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Items: 1 to 50 of 86

1.

Structural and mechanistic basis of mammalian Nudt12 RNA deNADding.

Grudzien-Nogalska E, Wu Y, Jiao X, Cui H, Mateyak MK, Hart RP, Tong L, Kiledjian M.

Nat Chem Biol. 2019 Jun;15(6):575-582. doi: 10.1038/s41589-019-0293-7. Epub 2019 May 17.

PMID:
31101919
2.

Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase.

Bird JG, Basu U, Kuster D, Ramachandran A, Grudzien-Nogalska E, Towheed A, Wallace DC, Kiledjian M, Temiakov D, Patel SS, Ebright RH, Nickels BE.

Elife. 2018 Dec 12;7. pii: e42179. doi: 10.7554/eLife.42179.

3.

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs.

Mlynarska-Cieslak A, Depaix A, Grudzien-Nogalska E, Sikorski PJ, Warminski M, Kiledjian M, Jemielity J, Kowalska J.

Org Lett. 2018 Dec 7;20(23):7650-7655. doi: 10.1021/acs.orglett.8b03386. Epub 2018 Nov 27.

PMID:
30479128
4.

"NAD-capQ" detection and quantitation of NAD caps.

Grudzien-Nogalska E, Bird JG, Nickels BE, Kiledjian M.

RNA. 2018 Oct;24(10):1418-1425. doi: 10.1261/rna.067686.118. Epub 2018 Jul 25.

PMID:
30045887
5.

CapZyme-Seq Comprehensively Defines Promoter-Sequence Determinants for RNA 5' Capping with NAD<sup/>.

Vvedenskaya IO, Bird JG, Zhang Y, Zhang Y, Jiao X, Barvík I, Krásný L, Kiledjian M, Taylor DM, Ebright RH, Nickels BE.

Mol Cell. 2018 May 3;70(3):553-564.e9. doi: 10.1016/j.molcel.2018.03.014. Epub 2018 Apr 19.

6.

Eukaryotic RNA 5'-End NAD+ Capping and DeNADding.

Kiledjian M.

Trends Cell Biol. 2018 Jun;28(6):454-464. doi: 10.1016/j.tcb.2018.02.005. Epub 2018 Mar 12. Review.

7.

5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding.

Jiao X, Doamekpor SK, Bird JG, Nickels BE, Tong L, Hart RP, Kiledjian M.

Cell. 2017 Mar 9;168(6):1015-1027.e10. doi: 10.1016/j.cell.2017.02.019.

8.

Reversible methylation of m6Am in the 5' cap controls mRNA stability.

Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS, Elemento O, Debart F, Kiledjian M, Jaffrey SR.

Nature. 2017 Jan 19;541(7637):371-375. doi: 10.1038/nature21022. Epub 2016 Dec 21.

9.

New insights into decapping enzymes and selective mRNA decay.

Grudzien-Nogalska E, Kiledjian M.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1379. Epub 2016 Jul 17. Review.

10.

The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex.

Popovitchenko T, Thompson K, Viljetic B, Jiao X, Kontonyiannis DL, Kiledjian M, Hart RP, Rasin MR.

Sci Rep. 2016 Jul 7;6:28998. doi: 10.1038/srep28998.

11.

A long noncoding RNA associated with susceptibility to celiac disease.

Castellanos-Rubio A, Fernandez-Jimenez N, Kratchmarov R, Luo X, Bhagat G, Green PH, Schneider R, Kiledjian M, Bilbao JR, Ghosh S.

Science. 2016 Apr 1;352(6281):91-5. doi: 10.1126/science.aad0467.

12.

Nudt3 is an mRNA decapping enzyme that modulates cell migration.

Grudzien-Nogalska E, Jiao X, Song MG, Hart RP, Kiledjian M.

RNA. 2016 May;22(5):773-81. doi: 10.1261/rna.055699.115. Epub 2016 Mar 1.

13.

Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.

Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR.

J Neurosci. 2015 Aug 5;35(31):10911-26. doi: 10.1523/JNEUROSCI.0601-15.2015.

14.

Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.

Wang VY, Jiao X, Kiledjian M, Tong L.

Nucleic Acids Res. 2015 Jul 27;43(13):6596-606. doi: 10.1093/nar/gkv620. Epub 2015 Jun 22.

15.

DcpS is a transcript-specific modulator of RNA in mammalian cells.

Zhou M, Bail S, Plasterer HL, Rusche J, Kiledjian M.

RNA. 2015 Jul;21(7):1306-12. doi: 10.1261/rna.051573.115. Epub 2015 May 22.

