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Items: 1 to 50 of 121

1.

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.

van Delft MF, Chappaz S, Khakham Y, Bui CT, Debrincat MA, Lowes KN, Brouwer JM, Grohmann C, Sharp PP, Dagley LF, Li L, McArthur K, Luo MX, Chin HS, Fairlie WD, Lee EF, Segal D, Duflocq S, Lessene R, Bernard S, Peilleron L, Nguyen T, Miles C, Wan SS, Lane RM, Wardak A, Lackovic K, Colman PM, Sandow JJ, Webb AI, Czabotar PE, Dewson G, Watson KG, Huang DCS, Lessene G, Kile BT.

Nat Chem Biol. 2019 Nov;15(11):1057-1066. doi: 10.1038/s41589-019-0365-8. Epub 2019 Oct 7.

PMID:
31591564
2.

Shared roles for Scl and Lyl1 in murine platelet production and function.

Chiu SK, Orive SL, Moon MJ, Saw J, Ellis S, Kile BT, Huang Y, Chacon D, Pimanda JE, Beck D, Hamilton JR, Tremblay CS, Curtis DJ.

Blood. 2019 Sep 5;134(10):826-835. doi: 10.1182/blood.2019896175. Epub 2019 Jul 12.

PMID:
31300405
3.

Genomic subtyping and therapeutic targeting of acute erythroleukemia.

Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG.

Nat Genet. 2019 Apr;51(4):694-704. doi: 10.1038/s41588-019-0375-1. Epub 2019 Mar 29.

4.

Acknowledgements: the Levin/Kile rule.

Levin J, Kile BT.

Platelets. 2019;30(2):280. doi: 10.1080/09537104.2019.1565938. No abstract available.

PMID:
30880570
5.

An essential role for α4A-tubulin in platelet biogenesis.

Strassel C, Magiera MM, Dupuis A, Batzenschlager M, Hovasse A, Pleines I, Guéguen P, Eckly A, Moog S, Mallo L, Kimmerlin Q, Chappaz S, Strub JM, Kathiresan N, de la Salle H, Van Dorsselaer A, Ferec C, Py JY, Gachet C, Schaeffer-Reiss C, Kile BT, Janke C, Lanza F.

Life Sci Alliance. 2019 Feb 13;2(1). pii: e201900309. doi: 10.26508/lsa.201900309. Print 2019 Feb.

6.

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.

7.

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes.

Jiao Y, Davis JE, Rautela J, Carrington EM, Ludford-Menting MJ, Goh W, Delconte RB, Souza-Fonseca-Guimaraes F, Koldej R, Gray D, Huang D, Kile BT, Lew AM, Ritchie DS, Huntington ND.

Cell Death Differ. 2019 Aug;26(8):1516-1530. doi: 10.1038/s41418-018-0228-y. Epub 2018 Nov 12.

PMID:
30420758
8.

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease.

Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Wilcox SA, Ogura Y, Corr SC, Kanojia K, Kouremenos KA, De Souza DP, McConville MJ, Flavell RA, Gerlic M, Kile BT, Papenfuss AT, Putoczki TL, Radford-Smith GL, Masters SL.

Nat Commun. 2018 Sep 13;9(1):3728. doi: 10.1038/s41467-018-06125-0.

9.

Characterization of Tfrc-mutant mice with microcytic phenotypes.

Conway AJ, Brown FC, Rank G, Kile BT, Morton CJ, Jane SM, Curtis DJ.

Blood Adv. 2018 Aug 14;2(15):1914-1922. doi: 10.1182/bloodadvances.2018018820.

10.

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.

Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC.

Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21.

PMID:
29784641
11.

Apoptotic Caspases: Multiple or Mistaken Identities?

McArthur K, Kile BT.

Trends Cell Biol. 2018 Jun;28(6):475-493. doi: 10.1016/j.tcb.2018.02.003. Epub 2018 Mar 15. Review.

PMID:
29551258
12.

