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Items: 1 to 50 of 62

1.

SMARCA4 inactivation defines a subset of undifferentiated uterine sarcomas with rhabdoid and small cell features and germline mutation association.

Lin DI, Allen JM, Hecht JL, Killian JK, Ngo NT, Edgerly C, Severson EA, Ali SM, Erlich RL, Ramkissoon SH, Vergilio JA, Ross JS, Elvin JA.

Mod Pathol. 2019 Jun 12. doi: 10.1038/s41379-019-0303-z. [Epub ahead of print]

PMID:
31190001
2.

Genomic Features of Metastatic Testicular Sex Cord Stromal Tumors.

Necchi A, Bratslavsky G, Shapiro O, Elvin JA, Vergilio JA, Killian JK, Ngo N, Ramkissoon S, Severson E, Hemmerich AC, Ali SM, Chung JH, Reddy P, Miller VA, Schrock AB, Gay LM, Ross JS, Jacob JM.

Eur Urol Focus. 2019 May 27. pii: S2405-4569(19)30149-X. doi: 10.1016/j.euf.2019.05.012. [Epub ahead of print]

PMID:
31147264
3.

Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity.

Bodelon C, Killian JK, Sampson JN, Anderson WF, Matsuno R, Brinton LA, Lissowska J, Anglesio MS, Bowtell DDL, Doherty JA, Ramus SJ, Talhouk A, Sherman ME, Wentzensen N.

Clin Cancer Res. 2019 May 29. doi: 10.1158/1078-0432.CCR-18-3720. [Epub ahead of print]

PMID:
31142506
4.

ONCOGENE PANEL SEQUENCING ANALYSIS IDENTIFIES CANDIDATE ACTIONABLE GENES IN ADVANCED WELL-DIFFERENTIATED GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS.

Tirosh A, Killian JK, Zhu YJ, Petersen D, Walling J, Mor-Cohen R, Neychev V, Stevenson H, Keutgen XM, Patel D, Nilubol N, Meltzer P, Kebebew E.

Endocr Pract. 2019 Jun;25(6):580-588. doi: 10.4158/EP-2018-0603. Epub 2019 Mar 13.

PMID:
30865533
5.

New fusion sarcomas: histopathology and clinical significance of selected entities.

Miettinen M, Felisiak-Golabek A, Luiña Contreras A, Glod J, Kaplan RN, Killian JK, Lasota J.

Hum Pathol. 2019 Apr;86:57-65. doi: 10.1016/j.humpath.2018.12.006. Epub 2019 Jan 8.

PMID:
30633925
6.

CDC73 Germline Mutation in a Family With Mixed Epithelial and Stromal Tumors.

Vocke CD, Ricketts CJ, Ball MW, Schmidt LS, Metwalli AR, Middelton LA, Killian JK, Khan J, Meltzer PS, Simonds WF, Merino MJ, Linehan WM.

Urology. 2019 Feb;124:91-97. doi: 10.1016/j.urology.2018.11.013. Epub 2018 Nov 16.

7.

Comparative Genomic Profiling of Refractory and Metastatic Penile and Nonpenile Cutaneous Squamous Cell Carcinoma: Implications for Selection of Systemic Therapy.

Jacob JM, Ferry EK, Gay LM, Elvin JA, Vergilio JA, Ramkissoon S, Severson E, Necchi A, Killian JK, Ali SM, Schrock AB, Liu NW, Chung J, Miller VA, Stephens PJ, Welsh A, Corona RJ, Ross JS, Bratslavsky G.

J Urol. 2019 Mar;201(3):541-548. doi: 10.1016/j.juro.2018.09.056.

PMID:
30291913
8.

Genomic Characterization of Testicular Germ Cell Tumors Relapsing After Chemotherapy.

Necchi A, Bratslavsky G, Corona RJ, Chung JH, Millis SZ, Elvin JA, Vergilio JA, Suh J, Ramkissoon S, Severson E, Daniel S, Killian JK, Ali SM, Schrock AB, Reddy P, Miller VA, Welsh A, Gay LM, Ross JS.

Eur Urol Focus. 2018 Jul 16. pii: S2405-4569(18)30179-2. doi: 10.1016/j.euf.2018.07.013. [Epub ahead of print]

PMID:
30025711
9.

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution.

