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Items: 1 to 50 of 194

1.

d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species.

Nagano T, Yamao S, Terachi A, Yarimizu H, Itoh H, Katasho R, Kawai K, Nakashima A, Iwasaki T, Kikkawa U, Kamada S.

Life Sci Alliance. 2019 Jan 18;2(1). pii: e201800045. doi: 10.26508/lsa.201800045. Print 2019 Feb.

2.

The story of PKC: A discovery marked by unexpected twists and turns.

Kikkawa U.

IUBMB Life. 2019 Jun;71(6):697-705. doi: 10.1002/iub.1963. Epub 2018 Nov 4. Review.

PMID:
30393952
3.

Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes.

Sawa R, Nishida H, Yamamoto Y, Wake I, Kai N, Kikkawa U, Okimura Y.

Growth Horm IGF Res. 2018 Oct - Dec;42-43:66-73. doi: 10.1016/j.ghir.2018.09.002. Epub 2018 Sep 23.

PMID:
30273774
4.

Proline dehydrogenase promotes senescence through the generation of reactive oxygen species.

Nagano T, Nakashima A, Onishi K, Kawai K, Awai Y, Kinugasa M, Iwasaki T, Kikkawa U, Kamada S.

J Cell Sci. 2017 Apr 15;130(8):1413-1420. doi: 10.1242/jcs.196469. Epub 2017 Mar 6.

5.

Identification of cellular senescence-specific genes by comparative transcriptomics.

Nagano T, Nakano M, Nakashima A, Onishi K, Yamao S, Enari M, Kikkawa U, Kamada S.

Sci Rep. 2016 Aug 22;6:31758. doi: 10.1038/srep31758.

6.

Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.

Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K.

Nucleic Acids Res. 2016 Oct 14;44(18):8704-8713. Epub 2016 Jun 20.

7.

The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast.

Ma N, Ma Y, Nakashima A, Kikkawa U, Furuyashiki T.

PLoS One. 2016 May 26;11(5):e0156239. doi: 10.1371/journal.pone.0156239. eCollection 2016.

8.

Versatile function of the circadian protein CIPC as a regulator of Erk activation.

Matsunaga R, Nishino T, Yokoyama A, Nakashima A, Kikkawa U, Konishi H.

Biochem Biophys Res Commun. 2016 Jan 15;469(3):377-83. doi: 10.1016/j.bbrc.2015.11.117. Epub 2015 Nov 30.

PMID:
26657846
9.

Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family.

Kawai M, Nakashima A, Kamada S, Kikkawa U.

J Biomed Sci. 2015 Jul 4;22:48. doi: 10.1186/s12929-015-0150-2.

10.
11.

Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex.

Santiago Lima AJ, Hoogeveen-Westerveld M, Nakashima A, Maat-Kievit A, van den Ouweland A, Halley D, Kikkawa U, Nellist M.

PLoS One. 2014 Apr 8;9(4):e93940. doi: 10.1371/journal.pone.0093940. eCollection 2014.

12.

Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.

Ooi EL, Chan ST, Cho NE, Wilkins C, Woodward J, Li M, Kikkawa U, Tellinghuisen T, Gale M Jr, Saito T.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1909-14. doi: 10.1073/pnas.1314268111. Epub 2014 Jan 21.

13.

Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein.

Nakano M, Nakashima A, Nagano T, Ishikawa S, Kikkawa U, Kamada S.

PLoS One. 2013 Nov 6;8(11):e80411. doi: 10.1371/journal.pone.0080411. eCollection 2013.

14.

Cyclin I is involved in the regulation of cell cycle progression.

Nagano T, Hashimoto T, Nakashima A, Hisanaga S, Kikkawa U, Kamada S.

Cell Cycle. 2013 Aug 15;12(16):2617-24. doi: 10.4161/cc.25623. Epub 2013 Jul 11.

15.

A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A.

Nakashima A, Tanimura-Ito K, Oshiro N, Eguchi S, Miyamoto T, Momonami A, Kamada S, Yonezawa K, Kikkawa U.

FEBS Lett. 2013 Sep 17;587(18):2924-9. doi: 10.1016/j.febslet.2013.07.027. Epub 2013 Jul 24.

