1038/nrm3838. Epub 2014 Jul 16. Review.


PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator.

Kim Y, Lee JH, Park JE, Cho J, Yi H, Kim VN.

Genes Dev. 2014 Jun 15;28(12):1310-22. doi: 10.1101/gad.242644.114.


MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1.

Han TS, Hur K, Xu G, Choi B, Okugawa Y, Toiyama Y, Oshima H, Oshima M, Lee HJ, Kim VN, Chang AN, Goel A, Yang HK.

Gut. 2015 Feb;64(2):203-14. doi: 10.1136/gutjnl-2013-306640. Epub 2014 May 28.


MeCP2 caught moonlighting as a suppressor of MicroRNA processing.

Woo JS, Kim VN.

Dev Cell. 2014 Mar 10;28(5):477-8. doi: 10.1016/j.devcel.2014.02.015.


TAIL-seq: genome-wide determination of poly(A) tail length and 3' end modifications.

Chang H, Lim J, Ha M, Kim VN.

Mol Cell. 2014 Mar 20;53(6):1044-52. doi: 10.1016/j.molcel.2014.02.007. Epub 2014 Feb 27.


A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer.

Tian Y, Simanshu DK, Ma JB, Park JE, Heo I, Kim VN, Patel DJ.

Mol Cell. 2014 Feb 20;53(4):606-16. doi: 10.1016/j.molcel.2014.01.003. Epub 2014 Jan 30.


TALEN-based knockout library for human microRNAs.

Kim YK, Wee G, Park J, Kim J, Baek D, Kim JS, Kim VN.

Nat Struct Mol Biol. 2013 Dec;20(12):1458-64. doi: 10.1038/nsmb.2701. Epub 2013 Nov 10.


The RNA-binding protein repertoire of embryonic stem cells.

Kwon SC, Yi H, Eichelbaum K, Föhr S, Fischer B, You KT, Castello A, Krijgsveld J, Hentze MW, Kim VN.

Nat Struct Mol Biol. 2013 Sep;20(9):1122-30. doi: 10.1038/nsmb.2638. Epub 2013 Aug 4.


Quantitative and multiplexed microRNA sensing in living cells based on peptide nucleic acid and nano graphene oxide (PANGO).

Ryoo SR, Lee J, Yeo J, Na HK, Kim YK, Jang H, Lee JH, Han SW, Lee Y, Kim VN, Min DH.

ACS Nano. 2013 Jul 23;7(7):5882-91. doi: 10.1021/nn401183s. Epub 2013 Jun 19.


Bringing single-molecule spectroscopy to macromolecular protein complexes.

Joo C, Fareh M, Kim VN.

Trends Biochem Sci. 2013 Jan;38(1):30-7. doi: 10.1016/j.tibs.2012.10.005. Epub 2012 Nov 28. Review.


MiRGator v3.0: a microRNA portal for deep sequencing, expression profiling and mRNA targeting.

Cho S, Jang I, Jun Y, Yoon S, Ko M, Kwon Y, Choi I, Chang H, Ryu D, Lee B, Kim VN, Kim W, Lee S.

Nucleic Acids Res. 2013 Jan;41(Database issue):D252-7. doi: 10.1093/nar/gks1168. Epub 2012 Nov 27.


LIN28A is a suppressor of ER-associated translation in embryonic stem cells.

Cho J, Chang H, Kwon SC, Kim B, Kim Y, Choe J, Ha M, Kim YK, Kim VN.

Cell. 2012 Nov 9;151(4):765-777. doi: 10.1016/j.cell.2012.10.019. Epub 2012 Oct 25.


Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.

Heo I, Ha M, Lim J, Yoon MJ, Park JE, Kwon SC, Chang H, Kim VN.

Cell. 2012 Oct 26;151(3):521-32. doi: 10.1016/j.cell.2012.09.022. Epub 2012 Oct 11.


The co-regulation mechanism of transcription factors in the human gene regulatory network.

Kim J, Choi M, Kim JR, Jin H, Kim VN, Cho KH.

Nucleic Acids Res. 2012 Oct;40(18):8849-61. doi: 10.1093/nar/gks664. Epub 2012 Jul 13.


Conserved microRNA miR-8 controls body size in response to steroid signaling in Drosophila.

Jin H, Kim VN, Hyun S.

Genes Dev. 2012 Jul 1;26(13):1427-32. doi: 10.1101/gad.192872.112.


Short structured RNAs with low GC content are selectively lost during extraction from a small number of cells.

Kim YK, Yeo J, Kim B, Ha M, Kim VN.

Mol Cell. 2012 Jun 29;46(6):893-5. doi: 10.1016/j.molcel.2012.05.036. No abstract available.

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