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Items: 41

1.
2.

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages.

Belchamber KBR, Singh R, Batista CM, Whyte MK, Dockrell DH, Kilty I, Robinson MJ, Wedzicha JA, Barnes PJ, Donnelly LE; COPD-MAP consortium.

Eur Respir J. 2019 Oct 10;54(4). pii: 1802244. doi: 10.1183/13993003.02244-2018. Print 2019 Oct.

PMID:
31320451
3.

PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.

Xu H, Jesson MI, Seneviratne UI, Lin TH, Sharif MN, Xue L, Nguyen C, Everley RA, Trujillo JI, Johnson DS, Point GR, Thorarensen A, Kilty I, Telliez JB.

ACS Chem Biol. 2019 Jun 21;14(6):1235-1242. doi: 10.1021/acschembio.9b00188. Epub 2019 May 22.

PMID:
31082193
4.

The role of phosphodiesterase 4 in the pathophysiology of atopic dermatitis and the perspective for its inhibition.

Guttman-Yassky E, Hanifin JM, Boguniewicz M, Wollenberg A, Bissonnette R, Purohit V, Kilty I, Tallman AM, Zielinski MA.

Exp Dermatol. 2019 Jan;28(1):3-10. doi: 10.1111/exd.13808. Epub 2018 Dec 12. Review.

PMID:
30332502
5.

Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function.

Adewoye AB, Shrine N, Odenthal-Hesse L, Welsh S, Malarstig A, Jelinsky S, Kilty I, Tobin MD, Hollox EJ, Wain LV.

Wellcome Open Res. 2018 Feb 21;3:13. doi: 10.12688/wellcomeopenres.13902.2. eCollection 2018.

6.

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC.

7.

Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid.

Rimington TL, Hodge E, Billington CK, Bhaker S, K C B, Kilty I, Jelinsky S, Hall IP, Sayers I.

F1000Res. 2017 Apr 11;6:460. doi: 10.12688/f1000research.10961.1. eCollection 2017.

8.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

Lee KL, Ambler CM, Anderson DR, Boscoe BP, Bree AG, Brodfuehrer JI, Chang JS, Choi C, Chung S, Curran KJ, Day JE, Dehnhardt CM, Dower K, Drozda SE, Frisbie RK, Gavrin LK, Goldberg JA, Han S, Hegen M, Hepworth D, Hope HR, Kamtekar S, Kilty IC, Lee A, Lin LL, Lovering FE, Lowe MD, Mathias JP, Morgan HM, Murphy EA, Papaioannou N, Patny A, Pierce BS, Rao VR, Saiah E, Samardjiev IJ, Samas BM, Shen MWH, Shin JH, Soutter HH, Strohbach JW, Symanowicz PT, Thomason JR, Trzupek JD, Vargas R, Vincent F, Yan J, Zapf CW, Wright SW.

J Med Chem. 2017 Jul 13;60(13):5521-5542. doi: 10.1021/acs.jmedchem.7b00231. Epub 2017 Jun 14.

PMID:
28498658
9.

Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis.

Hill A, Loh PR, Bharadwaj RB, Pons P, Shang J, Guinan E, Lakhani K, Kilty I, Jelinsky SA.

Gigascience. 2017 May 1;6(5):1-10. doi: 10.1093/gigascience/gix009.

10.

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline.

John C, Soler Artigas M, Hui J, Nielsen SF, Rafaels N, Paré PD, Hansel NN, Shrine N, Kilty I, Malarstig A, Jelinsky SA, Vedel-Krogh S, Barnes K, Hall IP, Beilby J, Musk AW, Nordestgaard BG, James A, Wain LV, Tobin MD.

Thorax. 2017 May;72(5):400-408. doi: 10.1136/thoraxjnl-2016-208448. Epub 2017 Feb 7.

11.

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.

Jones P, Storer RI, Sabnis YA, Wakenhut FM, Whitlock GA, England KS, Mukaiyama T, Dehnhardt CM, Coe JW, Kortum SW, Chrencik JE, Brown DG, Jones RM, Murphy JR, Yeoh T, Morgan P, Kilty I.

J Med Chem. 2017 Jan 26;60(2):767-786. doi: 10.1021/acs.jmedchem.6b01634. Epub 2017 Jan 4.

PMID:
27983835
12.

The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.

Miller S, Henry AP, Hodge E, Kheirallah AK, Billington CK, Rimington TL, Bhaker SK, Obeidat M, Melén E, Merid SK, Swan C, Gowland C, Nelson CP, Stewart CE, Bolton CE, Kilty I, Malarstig A, Parker SG, Moffatt MF, Wardlaw AJ, Hall IP, Sayers I.