16.

Twenty years of RNA and mRNA decay.

Kiledjian M.

RNA. 2015 Apr;21(4):664-6. doi: 10.1261/rna.050112.115. No abstract available.

17.

Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.

Ahmed I, Buchert R, Zhou M, Jiao X, Mittal K, Sheikh TI, Scheller U, Vasli N, Rafiq MA, Brohi MQ, Mikhailov A, Ayaz M, Bhatti A, Sticht H, Nasr T, Carter MT, Uebe S, Reis A, Ayub M, John P, Kiledjian M, Vincent JB, Jamra RA.

Hum Mol Genet. 2015 Jun 1;24(11):3172-80. doi: 10.1093/hmg/ddv069. Epub 2015 Feb 20.

18.

The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.

Tan D, Zhou M, Kiledjian M, Tong L.

Nat Struct Mol Biol. 2014 Aug;21(8):679-85. doi: 10.1038/nsmb.2857. Epub 2014 Jul 13.

19.

Structure and function of pre-mRNA 5'-end capping quality control and 3'-end processing.

Jurado AR, Tan D, Jiao X, Kiledjian M, Tong L.

Biochemistry. 2014 Apr 1;53(12):1882-98. doi: 10.1021/bi401715v. Epub 2014 Mar 20.

20.

The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models.

Gogliotti RG, Cardona H, Singh J, Bail S, Emery C, Kuntz N, Jorgensen M, Durens M, Xia B, Barlow C, Heier CR, Plasterer HL, Jacques V, Kiledjian M, Jarecki J, Rusche J, DiDonato CJ.

Hum Mol Genet. 2013 Oct 15;22(20):4084-101. doi: 10.1093/hmg/ddt258. Epub 2013 Jun 4.

21.

A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.

Jiao X, Chang JH, Kilic T, Tong L, Kiledjian M.

Mol Cell. 2013 Apr 11;50(1):104-15. doi: 10.1016/j.molcel.2013.02.017. Epub 2013 Mar 21.

22.

BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells.

Awe JP, Crespo AV, Li Y, Kiledjian M, Byrne JA.

Stem Cell Res Ther. 2013 Feb 6;4(1):15. doi: 10.1186/scrt163.

23.

Multiple Nudix family proteins possess mRNA decapping activity.

Song MG, Bail S, Kiledjian M.

RNA. 2013 Mar;19(3):390-9. doi: 10.1261/rna.037309.112. Epub 2013 Jan 25.

24.

Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity.

Chang JH, Jiao X, Chiba K, Oh C, Martin CE, Kiledjian M, Tong L.

Nat Struct Mol Biol. 2012 Oct;19(10):1011-7. doi: 10.1038/nsmb.2381. Epub 2012 Sep 9.

25.

Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast.

Sinturel F, Bréchemier-Baey D, Kiledjian M, Condon C, Bénard L.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8264-9. doi: 10.1073/pnas.1120090109. Epub 2012 May 8.

26.

Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7.

Li Y, Dai J, Song M, Fitzgerald-Bocarsly P, Kiledjian M.

Mol Cell Biol. 2012 Mar;32(6):1164-72. doi: 10.1128/MCB.06328-11. Epub 2012 Jan 17.

27.

Normal and Aberrantly Capped mRNA Decapping.

Kiledjian M, Zhou M, Jiao X.

Enzymes. 2012;31:165-80. doi: 10.1016/B978-0-12-404740-2.00008-2. Epub 2012 Sep 29.

PMID:
27166445
28.

Regulation of mRNA decapping.

Li Y, Kiledjian M.

Wiley Interdiscip Rev RNA. 2010 Sep-Oct;1(2):253-65. doi: 10.1002/wrna.15. Epub 2010 May 6. Review.

PMID:
21935889
29.

Differential utilization of decapping enzymes in mammalian mRNA decay pathways.

Li Y, Song M, Kiledjian M.

RNA. 2011 Mar;17(3):419-28. doi: 10.1261/rna.2439811. Epub 2011 Jan 11.

30.

Multiple mRNA decapping enzymes in mammalian cells.

Song MG, Li Y, Kiledjian M.

Mol Cell. 2010 Nov 12;40(3):423-32. doi: 10.1016/j.molcel.2010.10.010.

31.

Identification of a quality-control mechanism for mRNA 5'-end capping.

Jiao X, Xiang S, Oh C, Martin CE, Tong L, Kiledjian M.

Nature. 2010 Sep 30;467(7315):608-11. doi: 10.1038/nature09338. Epub 2010 Aug 29.