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT.

Science. 2018 Feb 23;359(6378). pii: eaao6047. doi: 10.1126/science.aao6047.

PMID:
29472455
13.

Apoptosis in megakaryocytes and platelets: the life and death of a lineage.

McArthur K, Chappaz S, Kile BT.

Blood. 2018 Feb 8;131(6):605-610. doi: 10.1182/blood-2017-11-742684. Epub 2017 Dec 19. Review.

PMID:
29259001
14.

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.

Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL.

Cell Death Differ. 2018 Mar;25(4):784-796. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11.

15.

Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice.

Lorenz V, Ramsey H, Liu ZJ, Italiano J Jr, Hoffmeister K, Bihorel S, Mager D, Hu Z, Slayton WB, Kile BT, Sola-Visner M, Ferrer-Marin F.

Thromb Haemost. 2017 Dec;117(12):2322-2333. doi: 10.1160/TH17-06-0433. Epub 2017 Dec 6.

16.

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.

Au AE, Lebois M, Sim SA, Cannon P, Corbin J, Gangatirkar P, Hyland CD, Moujalled D, Rutgersson A, Yassinson F, Kile BT, Mason KD, Ng AP, Alexander WS, Josefsson EC.

Sci Rep. 2017 Nov 2;7(1):14953. doi: 10.1038/s41598-017-15023-2.

17.

Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia.

Rabbolini DJ, Chun Y, Latimer M, Kunishima S, Fixter K, Valecha B, Tan P, Chew LP, Kile BT, Burt R, Radhakrishnan K, Bird R, Ockelford P, Gabrielli S, Chen Q, Stevenson WS, Ward CM, Morel-Kopp MC.

Platelets. 2017 Nov 1:1-8. doi: 10.1080/09537104.2017.1356920. [Epub ahead of print]

PMID:
29090586
18.

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP.

Sci Transl Med. 2017 Sep 27;9(409). pii: eaam5861. doi: 10.1126/scitranslmed.aam5861.

PMID:
28954929
19.

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.

Conway AJ, Brown FC, Fullinfaw RO, Kile BT, Jane SM, Curtis DJ.

Dis Model Mech. 2017 Aug 1;10(8):1005-1013. doi: 10.1242/dmm.029116. Epub 2017 Jun 9.

20.

Loss of Dynamin 2 GTPase function results in microcytic anaemia.

Brown FC, Collett M, Tremblay CS, Rank G, De Camilli P, Booth CJ, Bitoun M, Robinson PJ, Kile BT, Jane SM, Curtis DJ.

Br J Haematol. 2017 Aug;178(4):616-628. doi: 10.1111/bjh.14709. Epub 2017 May 3.

PMID:
28466468
21.

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

Thirant C, Ignacimouttou C, Lopez CK, Diop M, Le Mouël L, Thiollier C, Siret A, Dessen P, Aid Z, Rivière J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini P, Petit A, Raslova H, Carmichael CL, Kile BT, Soler E, Crispino JD, Wichmann C, Pflumio F, Schwaller J, Vainchenker W, Lobry C, Droin N, Bernard OA, Malinge S, Mercher T.

Cancer Cell. 2017 Mar 13;31(3):452-465. doi: 10.1016/j.ccell.2017.02.006.

22.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.

23.

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.

Viant C, Guia S, Hennessy RJ, Rautela J, Pham K, Bernat C, Goh W, Jiao Y, Delconte R, Roger M, Simon V, Souza-Fonseca-Guimaraes F, Grabow S, Belz GT, Kile BT, Strasser A, Gray D, Hodgkin PD, Beutler B, Vivier E, Ugolini S, Huntington ND.

J Exp Med. 2017 Feb;214(2):491-510. doi: 10.1084/jem.20160869. Epub 2017 Jan 5.

24.

Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling.

Lebois M, Dowling MR, Gangatirkar P, Hodgkin PD, Kile BT, Alexander WS, Josefsson EC.

