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Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy.

Williams RH, Tsunematsu T, Thomas AM, Bogyo K, Yamanaka A, Kilduff TS.

J Neurosci. 2019 Oct 18. pii: 0311-19. doi: 10.1523/JNEUROSCI.0311-19.2019. [Epub ahead of print]


REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories.

Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, Yamanaka A.

Science. 2019 Sep 20;365(6459):1308-1313. doi: 10.1126/science.aax9238.


Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques.

Goonawardena AV, Morairty SR, Orellana GA, Willoughby AR, Wallace TL, Kilduff TS.

Neurobiol Sleep Circadian Rhythms. 2018 Aug 22;6:9-23. doi: 10.1016/j.nbscr.2018.08.001. eCollection 2019 Jan.


Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques.

Goonawardena AV, Morairty SR, Dell R, Orellana GA, Hoener MC, Wallace TL, Kilduff TS.

Neuropsychopharmacology. 2019 Jul;44(8):1485-1493. doi: 10.1038/s41386-019-0386-8. Epub 2019 Apr 6.


Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.

Szabo ST, Thorpy MJ, Mayer G, Peever JH, Kilduff TS.

Sleep Med Rev. 2019 Feb;43:23-36. doi: 10.1016/j.smrv.2018.09.006. Epub 2018 Nov 8. Review.


Parallel Arousal Pathways in the Lateral Hypothalamus.

Heiss JE, Yamanaka A, Kilduff TS.

eNeuro. 2018 Aug 21;5(4). pii: ENEURO.0228-18.2018. doi: 10.1523/ENEURO.0228-18.2018. eCollection 2018 Jul-Aug.


Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis.

Williams RH, Black SW, Thomas AM, Piquet J, Cauli B, Kilduff TS.

Cereb Cortex. 2019 Mar 1;29(3):1090-1108. doi: 10.1093/cercor/bhy015.


Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine.

Schwartz MD, Palmerston JB, Lee DL, Hoener MC, Kilduff TS.

Front Pharmacol. 2018 Feb 2;9:35. doi: 10.3389/fphar.2018.00035. eCollection 2018.


Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder.

Thomas AM, Schwartz MD, Saxe MD, Kilduff TS.

Sleep. 2017 Oct 1;40(10). doi: 10.1093/sleep/zsx138.


Editorial overview: Neurobiology of sleep 2017.

Kilduff TS, Dan Y.

Curr Opin Neurobiol. 2017 Jun;44:A1-A3. doi: 10.1016/j.conb.2017.05.020. Epub 2017 Jun 10. No abstract available.


Plasticity-Related Gene Expression During Eszopiclone-Induced Sleep.

Gerashchenko D, Pasumarthi RK, Kilduff TS.

Sleep. 2017 Jul 1;40(7). doi: 10.1093/sleep/zsx098.


Cortical nNOS/NK1 Receptor Neurons are Regulated by Cholinergic Projections From the Basal Forebrain.

Williams RH, Vazquez-DeRose J, Thomas AM, Piquet J, Cauli B, Kilduff TS.

Cereb Cortex. 2018 Jun 1;28(6):1959-1979. doi: 10.1093/cercor/bhx102.


Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep-Wake Physiology.

Thomas AM, Schwartz MD, Saxe MD, Kilduff TS.

Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw026.


Mapping the Hypocretin/Orexin Neuronal System: An Unexpectedly Productive Journey.

Peyron C, Kilduff TS.

J Neurosci. 2017 Mar 1;37(9):2268-2272. doi: 10.1523/JNEUROSCI.1708-16.2016.


Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics.

Black SW, Schwartz MD, Chen TM, Hoener MC, Kilduff TS.

Biol Psychiatry. 2017 Nov 1;82(9):623-633. doi: 10.1016/j.biopsych.2016.10.012. Epub 2016 Oct 18.


Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.

Schwartz MD, Black SW, Fisher SP, Palmerston JB, Morairty SR, Hoener MC, Kilduff TS.

Neuropsychopharmacology. 2017 May;42(6):1305-1314. doi: 10.1038/npp.2016.216. Epub 2016 Sep 23.


Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep.

Schwartz MD, Nguyen AT, Warrier DR, Palmerston JB, Thomas AM, Morairty SR, Neylan TC, Kilduff TS.

eNeuro. 2016 Mar 21;3(2). pii: ENEURO.0018-16.2016. doi: 10.1523/ENEURO.0018-16.2016. eCollection 2016 Mar-Apr.


