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Items: 1 to 50 of 67


Comparison of the ligand-binding properties of fluorescent VEGF-A isoforms to VEGF receptor 2 in living cells and membrane preparations using NanoBRET.

Peach CJ, Kilpatrick LE, Woolard J, Hill SJ.

Br J Pharmacol. 2019 Sep;176(17):3220-3235. doi: 10.1111/bph.14755. Epub 2019 Jul 15.


Complex Formation between VEGFR2 and the β2-Adrenoceptor.

Kilpatrick LE, Alcobia DC, White CW, Peach CJ, Glenn JR, Zimmerman K, Kondrashov A, Pfleger KDG, Ohana RF, Robers MB, Wood KV, Sloan EK, Woolard J, Hill SJ.

Cell Chem Biol. 2019 Jun 20;26(6):830-841.e9. doi: 10.1016/j.chembiol.2019.02.014. Epub 2019 Apr 4.


The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation.

Yang Q, Langston JC, Tang Y, Kiani MF, Kilpatrick LE.

Int J Mol Sci. 2019 Mar 26;20(6). pii: E1498. doi: 10.3390/ijms20061498. Review.


Binding kinetics of ligands acting at GPCRs.

Sykes DA, Stoddart LA, Kilpatrick LE, Hill SJ.

Mol Cell Endocrinol. 2019 Apr 5;485:9-19. doi: 10.1016/j.mce.2019.01.018. Epub 2019 Feb 8. Review.


Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage.

Tang Y, Soroush F, Sun S, Liverani E, Langston JC, Yang Q, Kilpatrick LE, Kiani MF.

J Neuroinflammation. 2018 Nov 6;15(1):309. doi: 10.1186/s12974-018-1342-y.


Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation.

Soroush F, Tang Y, Guglielmo K, Engelmann A, Liverani E, Patel A, Langston J, Sun S, Kunapuli S, Kiani MF, Kilpatrick LE.

Shock. 2019 May;51(5):538-547. doi: 10.1097/SHK.0000000000001247.


Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells.

Peach CJ, Kilpatrick LE, Friedman-Ohana R, Zimmerman K, Robers MB, Wood KV, Woolard J, Hill SJ.

Cell Chem Biol. 2018 Oct 18;25(10):1208-1218.e5. doi: 10.1016/j.chembiol.2018.06.012. Epub 2018 Jul 26.


PKCδ inhibition as a novel medical countermeasure for radiation-induced vascular damage.

Soroush F, Tang Y, Zaidi HM, Sheffield JB, Kilpatrick LE, Kiani MF.

FASEB J. 2018 Jun 13:fj201701099. doi: 10.1096/fj.201701099. [Epub ahead of print]


Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2.

Peach CJ, Mignone VW, Arruda MA, Alcobia DC, Hill SJ, Kilpatrick LE, Woolard J.

Int J Mol Sci. 2018 Apr 23;19(4). pii: E1264. doi: 10.3390/ijms19041264. Review.


Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis.

Liverani E, Mondrinos MJ, Sun S, Kunapuli SP, Kilpatrick LE.

PLoS One. 2018 Apr 4;13(4):e0195379. doi: 10.1371/journal.pone.0195379. eCollection 2018.


Studying GPCR Pharmacology in Membrane Microdomains: Fluorescence Correlation Spectroscopy Comes of Age.

Briddon SJ, Kilpatrick LE, Hill SJ.

Trends Pharmacol Sci. 2018 Feb;39(2):158-174. doi: 10.1016/ Epub 2017 Dec 22. Review.


NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs.

Stoddart LA, Kilpatrick LE, Hill SJ.

Trends Pharmacol Sci. 2018 Feb;39(2):136-147. doi: 10.1016/ Epub 2017 Nov 10. Review.


Quantification of Total Vitamin-D-Binding Protein and the Glycosylated Isoforms by Liquid Chromatography-Isotope Dilution Mass Spectrometry.

Kilpatrick LE, Phinney KW.

J Proteome Res. 2017 Nov 3;16(11):4185-4195. doi: 10.1021/acs.jproteome.7b00560.


