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Items: 31


Interleukin-33 Contributes Toward Loss of Tolerance by Promoting B-Cell-Activating Factor of the Tumor-Necrosis-Factor Family (BAFF)-Dependent Autoantibody Production.

Rose WA 2nd, Okragly AJ, Hu NN, Daniels MR, Martin AP, Koh YT, Kikly K, Benschop RJ.

Front Immunol. 2018 Dec 6;9:2871. doi: 10.3389/fimmu.2018.02871. eCollection 2018.


Protection from Psoriasis-Related Thrombosis after Inhibition of IL-23 or IL-17A.

Li Y, Golden JB, Camhi MI, Zhang X, Fritz Y, Diaconu D, Ivanco TL, Simon DI, Kikly K, McCormick TS, Wang Y, Ward NL.

J Invest Dermatol. 2018 Feb;138(2):310-315. doi: 10.1016/j.jid.2017.09.021. Epub 2017 Sep 23.


Maternal Serum B-Cell Activating Factor Levels: Candidate Early Biomarker for Hypertensive Disorders of Pregnancy.

Stohl HE, Lee RH, Manetta J, Kikly K, Korst LM, Stohl W.

Hypertension. 2017 Nov;70(5):1007-1013. doi: 10.1161/HYPERTENSIONAHA.117.09775. Epub 2017 Sep 18.


BAFF Induces Tertiary Lymphoid Structures and Positions T Cells within the Glomeruli during Lupus Nephritis.

Kang S, Fedoriw Y, Brenneman EK, Truong YK, Kikly K, Vilen BJ.

J Immunol. 2017 Apr 1;198(7):2602-2611. doi: 10.4049/jimmunol.1600281. Epub 2017 Feb 24.


Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A.

Liu L, Lu J, Allan BW, Tang Y, Tetreault J, Chow CK, Barmettler B, Nelson J, Bina H, Huang L, Wroblewski VJ, Kikly K.

J Inflamm Res. 2016 Apr 19;9:39-50. doi: 10.2147/JIR.S100940. eCollection 2016.


Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor.

Manetta J, Bina H, Ryan P, Fox N, Witcher DR, Kikly K.

J Inflamm Res. 2014 Aug 20;7:121-31. doi: 10.2147/JIR.S67751. eCollection 2014.


Interleukin-23 mediates the intestinal response to microbial β-1,3-glucan and the development of spondyloarthritis pathology in SKG mice.

Benham H, Rehaume LM, Hasnain SZ, Velasco J, Baillet AC, Ruutu M, Kikly K, Wang R, Tseng HW, Thomas GP, Brown MA, Strutton G, McGuckin MA, Thomas R.

Arthritis Rheumatol. 2014 Jul;66(7):1755-67. doi: 10.1002/art.38638.


Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis.

Czyzyk TA, Andrews JL, Coskun T, Wade MR, Hawkins ED, Lockwood JF, Varga G, Sahr AE, Chen Y, Brozinick JT, Kikly K, Statnick MA.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E282-92. doi: 10.1152/ajpendo.00228.2013. Epub 2013 May 28.


IL-23 dependent and independent stages of experimental arthritis: no clinical effect of therapeutic IL-23p19 inhibition in collagen-induced arthritis.

Cornelissen F, Asmawidjaja PS, Mus AM, Corneth O, Kikly K, Lubberts E.

PLoS One. 2013;8(2):e57553. doi: 10.1371/journal.pone.0057553. Epub 2013 Feb 28.


β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice.

Ruutu M, Thomas G, Steck R, Degli-Esposti MA, Zinkernagel MS, Alexander K, Velasco J, Strutton G, Tran A, Benham H, Rehaume L, Wilson RJ, Kikly K, Davies J, Pettit AR, Brown MA, McGuckin MA, Thomas R.

Arthritis Rheum. 2012 Jul;64(7):2211-22. doi: 10.1002/art.34423.


The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.

Kikly K, Liu L, Na S, Sedgwick JD.

Curr Opin Immunol. 2006 Dec;18(6):670-5. Epub 2006 Sep 28. Review. Erratum in: Curr Opin Immunol. 2007 Feb;19(1):111.


B7-H3 promotes acute and chronic allograft rejection.

Wang L, Fraser CC, Kikly K, Wells AD, Han R, Coyle AJ, Chen L, Hancock WW.