16.

Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes.

Nakashima A, Kawanishi I, Eguchi S, Yu EH, Eguchi S, Oshiro N, Yoshino K, Kikkawa U, Yonezawa K.

J Biomed Sci. 2013 Apr 18;20:24. doi: 10.1186/1423-0127-20-24.

17.

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. 1979.

Takai Y, Kishimoto A, Kikkawa U, Mori T, Nishizuka Y.

Biochem Biophys Res Commun. 2012 Aug 31;425(3):571-7. doi: 10.1016/j.bbrc.2012.08.026. No abstract available.

PMID:
22925676
18.

Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells.

Chan SH, Kikkawa U, Matsuzaki H, Chen JH, Chang WC.

J Biomed Sci. 2012 Jul 12;19:64. doi: 10.1186/1423-0127-19-64.

19.

Preferential Fas-mediated apoptotic execution at G1 phase: the resistance of mitotic cells to the cell death.

Hashimoto T, Juso K, Nakano M, Nagano T, Kambayashi S, Nakashima A, Kikkawa U, Kamada S.

Cell Death Dis. 2012 May 24;3:e313. doi: 10.1038/cddis.2012.52.

20.

X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7.

Nagano T, Hashimoto T, Nakashima A, Kikkawa U, Kamada S.

FEBS Lett. 2012 Jun 4;586(11):1612-6. doi: 10.1016/j.febslet.2012.04.056. Epub 2012 May 11.

21.

Functional and direct interaction between the RNA binding protein HuD and active Akt1.

Fujiwara T, Fukao A, Sasano Y, Matsuzaki H, Kikkawa U, Imataka H, Inoue K, Endo S, Sonenberg N, Thoma C, Sakamoto H.

Nucleic Acids Res. 2012 Mar;40(5):1944-53. doi: 10.1093/nar/gkr979. Epub 2011 Nov 10.

22.

Contribution of caspase(s) to the cell cycle regulation at mitotic phase.

Hashimoto T, Kikkawa U, Kamada S.

PLoS One. 2011 Mar 30;6(3):e18449. doi: 10.1371/journal.pone.0018449.

23.

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N.

J Biol Chem. 2010 Jun 25;285(26):20109-16. doi: 10.1074/jbc.M110.121699. Epub 2010 Apr 28.

24.

Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells.

Oka M, Sakaguchi M, Okada T, Nagai H, Ozaki M, Yoshioka T, Inoue H, Mukaida N, Kikkawa U, Nishigori C.

Exp Dermatol. 2010 Aug;19(8):e50-5. doi: 10.1111/j.1600-0625.2009.00972.x.

25.

AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity.

Eguchi S, Oshiro N, Miyamoto T, Yoshino K, Okamoto S, Ono T, Kikkawa U, Yonezawa K.

Genes Cells. 2009 Feb;14(2):179-89. doi: 10.1111/j.1365-2443.2008.01260.x. Epub 2008 Jan 6.

26.

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.

Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, Oshiro N, Kikkawa U.

Biochem Soc Trans. 2009 Feb;37(Pt 1):223-6. doi: 10.1042/BST0370223. Review.

PMID:
19143636
27.

The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.

Nakashima A, Maruki Y, Imamura Y, Kondo C, Kawamata T, Kawanishi I, Takata H, Matsuura A, Lee KS, Kikkawa U, Ohsumi Y, Yonezawa K, Kamada Y.

PLoS One. 2008 May 21;3(5):e2223. doi: 10.1371/journal.pone.0002223.

28.

Possible involvement of caspase-7 in cell cycle progression at mitosis.

Hashimoto T, Yamauchi L, Hunter T, Kikkawa U, Kamada S.

Genes Cells. 2008 Jun;13(6):609-21. doi: 10.1111/j.1365-2443.2008.01192.x. Epub 2008 May 4.

29.

AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus.

Miyamoto T, Oshiro N, Yoshino K, Nakashima A, Eguchi S, Takahashi M, Ono Y, Kikkawa U, Yonezawa K.

J Biol Chem. 2008 Feb 15;283(7):4430-8. Epub 2007 Dec 6.

30.