H1N1 infection of sleep/wake regions results in narcolepsy-like symptoms.

Black SW, Kilduff TS.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):476-7. doi: 10.1073/pnas.1524150113. Epub 2016 Jan 8. No abstract available.


Challenges in the development of therapeutics for narcolepsy.

Black SW, Yamanaka A, Kilduff TS.

Prog Neurobiol. 2017 May;152:89-113. doi: 10.1016/j.pneurobio.2015.12.002. Epub 2015 Dec 23. Review.


The Neurobiology of Sleep and Wakefulness.

Schwartz MD, Kilduff TS.

Psychiatr Clin North Am. 2015 Dec;38(4):615-44. doi: 10.1016/j.psc.2015.07.002. Epub 2015 Aug 28. Review.


Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease.

Fisher SP, Schwartz MD, Wurts-Black S, Thomas AM, Chen TM, Miller MA, Palmerston JB, Kilduff TS, Morairty SR.

Sleep. 2016 Feb 1;39(2):379-91. doi: 10.5665/sleep.5448.


The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.

Parks GS, Warrier DR, Dittrich L, Schwartz MD, Palmerston JB, Neylan TC, Morairty SR, Kilduff TS.

Neuropsychopharmacology. 2016 Mar;41(4):1144-55. doi: 10.1038/npp.2015.256. Epub 2015 Aug 20.


Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.


Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain.

Vazquez-DeRose J, Schwartz MD, Nguyen AT, Warrier DR, Gulati S, Mathew TK, Neylan TC, Kilduff TS.

Brain Struct Funct. 2016 Mar;221(2):923-40. doi: 10.1007/s00429-014-0946-y. Epub 2014 Nov 28.


Homeostatic sleep pressure is the primary factor for activation of cortical nNOS/NK1 neurons.

Dittrich L, Morairty SR, Warrier DR, Kilduff TS.

Neuropsychopharmacology. 2015 Feb;40(3):632-9. doi: 10.1038/npp.2014.212. Epub 2014 Aug 20.


Optogenetic manipulation of activity and temporally controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation.

Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A.

J Neurosci. 2014 May 14;34(20):6896-909. doi: 10.1523/JNEUROSCI.5344-13.2014.


Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function.

Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A.

J Neurosci. 2014 May 7;34(19):6495-509. doi: 10.1523/JNEUROSCI.0073-14.2014.


GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy.

Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS.

J Neurosci. 2014 May 7;34(19):6485-94. doi: 10.1523/JNEUROSCI.0080-14.2014.


The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats.

Morairty SR, Wilk AJ, Lincoln WU, Neylan TC, Kilduff TS.

Front Neurosci. 2014 Jan 31;8:3. doi: 10.3389/fnins.2014.00003. eCollection 2014.


A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity.

Morairty SR, Dittrich L, Pasumarthi RK, Valladao D, Heiss JE, Gerashchenko D, Kilduff TS.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20272-7. doi: 10.1073/pnas.1314762110. Epub 2013 Nov 4.


Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.

Krystal AD, Benca RM, Kilduff TS.

J Clin Psychiatry. 2013;74 Suppl 1:3-20. doi: 10.4088/JCP.13011su1c. Review. No abstract available.


Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness.

Tabuchi S, Tsunematsu T, Kilduff TS, Sugio S, Xu M, Tanaka KF, Takahashi S, Tominaga M, Yamanaka A.

Sleep. 2013 Sep 1;36(9):1391-404. doi: 10.5665/sleep.2972.


Animal care practices in experiments on biological rhythms and sleep: report of the Joint Task Force of the Society for Research on Biological Rhythms and the Sleep Research Society.

Bittman EL, Kilduff TS, Kriegsfeld LJ, Szymusiak R, Toth LA, Turek FW; Joint Task Force of the Society for Research on Biological Rhythms and the Sleep Research Society.

J Am Assoc Lab Anim Sci. 2013 Jul;52(4):437-43.


Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease.

Fisher SP, Black SW, Schwartz MD, Wilk AJ, Chen TM, Lincoln WU, Liu HW, Kilduff TS, Morairty SR.

Brain. 2013 Jul;136(Pt 7):2159-72. doi: 10.1093/brain/awt132.


Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy.

Black SW, Morairty SR, Fisher SP, Chen TM, Warrier DR, Kilduff TS.

Sleep. 2013 Mar 1;36(3):325-36. doi: 10.5665/sleep.2442.


Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.

