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Items: 36

1.

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways.

Clements CS, Bikkul MU, Ofosu W, Eskiw C, Tree D, Makarov E, Kill IR, Bridger JM.

Biogerontology. 2019 Jun;20(3):337-358. doi: 10.1007/s10522-019-09807-4. Epub 2019 Apr 30.

2.

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform.

Bikkul MU, Faragher RGA, Worthington G, Meinke P, Kerr ARW, Sammy A, Riyahi K, Horton D, Schirmer EC, Hubank M, Kill IR, Anderson RM, Slijepcevic P, Makarov E, Bridger JM.

Genes Chromosomes Cancer. 2019 Jun;58(6):341-356. doi: 10.1002/gcc.22711. Epub 2019 Jan 7.

3.

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.

Bikkul MU, Clements CS, Godwin LS, Goldberg MW, Kill IR, Bridger JM.

Biogerontology. 2018 Dec;19(6):579-602. doi: 10.1007/s10522-018-9758-4. Epub 2018 Jun 15.

4.

A structured environment helps to regulate nuclear architecture in breast epithelial cells.

Bridger JM, Kill IR.

Cell Cycle. 2016 May 2;15(9):1178-9. doi: 10.1080/15384101.2016.1147114. Epub 2016 Apr 14. No abstract available.

5.

Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production.

Gillespie ZE, MacKay K, Sander M, Trost B, Dawicki W, Wickramarathna A, Gordon J, Eramian M, Kill IR, Bridger JM, Kusalik A, Mitchell JA, Eskiw CH.

Nucleus. 2015;6(6):490-506. doi: 10.1080/19491034.2015.1128610.

6.

The non-random repositioning of whole chromosomes and individual gene loci in interphase nuclei and its relevance in disease, infection, aging, and cancer.

Bridger JM, Arican-Gotkas HD, Foster HA, Godwin LS, Harvey A, Kill IR, Knight M, Mehta IS, Ahmed MH.

Adv Exp Med Biol. 2014;773:263-79. doi: 10.1007/978-1-4899-8032-8_12. Review. Erratum in: Adv Exp Med Biol. 2014;773:E1.

PMID:
24563352
7.

Progeria Research Day at Brunel University.

Bridger JM, Eskiw CH, Makarov EM, Tree D, Kill IR.

Nucleus. 2011 Nov-Dec;2(6):517-22. doi: 10.4161/nucl.2.6.17605. Epub 2011 Nov 1. Review.

8.

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells.

Mehta IS, Eskiw CH, Arican HD, Kill IR, Bridger JM.

Genome Biol. 2011 Aug 12;12(8):R74. doi: 10.1186/gb-2011-12-8-r74.

9.

Progeria, the nucleolus and farnesyltransferase inhibitors.

Mehta IS, Bridger JM, Kill IR.

Biochem Soc Trans. 2010 Feb;38(Pt 1):287-91. doi: 10.1042/BST0380287.

PMID:
20074076
10.

The in vitro kinetics of senescence of Fischer 344 rat embryo fibroblasts.

Faragher RG, Kill IR.

Biogerontology. 2009 Jun;10(3):285-9. doi: 10.1007/s10522-008-9198-7. Epub 2008 Dec 30.

PMID:
19115081
11.

Towards a Drosophila model of Hutchinson-Gilford progeria syndrome.

Beard GS, Bridger JM, Kill IR, Tree DR.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1389-92. doi: 10.1042/BST0361389.

PMID:
19021561
12.

Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?

Mehta IS, Elcock LS, Amira M, Kill IR, Bridger JM.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1384-8. doi: 10.1042/BST0361384. Review.

PMID:
19021560
13.

The nuclear lamina. Both a structural framework and a platform for genome organization.

Bridger JM, Foeger N, Kill IR, Herrmann H.

FEBS J. 2007 Mar;274(6):1354-61. Review.

PMID:
17489093
14.

