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Items: 25


Brain and Serum Androsterone Is Elevated in Response to Stress in Rats with Mild Traumatic Brain Injury.

Servatius RJ, Marx CE, Sinha S, Avcu P, Kilts JD, Naylor JC, Pang KC.

Front Neurosci. 2016 Aug 26;10:379. doi: 10.3389/fnins.2016.00379. eCollection 2016.


An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans.

Naylor JC, Kilts JD, Strauss JL, Szabo ST, Dunn CE, Wagner HR, Hamer RM, Shampine LJ, Zanga JR, Marx CE; Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup.

J Rehabil Res Dev. 2016;53(4):499-510. doi: 10.1682/JRRD.2014.11.0294.


Neurosteroids and Traumatic Brain Injury: Translating Biomarkers to Therapeutics; Overview and Pilot Investigations in Iraq and Afghanistan Era Veterans.

Marx CE, Naylor JC, Kilts JD, Dunn CE, Tupler LA, Szabo ST, Capehart BP, Morey RA, Shampine LJ, Acheson SK.

In: Laskowitz D, Grant G, editors. Translational Research in Traumatic Brain Injury. Boca Raton (FL): CRC Press/Taylor and Francis Group; 2016. Chapter 7.


Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.

Naylor JC, Kilts JD, Szabo ST, Dunn CE, Keefe FJ, Tupler LA, Shampine LJ, Morey RA, Strauss JL, Hamer RM, Wagner HR; MIRECC Workgroup, Marx CE.

Pain Med. 2016 Jan;17(1):25-32.


A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment.

Naylor JC, Kilts JD, Bradford DW, Strauss JL, Capehart BP, Szabo ST, Smith KD, Dunn CE, Conner KM, Davidson JR, Wagner HR, Hamer RM, Marx CE.

Int Clin Psychopharmacol. 2015 May;30(3):167-74. doi: 10.1097/YIC.0000000000000061.


Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.

Youssef NA, Bradford DW, Kilts JD, Szabo ST, Naylor JC, Allen TB, Strauss JL, Hamer RM, Brancu M, Shampine LJ, Marx CE.

Crisis. 2015;36(1):46-54. doi: 10.1027/0227-5910/a000280. Erratum in: Crisis. 2016;37(1):77. Brunca, Mira [corrected to Brancu, Mira].


Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia.

Marx CE, Lee J, Subramaniam M, Rapisarda A, Bautista DC, Chan E, Kilts JD, Buchanan RW, Wai EP, Verma S, Sim K, Hariram J, Jacob R, Keefe RS, Chong SA.

Psychopharmacology (Berl). 2014 Sep;231(17):3647-62. doi: 10.1007/s00213-014-3673-4. Epub 2014 Jul 17.


Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.

Szabo ST, Kilts JD, Naylor JC, Youssef NA, Strauss JL, Morey RA, Brancu M, Hamer RM, Bradford DW; VA Mid-Atlantic MIRECC Work Group, Marx CE.

Mil Med. 2014 May;179(5):486-91. doi: 10.7205/MILMED-D-13-00337.


A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

Naylor JC, Dolber TR, Strauss JL, Kilts JD, Strauman TJ, Bradford DW, Szabo ST, Youssef NA, Connor KM, Davidson JR, Marx CE.

Psychiatry Res. 2013 Apr 30;206(2-3):318-20. doi: 10.1016/j.psychres.2012.11.008. Epub 2012 Dec 29.


An open-label pilot study of aripiprazole for male and female veterans with chronic post-traumatic stress disorder who respond suboptimally to antidepressants.

Youssef NA, Marx CE, Bradford DW, Zinn S, Hertzberg MA, Kilts JD, Naylor JC, Butterfield MI, Strauss JL.

Int Clin Psychopharmacol. 2012 Jul;27(4):191-6. doi: 10.1097/YIC.0b013e328352ef4e.


Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.

Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD.

Neuroscience. 2011 Sep 15;191:78-90. doi: 10.1016/j.neuroscience.2011.06.076. Epub 2011 Jul 1. Review.


Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.

Kilts JD, Tupler LA, Keefe FJ, Payne VM, Hamer RM, Naylor JC, Calnaido RP, Morey RA, Strauss JL, Parke G, Massing MW, Youssef NA, Shampine LJ; tVeterans Affairs Mid-Atlantic Mental Illness, Research, Education and Clinical Center Workgroup, Marx CE.

Pain Med. 2010 Oct;11(10):1469-76. doi: 10.1111/j.1526-4637.2010.00927.x. Epub 2010 Aug 23.


Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.

Naylor JC, Kilts JD, Hulette CM, Steffens DC, Blazer DG, Ervin JF, Strauss JL, Allen TB, Massing MW, Payne VM, Youssef NA, Shampine LJ, Marx CE.

Biochim Biophys Acta. 2010 Aug;1801(8):951-9. doi: 10.1016/j.bbalip.2010.05.006. Epub 2010 May 19.


Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.

Marx CE, Keefe RS, Buchanan RW, Hamer RM, Kilts JD, Bradford DW, Strauss JL, Naylor JC, Payne VM, Lieberman JA, Savitz AJ, Leimone LA, Dunn L, Porcu P, Morrow AL, Shampine LJ.

Neuropsychopharmacology. 2009 Jul;34(8):1885-903. doi: 10.1038/npp.2009.26. Epub 2009 Apr 1.


Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.

Naylor JC, Hulette CM, Steffens DC, Shampine LJ, Ervin JF, Payne VM, Massing MW, Kilts JD, Strauss JL, Calhoun PS, Calnaido RP, Blazer DG, Lieberman JA, Madison RD, Marx CE.

J Clin Endocrinol Metab. 2008 Aug;93(8):3173-8. doi: 10.1210/jc.2007-1229. Epub 2008 May 13.


Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.

Marx CE, Yuan P, Kilts JD, Madison RD, Shampine LJ, Manji HK.

Int J Neuropsychopharmacol. 2008 Jun;11(4):547-52. doi: 10.1017/S1461145708008444. Epub 2008 Feb 8.


Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.

Kilts JD, Lin SS, Lowe JE, Kwatra MM.

J Cardiovasc Pharmacol. 2007 Sep;50(3):299-303.


G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta.

Kilts JD, Grocott HP, Kwatra MM.

J Mol Cell Cardiol. 2005 Feb;38(2):267-76. Epub 2005 Jan 20.


Age increases expression and receptor-mediated activation of G alpha i in human atria.

Kilts JD, Akazawa T, El-Moalem HE, Mathew JP, Newman MF, Kwatra MM.

J Cardiovasc Pharmacol. 2003 Nov;42(5):662-70.


Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.

Kilts JD, Akazawa T, Richardson MD, Kwatra MM.

J Biol Chem. 2002 Aug 23;277(34):31257-62. Epub 2002 Jun 13.


Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.

Kilts JD, Connery HS, Arrington EG, Lewis MM, Lawler CP, Oxford GS, O'Malley KL, Todd RD, Blake BL, Nichols DE, Mailman RB.

J Pharmacol Exp Ther. 2002 Jun;301(3):1179-89.


Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.

Mottola DM, Kilts JD, Lewis MM, Connery HS, Walker QD, Jones SR, Booth RG, Hyslop DK, Piercey M, Wightman RM, Lawler CP, Nichols DE, Mailman RB.

J Pharmacol Exp Ther. 2002 Jun;301(3):1166-78.


Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).

Kilts JD, Gerhardt MA, Richardson MD, Sreeram G, Mackensen GB, Grocott HP, White WD, Davis RD, Newman MF, Reves JG, Schwinn DA, Kwatra MM.

Circ Res. 2000 Oct 13;87(8):705-9.


Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.

Doll MK, Nichols DE, Kilts JD, Prioleau C, Lawler CP, Lewis MM, Mailman RB.

J Med Chem. 1999 Mar 11;42(5):935-40.


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