Peretti A, Geoghegan EM, Pastrana DV, Smola S, Feld P, Sauter M, Lohse S, Ramesh M, Lim ES, Wang D, Borgogna C, FitzGerald PC, Bliskovsky V, Starrett GJ, Law EK, Harris RS, Killian JK, Zhu J, Pineda M, Meltzer PS, Boldorini R, Gariglio M, Buck CB.

Cell Host Microbe. 2018 May 9;23(5):628-635.e7. doi: 10.1016/j.chom.2018.04.005.

10.

DNA Methylation-Based Classifier for Accurate Molecular Diagnosis of Bone Sarcomas.

Wu SP, Cooper BT, Bu F, Bowman CJ, Killian JK, Serrano J, Wang S, Jackson TM, Gorovets D, Shukla N, Meyers PA, Pisapia DJ, Gorlick R, Ladanyi M, Thomas K, Snuderl M, Karajannis MA.

JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.17.00031. Epub 2017 Oct 6.

11.

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.

Mishra P, Tang W, Putluri V, Dorsey TH, Jin F, Wang F, Zhu D, Amable L, Deng T, Zhang S, Killian JK, Wang Y, Minas TZ, Yfantis HG, Lee DH, Sreekumar A, Bustin M, Liu W, Putluri N, Ambs S.

J Clin Invest. 2018 Jan 2;128(1):323-340. doi: 10.1172/JCI93815. Epub 2017 Nov 27.

12.

Aneuploidy, TP53 mutation, and amplification of MYC correlate with increased intratumor heterogeneity and poor prognosis of breast cancer patients.

Oltmann J, Heselmeyer-Haddad K, Hernandez LS, Meyer R, Torres I, Hu Y, Doberstein N, Killian JK, Petersen D, Zhu YJ, Edelman DC, Meltzer PS, Schwartz R, Gertz EM, Schäffer AA, Auer G, Habermann JK, Ried T.

Genes Chromosomes Cancer. 2018 Apr;57(4):165-175. doi: 10.1002/gcc.22515. Epub 2018 Jan 9.

13.

Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276).

Yang Y, Vocke CD, Ricketts CJ, Wei D, Padilla-Nash HM, Lang M, Sourbier C, Killian JK, Boyle SL, Worrell R, Meltzer PS, Ried T, Merino MJ, Metwalli AR, Linehan WM.

Genes Chromosomes Cancer. 2017 Oct;56(10):719-729. doi: 10.1002/gcc.22476. Epub 2017 Jul 24.

14.

Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer.

Clarke MA, Luhn P, Gage JC, Bodelon C, Dunn ST, Walker J, Zuna R, Hewitt S, Killian JK, Yan L, Miller A, Schiffman M, Wentzensen N.

Int J Cancer. 2017 Aug 15;141(4):701-710. doi: 10.1002/ijc.30781. Epub 2017 May 26.

15.

Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.

Killian JK, Dorssers LC, Trabert B, Gillis AJ, Cook MB, Wang Y, Waterfall JJ, Stevenson H, Smith WI Jr, Noyes N, Retnakumar P, Stoop JH, Oosterhuis JW, Meltzer PS, McGlynn KA, Looijenga LH.

Genome Res. 2016 Nov;26(11):1490-1504. Epub 2016 Oct 20.

16.

Optimizing Workflows and Processing of Cytologic Samples for Comprehensive Analysis by Next-Generation Sequencing: Memorial Sloan Kettering Cancer Center Experience.

Tian SK, Killian JK, Rekhtman N, Benayed R, Middha S, Ladanyi M, Lin O, Arcila ME.

Arch Pathol Lab Med. 2016 Sep 2. [Epub ahead of print]

PMID:
27588332
17.

Molecular Subtypes of KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic.

Boikos SA, Pappo AS, Killian JK, LaQuaglia MP, Weldon CB, George S, Trent JC, von Mehren M, Wright JA, Schiffman JD, Raygada M, Pacak K, Meltzer PS, Miettinen MM, Stratakis C, Janeway KA, Helman LJ.

JAMA Oncol. 2016 Jul 1;2(7):922-8. doi: 10.1001/jamaoncol.2016.0256.

18.

Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion.