32.

Differential regulation of microRNA stability.

Bail S, Swerdel M, Liu H, Jiao X, Goff LA, Hart RP, Kiledjian M.

RNA. 2010 May;16(5):1032-9. doi: 10.1261/rna.1851510. Epub 2010 Mar 26.

33.

Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.

Jiao X, Chen H, Chen J, Herrup K, Firestein BL, Kiledjian M.

J Neurosci. 2009 Oct 7;29(40):12419-27. doi: 10.1523/JNEUROSCI.5954-08.2009.

34.

Tri- to be mono- for bacterial mRNA decay.

Bail S, Kiledjian M.

Structure. 2009 Mar 11;17(3):317-9. doi: 10.1016/j.str.2009.02.005.

35.

Mutational analysis of a Dcp2-binding element reveals general enhancement of decapping by 5'-end stem-loop structures.

Li Y, Ho ES, Gunderson SI, Kiledjian M.

Nucleic Acids Res. 2009 Apr;37(7):2227-37. doi: 10.1093/nar/gkp087. Epub 2009 Feb 20.

36.

RNA turnover in eukaryotes: analysis of specialized and quality control RNA decay pathways. Preface.

Maquat LE, Kiledjian M.

Methods Enzymol. 2008;449:xvii-xviii. doi: 10.1016/S0076-6879(08)02422-1. No abstract available.

PMID:
19215750
37.

Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.

Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L.

Nature. 2009 Apr 9;458(7239):784-8. doi: 10.1038/nature07731. Epub 2009 Feb 4.

38.

Analysis of mRNA decapping.

Liu SW, Jiao X, Welch S, Kiledjian M.

Methods Enzymol. 2008;448:3-21. doi: 10.1016/S0076-6879(08)02601-3.

PMID:
19111168
39.

RNA turnover in eukaryotes: nucleases, pathways and analysis of mRNA decay. Preface.

Maquat LE, Kiledjian M.

Methods Enzymol. 2008;448:xxi-xxii. doi: 10.1016/S0076-6879(08)02631-1. No abstract available.

PMID:
19111167
40.

DcpS, a general modulator of cap-binding protein-dependent processes?

Bail S, Kiledjian M.

RNA Biol. 2008 Oct-Dec;5(4):216-9. Epub 2008 Oct 9. Review.

PMID:
18948758
41.

DcpS as a therapeutic target for spinal muscular atrophy.

Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, Gurney ME.

ACS Chem Biol. 2008 Nov 21;3(11):711-22. doi: 10.1021/cb800120t.

42.

Drosophila processing bodies in oogenesis.

Lin MD, Jiao X, Grima D, Newbury SF, Kiledjian M, Chou TB.

Dev Biol. 2008 Oct 15;322(2):276-88. doi: 10.1016/j.ydbio.2008.07.033. Epub 2008 Aug 5.

43.

Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.

Liu SW, Rajagopal V, Patel SS, Kiledjian M.

J Biol Chem. 2008 Jun 13;283(24):16427-36. doi: 10.1074/jbc.M800341200. Epub 2008 Apr 25.

44.

DcpS scavenger decapping enzyme can modulate pre-mRNA splicing.

Shen V, Liu H, Liu SW, Jiao X, Kiledjian M.

RNA. 2008 Jun;14(6):1132-42. doi: 10.1261/rna.1008208. Epub 2008 Apr 21.

45.

Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein.

Li Y, Song MG, Kiledjian M.

Mol Cell Biol. 2008 Feb;28(3):939-48. Epub 2007 Nov 26.

46.

3' Terminal oligo U-tract-mediated stimulation of decapping.

Song MG, Kiledjian M.

RNA. 2007 Dec;13(12):2356-65. Epub 2007 Oct 17.

47.

An erythroid-enriched endoribonuclease (ErEN) involved in alpha-globin mRNA turnover.

Liu H, Kiledjian M.

Protein Pept Lett. 2007;14(2):131-6. Review.

PMID:
17305599
48.

A view to a kill: structure of the RNA exosome.

Shen V, Kiledjian M.

Cell. 2006 Dec 15;127(6):1093-5.

49.

Identification of an mRNA-decapping regulator implicated in X-linked mental retardation.

Jiao X, Wang Z, Kiledjian M.

Mol Cell. 2006 Dec 8;24(5):713-722. doi: 10.1016/j.molcel.2006.10.013.

50.

Decapper comes into focus.

Shen V, Kiledjian M.

Structure. 2006 Feb;14(2):171-2. No abstract available.

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