PLoS One. 2016 Oct 18;11(10):e0164041. doi: 10.1371/journal.pone.0164041. eCollection 2016.

13.

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

Bewley MA, Belchamber KB, Chana KK, Budd RC, Donaldson G, Wedzicha JA, Brightling CE, Kilty I, Donnelly LE, Barnes PJ, Singh D, Whyte MK, Dockrell DH; COPDMAP.

PLoS One. 2016 Sep 28;11(9):e0163139. doi: 10.1371/journal.pone.0163139. eCollection 2016.

14.

Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium.

Porter JD, Watson J, Roberts LR, Gill SK, Groves H, Dhariwal J, Almond MH, Wong E, Walton RP, Jones LH, Tregoning J, Kilty I, Johnston SL, Edwards MR.

J Antimicrob Chemother. 2016 Oct;71(10):2767-81. doi: 10.1093/jac/dkw222. Epub 2016 Jul 25.

15.

A novel flow cytometric-based method to measure kinase inhibition in sputum from COPD subjects.

Nicholson GC, Holloway RA, Leaker BR, Kilty I, Salganik M, Tan L, Barnes PJ, Donnelly LE.

BMJ Open Respir Res. 2016 Jun 22;3(1):e000140. doi: 10.1136/bmjresp-2016-000140. eCollection 2016.

16.

Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.

Ngkelo A, Hoffmann RF, Durham AL, Marwick JA, Brandenburg SM, de Bruin HG, Jonker MR, Rossios C, Tsitsiou E, Caramori G, Contoli M, Casolari P, Monaco F, Andò F, Speciale G, Kilty I, Chung KF, Papi A, Lindsay MA, Ten Hacken NH, van den Berge M, Timens W, Barnes PJ, van Oosterhout AJ, Adcock IM, Kirkham PA, Heijink IH.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1112-23. doi: 10.1152/ajplung.00077.2015. Epub 2015 Aug 28.

17.

Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects.

Singh D, Siew L, Christensen J, Plumb J, Clarke GW, Greenaway S, Perros-Huguet C, Clarke N, Kilty I, Tan L.

Eur J Clin Pharmacol. 2015 Oct;71(10):1175-84. doi: 10.1007/s00228-015-1920-1. Epub 2015 Aug 13.

18.

JAK-STAT pathway activation in COPD.

Yew-Booth L, Birrell MA, Lau MS, Baker K, Jones V, Kilty I, Belvisi MG.

Eur Respir J. 2015 Sep;46(3):843-5. doi: 10.1183/09031936.00228414. Epub 2015 Jun 25. No abstract available.

19.

Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells.

Fenwick PS, Macedo P, Kilty IC, Barnes PJ, Donnelly LE.

PLoS One. 2015 Jun 19;10(6):e0128757. doi: 10.1371/journal.pone.0128757. eCollection 2015.

20.

TAK1 selective inhibition: state of the art and future opportunities.

Kilty I, Jones LH.

Future Med Chem. 2015;7(1):23-33. doi: 10.4155/fmc.14.138. Review.

PMID:
25582331
21.

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

Wain LV, Sayers I, Soler Artigas M, Portelli MA, Zeggini E, Obeidat M, Sin DD, Bossé Y, Nickle D, Brandsma CA, Malarstig A, Vangjeli C, Jelinsky SA, John S, Kilty I, McKeever T, Shrine NR, Cook JP, Patel S, Spector TD, Hollox EJ, Hall IP, Tobin MD.

PLoS Genet. 2014 May 1;10(5):e1004314. doi: 10.1371/journal.pgen.1004314. eCollection 2014 May.

22.

TAK1 inhibition in the DFG-out conformation.

Kilty I, Green MP, Bell AS, Brown DG, Dodd PG, Hewson C, Hughes SJ, Phillips C, Ryckmans T, Smith RT, van Hoorn WP, Cohen P, Jones LH.

Chem Biol Drug Des. 2013 Nov;82(5):500-5. doi: 10.1111/cbdd.12169.

PMID:
23745990
23.

Cigarette smoke induced airway inflammation is independent of NF-κB signalling.

Rastrick JM, Stevenson CS, Eltom S, Grace M, Davies M, Kilty I, Evans SM, Pasparakis M, Catley MC, Lawrence T, Adcock IM, Belvisi MG, Birrell MA.

PLoS One. 2013;8(1):e54128. doi: 10.1371/journal.pone.0054128. Epub 2013 Jan 22. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/754d7b19-2dac-479b-a23c-db9fed0431be.

24.

Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.

Foster JG, Carter E, Kilty I, MacKenzie AB, Ward SG.

J Immunol. 2013 Feb 15;190(4):1551-9. doi: 10.4049/jimmunol.1201510. Epub 2013 Jan 14.