J Thromb Haemost. 2016 Sep;14(9):1882-7. doi: 10.1111/jth.13397. Epub 2016 Aug 11.

25.

Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).

Delbridge AR, Chappaz S, Ritchie ME, Kile BT, Strasser A, Grabow S.

Br J Haematol. 2016 Sep;174(6):962-9. doi: 10.1111/bjh.14155. Epub 2016 May 25.

PMID:
27221652
26.

Physiological restraint of Bak by Bcl-xL is essential for cell survival.

Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD.

Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19.

27.

Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing.

Keniry A, Gearing LJ, Jansz N, Liu J, Holik AZ, Hickey PF, Kinkel SA, Moore DL, Breslin K, Chen K, Liu R, Phillips C, Pakusch M, Biben C, Sheridan JM, Kile BT, Carmichael C, Ritchie ME, Hilton DJ, Blewitt ME.

Epigenetics Chromatin. 2016 May 18;9:16. doi: 10.1186/s13072-016-0064-6. eCollection 2016.

28.

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury.

Karve IP, Zhang M, Habgood M, Frugier T, Brody KM, Sashindranath M, Ek CJ, Chappaz S, Kile BT, Wright D, Wang H, Johnston L, Daglas M, Ates RC, Medcalf RL, Taylor JM, Crack PJ.

eNeuro. 2016 Feb 18;3(1). pii: ENEURO.0128-15.2016. doi: 10.1523/ENEURO.0128-15.2016. eCollection 2016 Jan-Feb.

29.

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets.

Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS.

Blood. 2016 Apr 7;127(14):1743-51. doi: 10.1182/blood-2015-07-661371. Epub 2016 Jan 14.

30.

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.

31.

Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals.

Chirn GW, Rahman R, Sytnikova YA, Matts JA, Zeng M, Gerlach D, Yu M, Berger B, Naramura M, Kile BT, Lau NC.

PLoS Genet. 2015 Nov 20;11(11):e1005652. doi: 10.1371/journal.pgen.1005652. eCollection 2015 Nov.

32.

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model.

Brown FC, Conway AJ, Cerruti L, Collinge JE, McLean C, Wiley JS, Kile BT, Jane SM, Curtis DJ.

Blood. 2015 Dec 24;126(26):2863-70. doi: 10.1182/blood-2014-10-609362. Epub 2015 Oct 8.

PMID:
26450986
33.

Mice Haploinsufficient for Ets1 and Fli1 Display Middle Ear Abnormalities and Model Aspects of Jacobsen Syndrome.

Carpinelli MR, Kruse EA, Arhatari BD, Debrincat MA, Ogier JM, Bories JC, Kile BT, Burt RA.

Am J Pathol. 2015 Jul;185(7):1867-76. doi: 10.1016/j.ajpath.2015.03.026.

PMID:
26093983
34.

SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.

Kedzierski L, Clemens EB, Bird NL, Kile BT, Belz GT, Nicola NA, Kedzierska K, Nicholson SE.

Immunol Cell Biol. 2015 Nov;93(10):909-13. doi: 10.1038/icb.2015.55. Epub 2015 Jun 16.

PMID:
26077508
35.

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts AW, Kastner DL, Lew AM, Lyras D, Kile BT, Croker BA, Masters SL.

J Exp Med. 2015 Jun 1;212(6):927-38. doi: 10.1084/jem.20142384. Epub 2015 May 25.

36.

Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.

Schevzov G, Kee AJ, Wang B, Sequeira VB, Hook J, Coombes JD, Lucas CA, Stehn JR, Musgrove EA, Cretu A, Assoian R, Fath T, Hanoch T, Seger R, Pleines I, Kile BT, Hardeman EC, Gunning PW.

Mol Biol Cell. 2015 Jul 1;26(13):2475-90. doi: 10.1091/mbc.E14-10-1453. Epub 2015 May 13.

37.