Selenium protein identification and profiling by mass spectrometry: A tool to assess progression of cardiomyopathy in a whale model.

Bryan CE, Bossart GD, Christopher SJ, Davis WC, Kilpatrick LE, McFee WE, O'Brien TX.

J Trace Elem Med Biol. 2017 Dec;44:40-49. doi: 10.1016/j.jtemb.2017.05.005. Epub 2017 Jun 6.


Optimizing High-Resolution Mass Spectrometry for the Identification of Low-Abundance Post-Translational Modifications of Intact Proteins.

Kilpatrick LE, Kilpatrick EL.

J Proteome Res. 2017 Sep 1;16(9):3255-3265. doi: 10.1021/acs.jproteome.7b00244. Epub 2017 Aug 8.


Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes.

Kilpatrick LE, Friedman-Ohana R, Alcobia DC, Riching K, Peach CJ, Wheal AJ, Briddon SJ, Robers MB, Zimmerman K, Machleidt T, Wood KV, Woolard J, Hill SJ.

Biochem Pharmacol. 2017 Jul 15;136:62-75. doi: 10.1016/j.bcp.2017.04.006. Epub 2017 Apr 7.


A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction.

Soroush F, Zhang T, King DJ, Tang Y, Deosarkar S, Prabhakarpandian B, Kilpatrick LE, Kiani MF.

J Leukoc Biol. 2016 Nov;100(5):1027-1035. Epub 2016 May 17.


Identification of Novel N-Glycosylation Sites at Noncanonical Protein Consensus Motifs.

Lowenthal MS, Davis KS, Formolo T, Kilpatrick LE, Phinney KW.

J Proteome Res. 2016 Jul 1;15(7):2087-101. doi: 10.1021/acs.jproteome.5b00733. Epub 2016 Jun 14.


The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors.

Kilpatrick LE, Hill SJ.

Biochem Soc Trans. 2016 Apr 15;44(2):624-9. doi: 10.1042/BST20150285. Review.


P2Y12 Receptor Modulates Sepsis-Induced Inflammation.

Liverani E, Rico MC, Tsygankov AY, Kilpatrick LE, Kunapuli SP.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):961-71. doi: 10.1161/ATVBAHA.116.307401. Epub 2016 Apr 7.


Biodistribution and Efficacy of Targeted Pulmonary Delivery of a Protein Kinase C-δ Inhibitory Peptide: Impact on Indirect Lung Injury.

Mondrinos MJ, Knight LC, Kennedy PA, Wu J, Kauffman M, Baker ST, Wolfson MR, Kilpatrick LE.

J Pharmacol Exp Ther. 2015 Oct;355(1):86-98. doi: 10.1124/jpet.115.224832. Epub 2015 Aug 4.


Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.

Stoddart LA, Kilpatrick LE, Briddon SJ, Hill SJ.

Neuropharmacology. 2015 Nov;98:48-57. doi: 10.1016/j.neuropharm.2015.04.033. Epub 2015 May 13. Review.


A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers.

Kilpatrick LE, Humphrys LJ, Holliday ND.

Mol Pharmacol. 2015 Apr;87(4):718-32. doi: 10.1124/mol.114.095356. Epub 2015 Jan 30.


Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.

Corriden R, Kilpatrick LE, Kellam B, Briddon SJ, Hill SJ.

FASEB J. 2014 Oct;28(10):4211-22. doi: 10.1096/fj.13-247270. Epub 2014 Jun 26.


Tandem mass spectral libraries of peptides in digests of individual proteins: Human Serum Albumin (HSA).

Dong Q, Yan X, Kilpatrick LE, Liang Y, Mirokhin YA, Roth JS, Rudnick PA, Stein SE.

Mol Cell Proteomics. 2014 Sep;13(9):2435-49. doi: 10.1074/mcp.O113.037135. Epub 2014 Jun 2.


The role of P2Y₁₂ receptor and activated platelets during inflammation.

Liverani E, Kilpatrick LE, Tsygankov AY, Kunapuli SP.

Curr Drug Targets. 2014;15(7):720-8. Review.


CGX1037 is a novel PKC isoform delta selective inhibitor in platelets.