25.

Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling.

Kojonazarov B, Sydykov A, Pullamsetti SS, Luitel H, Dahal BK, Kosanovic D, Tian X, Majewski M, Baumann C, Evans S, Phillips P, Fairman D, Davie N, Wayman C, Kilty I, Weissmann N, Grimminger F, Seeger W, Ghofrani HA, Schermuly RT.

Int J Cardiol. 2013 Sep 10;167(6):2630-7. doi: 10.1016/j.ijcard.2012.06.129. Epub 2012 Jul 31.

PMID:
22854298
26.

LPS challenge in healthy subjects: an investigation of neutrophil chemotaxis mechanisms involving CXCR1 and CXCR2.

Aul R, Patel S, Summerhill S, Kilty I, Plumb J, Singh D.

Int Immunopharmacol. 2012 Jul;13(3):225-31. doi: 10.1016/j.intimp.2012.04.008. Epub 2012 May 2.

PMID:
22561413
27.

Fragment based discovery of a novel and selective PI3 kinase inhibitor.

Hughes SJ, Millan DS, Kilty IC, Lewthwaite RA, Mathias JP, O'Reilly MA, Pannifer A, Phelan A, Stühmeier F, Baldock DA, Brown DG.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6586-90. doi: 10.1016/j.bmcl.2011.07.117. Epub 2011 Aug 6.

PMID:
21925880
28.

Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.

Millan DS, Bunnage ME, Burrows JL, Butcher KJ, Dodd PG, Evans TJ, Fairman DA, Hughes SJ, Kilty IC, Lemaitre A, Lewthwaite RA, Mahnke A, Mathias JP, Philip J, Smith RT, Stefaniak MH, Yeadon M, Phillips C.

J Med Chem. 2011 Nov 24;54(22):7797-814. doi: 10.1021/jm200677b. Epub 2011 Oct 28.

PMID:
21888439
29.

Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function.

Poliska S, Csanky E, Szanto A, Szatmari I, Mesko B, Szeles L, Dezso B, Scholtz B, Podani J, Kilty I, Takacs L, Nagy L.

Respiration. 2011;81(6):499-510. doi: 10.1159/000324297. Epub 2011 Mar 23.

30.

Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study.

Penyige A, Poliska S, Csanky E, Scholtz B, Dezso B, Schmelczer I, Kilty I, Takacs L, Nagy L.

BMC Med Genet. 2010 Nov 2;11:152. doi: 10.1186/1471-2350-11-152.

31.

Improved image analysis workflow for 2-D gels enables large-scale 2-D gel-based proteomics studies--COPD biomarker discovery study.

Bandow JE, Baker JD, Berth M, Painter C, Sepulveda OJ, Clark KA, Kilty I, VanBogelen RA.

Proteomics. 2008 Aug;8(15):3030-41. doi: 10.1002/pmic.200701184.

PMID:
18618493
33.

Antioxidant therapeutic targets in COPD.

Rahman I, Kilty I.

Curr Drug Targets. 2006 Jun;7(6):707-20. Review.

PMID:
16787173
34.

Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.

Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L46-57. Epub 2006 Feb 10.

35.

Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells.

Moodie FM, Marwick JA, Anderson CS, Szulakowski P, Biswas SK, Bauter MR, Kilty I, Rahman I.

FASEB J. 2004 Dec;18(15):1897-9. Epub 2004 Sep 28.

PMID:
15456740
36.

Gene expression and immunolocalization of 15-lipoxygenase isozymes in the airway mucosa of smokers with chronic bronchitis.

Zhu J, Kilty I, Granger H, Gamble E, Qiu YS, Hattotuwa K, Elston W, Liu WL, Oliva A, Pauwels RA, Kips JC, De Rose V, Barnes N, Yeadon M, Jenkinson S, Jeffery PK.

Am J Respir Cell Mol Biol. 2002 Dec;27(6):666-77.

PMID:
12444026
37.
38.

Studies of differential gene expression in clinically derived eosinophil populations.

Kilty IC, Vickers PJ.

Clin Exp Allergy. 1999 Dec;29(12):1671-80.

PMID:
10594544
39.
40.

Isolation of a potential neural stem cell line from the internal capsule of an adult transgenic rat brain.

Kilty IC, Barraclough R, Schmidt G, Rudland PS.

J Neurochem. 1999 Nov;73(5):1859-70.

41.

Hormonal control of transcription from two mammary specific promoters in a rat mammary epithelial cell line.

Kilty IC, Rudland PS, Barraclough R.

Biochem Soc Trans. 1996 Aug;24(3):351S. No abstract available.

PMID:
8878895

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