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Items: 4

1.

Toward an improved prediction of human in vivo brain penetration.

Summerfield SG, Lucas AJ, Porter RA, Jeffrey P, Gunn RN, Read KR, Stevens AJ, Metcalf AC, Osuna MC, Kilford PJ, Passchier J, Ruffo AD.

Xenobiotica. 2008 Dec;38(12):1518-35. doi: 10.1080/00498250802499459.

PMID:
18979396
2.

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

Kilford PJ, Stringer R, Sohal B, Houston JB, Galetin A.

Drug Metab Dispos. 2009 Jan;37(1):82-9. doi: 10.1124/dmd.108.023853. Epub 2008 Oct 2.

PMID:
18832476
3.

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.

Kilford PJ, Gertz M, Houston JB, Galetin A.

Drug Metab Dispos. 2008 Jul;36(7):1194-7. doi: 10.1124/dmd.108.020834. Epub 2008 Apr 14.

PMID:
18411401
4.

Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations.

Gertz M, Kilford PJ, Houston JB, Galetin A.

Drug Metab Dispos. 2008 Mar;36(3):535-42. Epub 2007 Dec 20.

PMID:
18096674

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