Bhavanasi D, Kostyak JC, Swindle J, Kilpatrick LE, Kunapuli SP.

Platelets. 2015;26(1):2-9. doi: 10.3109/09537104.2013.868877. Epub 2014 Jan 16.


Pulmonary endothelial protein kinase C-delta (PKCδ) regulates neutrophil migration in acute lung inflammation.

Mondrinos MJ, Zhang T, Sun S, Kennedy PA, King DJ, Wolfson MR, Knight LC, Scalia R, Kilpatrick LE.

Am J Pathol. 2014 Jan;184(1):200-13. doi: 10.1016/j.ajpath.2013.09.010. Epub 2013 Nov 6.


Metabolite profiling of a NIST Standard Reference Material for human plasma (SRM 1950): GC-MS, LC-MS, NMR, and clinical laboratory analyses, libraries, and web-based resources.

Simón-Manso Y, Lowenthal MS, Kilpatrick LE, Sampson ML, Telu KH, Rudnick PA, Mallard WG, Bearden DW, Schock TB, Tchekhovskoi DV, Blonder N, Yan X, Liang Y, Zheng Y, Wallace WE, Neta P, Phinney KW, Remaley AT, Stein SE.

Anal Chem. 2013 Dec 17;85(24):11725-31. doi: 10.1021/ac402503m. Epub 2013 Dec 3.


LPS-induced systemic inflammation is more severe in P2Y12 null mice.

Liverani E, Rico MC, Yaratha L, Tsygankov AY, Kilpatrick LE, Kunapuli SP.

J Leukoc Biol. 2014 Feb;95(2):313-23. doi: 10.1189/jlb.1012518. Epub 2013 Oct 18.


What's new in Shock? July 2013.

Kilpatrick LE.

Shock. 2013 Jul;40(1):1-4. doi: 10.1097/SHK.0b013e31829cb8f6. No abstract available.


Protein kinase C and acute respiratory distress syndrome.

Mondrinos MJ, Kennedy PA, Lyons M, Deutschman CS, Kilpatrick LE.

Shock. 2013 Jun;39(6):467-79. doi: 10.1097/SHK.0b013e318294f85a. Review.


Prasugrel metabolites inhibit neutrophil functions.

Liverani E, Rico MC, Garcia AE, Kilpatrick LE, Kunapuli SP.

J Pharmacol Exp Ther. 2013 Jan;344(1):231-43. doi: 10.1124/jpet.112.195883. Epub 2012 Oct 24.


Early inflammatory markers for prediction of cholestasis in very-low-birth-weight infants.

DeMauro SB, Kilpatrick LE, Gerdes JS, Abbasi S.

Neonatology. 2012;102(3):229-34. Epub 2012 Aug 15.


Dissecting the pharmacology of G protein-coupled receptor signaling complexes using bimolecular fluorescence complementation.

Kilpatrick LE, Holliday ND.

Methods Mol Biol. 2012;897:109-38. doi: 10.1007/978-1-61779-909-9_6.


Multiple forms of selenoprotein P in a candidate human plasma standard reference material.

Ballihaut G, Kilpatrick LE, Kilpatrick EL, Davis WC.

Metallomics. 2012 Jun;4(6):533-8. doi: 10.1039/c2mt20059g. Epub 2012 May 3.


Formation of y + 10 and y + 11 ions in the collision-induced dissociation of peptide ions.

Kilpatrick LE, Neta P, Yang X, Simón-Manso Y, Liang Y, Stein SE.

J Am Soc Mass Spectrom. 2012 Apr;23(4):655-63. doi: 10.1007/s13361-011-0277-7. Epub 2011 Dec 8.


Detection, identification, and quantification of selenoproteins in a candidate human plasma standard reference material.

Ballihaut G, Kilpatrick LE, Davis WC.

Anal Chem. 2011 Nov 15;83(22):8667-74. doi: 10.1021/ac2021147. Epub 2011 Oct 18.


Broad-range bacterial polymerase chain reaction in the microbiologic diagnosis of complicated pneumonia.

Gollomp K, Rankin SC, White C, Mattei P, Harris MC, Kilpatrick LE, Sheffler-Collins S, McGowan KL, Shah SS.