Sorber R, Teper Y, Abisoye-Ogunniyan A, Waterfall JJ, Davis S, Killian JK, Pineda M, Ray S, McCord MR, Pflicke H, Burkett SS, Meltzer PS, Rudloff U.

PLoS One. 2016 Mar 10;11(3):e0149833. doi: 10.1371/journal.pone.0149833. eCollection 2016.

19.

SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery.

Saxena N, Maio N, Crooks DR, Ricketts CJ, Yang Y, Wei MH, Fan TW, Lane AN, Sourbier C, Singh A, Killian JK, Meltzer PS, Vocke CD, Rouault TA, Linehan WM.

J Natl Cancer Inst. 2016 Jan;108(1). doi: 10.1093/jnci/djv287.

20.

Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer.

Torabi K, Miró R, Fernández-Jiménez N, Quintanilla I, Ramos L, Prat E, del Rey J, Pujol N, Killian JK, Meltzer PS, Fernández PL, Ried T, Lozano JJ, Camps J, Ponsa I.

Carcinogenesis. 2015 Oct;36(10):1103-10. doi: 10.1093/carcin/bgv115. Epub 2015 Aug 4.

21.

Characterization of genomic alterations in radiation-associated breast cancer among childhood cancer survivors, using comparative genomic hybridization (CGH) arrays.

Yang XR, Killian JK, Hammond S, Burke LS, Bennett H, Wang Y, Davis SR, Strong LC, Neglia J, Stovall M, Weathers RE, Robison LL, Bhatia S, Mabuchi K, Inskip PD, Meltzer P.

PLoS One. 2015 Mar 12;10(3):e0116078. doi: 10.1371/journal.pone.0116078. eCollection 2015.

22.

Recurrent epimutation of SDHC in gastrointestinal stromal tumors.

Killian JK, Miettinen M, Walker RL, Wang Y, Zhu YJ, Waterfall JJ, Noyes N, Retnakumar P, Yang Z, Smith WI Jr, Killian MS, Lau CC, Pineda M, Walling J, Stevenson H, Smith C, Wang Z, Lasota J, Kim SY, Boikos SA, Helman LJ, Meltzer PS.

Sci Transl Med. 2014 Dec 24;6(268):268ra177. doi: 10.1126/scitranslmed.3009961.

PMID:
25540324
23.

Mutations of epigenetic regulatory genes are common in thymic carcinomas.

Wang Y, Thomas A, Lau C, Rajan A, Zhu Y, Killian JK, Petrini I, Pham T, Morrow B, Zhong X, Meltzer PS, Giaccone G.

Sci Rep. 2014 Dec 8;4:7336. doi: 10.1038/srep07336.

24.

The role of mutation of metabolism-related genes in genomic hypermethylation.

Waterfall JJ, Killian JK, Meltzer PS.

Biochem Biophys Res Commun. 2014 Dec 5;455(1-2):16-23. doi: 10.1016/j.bbrc.2014.08.003. Epub 2014 Aug 8. Review.

PMID:
25111818
25.

Discovery and validation of methylation markers for endometrial cancer.

Wentzensen N, Bakkum-Gamez JN, Killian JK, Sampson J, Guido R, Glass A, Adams L, Luhn P, Brinton LA, Rush B, d'Ambrosio L, Gunja M, Yang HP, Garcia-Closas M, Lacey JV Jr, Lissowska J, Podratz K, Meltzer P, Shridhar V, Sherman ME.

Int J Cancer. 2014 Oct 15;135(8):1860-8. doi: 10.1002/ijc.28843. Epub 2014 Mar 31.

26.

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.

Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S.

J Clin Invest. 2014 Jan;124(1):398-412. doi: 10.1172/JCI71180. Epub 2013 Dec 9.

27.

High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.

Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ, Meltzer PS.

Nat Genet. 2014 Jan;46(1):8-10. doi: 10.1038/ng.2828. Epub 2013 Nov 17.

28.

Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST].

Kelly L, Bryan K, Kim SY, Janeway KA, Killian JK, Schildhaus HU, Miettinen M, Helman L, Meltzer PS, van de Rijn M, Debiec-Rychter M, O'Sullivan M; NIH Pediatric and Wild-Type GIST Clinic.

PLoS One. 2013 May 24;8(5):e64102. doi: 10.1371/journal.pone.0064102. Print 2013.

29.

Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.