Eur J Immunol. 2005 Feb;35(2):428-38.


Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes.

Erickson-Miller CL, Freeman SD, Hopson CB, D'Alessio KJ, Fischer EI, Kikly KK, Abrahamson JA, Holmes SD, King AG.

Exp Hematol. 2003 May;31(5):382-8.


Role of caspases in human renal proximal tubular epithelial cell apoptosis.

Wong VY, Keller PM, Nuttall ME, Kikly K, DeWolf WE Jr, Lee D, Ali SM, Nadeau DP, Grygielko ET, Laping NJ, Brooks DP.

Eur J Pharmacol. 2001 Dec 21;433(2-3):135-40.


Potent and selective nonpeptide inhibitors of caspases 3 and 7.

Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD, Levy MA, Keller PM, DeWolf WE Jr.

J Med Chem. 2001 Jun 7;44(12):2015-26.


Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

Hartmann A, Troadec JD, Hunot S, Kikly K, Faucheux BA, Mouatt-Prigent A, Ruberg M, Agid Y, Hirsch EC.

J Neurosci. 2001 Apr 1;21(7):2247-55.


Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation.

Qin ZH, Wang Y, Kikly KK, Sapp E, Kegel KB, Aronin N, DiFiglia M.

J Biol Chem. 2001 Mar 16;276(11):8079-86. Epub 2000 Dec 1.


Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.

Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ.

Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44.


A modified metal-ion affinity chromatography procedure for the purification of histidine-tagged recombinant proteins expressed in Drosophila S2 cells.

Lehr RV, Elefante LC, Kikly KK, O'Brien SP, Kirkpatrick RB.

Protein Expr Purif. 2000 Aug;19(3):362-8.


Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils.

Kikly KK, Bochner BS, Freeman SD, Tan KB, Gallagher KT, D'alessio KJ, Holmes SD, Abrahamson JA, Erickson-Miller CL, Murdock PR, Tachimoto H, Schleimer RP, White JR.

J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1093-100.


Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, Kikly K, Winkler JD, Sung CM, Debouck C, Richardson S, Levy MA, DeWolf WE Jr, Keller PM, Tomaszek T, Head MS, Ryan MD, Haltiwanger RC, Liang PH, Janson CA, McDevitt PJ, Johanson K, Concha NO, Chan W, Abdel-Meguid SS, Badger AM, Lark MW, Nadeau DP, Suva LJ, Gowen M, Nuttall ME.

J Biol Chem. 2000 May 26;275(21):16007-14.


Apoptosis in polycystic kidney disease: involvement of caspases.

Ali SM, Wong VY, Kikly K, Fredrickson TA, Keller PM, DeWolf WE Jr, Lee D, Brooks DP.

Am J Physiol Regul Integr Comp Physiol. 2000 Mar;278(3):R763-9.


Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat.

Velier JJ, Ellison JA, Kikly KK, Spera PA, Barone FC, Feuerstein GZ.

J Neurosci. 1999 Jul 15;19(14):5932-41.


Synthesis of procaspases-3 and -7 during apoptosis in prostate cancer cells.

Bowen C, Voeller HJ, Kikly K, Gelmann EP.

Cell Death Differ. 1999 May;6(5):394-401.


Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.

Yue TL, Wang C, Romanic AM, Kikly K, Keller P, DeWolf WE Jr, Hart TK, Thomas HC, Storer B, Gu JL, Wang X, Feuerstein GZ.

J Mol Cell Cardiol. 1998 Mar;30(3):495-507.


Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice.

Erickson SL, de Sauvage FJ, Kikly K, Carver-Moore K, Pitts-Meek S, Gillett N, Sheehan KC, Schreiber RD, Goeddel DV, Moore MW.

Nature. 1994 Dec 8;372(6506):560-3.


Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog.

Cacalano G, Lee J, Kikly K, Ryan AM, Pitts-Meek S, Hultgren B, Wood WI, Moore MW.

Science. 1994 Jul 29;265(5172):682-4. Erratum in: Science 1995 Oct 20;270(5235):365.


Induction of tolerance to parental marrow grafts in F1 hybrid mice. Evidence for recognition of self-antigens.

Nowicki M, Yankelevich B, Kikly K, Dennert G.

J Immunol. 1990 Jan 1;144(1):47-52.


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