J Hosp Med. 2012 Jan;7(1):8-13. doi: 10.1002/jhm.911. Epub 2011 Oct 12.


Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor.

Monaco-Shawver L, Schwartz L, Tuluc F, Guo CJ, Lai JP, Gunnam SM, Kilpatrick LE, Banerjee PP, Douglas SD, Orange JS.

J Leukoc Biol. 2011 Jan;89(1):113-25. doi: 10.1189/jlb.0410200. Epub 2010 Oct 12.


Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC).

Kilpatrick LE, Standage SW, Li H, Raj NR, Korchak HM, Wolfson MR, Deutschman CS.

J Leukoc Biol. 2011 Jan;89(1):3-10. doi: 10.1189/jlb.0510281. Epub 2010 Aug 19.


Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation.

Kilpatrick LE, Briddon SJ, Hill SJ, Holliday ND.

Br J Pharmacol. 2010 Jun;160(4):892-906. doi: 10.1111/j.1476-5381.2010.00676.x. Epub 2010 Apr 28.


Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.

Tabb DL, Vega-Montoto L, Rudnick PA, Variyath AM, Ham AJ, Bunk DM, Kilpatrick LE, Billheimer DD, Blackman RK, Cardasis HL, Carr SA, Clauser KR, Jaffe JD, Kowalski KA, Neubert TA, Regnier FE, Schilling B, Tegeler TJ, Wang M, Wang P, Whiteaker JR, Zimmerman LJ, Fisher SJ, Gibson BW, Kinsinger CR, Mesri M, Rodriguez H, Stein SE, Tempst P, Paulovich AG, Liebler DC, Spiegelman C.

J Proteome Res. 2010 Feb 5;9(2):761-76. doi: 10.1021/pr9006365.


Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.

Rudnick PA, Clauser KR, Kilpatrick LE, Tchekhovskoi DV, Neta P, Blonder N, Billheimer DD, Blackman RK, Bunk DM, Cardasis HL, Ham AJ, Jaffe JD, Kinsinger CR, Mesri M, Neubert TA, Schilling B, Tabb DL, Tegeler TJ, Vega-Montoto L, Variyath AM, Wang M, Wang P, Whiteaker JR, Zimmerman LJ, Carr SA, Fisher SJ, Gibson BW, Paulovich AG, Regnier FE, Rodriguez H, Spiegelman C, Tempst P, Liebler DC, Stein SE.

Mol Cell Proteomics. 2010 Feb;9(2):225-41. doi: 10.1074/mcp.M900223-MCP200. Epub 2009 Oct 16.


Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC.

Kilpatrick LE, Sun S, Li H, Vary TC, Korchak HM.

J Leukoc Biol. 2010 Jan;87(1):153-64. doi: 10.1189/jlb.0408230. Epub 2009 Oct 2.


Neurokinin 1 receptor isoforms and the control of innate immunity.

Tuluc F, Lai JP, Kilpatrick LE, Evans DL, Douglas SD.

Trends Immunol. 2009 Jun;30(6):271-6. doi: 10.1016/ Epub 2009 May 7. Review.


Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism.

Meshki J, Douglas SD, Lai JP, Schwartz L, Kilpatrick LE, Tuluc F.

J Biol Chem. 2009 Apr 3;284(14):9280-9. doi: 10.1074/jbc.M808825200. Epub 2009 Jan 28.


Neurokinin-1 receptor expression and function in human macrophages and brain: perspective on the role in HIV neuropathogenesis.

Douglas SD, Lai JP, Tuluc F, Schwartz L, Kilpatrick LE.

Ann N Y Acad Sci. 2008 Nov;1144:90-6. doi: 10.1196/annals.1418.007.


Changes in protein expression in Burkholderia vietnamiensis PR1 301 at pH 5 and 7 with and without nickel.

Van Nostrand JD, Arthur JM, Kilpatrick LE, Neely BA, Bertsch PM, Morris PJ.

Microbiology. 2008 Dec;154(Pt 12):3813-24. doi: 10.1099/mic.0.2008/017178-0.


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