Epidermal growth factor receptor phosphorylates protein kinase C {delta} at Tyr332 to form a trimeric complex with p66Shc in the H2O2-stimulated cells.

Morita M, Matsuzaki H, Yamamoto T, Fukami Y, Kikkawa U.

J Biochem. 2008 Jan;143(1):31-8. Epub 2007 Oct 23.

PMID:
17956904
31.

Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation.

Huang CC, Wang JM, Kikkawa U, Mukai H, Shen MR, Morita I, Chen BK, Chang WC.

Oncogene. 2008 Apr 10;27(17):2422-9. Epub 2007 Oct 22.

PMID:
17952113
32.

Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex.

Nakashima A, Yoshino K, Miyamoto T, Eguchi S, Oshiro N, Kikkawa U, Yonezawa K.

Biochem Biophys Res Commun. 2007 Sep 14;361(1):218-23. Epub 2007 Jul 16.

PMID:
17658474
34.

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.

Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K.

J Biol Chem. 2007 Jul 13;282(28):20329-39. Epub 2007 May 21.

35.

Biochemical assays for multiple activation states of protein kinase C.

Yamamoto T, Matsuzaki H, Kamada S, Ono Y, Kikkawa U.

Nat Protoc. 2006;1(6):2791-5.

PMID:
17406536
36.

PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells.

Chen BK, Huang CC, Chang WC, Chen YJ, Kikkawa U, Nakahama K, Morita I, Chang WC.

Mol Biol Cell. 2007 Mar;18(3):1118-27. Epub 2007 Jan 10.

37.
38.

Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin.

Ohji G, Hidayat S, Nakashima A, Tokunaga C, Oshiro N, Yoshino K, Yokono K, Kikkawa U, Yonezawa K.

J Biochem. 2006 Jan;139(1):129-35.

PMID:
16428328
39.

The complex formation of PKCdelta through its C1- and C2-like regions in H2O2-stimulated cells.

Umada-Kajimoto S, Yamamoto T, Matsuzaki H, Kikkawa U.

Biochem Biophys Res Commun. 2006 Mar 3;341(1):101-7. Epub 2006 Jan 6.

PMID:
16412390
40.

Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus.

Matsubara T, Shirai Y, Miyasaka K, Murakami T, Yamaguchi Y, Ueyama T, Kai M, Sakane F, Kanoh H, Hashimoto T, Kamada S, Kikkawa U, Saito N.

J Biol Chem. 2006 Mar 10;281(10):6152-64. Epub 2005 Dec 30.

41.
43.

Protein kinase C in melanoma.

Oka M, Kikkawa U.

Cancer Metastasis Rev. 2005 Jun;24(2):287-300. Review.

PMID:
15986138
44.

Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s).

Kamada S, Kikkawa U, Tsujimoto Y, Hunter T.

J Biol Chem. 2005 Jan 14;280(2):857-60. Epub 2004 Nov 29.

45.

Distinct activation mechanisms of protein kinase B by growth-factor stimulation and heat-shock treatment.

Matsuzaki H, Yamamoto T, Kikkawa U.

Biochemistry. 2004 Apr 13;43(14):4284-93.

PMID:
15065872
46.

Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex.

Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U, Saito N.

J Biol Chem. 2004 Mar 26;279(13):12668-76. Epub 2004 Jan 10.

47.

PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activity.

Oka M, Okada T, Nakamura S, Ohba M, Kuroki T, Kikkawa U, Nagai H, Ichihashi M, Nishigori C.

FEBS Lett. 2003 Nov 6;554(1-2):179-83.

48.

Tyrosine phosphorylation of protein kinase C.

Yamamoto T, Yamauchi E, Taniguchi H, Matsuzaki H, Kikkawa U.

Methods Mol Biol. 2003;233:207-16. No abstract available.

PMID:
12840509
49.

Early studies of protein kinase C: a historical perspective.

Nishizuka Y, Kikkawa U.

Methods Mol Biol. 2003;233:9-18. No abstract available.

PMID:
12840494
50.

Protein kinase C delta (PKC delta): activation mechanisms and functions.

Kikkawa U, Matsuzaki H, Yamamoto T.

J Biochem. 2002 Dec;132(6):831-9. Review.

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