Killian JK, Kim SY, Miettinen M, Smith C, Merino M, Tsokos M, Quezado M, Smith WI Jr, Jahromi MS, Xekouki P, Szarek E, Walker RL, Lasota J, Raffeld M, Klotzle B, Wang Z, Jones L, Zhu Y, Wang Y, Waterfall JJ, O'Sullivan MJ, Bibikova M, Pacak K, Stratakis C, Janeway KA, Schiffman JD, Fan JB, Helman L, Meltzer PS.

Cancer Discov. 2013 Jun;3(6):648-57. doi: 10.1158/2159-8290.CD-13-0092. Epub 2013 Apr 2.

30.

CD8(+) lymphocytes suppress human immunodeficiency virus 1 replication by secreting type I interferons.

Killian MS, Teque F, Walker RL, Meltzer PS, Killian JK.

J Interferon Cytokine Res. 2013 Nov;33(11):632-45. doi: 10.1089/jir.2012.0067. Epub 2013 Feb 12.

31.

Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation.

Miettinen M, Killian JK, Wang ZF, Lasota J, Lau C, Jones L, Walker R, Pineda M, Zhu YJ, Kim SY, Helman L, Meltzer P.

Am J Surg Pathol. 2013 Feb;37(2):234-40. doi: 10.1097/PAS.0b013e3182671178.

32.

G-cimp status prediction of glioblastoma samples using mRNA expression data.

Baysan M, Bozdag S, Cam MC, Kotliarova S, Ahn S, Walling J, Killian JK, Stevenson H, Meltzer P, Fine HA.

PLoS One. 2012;7(11):e47839. doi: 10.1371/journal.pone.0047839. Epub 2012 Nov 6.

33.

Molecular patterns in the evolution of serrated lesion of the colorectum.

Gaiser T, Meinhardt S, Hirsch D, Killian JK, Gaedcke J, Jo P, Ponsa I, Miró R, Rüschoff J, Seitz G, Hu Y, Camps J, Ried T.

Int J Cancer. 2013 Apr 15;132(8):1800-10. doi: 10.1002/ijc.27869. Epub 2012 Oct 17.

34.

Detection and therapeutic implications of c-Met mutations in small cell lung cancer and neuroendocrine tumors.

Voortman J, Harada T, Chang RP, Killian JK, Suuriniemi M, Smith WI, Meltzer PS, Lucchi M, Wang Y, Giaccone G.

Curr Pharm Des. 2013;19(5):833-40.

PMID:
22973954
35.

Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes.

Parker SC, Gartner J, Cardenas-Navia I, Wei X, Ozel Abaan H, Ajay SS, Hansen NF, Song L, Bhanot UK, Killian JK, Gindin Y, Walker RL, Meltzer PS, Mullikin JC, Furey TS, Crawford GE, Rosenberg SA, Samuels Y, Margulies EH.

PLoS Genet. 2012;8(8):e1002871. doi: 10.1371/journal.pgen.1002871. Epub 2012 Aug 9.

36.

DNA methylation profiling identifies global methylation differences and markers of adrenocortical tumors.

Rechache NS, Wang Y, Stevenson HS, Killian JK, Edelman DC, Merino M, Zhang L, Nilubol N, Stratakis CA, Meltzer PS, Kebebew E.

J Clin Endocrinol Metab. 2012 Jun;97(6):E1004-13. doi: 10.1210/jc.2011-3298. Epub 2012 Apr 3.

37.

Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples.

Killian JK, Walker RL, Bilke S, Chen Y, Davis S, Cornelison R, Smith WI, Meltzer PS.

Methods Mol Biol. 2012;823:107-18. doi: 10.1007/978-1-60327-216-2_8.

PMID:
22081342
38.

Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.

Qian Y, Hua E, Bisht K, Woditschka S, Skordos KW, Liewehr DJ, Steinberg SM, Brogi E, Akram MM, Killian JK, Edelman DC, Pineda M, Scurci S, Degenhardt YY, Laquerre S, Lampkin TA, Meltzer PS, Camphausen K, Steeg PS, Palmieri D.

Clin Exp Metastasis. 2011 Dec;28(8):899-908. doi: 10.1007/s10585-011-9421-9. Epub 2011 Sep 21.

PMID:
21953073
39.

A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology.