Morairty SR, Revel FG, Malherbe P, Moreau JL, Valladao D, Wettstein JG, Kilduff TS, Borroni E.

PLoS One. 2012;7(7):e39131. doi: 10.1371/journal.pone.0039131. Epub 2012 Jul 2.


Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.

Revel FG, Moreau JL, Gainetdinov RR, Ferragud A, Velázquez-Sánchez C, Sotnikova TD, Morairty SR, Harmeier A, Groebke Zbinden K, Norcross RD, Bradaia A, Kilduff TS, Biemans B, Pouzet B, Caron MG, Canales JJ, Wallace TL, Wettstein JG, Hoener MC.

Biol Psychiatry. 2012 Dec 1;72(11):934-42. doi: 10.1016/j.biopsych.2012.05.014. Epub 2012 Jun 16.


Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species.

Dittrich L, Heiss JE, Warrier DR, Perez XA, Quik M, Kilduff TS.

Front Neural Circuits. 2012 Jun 5;6:31. doi: 10.3389/fncir.2012.00031. eCollection 2012.


A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.

Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC.

Mol Psychiatry. 2013 May;18(5):543-56. doi: 10.1038/mp.2012.57. Epub 2012 May 29.


Sleep-active neuronal nitric oxide synthase-positive cells of the cerebral cortex: a local regulator of sleep?

Wisor JP, Gerashchenko D, Kilduff TS.

Curr Top Med Chem. 2011;11(19):2483-9. Review.


Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice.

Tsunematsu T, Kilduff TS, Boyden ES, Takahashi S, Tominaga M, Yamanaka A.

J Neurosci. 2011 Jul 20;31(29):10529-39. doi: 10.1523/JNEUROSCI.0784-11.2011.


Sleep-active cells in the cerebral cortex and their role in slow-wave activity.

Gerashchenko D, Wisor JP, Kilduff TS.

Sleep Biol Rhythms. 2011 Jan;9(s1):71-77.


Neuropeptide B induces slow wave sleep in mice.

Hirashima N, Tsunematsu T, Ichiki K, Tanaka H, Kilduff TS, Yamanaka A.

Sleep. 2011 Jan 1;34(1):31-7.


Molecular and anatomical signatures of sleep deprivation in the mouse brain.

Thompson CL, Wisor JP, Lee CK, Pathak SD, Gerashchenko D, Smith KA, Fischer SR, Kuan CL, Sunkin SM, Ng LL, Lau C, Hawrylycz M, Jones AR, Kilduff TS, Lein ES.

Front Neurosci. 2010 Oct 21;4:165. doi: 10.3389/fnins.2010.00165. eCollection 2010.


Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?

Kilduff TS, Cauli B, Gerashchenko D.

Trends Neurosci. 2011 Jan;34(1):10-9. doi: 10.1016/j.tins.2010.09.005. Epub 2010 Oct 26.


Further characterization of sleep-active neuronal nitric oxide synthase neurons in the mouse brain.

Pasumarthi RK, Gerashchenko D, Kilduff TS.

Neuroscience. 2010 Aug 11;169(1):149-57. doi: 10.1016/j.neuroscience.2010.04.066. Epub 2010 May 8.


Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia.

Teegarden BR, Li H, Jayakumar H, Strah-Pleynet S, Dosa PI, Selaya SD, Kato N, Elwell KH, Davidson J, Cheng K, Saldana H, Frazer JM, Whelan K, Foster J, Espitia S, Webb RR, Beeley NR, Thomsen W, Morairty SR, Kilduff TS, Al-Shamma HA.

J Med Chem. 2010 Mar 11;53(5):1923-36. doi: 10.1021/jm9007328.


The wake-promoting effects of hypocretin-1 are attenuated in old rats.

Morairty SR, Wisor J, Silveira K, Sinko W, Kilduff TS.

Neurobiol Aging. 2011 Aug;32(8):1514-27. doi: 10.1016/j.neurobiolaging.2009.07.017. Epub 2009 Sep 24.


Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons.

Hara J, Gerashchenko D, Wisor JP, Sakurai T, Xie X, Kilduff TS.

J Neurosci. 2009 Mar 25;29(12):3705-14. doi: 10.1523/JNEUROSCI.0431-09.2009.


Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.

Matsuki T, Nomiyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami K, Kilduff TS, Bettler B, Yanagisawa M, Sakurai T.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4459-64. doi: 10.1073/pnas.0811126106. Epub 2009 Feb 25. Erratum in: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8790.

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