Alterations to nuclear architecture and genome behavior in senescent cells.

Mehta IS, Figgitt M, Clements CS, Kill IR, Bridger JM.

Ann N Y Acad Sci. 2007 Apr;1100:250-63. Review.

PMID:
17460187
15.

Primary laminopathy fibroblasts display altered genome organization and apoptosis.

Meaburn KJ, Cabuy E, Bonne G, Levy N, Morris GE, Novelli G, Kill IR, Bridger JM.

Aging Cell. 2007 Apr;6(2):139-53. Epub 2007 Feb 5.

16.

Heterogeneity of dimer excision in young and senescent human dermal fibroblasts.

Boyle J, Kill IR, Parris CN.

Aging Cell. 2005 Oct;4(5):247-55.

17.

Analysis of UV-induced damage and repair in young and senescent human dermal fibroblasts using the comet assay.

Al-Baker EA, Oshin M, Hutchison CJ, Kill IR.

Mech Ageing Dev. 2005 Jun-Jul;126(6-7):664-72. Epub 2005 Jan 26.

PMID:
15888320
18.
19.
20.

Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts.

Bridger JM, Boyle S, Kill IR, Bickmore WA.

Curr Biol. 2000 Feb 10;10(3):149-52.

22.

Association of pKi-67 with satellite DNA of the human genome in early G1 cells.

Bridger JM, Kill IR, Lichter P.

Chromosome Res. 1998 Jan;6(1):13-24.

PMID:
9510506
23.

The kinetics of senescence in retinal pigmented epithelial cells: a test for the telomere hypothesis of ageing?

Rawes V, Kipling D, Kill IR, Faragher RG.

Biochemistry (Mosc). 1997 Nov;62(11):1291-5.

PMID:
9467853
24.

Cell cycle changes in A-type lamin associations detected in human dermal fibroblasts using monoclonal antibodies.

Dyer JA, Kill IR, Pugh G, Quinlan RA, Lane EB, Hutchison CJ.

Chromosome Res. 1997 Sep;5(6):383-94.

PMID:
9364940
25.

Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells.

Thomas E, al-Baker E, Dropcova S, Denyer S, Ostad N, Lloyd A, Kill IR, Faragher RG.

Exp Cell Res. 1997 Oct 10;236(1):355-8.

PMID:
9344618
27.

S-phase phosphorylation of lamin B2.

Kill IR, Hutchison CJ.

FEBS Lett. 1995 Dec 11;377(1):26-30.

28.

Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication.

Hutchison CJ, Bridger JM, Cox LS, Kill IR.

J Cell Sci. 1994 Dec;107 ( Pt 12):3259-69. Review.

29.
30.

The gene responsible for Werner syndrome may be a cell division "counting" gene.

Faragher RG, Kill IR, Hunter JA, Pope FM, Tannock C, Shall S.

Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):12030-4.

31.

Internal lamin structures within G1 nuclei of human dermal fibroblasts.

Bridger JM, Kill IR, O'Farrell M, Hutchison CJ.

J Cell Sci. 1993 Feb;104 ( Pt 2):297-306.

32.

The timing of the formation and usage of replicase clusters in S-phase nuclei of human diploid fibroblasts.

Kill IR, Bridger JM, Campbell KH, Maldonado-Codina G, Hutchison CJ.

J Cell Sci. 1991 Dec;100 ( Pt 4):869-76.

35.

DNA replication and cell cycle control in Xenopus egg extracts.

Hutchison CJ, Brill D, Cox R, Gilbert J, Kill I, Ford CC.

J Cell Sci Suppl. 1989;12:197-212.

PMID:
2576847
36.

Liver function tests and electrophoretic pattern of serum protein in intestinal amoebiasis.

Maamoun MH, Farrag SA, Morsy TA, Goubran F, Makarem SS, Al Kill IE.

J Egypt Soc Parasitol. 1983 Dec;13(2):301-18. No abstract available.

PMID:
6663095

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