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2979. doi: 10.1073/pnas.1507812112. Epub 2015 May 8. No abstract available.

38.

BCL-2 is dispensable for thrombopoiesis and platelet survival.

Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, Kile BT, Josefsson EC.

Cell Death Dis. 2015 Apr 16;6:e1721. doi: 10.1038/cddis.2015.97.

39.

Stressed mitochondria sound the alarm.

White MJ, Kile BT.

Immunol Cell Biol. 2015 May-Jun;93(5):427-8. doi: 10.1038/icb.2015.31. Epub 2015 Mar 10. No abstract available.

PMID:
25753269
40.

Aging platelets stimulate TPO production.

Kile BT.

Nat Med. 2015 Jan;21(1):11-2. doi: 10.1038/nm.3780. No abstract available.

PMID:
25569543
41.

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.

White MJ, McArthur K, Metcalf D, Lane RM, Cambier JC, Herold MJ, van Delft MF, Bedoui S, Lessene G, Ritchie ME, Huang DC, Kile BT.

Cell. 2014 Dec 18;159(7):1549-62. doi: 10.1016/j.cell.2014.11.036.

42.

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis.

Cottle DL, Ursino GM, Ip SC, Jones LK, Ditommaso T, Hacking DF, Mangan NE, Mellett NA, Henley KJ, Sviridov D, Nold-Petry CA, Nold MF, Meikle PJ, Kile BT, Smyth IM.

Hum Mol Genet. 2015 Jan 15;24(2):436-49. doi: 10.1093/hmg/ddu459. Epub 2014 Sep 10.

PMID:
25209981
43.

Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia.

Mitchell WB, Pinheiro MP, Boulad N, Kaplan D, Edison MN, Psaila B, Karpoff M, White MJ, Josefsson EC, Kile BT, Bussel JB.

Am J Hematol. 2014 Dec;89(12):E228-34. doi: 10.1002/ajh.23832. Epub 2014 Sep 2.

44.

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo.

Potts KS, Sargeant TJ, Markham JF, Shi W, Biben C, Josefsson EC, Whitehead LW, Rogers KL, Liakhovitskaia A, Smyth GK, Kile BT, Medvinsky A, Alexander WS, Hilton DJ, Taoudi S.

Blood. 2014 Oct 23;124(17):2725-9. doi: 10.1182/blood-2014-02-559468. Epub 2014 Jul 25.

PMID:
25079356
45.

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

EMBO Rep. 2014 Sep;15(9):982-90. doi: 10.15252/embr.201438463. Epub 2014 Jul 2.

46.

CHD7 deficiency in "Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment.

Ogier JM, Carpinelli MR, Arhatari BD, Symons RC, Kile BT, Burt RA.

PLoS One. 2014 May 19;9(5):e97559. doi: 10.1371/journal.pone.0097559. eCollection 2014.

47.

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE.

PLoS Pathog. 2014 May 8;10(5):e1004134. doi: 10.1371/journal.ppat.1004134. eCollection 2014 May.

48.

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination.

Carpinelli MR, Voss AK, Manning MG, Perera AA, Cooray AA, Kile BT, Burt RA.

Dis Model Mech. 2014 Jun;7(6):649-57. doi: 10.1242/dmm.014605. Epub 2014 Mar 28.

49.

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.

Josefsson EC, Burnett DL, Lebois M, Debrincat MA, White MJ, Henley KJ, Lane RM, Moujalled D, Preston SP, O'Reilly LA, Pellegrini M, Metcalf D, Strasser A, Kile BT.

Nat Commun. 2014 Mar 17;5:3455. doi: 10.1038/ncomms4455.

PMID:
24632563
50.

NLRP1a expression in Srebp-1a-deficient mice.

Gerlic M, Croker BA, Cengia LH, Moayeri M, Kile BT, Masters SL.

Cell Metab. 2014 Mar 4;19(3):345-6. doi: 10.1016/j.cmet.2014.02.002. No abstract available.

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