Killian JK, Bilke S, Davis S, Walker RL, Jaeger E, Killian MS, Waterfall JJ, Bibikova M, Fan JB, Smith WI Jr, Meltzer PS.

Am J Pathol. 2011 Jul;179(1):55-65. doi: 10.1016/j.ajpath.2011.03.022. Epub 2011 May 13.

40.

Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma.

Eberle FC, Rodriguez-Canales J, Wei L, Hanson JC, Killian JK, Sun HW, Adams LG, Hewitt SM, Wilson WH, Pittaluga S, Meltzer PS, Staudt LM, Emmert-Buck MR, Jaffe ES.

Haematologica. 2011 Apr;96(4):558-66. doi: 10.3324/haematol.2010.033167.

41.

Archival fine-needle aspiration cytopathology (FNAC) samples: untapped resource for clinical molecular profiling.

Killian JK, Walker RL, Suuriniemi M, Jones L, Scurci S, Singh P, Cornelison R, Harmon S, Boisvert N, Zhu J, Wang Y, Bilke S, Davis S, Giaccone G, Smith WI Jr, Meltzer PS.

J Mol Diagn. 2010 Nov;12(6):739-45. doi: 10.2353/jmoldx.2010.090238.

42.

Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.

Voortman J, Lee JH, Killian JK, Suuriniemi M, Wang Y, Lucchi M, Smith WI Jr, Meltzer P, Wang Y, Giaccone G.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13040-5. doi: 10.1073/pnas.1008132107. Epub 2010 Jul 6.

43.

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate.

Liu F, Killian JK, Yang M, Walker RL, Hong JA, Zhang M, Davis S, Zhang Y, Hussain M, Xi S, Rao M, Meltzer PA, Schrump DS.

Oncogene. 2010 Jun 24;29(25):3650-64. doi: 10.1038/onc.2010.129. Epub 2010 May 3.

44.

Immunoguided laser assisted microdissection techniques for DNA methylation analysis of archival tissue specimens.

Eberle FC, Hanson JC, Killian JK, Wei L, Ylaya K, Hewitt SM, Jaffe ES, Emmert-Buck MR, Rodriguez-Canales J.

J Mol Diagn. 2010 Jul;12(4):394-401. doi: 10.2353/jmoldx.2010.090200. Epub 2010 Apr 22.

45.

Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome.

Killian JK, Bilke S, Davis S, Walker RL, Killian MS, Jaeger EB, Chen Y, Hipp J, Pittaluga S, Raffeld M, Cornelison R, Smith WI Jr, Bibikova M, Fan JB, Emmert-Buck MR, Jaffe ES, Meltzer PS.

Cancer Res. 2009 Feb 1;69(3):758-64. doi: 10.1158/0008-5472.CAN-08-2984. Epub 2009 Jan 20.

46.

Fluorescence-based analysis of cellular protein lysate arrays using quantum dots.

Geho DH, Killian JK, Nandi A, Pastor J, Gurnani P, Rosenblatt KP.

Methods Mol Biol. 2007;374:229-37.

PMID:
17237542
47.

Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry.

Cabral ES, Auerbach A, Killian JK, Barrett TL, Cassarino DS.

Am J Dermatopathol. 2006 Dec;28(6):465-71.

PMID:
17122489
48.

Accurate diagnosis of acute graft-versus-host disease using serum proteomic pattern analysis.

Srinivasan R, Daniels J, Fusaro V, Lundqvist A, Killian JK, Geho D, Quezado M, Kleiner D, Rucker S, Espina V, Whiteley G, Liotta L, Petricoin E, Pittaluga S, Hitt B, Barrett AJ, Rosenblatt K, Childs RW.

Exp Hematol. 2006 Jun;34(6):796-801.

PMID:
16728285
49.

MRI of angiolipoma of the breast in Turner's syndrome.

Killian JK, Merino M, Bondy C, Bakalov V, Chow C.

AJR Am J Roentgenol. 2004 Dec;183(6):1843-4. No abstract available.

PMID:
15547244
50.

Serum proteomics in cancer diagnosis and management.

Rosenblatt KP, Bryant-Greenwood P, Killian JK, Mehta A, Geho D, Espina V, Petricoin EF 3rd, Liotta LA.

Annu Rev Med. 2004;55:97-112. Review.

PMID:
14746511

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